메뉴 건너뛰기




Volumn 53, Issue 4, 2012, Pages 699-709

Alemtuzumab induction of intracellular signaling and apoptosis in malignant B lymphocytes

Author keywords

Alemtuzumab; Apoptosis; CD52; Cell signaling; Cross linking

Indexed keywords

ALEMTUZUMAB; CALCIUM ION; CASPASE; CD32 ANTIGEN; CD52 ANTIGEN; FC RECEPTOR IIB; PHOSPHOTRANSFERASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84859055244     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.623253     Document Type: Article
Times cited : (11)

References (42)
  • 1
    • 0025878925 scopus 로고
    • Characterization of the CAMPATH-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone
    • Xia MQ, Tone M, Packman L, et al. Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. Eur J Immunol 1991;21:1677-1684.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1677-1684
    • Xia, M.Q.1    Tone, M.2    Packman, L.3
  • 2
    • 0027194472 scopus 로고
    • Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol- anchored glycoprotein which is an exceptionally good target for complement lysis
    • Pt 3
    • Xia MQ, Hale G, Lifely MR, et al. Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis. Biochem J 1993;293(Pt 3):633-640.
    • (1993) Biochem. J. , vol.293 , pp. 633-640
    • Xia, M.Q.1    Hale, G.2    Lifely, M.R.3
  • 3
    • 0027462047 scopus 로고
    • Th e glycosylphosphatidylinositolanchored lymphocyte antigen CDw52 is associated with theepididymal maturation of human spermatozoa
    • Hale G, Rye PD, Warford A, et al. Th e glycosylphosphatidylinositolanchored lymphocyte antigen CDw52 is associated with theepididymal maturation of human spermatozoa. J Reprod Immunol 1993;23:189-205.
    • (1993) J. Reprod. Immunol. , vol.23 , pp. 189-205
    • Hale, G.1    Rye, P.D.2    Warford, A.3
  • 4
    • 0032005642 scopus 로고    scopus 로고
    • Levels of expression of CD52 in normal and leukemic B and T cells: Correlation with in vivo therapeutic responses to Campath-1H
    • Ginaldi L, De Martinis M, Matutes E, et al. Levels of expression of CD52 in normal and leukemic B and T cells: correlation with in vivo therapeutic responses to Campath-1H. Leuk Res 1998;22:185-191.
    • (1998) Leuk. Res. , vol.22 , pp. 185-191
    • Ginaldi, L.1    De Martinis, M.2    Matutes, E.3
  • 5
    • 40149098173 scopus 로고    scopus 로고
    • Campath 1-H treatment in patients with aggressive relapsing remitting multiple sclerosis
    • Hirst CL, Pace A, Pickersgill TP, et al. Campath 1-H treatment in patients with aggressive relapsing remitting multiple sclerosis. J Neurol 2008;255:231-238.
    • (2008) J. Neurol. , vol.255 , pp. 231-238
    • Hirst, C.L.1    Pace, A.2    Pickersgill, T.P.3
  • 6
    • 37149040149 scopus 로고    scopus 로고
    • Campath-1H treatment of multiple sclerosis
    • Jones JL, Coles AJ. Campath-1H treatment of multiple sclerosis. Neurodegener Dis 2008;5:27-31.
    • (2008) Neurodegener. Dis. , vol.5 , pp. 27-31
    • Jones, J.L.1    Coles, A.J.2
  • 7
    • 0033949148 scopus 로고    scopus 로고
    • CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells
    • Hale G, Jacobs P, Wood L, et al. CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells. Bone Marrow Transplant 2000;26:69-76.
    • (2000) Bone Marrow Transplant , vol.26 , pp. 69-76
    • Hale, G.1    Jacobs, P.2    Wood, L.3
  • 8
    • 33746836125 scopus 로고    scopus 로고
    • CD52 is a novel costimulatory molecule for induction of CD4+regulatory T cells
    • Watanabe T, Masuyama J, Sohma Y, et al. CD52 is a novel costimulatory molecule for induction of CD4+regulatory T cells. Clin Immunol 2006;120 :247-259.
    • (2006) Clin. Immunol. , vol.120 , pp. 247-259
    • Watanabe, T.1    Masuyama, J.2    Sohma, Y.3
  • 9
    • 40449101381 scopus 로고    scopus 로고
    • CD4+CD25+FOXP3+regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H
    • Bloom DD, Chang Z, Fechner JH, et al. CD4+CD25+FOXP3+regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. Am J Transplant 2008;8:793-802.
    • (2008) Am. J. Transplant. , vol.8 , pp. 793-802
    • Bloom, D.D.1    Chang, Z.2    Fechner, J.H.3
  • 10
    • 37149045571 scopus 로고    scopus 로고
