-
1
-
-
36849061558
-
Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: A meta-analysis of 18 trials involving 2,621 patients
-
DOI 10.1200/JCO.2007.12.0253
-
Ives NJ, Stowe RL, Lorigan P, Wheatley K. Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: a meta-analysis of 18 trials involving 2,621 patients. J Clin Oncol 2007;25:5426-34 (Pubitemid 350232219)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.34
, pp. 5426-5434
-
-
Ives, N.J.1
Stowe, R.L.2
Lorigan, P.3
Wheatley, K.4
-
2
-
-
80052536175
-
New drugs in melanoma: It's a whole new world
-
Eggermont AM, Robert C. New drugs in melanoma: it's a whole new world. Eur J Cancer 2011;47:2150-7
-
(2011)
Eur J Cancer
, vol.47
, pp. 2150-2157
-
-
Eggermont, A.M.1
Robert, C.2
-
3
-
-
0024205313
-
Human Ig superfamily CTLA-4 gene: Chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains
-
DOI 10.1002/eji.1830181206
-
Dariavach P, Mattei MG, Golstein P, Lefranc MP. Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur J Immunol 1988;18:1901-5 (Pubitemid 19046203)
-
(1988)
European Journal of Immunology
, vol.18
, Issue.12
, pp. 1901-1905
-
-
Dariavach, P.1
Mattei, M.-G.2
Golstein, P.3
Lefranc, M.-P.4
-
4
-
-
0033024863
-
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
-
Atkins MB, Lotze MT, Dutcher JP, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999;17:2105-16 (Pubitemid 29318842)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.7
, pp. 2105-2116
-
-
Atkins, M.B.1
Lotze, M.T.2
Dutcher, J.P.3
Fisher, R.I.4
Weiss, G.5
Margolin, K.6
Abrams, J.7
Sznol, M.8
Parkinson, D.9
Hawkins, M.10
Paradise, C.11
Kunkel, L.12
Rosenberg, S.A.13
-
6
-
-
55949125601
-
Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
-
Dudley ME, Yang JC, Sherry R, et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol 2008;26:5233-23
-
(2008)
J Clin Oncol
, vol.26
, pp. 5233-5323
-
-
Dudley, M.E.1
Yang, J.C.2
Sherry, R.3
-
7
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 Blockade
-
This is a key paper regarding the antitumoral activity of anti CTLA4 monoclonal antibody
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 Blockade. Science 1996;271:1734-6 This is a key paper regarding the antitumoral activity of anti CTLA4 monoclonal antibody.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
8
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
DOI 10.1038/nrc2051, PII NRC2051
-
Melero I, Hervas-Stubbs S, Glennie M, et al. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 2007;7:95-106 (Pubitemid 46160986)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
9
-
-
33744792341
-
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
-
DOI 10.1200/JCO.2005.04.5716
-
Beck KE, Blansfield JA, Tran KQ, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 2006;24:2283-9 (Pubitemid 46630658)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.15
, pp. 2283-2289
-
-
Beck, K.E.1
Blansfield, J.A.2
Tran, K.Q.3
Feldman, A.L.4
Hughes, M.S.5
Royal, R.E.6
Kammula, U.S.7
Topalian, S.L.8
Sherry, R.M.9
Kleiner, D.10
Quezado, M.11
Lowy, I.12
Yellin, M.13
Rosenberg, S.A.14
Yang, J.C.15
-
10
-
-
32644467549
-
Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
-
DOI 10.1200/JCO.2005.01.109
-
Ribas A, Camacho LH, Lopez-Berestein G, et al. Antitumor activity in melanoma and anti-self responses in a Phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol 2005;23:8968-77 (Pubitemid 46217464)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.35
, pp. 8968-8977
-
-
Ribas, A.1
Camacho, L.H.2
Lopez-Berestein, G.3
Pavlov, D.4
Bulanhagui, C.A.5
Millham, R.6
Comin-Anduix, B.7
Reuben, J.M.8
Seja, E.9
Parker, C.A.10
Sharma, A.11
Glaspy, J.A.12
Gomez-Navarro, J.13
-
11
-
-
61449090474
-
Phase I/II trial of tremelimumab in patients with metastatic melanoma
-
Camacho LH, Antonia S, Sosman J, et al. Phase I/II trial of tremelimumab in patients with metastatic melanoma. J Clin Oncol 2009;27:1075-81
-
(2009)
J Clin Oncol
, vol.27
, pp. 1075-1081
-
-
Camacho, L.H.1
Antonia, S.2
Sosman, J.3
-
12
-
-
55949137090
-
Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma
-
ASCO meeting 2008. abstract LBA9011
-
Ribas A, Hauschild A, Kefford R, et al. Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma. ASCO meeting 2008. J Clin Oncol 2008;26(20 Suppl):abstract LBA9011
-
(2008)
J Clin Oncol
, vol.26
, Issue.20 SUPPL.
