Understanding how the brain changes its mind: Microstimulation in the macaque frontal eye field reveals how saccade plans are changed

Journal of Neuroscience

Volumn 32, Issue 13, 2012, Pages 4457-4472

  Ramakrishnan, Arjun ^a   Sureshbabu, Ramakrishnan ^a   Murthy, Aditya ^b  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; EVOKED RESPONSE; FEMALE; FRONTAL EYE FIELD; MACACA MULATTA; MALE; NONBIOLOGICAL MODEL; NONHUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RESPONSE TIME; SACCADIC EYE MOVEMENT; SIMULATION; STIMULATION; TASK PERFORMANCE;

ANIMALS; ELECTRIC STIMULATION; FEMALE; FRONTAL LOBE; INHIBITION (PSYCHOLOGY); MACACA MULATTA; MALE; MODELS, STATISTICAL; SACCADES; TIME FACTORS; VISUAL FIELDS;

EID: 84859047086     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3668-11.2012     Document Type: Article

References (53)

1. Aron AR, Verbruggen F (2008) Stop the presses: dissociating a selective from a global mechanism for stopping. Psychol Sci 19:1146-1153.
2. Aslin RN, Shea SL (1987) The amplitude and angle of saccades to doublestep target displacements. Vision Res 27:1925-1942.
3. Barborica A, Ferrera VP (2004) Modification of saccades evoked by stimulation of frontal eye field during invisible target tracking. J Neurosci 24:3260-3267.
4. Becker W, Jürgens R (1979) An analysis of the saccadic system by means of double step stimuli. Vision Res 19:967-983.
5. Boucher L, Palmeri TJ, Logan GD, Schall JD (2007) Inhibitory control in mind and brain: an interactive race model of countermanding saccades. Psychol Rev 114:376-397.
6. Bruce CJ, Goldberg ME, Bushnell MC, Stanton GB (1985) Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. J Neurophysiol 54:714-734.
7. Camalier CR, Gotler A, Murthy A, Thompson KG, Logan GD, Palmeri TJ, Schall JD (2007) Dynamics of saccade target selection: race model analysis of double step and search step saccade production in human and macaque. Vision Res 47:2187-2211.
8. Carpenter RH, Williams ML (1995) Neural computation of log likelihood in control of saccadic eye movements. Nature 377:59-62.
9. Coxon JP, Stinear CM, Byblow WD (2007) Selective inhibition of movement. J Neurophysiol 97:2480-2489.
10. Cronbach LJ (1951) Coefficient alpha and the internal structure of tests. Psychometrika 16:297-334.
11. De Jong R, Coles MG, Logan GD (1995) Strategies and mechanisms in nonselective and selective inhibitory motor control. J Exp Psychol Hum Percept Perform 21:498-511.
12. Georgopoulos AP, Schwartz AB, Kettner RE (1986) Neuronal population coding of movement direction. Science 233:1416-1419.
13. Gold JI, Shadlen MN (2000) Representation of a perceptual decision in developing oculomotor commands. Nature 404:390-394.
14. Gold JI, Shadlen MN (2001) Neural computations that underlie decisions about sensory stimuli. Trends Cogn Sci 5:10-16.
15. Gold JI, Shadlen MN (2003) The influence of behavioral context on the representation of a perceptual decision in developing oculomotor commands. J Neurosci 23:632-651.
16. Hanes DP, Schall JD (1996) Neural control of voluntary movement initiation. Science 274:427-430.
17. Hanes DP, Patterson WF 2nd, Schall JD (1998) The role of frontal eye field in countermanding saccades: visual, movement and fixation activity. J Neurophysiol 79:817-834.
18. Hasegawa RP, Peterson BW, Goldberg ME (2004) Prefrontal neurons coding suppression of specific saccades. Neuron 43:415-425.
19. Holmqvist K, Nystrom M, Andersson R, Dewhurst R, Jarodzka H, Van de Weijer J (2011) Eye tracking: a comprehensive guide to methods and measures. Oxford: Oxford UP.
20. Hornof AJ, Halverson T (2002) Cleaning up systematic error in eye-tracking data by using required fixation location. Behav Res Methods Instrum Comput 34:592-604.
21. Horwitz GD, Newsome WT (1999) Separate signals for target selection and movement specification in the superior colliculus. Science 284:1158-1161.
22. Isoda M, Hikosaka O (2007) Switching from automatic to controlled action by monkey medial frontal cortex. Nat Neurosci 10:240-248.
23. Juan CH, Shorter-Jacobi SM, Schall JD (2004) Dissociation of spatial attention and saccade preparation. Proc Natl Acad SciU S A101:15541-15544.
24. Kiani R, Hanks TD, Shadlen MN (2008) Bounded integration in parietal cortex underlies decisions even when viewing duration is dictated by the environment. J Neurosci 28:3017-3029.
25. Kim JN, Shadlen MN (1999) Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque. Nat Neurosci 2:176-185.
