Arsenite exposure altered the expression of NMDA receptor and postsynaptic signaling proteins in rat hippocampus

Toxicology Letters

Volumn 211, Issue 1, 2012, Pages 39-44

  Luo, Jiao Hua ^a   Qiu, Zhi Qun ^a   Zhang, Liang ^a   Shu, Wei Qun ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Arsenite; CaMKII; ERK; Neurotoxicity; NMDA receptor; PSD 95; SynGAP

Indexed keywords

ARSENIC TRIOXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; POSTSYNAPTIC DENSITY PROTEIN 95; RAS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ARSENITES; BLOTTING, WESTERN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; GTPASE-ACTIVATING PROTEINS; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

RATTUS;

EID: 84859073124     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.02.021     Document Type: Article

References (55)

1. Bayer K.U., De Koninck P., Leonard A.S., Hell J.W., Schulman H. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 2001, 411:801-805.
2. Béïque J.C., Andrade R. PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex. J. Physiol. (Lond.) 2003, 546:859-867.
3. Blum S., Moore A.N., Adams F., Dash P.K. A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J. Neurosci. 1999, 19:3535-3544.
4. Calderon J., Navarro M.E., Jimenez-Capdeville M.E., Santos-Diaz M.A., Golden A., Rodriguez-Leyva I., Borja-Aburto V., Diaz-Barriga F. Exposure to arsenic and lead and neuropsychological development in Mexican children. Environ. Res. 2001, 85:69-76.
5. Chen H.J., Rojas-Soto M., Oguni A., Kennedy M.B. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 1998, 20:895-904.
6. Chen X.B., Nelson C.D., Li X., Winters C.A., Azzam R., Sousa A.A., Leapman R.D., Gainer H., Sheng M., Reese T.S. PSD-95 is required to sustain the molecular organization of the postsynaptic density. J. Neurosci. 2011, 31(17):6329-6338.
7. Cull-Candy S.G., Brickley S.G. NMDA Receptors. Encyclopedia of Life Sciences 2001, Nature Publishing Group, pp. 1-8.
8. Currier J.M., Svoboda M., Matoušek T., Dědina J., Stýblo M. Direct analysis and stability of methylated trivalent arsenic metabolites in cells and tissues. Metallomics 2011, 3(12):1347-1354.
9. Davis S., Laroche S. Mitogen-activated protein kinase, extracellular regulated kinase signaling and memory stabilization, a review. Genes Brain Behav. 2006, 5(Suppl. 2):61-72.
10. Duker A.A., Carranza E.J.M., Hale M. Arsenic geochemistry and health. Environ. Int. 2005, 31:631-641.
11. Ehrlich I., Klein M., Rumpel S., Malinow R. PSD-95 is required for activity-driven synapse stabilization. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:4176-4181.
12. Griffith L.C. Calcium/calmodulin-dependent protein kinase II: an unforgettable kinase. J. Neurosci. 2004, 24(39):8391-8393.
13. Guilarte T.R., McGlothan J.L. Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure. Brain Res. 1998, 790:98-107.
14. Hardingham N., Glazewski S., Pakhotin P., Mizuno K., Chapman P.F., Giese K.P., Fox K. Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin dependent protein kinase II autophosphorylation. J. Neurosci. 2003, 23:4428-4436.
15. Jin Y.P., Xi S.H., Li X., Lu C.W., Li G.X., Xu Y.Y., Qu C.Q., Niu Y.H., Sun G.F. Arsenic speciation transported through the placenta from mother mice to their newborn pups. Environ. Res. 2006, 101:349-355.
16. Jomova K., Valko M. Advances in metal-induced oxidative stress and human disease?. Toxicology 2011, 283(2-3):65-87.
17. Kennedy M.B. Signal-processing machines at the postsynaptic density. Science 2000, 290:750-754.
18. Kim J.H., Liao D., Lau L.F., Huganir R.L. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 1998, 20(4):683-691.
19. Kruger K., Binding N., Straub H., Mußhoff U. Effects of arsenite on long-term potentiation in hippocampal slices from young and adult rats. Toxicol. Lett. 2006, 165:167-173.
20. Lisman J., Schulman H., Cline H. The molecular basis of CaMKII function in synaptic and behavioral memory. Nat. Rev. Neurosci. 2002, 3:175-190.
21. Liu L.D., Wong T.P., Pozza M.F., Lingenhoehl K., Wang Y.S., Sheng M.G., Auberson Y.P., Wang Y.T. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 2004, 304:1021-1024.
22. Luo J.H., Qiu Z.Q., Shu W.Q., Zhang Y.Y., Zhang L., Chen J.A. Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats. Toxicol. Lett. 2009, 184(2):121-125.
23. Martinez-Finley E.J., Kolb B.L., Bell A., Savage D.D., Allan A.M. Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring. Neurotoxicology 2008, 29:647-655.
24. Martinez-Finley E.J., Ali A.M.S., Allan A.M. Learning deficits in C57BL/6J mice following perinatal arsenic exposure: consequence of lower corticosterone receptor levels?. Pharmacol. Biochem. Behav. 2009, 94:271-277.
25. Martinez-Finley E.J., Goggin S.L., Labrecque M.T., Allan A.M. Reduced expression of MAPK/ERK genes in perinatal arsenic-exposed offspring induced by glucocorticoid receptor deficits. Neurotoxicol. Teratol. 2011, 33:530-537.
26. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Meth. 1984, 11:47-60.
27. Moyano S., Frechilla D., Del Río J. NMDA receptor subunit and CaMKII changes in rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment. Psychopharmacology 2004, 173:337-345.
28. 2+ induced deficits of LTP and spatial learning. Neuroscience 2000, 99:233-242.
29. Nihei M.K., Guilarte T.R. NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb during development. Mol. Brain Res. 1999, 66:42-49.
30. Paoletti P., Neyton J. NMDA receptor subunits: function and pharmacology. Curr. Opin. Pharmacol. 2007, 7:39-47.
31. Papadia S., Hardingham G.E. The dichotomy of NMDA receptor signaling. Neuroscientist 2007, 13(6):572-579.
32. Proctor D.T., Coulson E.J., Dodd P.R. Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology. J. Alzheimers Dis. 2010, 21:795-811.
33. Ratnaike R.N. Acute and chronic arsenic toxicity. Postgrad. Med. J. 2003, 79:391-396.
34. Rodriguez V.M., Carrizales L., Jimenez-Capdeville M.E., Dufour L., Giordano M. The effects of sodium arsenite exposure on behavioral parameters in the rat. Brain Res. Bull. 2001, 55:301-308.
35. Rodriguez V.M., Carrizales L., Mendoza M.S., Fajardo O.R., Giordano M. Effects of sodium arsenite exposure on development and behavior in the rat. Neurotoxicol. Teratol. 2002, 24:743-750.
36. Rongo C. A fresh look at the role of CaMKII. Bioessays 2002, 24(3):223-233.
37. Rosado J.L., Ronquillo D., Kordas K., Rojas O., Alatorre J., Lopez P., Garcia-Vargas G., Caamaño M.D.C., Cebrián M.E., Stoltzfus R.J. Arsenic exposure and cognitive performance in Mexican schoolchildren. Environ. Health Perspect. 2007, 115:1371-1375.
38. Rumbaugh G., Adams J.P., Kim J.H., Huganir R.L. SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Proc. Natl. Acad. Sci. U.S.A. 2006, 103(12):4344-4351.
39. Schaeffer H.J., Weber M.J. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell Biol. 1999, 19:2435-2444.
40. Selcher J.C., Atkins C.M., Trzaskos J.M., Paylor R., Sweatt J.D. A necessity for MAP kinase activation in mammalian spatial learning. Learn Mem. 1999, 6:478-490.
41. Sheng M., Kim M.J. Postsynaptic signaling and plasticity mechanisms. Science 2002, 298:776-780.
42. Smith A.H., Marshall G., Yuan Y., Liaw J., Ferreccio C., Steinmaus C. Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis. Am. J. Epidemiol. 2011, 173:414-420.
43. Stein V., House D.R., Bredt D.S., Nicoll R.A. Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. J. Neurosci. 2003, 23:5503-5506.
44. Sweatt J.D. Mitogen-activated protein kinases in synaptic plasticity and memory. Curr. Opin. Neurobiol. 2004, 14:311-317.
45. 2+-exposed rats. Brain Res. 2005, 1044:51-58.
46. Tsai S.Y., Chou H.Y., The H.W., Chen C.M., Chen C.J. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 2003, 24:747-753.
47. von Ehrenstein O.S., Poddar S., Yuan Y., Mazumder D.G., Eskenazi B., Basu A., Hira-Smith M., Ghosh N., Lahiri S., Haque R., Ghosh A., Kalman D., Das S., Smith A.H. Children's intellectual function in relation to arsenic exposure. Epidemiology 2007, 18:44-51.
48. Wang S.X., Wang Z.H., Cheng X.T., Li J., Sang Z.P., Zhang X.D., Han L.L., Qiao X.Y., Wu Z.M., Wang Z.Q. Arsenic and fluoride exposure in drinking water: children's IQ and growth in Shanyin county, Shanxi Province, China. Environ. Health Perspect. 2007, 115:643-647.
49. Wang X., Meng D., Chang Q.S., Pan J.J., Zhang Z., Chen G., Ke Z.J., Luo J., Shi X.L. Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway. Environ. Health Perspect. 2010, 118:627-634.
50. Wasserman G.A., Liu X.H., Parvez F., Ahsan H., Factor-Litvak P., van Geen A., Slavkovich V., LoIacono N.J., Cheng Z.Q., Hussain I., Momotaj H., Graziano J.H. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ. Health Perspect. 2004, 112:1329-1333.
51. Wasserman G.A., Liu X.H., Parvez F., Ahsan H., Factor-Litvak P., Kline J., van Geen A., Slavkovich V., LoIacono N.J., Levy D., Cheng Z.Q., Graziano J.H. Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh. Environ. Health Perspect. 2007, 115:285-289.
52. Xu W., Schlüter O.M., Steiner P., Czervionke B.L., Sabatini B., Malenka R.C. Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron 2008, 57:248-262.
53. Xu W.F. PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity. Curr. Opin. Neurobiol. 2011, 21:306-312.
54. Yan W.S., Zhang Y.H., Zhang J., Liu S., Cho S.J., Chen X.B. Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. J. Biol. Chem. 2011, 286:17478-17486.
55. Zhang X.Y., Liu A.P., Ruan D.Y., Liu J. Effect of developmental lead exposure on the expression of specific NMDA receptor subunit mRNAs in the hippocampus of neonatal rats by digoxigenin-labeled in situ hybridization histochemistry. Neurotoxicol. Teratol. 2002, 24:149-160.