-
-
Ribas, A.1
Hauschild, A.2
Kefford, R.3
-
13
-
-
76049092889
-
Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
-
Kirkwood JM, Lorigan P, Hersey P, et al. Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res 2010;16:1042-8
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1042-1048
-
-
Kirkwood, J.M.1
Lorigan, P.2
Hersey, P.3
-
14
-
-
84870247621
-
Patient responses to Ipilimumab, a novel immunopotentiator for metastatic melanoma: How different are these from conventional treatment responses?
-
Epub ahead of print
-
Pennock GK, Waterfield W, Wolchok JD. Patient responses to Ipilimumab, a novel immunopotentiator for metastatic melanoma: how different are these from conventional treatment responses? Am J Clin Oncol 2011; [Epub ahead of print]
-
(2011)
Am J Clin Oncol
-
-
Pennock, G.K.1
Waterfield, W.2
Wolchok, J.D.3
-
15
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, Phase II, dose-ranging study
-
Wolchok JD, Neyns B, Linette G, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, Phase II, dose-ranging study. Lancet Oncol 2010;11:155-64
-
(2010)
Lancet Oncol
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
-
16
-
-
24944459890
-
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
-
Attia P, Phan GQ, Maker AV, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005;23:6043-53
-
(2005)
J Clin Oncol
, vol.23
, pp. 6043-6053
-
-
Attia, P.1
Phan, G.Q.2
Maker, A.V.3
-
17
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
This is the registrative study of the monoclonal antibody anti CTLA4 Ipilimumab for second-line metastatic melanoma therapy
-
Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23 This is the registrative study of the monoclonal antibody anti CTLA4 Ipilimumab for second-line metastatic melanoma therapy.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
18
-
-
78650439466
-
Ipilimumab efficacy and safety in patients with advanced melanoma: A retrospective analysis of HLA subtype from four trials
-
Wolchok JD, Weber JS, Hamid O, et al. Ipilimumab efficacy and safety in patients with advanced melanoma: a retrospective analysis of HLA subtype from four trials. Cancer Immun 2010;10:9
-
(2010)
Cancer Immun
, vol.10
, pp. 9
-
-
Wolchok, J.D.1
Weber, J.S.2
Hamid, O.3
-
19
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
This is the registrative study of the monoclonal antibody anti CTLA4 Ipilimumab as first line-therapy in metastatic melanoma
-
Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26 This is the registrative study of the monoclonal antibody anti CTLA4 Ipilimumab as first line-therapy in metastatic melanoma.
