Effect of lead on apoptosis in cultured rat primary osteoblasts

Toxicology and Industrial Health

Volumn 28, Issue 2, 2012, Pages 136-146

  Ma, Yushui ^a   Fu, Da ^b   Liu, Zongping ^a  

^a YANGZHOU UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Ca 2+ i; apoptosis; Pb; PC PLC; ROBs

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; FLUORESCEIN ISOTHIOCYANATE; LEAD; LIPOCORTIN 5; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; PROPIDIUM IODIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE MATRIX; BONE MINERALIZATION; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALVARIA; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; IMMUNOBLOTTING; NEWBORN; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; RAT; STAINING;

ALKALINE PHOSPHATASE; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CALCIUM; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; LEAD; OSTEOBLASTS; RATS; RATS, SPRAGUE-DAWLEY; TYPE C PHOSPHOLIPASES;

RATTUS;

EID: 84859025352     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233711407956     Document Type: Article

References (32)

1. Aufderheide AC, Wittmers LE (1992) Selected aspects ofthe spatial distribution of lead in bone. Neuro Toxicology 13(4): 809-820. (Pubitemid 23086681)
2. Bagchi D, Preuss HG (2005) Effects ofacute and chronic oval exposure of lead on blood pressure and bone mineral density in rats. Journal of Inorganic Biochemistry 99(5): 1155-1164.
3. Berglund M, Akesson A, Bjellerup P, et al. (2000) Metal-bone interactions. Toxicology Letters 112-113: 219-225. (Pubitemid 30138126)
4. Berridge MV, Tan AS (1993) Characterization ofthe cellular reduction of MTT: subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Archives of Biochemistry and Biophysics 303(2): 474-482. (Pubitemid 23199849)
5. Carriere M, Thiebault C, Milgram S, et al. (2006) Citrate does not change uranium chemical speciation in cell culture medium but increases its toxicity and accumulation in NRK-52E cells. Chemical Research in Toxicology 19(12): 1637-1642. (Pubitemid 44975126)
6. Del FA, Capannolo M, and Rucci N (2010) Bone and bone marrow: the same organ. Archives of Biochemistry and Biophysics 503(1): 28-34.
7. Diamond GL, Morrow PE, Panner BJ, et al. (1989) Reversible uranyl fluoride nephrotoxicity in the Long Evans rat. Fundamental and Applied Toxicology 13(1): 65-78. (Pubitemid 19168779)
8. Durbin PW (1992) Distribution oftransuranic elements in bone. Neurotoxicology 13(4): 821-824.
9. Flora SJ, Saxena G, and Mehta A (2007) Reversal oflead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca2+. Journal of Pharmacology and Experimental Therapy 322(1): 108-116. (Pubitemid 46956385)
10. Fu D, Ma Y, Wu W, et al. (2009) Cell-cycle-dependent PC-PLC regulation byAPC/C(Cdc20)-mediated ubiquitin-proteasome pathway. Journal of Cell Biochemistry 107(4): 686-696.
11. Garza A, Vega R, and Soto E (2006) Cellular mechanisms oflead neurotoxicity. Medical Science Monitor 12(3): 57-65.
12. Gerhardsson L, Akantis A, Lundstrom NG, et al. (2005) Lead concentrations incortical and trabecular bones in deceased smelter workers. Journal of Trace Elements in Medicine and Biology 19(2-3): 209-215. (Pubitemid 41606718)
13. Jonathan DH, Tzong-jen S, Hicham D, et al. (2007) Environmental agents affect skeletal growth and development. Birth Defects Research Part C: Embryo Today 81(1): 41-50.
14. Leggett RW, Pellmar TC (2003) The biokinetics ofuranium migrating from embedded DU fragments. Journal of Environmental Radioactivity 64(2-3): 205-225. (Pubitemid 35341752)