    • CD52 over-expression aff ects rituximab-associated complement-mediated cytotoxicity but not antibody-dependent cellular cytotoxicity: Preclinical evidence that targeting CD52 with alemtuzumab may reverse acquired resistance to rituximab in non-Hodgkin lymphoma
    • Cruz RI, Hernandez-Ilizaliturri FJ, Olejniczak S, et al. CD52 over-expression aff ects rituximab-associated complement-mediated cytotoxicity but not antibody-dependent cellular cytotoxicity: preclinical evidence that targeting CD52 with alemtuzumab may reverse acquired resistance to rituximab in non-Hodgkin lymphoma. Leuk Lymphoma 2007;48:2424-2436.
    • (2007) Leuk. Lymphoma. , vol.48 , pp. 2424-2436
    • Cruz, R.I.1    Hernandez-Ilizaliturri, F.J.2    Olejniczak, S.3
  • 11
    • 51649110602 scopus 로고    scopus 로고
    • Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk earlyintermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab
    • Zent CS, Secreto CR, LaPlant BR, et al. Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk earlyintermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab. Leuk Res 2008;32:1849-1856.
    • (2008) Leuk. Res. , vol.32 , pp. 1849-1856
    • Zent, C.S.1    Secreto, C.R.2    LaPlant, B.R.3
  • 12
    • 19744361832 scopus 로고    scopus 로고
    • Eff ect of alemtuzumab on neoplastic B cells
    • Golay J, Manganini M, Rambaldi A, et al. Eff ect of alemtuzumab on neoplastic B cells. Haematologica 2004;89:1476-1483.
    • (2004) Haematologica , vol.89 , pp. 1476-1483
    • Golay, J.1    Manganini, M.2    Rambaldi, A.3
  • 13
    • 69949120991 scopus 로고    scopus 로고
    • Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model
    • Hu Y, Turner MJ, Shields J, et al. Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model. Immunology 2009;128:260-270.
    • (2009) Immunology , vol.128 , pp. 260-270
    • Hu, Y.1    Turner, M.J.2    Shields, J.3
  • 14
    • 77954136419 scopus 로고    scopus 로고
    • Involvement of neutrophils and natural killer cells in the anti-tumor activity of alemtuzumab in xenograft tumor models
    • Siders WM, Shields J, Garron C, et al. Involvement of neutrophils and natural killer cells in the anti-tumor activity of alemtuzumab in xenograft tumor models. Leuk Lymphoma 2010;51:1293-1304.
    • (2010) Leuk. Lymphoma. , vol.51 , pp. 1293-1304
    • Siders, W.M.1    Shields, J.2    Garron, C.3
  • 15
    • 0031790767 scopus 로고    scopus 로고
    • Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-defi cient cells
    • Rowan W, Tite J, Topley P, et al. Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-defi cient cells. Immunology 1998;95:427-436.
    • (1998) Immunology , vol.95 , pp. 427-436
    • Rowan, W.1    Tite, J.2    Topley, P.3
  • 16
    • 19444377855 scopus 로고    scopus 로고
    • Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity
    • Nuckel H, Frey UH, Roth A, et al. Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity. Eur J Pharmacol 2005;514:217-224.
    • (2005) Eur. J. Pharmacol. , vol.514 , pp. 217-224
    • Nuckel, H.1    Frey, U.H.2    Roth, A.3
  • 17
    • 31444453579 scopus 로고    scopus 로고
    • Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism
    • Mone AP, Cheney C, Banks AL, et al. Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism. Leukemia 2006;20:272-279.
    • (2006) Leukemia , vol.20 , pp. 272-279
    • Mone, A.P.1    Cheney, C.2    Banks, A.L.3
  • 18
    • 4844229401 scopus 로고    scopus 로고
    • Rituximab anDalemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in B-lymphoid cell lines and in chronic lymphocytic leukemia cells
    • Stanglmaier M, Reis S, Hallek M. Rituximab anDalemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in B-lymphoid cell lines and in chronic lymphocytic leukemia cells. Ann Hematol 2004;83:634-645.
    • (2004) Ann. Hematol. , vol.83 , pp. 634-645
    • Stanglmaier, M.1    Reis, S.2    Hallek, M.3
  • 19
    • 0026090660 scopus 로고
    • Growth regulation of a human mature B cell line B104, by anti-IgM and anti-IgD antibodies
    • Kim KM, Yoshimura T, Watanabe H, et al. Growth regulation of a human mature B cell line, B104, by anti-IgM and anti-IgD antibodies. J Immunol 1991;146:819-825.
    • (1991) J. Immunol. , vol.146 , pp. 819-825
    • Kim, K.M.1    Yoshimura, T.2    Watanabe, H.3
