Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: Influence of administration and gender

Indian Journal of Pharmacology

Volumn 44, Issue 2, 2012, Pages 189-192

  Taiwo, Adefunmilayo E ^a   Leite, Franco B ^a   Lucena, Greice M ^a   Barros, Marilia ^a   Silveira, Dâmaris ^a   Silva, Mônica V ^a   Ferreira, Vania M ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Anxiety; depression; gender; locomotion; Melissa officinalis

Indexed keywords

DIAZEPAM; FLUOXETINE; MELISSA OFFICINALIS EXTRACT;

ANIMAL EXPERIMENT; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FORCED SWIMMING TEST; GENDER; IMMOBILIZATION; LOCOMOTION; MALE; MAZE TEST; MELISSA OFFICINALIS; NONHUMAN; OPEN FIELD BEHAVIOR; RAT; TRANQUILIZING ACTIVITY;

EID: 84858994545     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.93846     Document Type: Article

References (24)

1. Koch-Heitzmann I, Schultze W. 2000 Jahre Melissa officinalis. Z Phytother 1988;9:77-85.
2. Obulesu M, Rao DM. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues. J Neurosci Rural Pract 2011;2:56-61.
3. Guginski G, Luiz AP, Silva MD, Massaro M, Martins DF, Chaves J, et al. Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. Pharmacol Biochem Behav 2009;93:10-6.
4. Pereira P, Tysca D, Oliveira P, Brum LF, Picada JN, Ardenghi P. Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol Res 2005;52:199-203.
5. Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, et al. Modulation of mood and cognitive performance following administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor binding properties. Neuropsychopharmacology 2003;28:1871-81.
6. Pellow S, Chopin P, File SE, Briley M. Validation of open: Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985;14:149-67.
7. Porsolt RD, Lepichon M, Jalfre M. Depression - New animal-model sensitive to antidepressant treatments. Nature 1977;266:730-2.
8. Palanza P. Animal models of anxiety and depression: How are females different? Neurosci Biobehav Rev 2001;25:219-33.
9. Yonkers KA, Kando JC, Cole JO, Blummenthal S. Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. Am J Psychiatry 1992;149:587-95.
10. Doering LV, Eastwood JA. A literature review of depression, anxiety, and cardiovascular disease in women. J Obstet Gynecol Neonatal Nurs 2011;40:348-61.
11. Gater R, Tansella M, Korten A, Tiemens BG, Mavreas VG, Olatawura MO. Sex differences in the prevalence and detection of depressive and anxiety disorders in general health care settings - Report from the World Health Organization collaborative study on Psychological Problems in General Health Care. Arch Gen Psychiatry 1998;55:405-13.
12. Ibarra A, Feuillere N, Roller M, Lesburgere E, Beracochea D. Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. Phytomedicine 2010;17:397-403.
13. Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res 2006;20:96-102.
14. Wong DT, Perry KW, Bymaster FP. The discovery of fluoxetine hydrochloride (Prozac). Nat Rev Drug Discov 2005;4:764-74.
15. Negrigo A, Medeiros M, Guinsburg R, Covolan L. Long-term gender behavioral vulnerability after nociceptive neonatal formalin stimulation in rats. Neurosci Lett 2011;490:196-9.
16. Drossopoulou G, Antoniou K, Kitraki E, Papathanasiou G, Papalexi E, Dalla C, et al. Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the Forced Swim Test in rats. Neuroscience 2004;126:849-57.
17. Keers R, Aitchison KJ. Gender differences in antidepressant drug response. Int Rev Psychiatry 2010;22:485-500.
18. Leuner B, Mendolia-Loffredo S, Shors TJ. Males and females respond differently to controllability and antidepressant treatment. Biol Psychiatry 2004;56:964-70.
19. Goel N, Bale TL. Sex differences in the serotonergic influence on the hypothalamic-pituitary-adrenal stress axis. Endocrinology 2010;151:1784-94.
20. Jain SK, Zelena D. Gender specific influence of endogenous glutamate release on stress-induced fear in rats. Endocr Regul 2011;45:13-21.
21. Sutcliffe JS. Female rats are smarter than males: Influence of test, oestrogen receptor subtypes and glutamate. Curr Top Behav Neurosci 2011;8:37-56.
22. Basso AM, Gallagher KB, Mikusa JP, Rueter LE. Vogel conflict test: Sex differences and pharmacological validation of the model. Behav Brain Res 2011;218:174-83.
23. García-Cáceres C, Lagunas N, Calmarza-Font I, Azcoitia I, Diz-Chaves Y, García-Segura LM, et al. Gender differences in the long-term effects of chronic prenatal stress on the HPA axis and hypothalamic structure in rats. Psychoneuroendocrinology 2010;35:1525-35.
24. Imhof JT, Coelho ZM, Schmitt ML, Morato GS, Carobrez AP. Influence of gender and age on performance of rats in the elevated plus maze apparatus. Behav Brain Res 1993;56:177-80.