26. Komoda MK, Festinger L, Phillips LJ, Duckman RH, Young RA (1973) Some observations concerning saccadic eye movements. Vision Res 13:1009-1020.
27. Kornylo K, Dill N, Saenz M, Krauzlis RJ (2003) Cancelling of persuit and saccadic eye movements in humans and monkeys. J Neurophysiol 89: 2984-2999.
28. Krauzlis R, Dill N (2002) Neural correlates of target choice for pursuit and saccades in the primate superior colliculus. Neuron 35:355-363.
29. Kustov AA, Robinson DL (1996) Shared neural control of attentional shifts and eye movements. Nature 384:74-77.
30. Lisberger SG, Fuchs AF, King WM, Evinger LC (1975) Effect of mean reaction time on saccadic responses to two-step stimuli with horizontal and vertical components. Vision Res 15:1021-1025.
31. Lo CC, Wang XJ (2006) Cortico-basal ganglia circuit mechanism for a decision threshold in reaction time tasks. Nat Neurosci 9:956-963.
32. Logan GD, Burkell J (1986) Dependence and independence in responding to double stimulation: a comparison of stop, change, and dual-task paradigms. J Exp Psychol Hum Percept Perform 12:549-563.
33. Logan GD, Cowan WB (1994) On the ability to inhibit thought and action: a users' guide to the stop signal paradigm. In: Inhibitory processes in attention, memory and language (Dagenbach D, Carr TH, eds), pp 189-239. San Diego: Academic.
34. Ludwig CJ, Mildinhall JW, Gilchrist ID (2007) Apopulation coding account for systematic variation in saccadic dead time. J Neurophysiol 97: 795-805.
35. Murphey DK, Maunsell JH (2008) Electrical microstimulation thresholds for behavioral detection and saccades in monkey frontal eye fields. Proc Natl Acad Sci U S A 105:7315-7320.
36. Murthy A, Ray S, Shorter SM, Priddy EG, Schall JD, Thompson KG (2007) Frontal eye field contributions to rapid corrective saccades. J Neurophysiol 97:1457-1469.
37. Murthy A, Ray S, Shorter SM, Schall JD, Thompson KG (2009) Neural control of visual search by frontal eye field: effects of unexpected target displacement on visual selection and saccade preparation. J Neurophysiol 101:2485-2506.
38. Paré M, Hanes DP (2003) Controlled movement processing: superior colliculus activity associated with countermanded saccades. J Neurosci 23:6480-6489.
39. Pouget P, Emeric EE, Stuphorn V, Reis K, Schall JD (2005) Chronometry of visual responses in frontal eye field, supplementary eye field, and anterior cingulate cortex. J Neurophysiol 94:2086-2092.
40. Ramakrishnan A, Chokhandre S, Murthy A (2010) Voluntary control of multisaccade gaze shifts during movement preparation and execution. J Neurophysiol 103:2400-2416.
41. Ratcliff R, Rouder J (1998) Modeling response times for two-choice decisions. Psychol Sci 9:347-356.
42. Ratcliff R, Smith PL (2004) Acomparison of sequential sampling models for two-choice reaction time. Psychol Rev 111:333-367.
43. Ratcliff R, Van Zandt T, McKoon G (1999) Connectionist and diffusion models of reaction time. Psychol Rev 106:261-300.
44. Ray S, Schall JD, Murthy A (2004) Programming of double-step saccade sequences: modulation by cognitive control. Vision Res 44:2707-2718.
45. Ray S, Pouget P, Schall JD (2009) Functional distinction between visuomovement and movement neurons in macaque frontal eye field during saccade countermanding. J Neurophysiol 102:3091-3100.
46. Roitman JD, Shadlen MN (2002) Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task. J Neurosci 22:9475-9489.
47. Schiller PH, Sandell JH (1983) Interactions between visually and electrically elicited saccades before and after superior colliculus and frontal eye field ablations in the rhesus monkey. Exp Brain Res 49:381-392.
48. Schmolesky MT, Wang Y, Hanes DP, Thompson KG, Leutgeb S, Schall JD, Leventhal AG (1998) Signal timing across the macaque visual system. J Neurophysiol 79:3272-3278.
49. Sparks DL, Mays LE (1983) Spatial localization of saccade targets. I. Compensation for stimulation-induced perturbations in eye position. J Neurophysiol 49:45-63.
50. Usher M, McClelland JL (2001) The time course of perceptual choice: the leaky, competing accumulator model. Psychol Rev 108:550-592.
51. Verbruggen F, Schneider DW, Logan GD (2008) How to stop and change a response: the role of goal activation in multitasking. J Exp Psychol Hum Percept Perform 34:1212-1228.
52. Westheimer G (1954) Eye movement responses to a horizontally moving visual stimulus. AMA Arch Ophthalmol 52:932-941.
53. Wheeless LL, Boynton RM, Cohen GH (1966) Eye movement responses to step and pulse-step stimuli. J Opt Soc Am 56:856-960.