  • 20
    • 0021212984 scopus 로고
    • Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma
    • Siebenlist U, Hennighausen L, Battey J, et al. Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell 1984;37:381-391.
    • (1984) Cell , vol.37 , pp. 381-391
    • Siebenlist, U.1    Hennighausen, L.2    Battey, J.3
  • 21
    • 0023230248 scopus 로고
    • Complex translocation t(8;12;14) in a cell line derived from a child with nonendemic Burkitt-type acute lymphoblastic leukemia
    • Nacheva E, Fischer P, Karpas A, et al. Complex translocation t(8;12;14) in a cell line derived from a child with nonendemic Burkitt-type acute lymphoblastic leukemia. Cancer Genet Cytogenet 1987;28:145-153.
    • (1987) Cancer Genet. Cytogenet. , vol.28 , pp. 145-153
    • Nacheva, E.1    Fischer, P.2    Karpas, A.3
  • 22
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 1979;76:4350-4354.
    • (1979) Proc. Natl. Acad. Sci. U S A , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 23
    • 0037025303 scopus 로고    scopus 로고
    • Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420
    • Nguyen TH, Liu J, Lombroso PJ. Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420. J Biol Chem 2002;277:24274-24279.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24274-24279
    • Nguyen, T.H.1    Liu, J.2    Lombroso, P.J.3
  • 24
    • 23844551199 scopus 로고    scopus 로고
    • Stochastic models inspired by hybridization theory for short oligonucleotide arrays
    • Wu Z, Irizarry RA. Stochastic models inspired by hybridization theory for short oligonucleotide arrays. J Comput Biol 2005;12:882-893.
    • (2005) J. Comput. Biol. , vol.12 , pp. 882-893
    • Wu, Z.1    Irizarry, R.A.2
  • 25
    • 10844290766 scopus 로고    scopus 로고
    • A model-based background adjustment for oligonucleotide expression arrays
    • Wu Z, Irizarry RA, Gentleman R, et al. A Model-Based Background Adjustment for Oligonucleotide Expression Arrays. J Am Statist Assoc 2004;99:909-917.
    • (2004) J. Am. Statist. Assoc. , vol.99 , pp. 909-917
    • Wu, Z.1    Irizarry, R.A.2    Gentleman, R.3
  • 26
    • 0029790656 scopus 로고    scopus 로고
    • FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
    • Tan Y, Rouse J, Zhang A, et al. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J 1996;15:4629-4642.
    • (1996) EMBO J. , vol.15 , pp. 4629-4642
    • Tan, Y.1    Rouse, J.2    Zhang, A.3
  • 27
    • 0141705293 scopus 로고    scopus 로고
    • Expression of Fcgamma receptors type II (FcgammaRII) in chronic lymphocytic leukemia B cells
    • Gamberale R, Geff ner JR, Sanjurjo J, et al. Expression of Fcgamma receptors type II (FcgammaRII) in chronic lymphocytic leukemia B cells. Blood 2003;102:2698-2699.
    • (2003) Blood , vol.102 , pp. 2698-2699
    • Gamberale, R.1    Geffner, J.R.2    Sanjurjo, J.3
  • 28
    • 0345802753 scopus 로고    scopus 로고
    • FcgammaRIIB is diff erentially expressed during B cell maturation and in B-cell lymphomas
    • Camilleri-Broet S, Cassard L, Broet P, et al. FcgammaRIIB is diff erentially expressed during B cell maturation and in B-cell lymphomas. Br J Haematol 2004;124:55-62.
    • (2004) Br. J. Haematol. , vol.124 , pp. 55-62
    • Camilleri-Broet, S.1    Cassard, L.2    Broet, P.3
  • 29
    • 0036132559 scopus 로고    scopus 로고
    • Evidence for a physiological role for membrane rafts in human platelets
    • Gousset K, Wolkers WF, Tsvetkova NM, et al. Evidence for a physiological role for membrane rafts in human platelets. J Cell Physiol 2002;190:117-128.
    • (2002) J. Cell Physiol. , vol.190 , pp. 117-128
    • Gousset, K.1    Wolkers, W.F.2    Tsvetkova, N.M.3
  • 30
    • 33644511073 scopus 로고    scopus 로고
    • Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity
    • Omidvar N, Wang EC, Brennan P, et al. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. J Immunol 2006;176:2915-2923.
    • (2006) J. Immunol. , vol.176 , pp. 2915-2923
    • Omidvar, N.1    Wang, E.C.2    Brennan, P.3
  • 31
    • 0027437247 scopus 로고
    • Cross-linking of CD59 and of other glycosyl phosphatidylinositol-anchored molecules on neutrophils triggers cell activation via tyrosine kinase