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
-
20
-
-
84856008240
-
Ipilimumab safety profile: Summary of findings from completed trials in advanced melanoma. ASCO meeting 2011
-
abstract 8583
-
Ibrahim RA, Berman DM, DePril V, et al. Ipilimumab safety profile: summary of findings from completed trials in advanced melanoma. ASCO meeting 2011. J Clin Oncol 2011;29(Suppl):abstract 8583
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Ibrahim, R.A.1
Berman, D.M.2
DePril, V.3
-
21
-
-
80052678064
-
Safety and survival analysis of ipilimumab therapy in patients withstable asymptomatic brain metastases. ASCO meeting 2011
-
abstract 8581
-
Heller KN, Pavlick AC, Hodi FS, et al. Safety and survival analysis of ipilimumab therapy in patients withstable asymptomatic brain metastases. ASCO meeting 2011. J Clin Oncol 2011;29(Suppl):abstract 8581
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Heller, K.N.1
Pavlick, A.C.2
Hodi, F.S.3
-
22
-
-
77957587190
-
Phase II trial of ipilimumab monotherapy in melanoma patients with brain metastases
-
ASCO meeting 2010. abstract 8523
-
Lawrence DP, Hamid O, McDermott DF, et al. Phase II trial of ipilimumab monotherapy in melanoma patients with brain metastases. ASCO meeting 2010. J Clin Oncol 2010;28(15(Suppl):abstract 8523
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Lawrence, D.P.1
Hamid, O.2
McDermott, D.F.3
-
23
-
-
33747878218
-
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma
-
DOI 10.1097/01.cji.0000208259.73167.58, PII 0000237120060700000012
-
Maker AV, Yang JC, Sherry RM, et al. Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. J Immunother 2006;29:455-63 (Pubitemid 44288958)
-
(2006)
Journal of Immunotherapy
, vol.29
, Issue.4
, pp. 455-463
-
-
Maker, A.V.1
Yang, J.C.2
Sherry, R.M.3
Topalian, S.L.4
Kammula, U.S.5
Royal, R.E.6
Hughes, M.7
Yellin, M.J.8
Haworth, L.R.9
Levy, C.10
Allen, T.11
Mavroukakis, S.A.12
Attia, P.13
Rosenberg, S.A.14
-
24
-
-
80052544390
-
A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma
-
ASCO meeting 2011. abstract 8511
-
Hodi FS, Friedlander PA, Atkins MB, et al. A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma. ASCO meeting 2011. J Clin Oncol 2011;29(Suppl):abstract 8511
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Hodi, F.S.1
Friedlander, P.A.2
Atkins, M.B.3
-
25
-
-
34447646310
-
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
-
DOI 10.1016/j.immuni.2007.05.016, PII S1074761307003287
-
Butte MJ, Keir ME, Phamduy TB, et al. Programmed death-1 ligand interacts specifically with the B7-1 costimulatory molecules to inhibit T cell responses. Immunity 2007;27:111-22 (Pubitemid 47089023)
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
26
-
-
49649114804
-
Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger R, Rotem-Yehudar R, Slama G, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 2008;14:3044-51
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
-
27
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
DOI 10.1038/nrc2051, PII NRC2051
-
Melero I, Hervas-Stubbs S, Glennie M, et al. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 2007;7:95-106 (Pubitemid 46160986)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
28
-
-
55949113750
-
Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
-
ASCO Meeting 2008. abstract 3007
-
Sznol M, Hodi FS, Margolin K, et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). ASCO Meeting 2008. J Clin Oncol 2008;26(Suppl):abstract 3007
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Sznol, M.1
Hodi, F.S.2
Margolin, K.3
-
30
-
-
28144457350
-
Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer
-
DOI 10.1158/1078-0432.CCR-05-1203
-
Gure AO, Chua R, Williamson B, et al. Cancer-testis genes are co-ordinately expressed and are markers of poor outcome in non-small cell lung cancer. Clin Cancer Res 2005;11:8055-62 (Pubitemid 41698748)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.22
, pp. 8055-8062
