Negative feedback mechanisms surpass the effect of intrinsic EGFR activation during skin chemical carcinogenesis

American Journal of Pathology

Volumn 180, Issue 4, 2012, Pages 1378-1385

  Dahlhoff, Maik ^a   Rose, Christian ^b   De Angelis, Martin Hrabé ^c,d   Wolf, Eckhard ^a   Schneider, Marlon R ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PERILIPIN; SCATTER FACTOR; TUBULIN;

ADENOMA; ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; EAR; ENDOCYTOSIS; FEMALE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; IN VIVO STUDY; LIVER CELL; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SEBACEOUS GLAND; SEBACEOUS GLAND ADENOMA; SKIN CARCINOGENESIS; TUMOR GROWTH;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADENOMA; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; EAR NEOPLASMS; FEEDBACK, PHYSIOLOGICAL; FEMALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEOPLASM PROTEINS; POINT MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SKIN NEOPLASMS;

EID: 84859068481     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.12.017     Document Type: Article

References (29)

1. Y. Yarden, M.X. Sliwkowski Untangling the ErbB signalling network Nat Rev Mol Cell Biol 2 2001 127 137
2. T. Holbro, N.E. Hynes ErbB receptors: directing key signaling networks throughout life Annu Rev Pharmacol Toxicol 44 2004 195 217
3. A. Citri, Y. Yarden EGF-ERBB signalling: towards the systems level Nat Rev Mol Cell Biol 7 2006 505 516
4. Y. Yarden, B.Z. Shilo SnapShot: EGFR signaling pathway Cell 131 2007 1018
5. N. Gotoh Feedback inhibitors of the epidermal growth factor receptor signaling pathways Int J Biochem Cell Biol 41 2009 511 515
6. R. Avraham, Y. Yarden Feedback regulation of EGFR signalling: decision making by early and delayed loops Nat Rev Mol Cell Biol 12 2011 104 117
7. T.F. Cloughesy, K. Yoshimoto, P. Nghiemphu, K. Brown, J. Dang, S. Zhu, T. Hsueh, Y. Chen, W. Wang, D. Youngkin, L. Liau, N. Martin, D. Becker, M. Bergsneider, A. Lai, R. Green, T. Oglesby, M. Koleto, J. Trent, S. Horvath, P.S. Mischel, I.K. Mellinghoff, C.L. Sawyers Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma PLoS Med 5 2008 e8
8. K. Shtiegman, B.S. Kochupurakkal, Y. Zwang, G. Pines, A. Starr, A. Vexler, A. Citri, M. Katz, S. Lavi, Y. Ben Basat, S. Benjamin, S. Corso, J. Gan, R.B. Yosef, S. Giordano, Y. Yarden Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling Oncogene 26 2007 6968 6978
9. M.R. Schneider, S. Werner, R. Paus, E. Wolf Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology Am J Pathol 173 2008 14 24
10. K.R. Fitch, K.A. McGowan, C.D. van Raamsdonk, H. Fuchs, D. Lee, A. Puech, Y. Herault, D.W. Threadgill, d.A. Hrabe, G.S. Barsh Genetics of dark skin in mice Genes Dev 17 2003 214 228
11. R. Vassar, E. Fuchs Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation Genes Dev 5 1991 714 727
12. A.M. Dominey, X.J. Wang, L.E. King Jr, L.B. Nanney, T.A. Gagne, K. Sellheyer, D.S. Bundman, M.A. Longley, J.A. Rothnagel, D.A. Greenhalgh, D.R. Roop Targeted overexpression of transforming growth factor α in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas Cell Growth Differ 4 1993 1071 1082
13. P.W. Cook, M. Piepkorn, C.H. Clegg, G.D. Plowman, J.M. DeMay, J.R. Brown, M.R. Pittelkow Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype J Clin Invest 100 1997 2286 2294
14. P.W. Cook, J.R. Brown, K.A. Cornell, M.R. Pittelkow Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis Exp Dermatol 13 2004 347 356
15. M. Dahlhoff, A.K. Muller, E. Wolf, S. Werner, M.R. Schneider Epigen transgenic mice develop enlarged sebaceous glands J Invest Dermatol 130 2010 623 626
16. S.H. Yuspa, M.C. Poirier Chemical carcinogenesis: from animal models to molecular models in one decade Adv Cancer Res 50 1988 25 70
17. E.L. Abel, J.M. Angel, K. Kiguchi, J. Digiovanni Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications Nat Protoc 4 2009 1350 1362
18. H. Nagase, J.H. Mao, A. Balmain Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice Cancer Res 63 2003 4849 4853
19. M. Dahlhoff, H. Algul, J.T. Siveke, M. Lesina, R. Wanke, T. Wartmann, W. Halangk, R.M. Schmid, E. Wolf, M.R. Schneider Betacellulin protects from pancreatitis by activating stress-activated protein kinase Gastroenterology 138 2010 1585 1594
20. D.B. Eisen, D.J. Michael Sebaceous lesions and their associated syndromes: part I J Am Acad Dermatol 61 2009 549 560
21. Y. Xu, L.J. Tan, V. Grachtchouk, J.J. Voorhees, G.J. Fisher Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function J Biol Chem 280 2005 42694 42700
22. G. Levkowitz, H. Waterman, E. Zamir, Z. Kam, S. Oved, W.Y. Langdon, L. Beguinot, B. Geiger, Y. Yarden c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor Genes Dev 12 1998 3663 3674
23. L.S. Chin, M.C. Raynor, X. Wei, H.Q. Chen, L. Li Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor J Biol Chem 276 2001 7069 7078
24. G. Gur, C. Rubin, M. Katz, I. Amit, A. Citri, J. Nilsson, N. Amariglio, R. Henriksson, G. Rechavi, H. Hedman, R. Wides, Y. Yarden LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation EMBO J 23 2004 3270 3281
25. M.B. Laederich, M. Funes-Duran, L. Yen, E. Ingalla, X. Wu, K.L. Carraway III, C. Sweeney The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases J Biol Chem 279 2004 47050 47056
26. J.P. Sundberg, B.A. Sundberg, W.G. Beamer Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen Mol Carcinog 20 1997 19 32
27. G.M. Zinser, J.P. Sundberg, J. Welsh Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis Carcinogenesis 23 2002 2103 2109
28. M. Ito, K. Motoyoshi, M. Suzuki, Y. Sato Sebaceous gland hyperplasia on rabbit pinna induced by tetradecane J Invest Dermatol 85 1985 249 254
29. J.M. Rice, L.M. Anderson Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens Cancer Lett 33 1986 295 306