    • Morgan BP, van den Berg CW, Davies EV, et al. Cross-linking of CD59 and of other glycosyl phosphatidylinositol-anchored molecules on neutrophils triggers cell activation via tyrosine kinase. Eur J Immunol 1993;23:2841-2850.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2841-2850
    • Morgan, B.P.1    Van Den Berg, C.W.2    Davies, E.V.3
  • 32
    • 0031750335 scopus 로고    scopus 로고
    • Lipid domain structure of the plasma membrane revealed by patching of membrane components
    • Harder T, Scheiff ele P, Verkade P, et al. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol 1998;141:929-942.
    • (1998) J. Cell Biol. , vol.141 , pp. 929-942
    • Harder, T.1    Scheiffele, P.2    Verkade, P.3
  • 33
    • 33744494534 scopus 로고    scopus 로고
    • Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptormediated lipid raft dynamics
    • Gupta N, Wollscheid B, Watts JD, et al. Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptormediated lipid raft dynamics. Nat Immunol 2006;7:625-633.
    • (2006) Nat. Immunol. , vol.7 , pp. 625-633
    • Gupta, N.1    Wollscheid, B.2    Watts, J.D.3
  • 34
    • 0347052900 scopus 로고    scopus 로고
    • Phosphatidylinositide 3-kinase priming couples c-FLIP to T cell activation
    • Fang LW, Tai TS, Yu WN, et al. Phosphatidylinositide 3-kinase priming couples c-FLIP to T cell activation. J Biol Chem 2004;279:13-18.
    • (2004) J. Biol. Chem. , vol.279 , pp. 13-18
    • Fang, L.W.1    Tai, T.S.2    Yu, W.N.3
  • 35
    • 0033523709 scopus 로고    scopus 로고
    • Receptor avidity and costimulation specify the intracellular Ca2+signaling pattern in CD4(+)CD8(+) thymocytes
    • Freedman BD, Liu QH, Somersan S, et al. Receptor avidity and costimulation specify the intracellular Ca2+signaling pattern in CD4(+)CD8(+) thymocytes. J Exp Med 1999;190:943-952.
    • (1999) J. Exp. Med. , vol.190 , pp. 943-952
    • Freedman, B.D.1    Liu, Q.H.2    Somersan, S.3
  • 36
    • 34447302006 scopus 로고    scopus 로고
    • Ca(2+) signaling in antigen receptor-activated B lymphocytes
    • Engelke M, Engels N, Dittmann K, et al. Ca(2+) signaling in antigen receptor-activated B lymphocytes. Immunol Rev 2007;218:235-246.
    • (2007) Immunol. Rev. , vol.218 , pp. 235-246
    • Engelke, M.1    Engels, N.2    Dittmann, K.3
  • 37
    • 57849148942 scopus 로고    scopus 로고
    • Calcium signaling in immune cells
    • Vig M, Kinet JP. Calcium signaling in immune cells. Nat Immunol 2009;10:21-27.
    • (2009) Nat. Immunol. , vol.10 , pp. 21-27
    • Vig, M.1    Kinet, J.P.2
  • 39
    • 33646595301 scopus 로고    scopus 로고
    • Strategies in the management of alemtuzumab-related side eff ects
    • Osterborg A, Karlsson C, Lundin J, et al. Strategies in the management of alemtuzumab-related side eff ects. Semin Oncol 2006;33:S29-S35.
    • (2006) Semin. Oncol. , vol.33
    • Osterborg, A.1    Karlsson, C.2    Lundin, J.3
  • 40
    • 0029869119 scopus 로고    scopus 로고
    • Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis
    • Pt 1
    • Moreau T, Coles A, Wing M, et al. Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 1996;119(Pt 1):225-237.
    • (1996) Brain , vol.119 , pp. 225-237
    • Moreau, T.1    Coles, A.2    Wing, M.3
  • 41
    • 0030453977 scopus 로고    scopus 로고
    • Mechanism of fi rst-dose cytokine-release syndrome by CAMPATH 1-H: Involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells
    • Wing MG, Moreau T, Greenwood J, et al. Mechanism of fi rst-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells. J Clin Invest 1996;98:2819-2826.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2819-2826
    • Wing, M.G.1    Moreau, T.2    Greenwood, J.3
  • 42
    • 33750214234 scopus 로고    scopus 로고
    • Additive cytotoxic eff ect of bortezomib in combination with anti-CD20 or anti-CD52 monoclonal antibodies on chronic lymphocytic leukemia cells
    • Smolewski P, Duechler M, Linke A, et al. Additive cytotoxic eff ect of bortezomib in combination with anti-CD20 or anti-CD52 monoclonal antibodies on chronic lymphocytic leukemia cells. Leuk Res 2006;30:1521-9.
    • (2006) Leuk. Res. , vol.30 , pp. 1521-9
    • Smolewski, P.1    Duechler, M.2    Linke, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.