Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance

BMC Medical Genetics

Volumn 13, Issue , 2012, Pages

  Jiang, Shan ^a   Fang, Qichen ^a   Yu, Weihui ^a   Zhang, Rong ^a   Hu, Cheng ^a   Dong, Kun ^a   Bao, Yuqian ^a   Wang, Chen ^a   Xiang, Kunsan ^a   Jia, Weiping ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN PHOSPHOTYROSINE INTERACTION PH DOMAIN AND LEUCINE ZIPPER CONTAINING 2; GLUCOSE; UNCLASSIFIED DRUG; APPL2 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ALLELE; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHINESE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE TOLERANCE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE; WAIST HIP RATIO; AGED; ASIAN; BLOOD; CHINA; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GLUCOSE TOLERANCE TEST; MIDDLE AGED; QUANTITATIVE TRAIT LOCUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GLUCOSE TOLERANCE TEST; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 84859017120     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-13-22     Document Type: Article

References (21)

1. Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 2008, 32(9):1431-1437.
2. Walley AJ, Asher JE, Froguel P. The genetic contribution to non-syndromic human obesity. Nat Rev Genet 2009, 10(7):431-442. 10.1038/nrg2594, 19506576.
3. McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med 2010, 363(24):2339-2350. 10.1056/NEJMra0906948, 21142536.
4. Wang C, Xin X, Xiang R, Ramos FJ, Liu M, Lee HJ, Chen H, Mao X, Kikani CK, Liu F, Dong LQ. Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem 2009, 284(46):31608-31615. 10.1074/jbc.M109.010355, 2797231, 19661063.
5. Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006, 8(5):516-523. 10.1038/ncb1404, 16622416.
6. Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton RG, Zerial M. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 2004, 116(3):445-456. 10.1016/S0092-8674(04)00117-5, 15016378.
7. Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 1999, 18(35):4891-4898. 10.1038/sj.onc.1203080, 10490823.
8. Fang QC, Jia WP, Gao F, Zhang R, Hu C, Wang CR, Wang C, Ma XJ, Lu JX, Xu J, Chen HZ, Xiang KS. Association of variants in APPL1 gene with body fat and its distribution in Chinese patients with type 2 diabetic mellitus. Zhonghua Yi Xue Za Zhi 2008, 88(6):369-373.
9. Hu C, Wang C, Zhang R, Ng MC, Bao Y, So WY, Ma RC, Ma X, Chan JC, Xiang K, Jia W. Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population. Diabetologia 2010, 53(2):290-298. 10.1007/s00125-009-1594-2, 19937226.
10. Bei-Fan Z. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults: study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Asia Pac J Clin Nutr 2002, 11(Suppl 8):S685-693.
11. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265. 10.1093/bioinformatics/bth457, 15297300.
12. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. The structure of haplotype blocks in the human genome. Science 2002, 296(5576):2225-2229. 10.1126/science.1069424, 12029063.
13. Qin ZS, Niu T, Liu JS. Partition-ligation-expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms. Am J Hum Genet 2002, 71(5):1242-1247. 10.1086/344207, 385113, 12452179.
14. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81(3):559-575. 10.1086/519795, 1950838, 17701901.
15. Nechamen CA, Thomas RM, Dias JA. APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol 2007, 260-262:93-99. 1782224, 17030088.
16. Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic 2008, 9(2):215-229.
17. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P, Kadowaki T. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002, 51(2):536-540.
18. Katsuda Y, Asano A, Murase Y, Chujo D, Yagi K, Kobayashi J, Mabuchi H, Yamagishi M. Association of genetic variation of the adiponectin gene with body fat distribution and carotid atherosclerosis in Japanese obese subjects. J Atheroscler Thromb 2007, 14(1):19-26. 10.5551/jat.14.19, 17332688.
19. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002, 51(7):2306-2312. 10.2337/diabetes.51.7.2306, 12086965.
20. Vaxillaire M, Dechaume A, Vasseur-Delannoy V, Lahmidi S, Vatin V, Lepretre F, Boutin P, Hercberg S, Charpentier G, Dina C, Froguel P. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes 2006, 55(3):856-861. 10.2337/diabetes.55.03.06.db05-0665, 16505255.
21. Stefan N, Machicao F, Staiger H, Machann J, Schick F, Tschritter O, Spieth C, Weigert C, Fritsche A, Stumvoll M, Haring HU. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 2005, 48(11):2282-2291. 10.1007/s00125-005-1948-3, 16205883.