-
-
Gure, A.O.1
Chua, R.2
Williamson, B.3
Gonen, M.4
Ferrera, C.A.5
Gnjatic, S.6
Ritter, G.7
Simpson, A.J.G.8
Chen, Y.-T.9
Old, L.J.10
Altorki, N.K.11
-
31
-
-
0036894242
-
Tissue microarray evaluation of melanoma antigen E (MAGE) tumor-associated antigen expression: Potential indications for specific immunotherapy and prognostic relevance in squamous cell lung carcinoma
-
DOI 10.1097/00000658-200212000-00011
-
Bolli M, Kocher T, Adamina M, et al. Tissue microarray evaluation of Melanoma antigen E (MAGE) tumor-associated antigen expression: potential indications for specific immunotherapy and prognostic relevance in squamous cell lung carcinoma. Ann Surg 2002;236:785-93 (Pubitemid 35403234)
-
(2002)
Annals of Surgery
, vol.236
, Issue.6
, pp. 785-793
-
-
Bolli, M.1
Kocher, T.2
Adamina, M.3
Guller, U.4
Dalquen, P.5
Haas, P.6
Mirlacher, M.7
Gambazzi, F.8
Harder, F.9
Heberer, M.10
Sauter, G.11
Spagnoli, G.C.12
Buchler, M.W.13
Mendes De, A.J.M.14
O'Sullivan, G.C.15
-
32
-
-
77950968549
-
Serial monitoring of circulating tumor cells predicts outcome of induction biochemotherapy plus maintenance biotherapy for metastatic melanoma
-
Koyanagi O'Day SJ, HoonDS, Serial monitoring of circulating tumor cells predicts outcome of induction biochemotherapy plus maintenance biotherapy for metastatic melanoma. Clin Cancer Res 2010(16):2402-8
-
(2010)
Clin Cancer Res
, Issue.16
, pp. 2402-2408
-
-
Koyanagi O'Day, S.J.1
Hoon, D.S.2
-
33
-
-
71049153709
-
Cancer/testis (CT) antigens: Potential targets for immunotherapy
-
Caballero OL, Chen YT. Cancer/testis (CT) antigens: potential targets for immunotherapy. Cancer Sci 2009;100:2014-21
-
(2009)
Cancer Sci
, vol.100
, pp. 2014-2021
-
-
Caballero, O.L.1
Chen, Y.T.2
-
34
-
-
79957709717
-
Vaccines for the treatment of non-small cell lung cancer: Investigational approaches and clinical experience
-
Mellstedt H, Vansteenkiste J, Thatcher N. Vaccines for the treatment of non-small cell lung cancer: investigational approaches and clinical experience. Lung Cancer 2011;73:11-17
-
(2011)
Lung Cancer
, vol.73
, pp. 11-17
-
-
Mellstedt, H.1
Vansteenkiste, J.2
Thatcher, N.3
-
35
-
-
65649129679
-
Immunization with recombinant MAGE-A3 protein combined with adjuvant systems AS15 or AS02B in patients with unresectable and progressive metastatic cutaneous melanoma: A randomized open-label phase II study of the EORTC Melanoma Group (16032-18031)
-
ASCO meeting 2008. abstract 9065
-
Kruit WH, Suciu S, Dreno B, et al. Immunization with recombinant MAGE-A3 protein combined with adjuvant systems AS15 or AS02B in patients with unresectable and progressive metastatic cutaneous melanoma: a randomized open-label phase II study of the EORTC Melanoma Group (16032-18031). ASCO meeting 2008. J Clin Oncol 2008;26(20 Suppl):abstract 9065
-
(2008)
J Clin Oncol
, vol.26
, Issue.20 SUPPL.
-
-
Kruit, W.H.1
Suciu, S.2
Dreno, B.3
-
36
-
-
67649362302
-
Safety and immunogenicity of a human and mouse gp100 DNA vaccine in a phase I trial of patients with melanoma
-
Yuan J, Ku GY, Gallardo HF, et al. Safety and immunogenicity of a human and mouse gp100 DNA vaccine in a phase I trial of patients with melanoma. Cancer Immun 2009;9:5
-
(2009)
Cancer Immun
, vol.9
, pp. 5
-
-
Yuan, J.1
Ku, G.Y.2
Gallardo, H.F.3
-
37
-
-
79957831345
-
Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
-
Schwartzentruber DJ, Lawson DH, Richards JM, et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med 2011;364:2119-27
-
(2011)
N Engl J Med
, vol.364
, pp. 2119-2127
-
-
Schwartzentruber, D.J.1
Lawson, D.H.2
Richards, J.M.3
-
38
-
-
84858954334
-
Combination immunotherapy for high-risk and advanced melanoma patients
-
ASCO meeting 2011. abstract 8534
-
Riker AI, Vahanian NN, Link CJ, et al. Combination immunotherapy for high-risk and advanced melanoma patients. ASCO meeting 2011. J Clin Oncol 2011;29(Suppl):abstract 8534
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Riker, A.I.1
Vahanian, N.N.2
Link, C.J.3