15. Lemasters JJ, Theruvath TP, Zhong Z, et al. (2009) Mitochondrial calcium and the permeability transition in cell death. Biochimica et Biophysica Acta 1787(11): 1395-1401.
16. Lin CC, Hsiao LD, Chien CS, et al. (2004) Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in human tracheal smooth muscle cells: involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-kappa B. Cell Signal 16(5): 597-607.
17. Milgram S, Carriere M, Thiebault C, et al. (2008) Cytotoxic and phenotypic effects of uranium and lead on osteoblastic cells are highly dependenton metal speciation. Toxicology 250(1): 62-69.
18. Moreira EG, Vassilieff I, and Vassilieff VS (2001) Developmental lead exposure: behavioral alterations in the short and long term. Neurotoxicology and Teratology 23(5): 489-495. (Pubitemid 33044565)
19. Moreno-Garcia ME, Lopez-Bojorques LN, Zentella A, et al. (2005) CD38 signaling regulates Blymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade. Journal of Immunology 174(5): 2687-2695. (Pubitemid 40279683)
20. Mousa HM, Al-Qarawi AA, Ali BH, et al. (2002) Effect oflead exposure on the erythrocytic antioxidant levels in goats. Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine 49(10): 531-534. (Pubitemid 135747839)
21. Nofer JR, Junker R, Seedorf U, et al. (2000) D609-phosphatidyl choline-specific phospholipase Cinhibitor attenuates thapsigargin-induced sodium influx in human lymphocytes. Cell Signal 12(2): 289-296. (Pubitemid 30261543)
22. Nofer JR, Tepel M, Walter M, et al. (1997) Phosphatidylcholine-specific phospholipase Cregulates thapsigargin-induced calcium influx in human lymphocytes. Journal of Biological Chemistry 272(25): 32861-32868. (Pubitemid 28023622)
23. Patra RC, Swarup D, and Dwivedi SK (2001) Antioxidant effects of a-tocopherol, ascorbic acid and L-methionine on lead-induced oxidativestress to the liver, kidney and brain in rats. Toxicology 162(2): 81-88. (Pubitemid 32411464)
24. Plo I, Lautier D, Levade T, et al. (2000) Phosphatidylcholine-specific phospholipase Cand phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor kappaB activation in tumour-necrosis-factor-alpha-treated immature acute-myeloid-leukaemia cells. Biochemistry Journal 2(3): 459-467.
25. Potula V, Kleinbaum D, and Kaye W (2006) Lead exposure and spine bone mineral density. Journal of Occupational Environmental Medicine 48(6): 556-564. (Pubitemid 43904246)
26. Shalan MG, Mostafa MS, Hassouna MM, et al. (2005) Amelioration oflead toxicity on rat liver with vitamin C and silymarin supplements. Toxicology 206(1): 1-15. (Pubitemid 39601041)
27. Soltaninejad K, Kebriaeezadeh A, Minaiee B, et al. (2003) Biochemical and ultrastructural evidences for toxicity of lead through free radicals in rat brain. Human and Experimental Toxicology 22(8): 417-423. (Pubitemid 37038835)
28. Sudo H (1983) In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. Journal of Cell Biology 96(1): 191-198.
29. Tasat DR, Orona NS, Mandalunis PM, et al. (2007) Ultrastructural and metabolic changes in osteoblasts exposed to uranyl nitrate. Archives of Toxicology 81(5): 319-326. (Pubitemid 46701594)
30. Taylor RC, Cullen SP, and Martin SJ (2008) Apoptosis: controlled demolition atthe cellular level. Nature Reviews Molecular Cell Biology 9(3): 231-241. (Pubitemid 351301823)
31. Williams JP, Micoli K, and McDonald JM (2010) Calmodulin-an often-ignored signal inosteoclasts. Annals of New York Academy of Sciences 1192(1): 358-364.
32. Vargas I, Castillo C, Posadas F, et al. (2003) Acute lead exposure induces renal haeme oxygenase-1 and decreases urinary Na+ excretion. Human and Experimental Toxicology 22(5): 237-244. (Pubitemid 36626420)