Utility of nuclear magnetic resonance spectroscopy for pancreatic cancer studies

Pancreas

Volumn 41, Issue 3, 2012, Pages 474-480

  Tesiram, Yasvir A ^a   Lerner, Megan ^b   Stewart, Charles ^a   Njoku, Charity ^a   Brackett, Daniel J ^b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

human serum samples; metabolic profile; nuclear magnetic resonance (NMR) spectroscopy; quantitative analysis; unresolved complex matter (UCM)

Indexed keywords

CHOLINE; GLUCOSE; TAURINE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; GLUCOSE BLOOD LEVEL; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN TISSUE; MALE; METABOLIC PARAMETERS; METABOLITE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PANCREAS CANCER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL; UNRESOLVED COMPLEX MATTER;

BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHOLINE; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; OKLAHOMA; PANCREATIC NEOPLASMS; PILOT PROJECTS; TAURINE; TRIGLYCERIDES; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84859043822     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31822a708c     Document Type: Article

References (18)

1. Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature. 2008;455(7216):1054-1056.
2. Holmes E, Loo RL, Stamler J, et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature. 2008;453(7193):396- 400. (Pubitemid 351693125)
3. Assfalg M, Bertini I, Colangiuli D, et al. Evidence of different metabolic phenotypes in humans. Proc Natl Acad Sci U S A. 2008;105(5):1420-1424. (Pubitemid 351346527)
4. Fang F, He X, Deng H, et al. Discrimination of metabolic profiles of pancreatic cancer from chronic pancreatitis by high-resolution magic angle spinning 1H nuclear magnetic resonance and principal components analysis. Cancer Sci. 2007;98(11):1678-1682. (Pubitemid 47487900)
5. 23Na, and 1HMRS studies of three models of pancreatic cancer. Cancer Res. 1997;57(8):1452-1459.
6. Tesiram YA, Saunders D, Towner RA. Chemical speciation byselective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds. NMR Biomed. 2008;21(4):345-356. (Pubitemid 351771884)
7. Tesiram YA, Saunders D, Towner RA. Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model. Biochim Biophys Acta. 2005;1737(1):61-68. (Pubitemid 41550384)
8. Griffitts J, Saunders D, Tesiram YA, et al. Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model omega-3 fatty acids prevent liver neoplasia. Biochim Biophys Acta. 2010;1801(10):1133- 1144.
9. Ford JH. Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging. Age (Dordr). 2010;32(2):231-237.
10. Puig T, Vazquez-Martin A, Relat J, et al. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. Breast Cancer Res Treat. 2008;109(3):471-479. (Pubitemid 351692064)
11. Edmonson JH. Fatty acid mobilization and glucose metabolism in patients with cancer. Cancer. 1966;19(2):277-280.
12. Cho SG, Lee DH, Lee KY, et al. Differentiation of chronic focal pancreatitis from pancreatic carcinoma by in vivo proton magnetic resonance spectroscopy. J Comput Assist Tomogr. 2005;29(2):163-169. (Pubitemid 40411298)
13. Zyromski NJ, Mathur A, Gowda GA, et al. Nuclear magnetic resonance spectroscopy-based metabolomics of the fatty pancreas: implicating fat in pancreatic pathology. Pancreatology. 2009;9(4):410-419.
14. Kay LE, Keifer P, Saarinen T. Pure absorption gradient enhanced single quantum correlation spectroscopy with improved sensitivity. J Am Chem Soc. 1992;114:10663-10665.
15. Stocks T, Rapp K, Bjorge T, et al. Blood glucose and risk of incident and fatal cancer in the Metabolic Syndrome and Cancer Project (Me-Can): analysis of six prospective cohorts. PLoS Med. 2009;6(12):e1000201.
16. Sheedy JR, Ebeling PR, Gooley PR, et al. A sample preparation protocol for 1H nuclear magnetic resonance studies of water-soluble metabolites in blood and urine. Anal Biochem. 2010;398(2):263-265.
17. Falconer JS, Ross JA, Fearon KC, et al. Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines. Br J Cancer. 1994;69(5):826-832. (Pubitemid 24140659)
18. De Meyer T, Sinnaeve D, Van Gasse B, et al. Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum (1)H-NMR spectra. Anal Bioanal Chem. 2010;398(4):1781-1790.