-
39
-
-
70349680756
-
Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
-
Ribas A, Comin-Anduix B, Chmielowski B, et al. Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res 2009;15:6267-76
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6267-6276
-
-
Ribas, A.1
Comin-Anduix, B.2
Chmielowski, B.3
-
40
-
-
79960895501
-
CTLA-4 blockade increases antigen-specific CD8+ T cells in prevaccinated patients with melanoma: Three cases
-
Yuan J, Ginsberg B, Page D, et al. CTLA-4 blockade increases antigen-specific CD8+ T cells in prevaccinated patients with melanoma: three cases. Cancer Immunol Immunother 2011;60:1137-46
-
(2011)
Cancer Immunol Immunother
, vol.60
, pp. 1137-1146
-
-
Yuan, J.1
Ginsberg, B.2
Page, D.3
-
41
-
-
33845336115
-
GM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor
-
DOI 10.1158/1078-0432.CCR-06-0759
-
Hu JC, Coffin RS, Davis CJ, et al. A Phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor. Clin Cancer Res 2006;12:6737-47 (Pubitemid 44876843)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.22
, pp. 6737-6747
-
-
Hu, J.C.C.1
Coffin, R.S.2
Davis, C.J.3
Graham, N.J.4
Groves, N.5
Guest, P.J.6
Harrington, K.J.7
James, N.D.8
Love, C.A.9
McNeish, I.10
Medley, L.C.11
Michael, A.12
Nutting, C.M.13
Pandha, H.S.14
Shorrock, C.A.15
Simpson, J.16
Steiner, J.17
Steven, N.M.18
Wright, D.19
Coombes, R.C.20
more..
-
42
-
-
65649122643
-
Phase II clinical trial with a second generation, GM-CSF encoding, oncolytic herpesvirus in unresectable metastatic melanoma
-
ASCO Meeting 2008. abstract 9008
-
Senzer NN, Kaufman HL, Amatruda T, et al. Phase II clinical trial with a second generation, GM-CSF encoding, oncolytic herpesvirus in unresectable metastatic melanoma. ASCO Meeting 2008. J Clin Oncol 2008;26:abstract 9008
-
(2008)
J Clin Oncol
, vol.26
-
-
Senzer, N.N.1
Kaufman, H.L.2
Amatruda, T.3
-
43
-
-
0034885426
-
Phase II study of direct intralesional gene transfer of Allovectin-7, an HLA-B7/beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma
-
Stopeck AT, Jones A, Hersh EM, et al. Phase II study of direct intralesional gene transfer of allovectin-7, an HLA-B7/beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma. Clin Cancer Res 2001;7:2285-91 (Pubitemid 32751626)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.8
, pp. 2285-2291
-
-
Stopeck, A.T.1
Jones, A.2
Hersh, E.M.3
Thompson, J.A.4
Finucane, D.M.5
Gutheil, J.C.6
Gonzalez, R.7
-
44
-
-
77952238515
-
A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma
-
Bedikian AY, Richards J, Kharkevitch D, et al. A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma. Melanoma Res 2010;20:218-26
-
(2010)
Melanoma Res
, vol.20
, pp. 218-226
-
-
Bedikian, A.Y.1
Richards, J.2
Kharkevitch, D.3
-
45
-
-
34248227617
-
Toward a molecular classification of melanoma
-
DOI 10.1200/JCO.2006.06.0442
-
Fecher LA, Cummings SD, Keefe MJ, Alani RM. Toward a molecular classification of melanoma. J Clin Oncol 2007;25:1606-20 (Pubitemid 46733089)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.12
, pp. 1606-1620
-
-
Fecher, L.A.1
Cummings, S.D.2
Keefe, M.J.3
Alani, R.M.4
-
46
-
-
58149260596
-
KIT gene mutations and copy number in melanoma subtypes
-
Beadling C, Jacobson-Dunlop E, Hodi FS, et al. KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 2008;14:6821-8
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6821-6828
-
-
Beadling, C.1
Jacobson-Dunlop, E.2
Hodi, F.S.3
-
47
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
DOI 10.1038/nature00766
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54 (Pubitemid 34716871)
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmleri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
48
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
DOI 10.1038/nature04304, PII NATURE04304
-
Solit DB, Garraway LA, Pratilas CA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006;439:358-62 (Pubitemid 43128863)
-
(2006)
Nature
, vol.439
, Issue.7074
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
Ye, Q.7
Lobo, J.M.8
She, Y.9
Osman, I.10
Golub, T.R.11
Sebolt-Leopold, J.12
Sellers, W.R.13
Rosen, N.14
-
49
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
DOI 10.1056/NEJMoa050092
-
Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005;353:2135-47 This is the key paper regarding the new biomolecular classification of melanoma patients. (Pubitemid 41653105)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.20
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
Patel, H.N.4
Busam, K.J.5
Kutzner, H.6
Cho, K.-H.7
Aiba, S.8
Brocker, E.-B.9
LeBoit, P.E.10
Pinkel, D.11
Bastian, B.C.12
-
50
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
DOI 10.1200/JCO.2006.06.2984
-
Curtin JA, Busam K, Pinkel D, Bastian BC. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 2006;24:4340-6 (Pubitemid 46630793)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.26
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
Bastian, B.C.4
-
51
-
-
84978034236
-
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
-
Long GV, Menzies AM, Nagrial AM, et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol 2011;29:1239-46
-
(2011)
J Clin Oncol
, vol.29
, pp. 1239-1246
-
-
Long, G.V.1
Menzies, A.M.2
Nagrial, A.M.3
-
52
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broadtarget blockade in BRAF-mutant melanoma
-
This is one of the first studies showing the clinical activity of BRAF inhibitors in BRAF-mutated melanoma
-
Bollag G, Hirth P, Tsai J, et al. Clinical efficacy of a RAF inhibitor needs broadtarget blockade in BRAF-mutant melanoma. Nature 2010;467:596-9 This is one of the first studies showing the clinical activity of BRAF inhibitors in BRAF-mutated melanoma.
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
-
53
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
This is one of the first papers demonstrating the activity of an anti BRAF drug in BRAF-mutated melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-19 This is one of the first papers demonstrating the activity of an anti BRAF drug in BRAF-mutated melanoma.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
54
-
-
77957350123
-
Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors
-
ASCO meeting 2011 abstract 8503
-
Kefford R, Arkenau H, Brown MP, et al. Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. ASCO meeting 2011. J Clin Oncol 2010;28(15 Suppl):abstract 8503
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Kefford, R.1
Arkenau, H.2
Brown, M.P.3
-
55
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
BRIM-3 Study Group. This is the registrative study of the anti BRAF drug vemurafenib as first-line therapy in metastatic melanoma patients
-
Chapman PB, Hauschild A, Robert C, et al. BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364(26):2507-16 This is the registrative study of the anti BRAF drug vemurafenib as first-line therapy in metastatic melanoma patients.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
56
-
-
79959776574
-
BRIM-2: An open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAFV600E mutation positive melanoma
-
ASCO meeting 2011 abstract 8509
-
Ribas A, Kim KB, Schuchter LM, et al. BRIM-2: an open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAFV600E mutation positive melanoma. ASCO meeting 2011. J Clin Oncol 2011;29(Suppl): abstract 8509
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Ribas, A.1
Kim, K.B.2
Schuchter, L.M.3
-
58
-
-
77953276524
-
Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
-
Paraiso KH, Fedorenko IV, Cantini LP, et al. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer 2010;102:1724-30
-
(2010)
Br J Cancer
, vol.102
, pp. 1724-1730
-
-
Paraiso, K.H.1
Fedorenko, I.V.2
Cantini, L.P.3
-
59
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
Emery CM, Vijayendran KG, Zipser MC, et al. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci USA 2009;106(48):20411-16
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.48
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
-
60
-
-
80053154225
-
Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436)
-
ASCO meeting 2011. abstract CRA8503
-
Infante JR, Falchook GS, Lawrence DP, et al. Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436). ASCO meeting 2011. J Clin Oncol 2011;29(Suppl):abstract CRA8503
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Infante, J.R.1
Falchook, G.S.2
Lawrence, D.P.3
-
61
-
-
72049121189
-
Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene
-
Terheyden P, Houben R, Pajouh P, et al. Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene. J Invest Dermatol 2010;130:314-16
-
(2010)
J Invest Dermatol
, vol.130
, pp. 314-316
-
-
Terheyden, P.1
Houben, R.2
Pajouh, P.3
-
62
-
-
77954216079
-
Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics
-
Woodman SE, Davies MA. Targeting KIT in melanoma: a paradigm of molecular medicine and targeted therapeutics. Biochem Pharmacol 2010;80:568-74
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 568-574
-
-
Woodman, S.E.1
Davies, M.A.2
-
63
-
-
33646268037
-
Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
-
DOI 10.1002/cncr.21834
-
Wyman K, Atkins MB, Prieto V, et al. Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 2006;106:2005-11 (Pubitemid 43673217)
-
(2006)
Cancer
, vol.106
, Issue.9
, pp. 2005-2011
-
-
Wyman, K.1
Atkins, M.B.2
Prieto, V.3
Eton, O.4
McDermott, D.F.5
Hubbard, F.6
Byrnes, C.7
Sanders, K.8
Sosman, J.A.9
-
64
-
-
68949132133
-
A phase II study of imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT
-
ASCO meeting 2009 abstract 9001
-
Carvajal RD, Chapman PB, Wolchok JD, et al. A phase II study of imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT. ASCO meeting 2009. J Clin Oncol 2009;27(15 Suppl):abstract 9001
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Carvajal, R.D.1
Chapman, P.B.2
Wolchok, J.D.3
-
65
-
-
79958066836
-
KIT as a therapeutic target in metastatic melanoma
-
Carvajal RD, Antonescu CR, Wolchok JD, et al. KIT as a therapeutic target in metastatic melanoma. JAMA 2011;305:2327-34
-
(2011)
JAMA
, vol.305
, pp. 2327-2334
-
-
Carvajal, R.D.1
Antonescu, C.R.2
Wolchok, J.D.3
-
66
-
-
84858993825
-
A phase II trial of nilotinib in the treatment of patients with KIT mutated advanced acral and mucosal melanoma (NICAM)
-
ASCO meeting 2011 abstract TPS229
-
Larkin JM, Turajlic S, Nathan PD, et al. A phase II trial of nilotinib in the treatment of patients with KIT mutated advanced acral and mucosal melanoma (NICAM). ASCO meeting 2011. J Clin Oncol 2011;29(Suppl):abstract TPS229
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Larkin, J.M.1
Turajlic, S.2
Nathan, P.D.3
-
67
-
-
79960554999
-
E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion
-
Glen H, Mason S, Patel H, et al. E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion. BMC Cancer 2011;11:309
-
(2011)
BMC Cancer
, vol.11
, pp. 309
-
-
Glen, H.1
Mason, S.2
Patel, H.3
-
68
-
-
84858969868
-
The effect of E7080, a VEGFR and FGFR tyrosine kinase inhibitor (TKI), on BRAF wild-type melanoma
-
ASCO 2011. abstract 8566
-
Funahashi Y, Matsui J, Minoshima Y, et al. The effect of E7080, a VEGFR and FGFR tyrosine kinase inhibitor (TKI), on BRAF wild-type melanoma. ASCO 2011. J Clin Oncol 2011;29(Suppl):abstract 8566
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Funahashi, Y.1
Matsui, J.2
Minoshima, Y.3
-
69
-
-
84873366315
-
Assessment of clinical activity of E7080, a multitargeted kinase inhibitor, in patients with advanced melanoma treated in two phase I trials
-
ASCO meeting 2011. abstract 8527
-
Hong DS, Boss DS, Glen H, et al. Assessment of clinical activity of E7080, a multitargeted kinase inhibitor, in patients with advanced melanoma treated in two phase I trials. ASCO meeting 2011. J Clin Oncol 2011;29(Suppl):abstract 8527
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Hong, D.S.1
Boss, D.S.2
Glen, H.3
|