-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
[June 17, EPub ahead of print]
-
Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, [June 17, EPub ahead of print].
-
(2010)
Int J Cancer
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
2
-
-
44249086425
-
Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship
-
Molina J.R., Yang P., Cassivi S.D., Schild S.E., Adjei A.A. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 2008, 83:584-594.
-
(2008)
Mayo Clin Proc
, vol.83
, pp. 584-594
-
-
Molina, J.R.1
Yang, P.2
Cassivi, S.D.3
Schild, S.E.4
Adjei, A.A.5
-
4
-
-
77949891126
-
Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099
-
Lynch T.J., Patel T., Dreisbach L., McCleod M., Heim W.J., Hermann R.C., et al. Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099. J Clin Oncol 2010, 28:911-917.
-
(2010)
J Clin Oncol
, vol.28
, pp. 911-917
-
-
Lynch, T.J.1
Patel, T.2
Dreisbach, L.3
McCleod, M.4
Heim, W.J.5
Hermann, R.C.6
-
5
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
-
Pirker R., Pereira J.R., Szczesna A., von Pawel J., Krzakowski M., Ramlau R., et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009, 373:1525-1531.
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
von Pawel, J.4
Krzakowski, M.5
Ramlau, R.6
-
6
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
-
Reck M., von Pawel J., Zatloukal P., Ramlau R., Gorbounova V., Hirsh V., et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 2010, 21:1804-1809.
-
(2010)
Ann Oncol
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
von Pawel, J.2
Zatloukal, P.3
Ramlau, R.4
Gorbounova, V.5
Hirsh, V.6
-
7
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A., Gray R., Perry M.C., Brahmer J., Schiller J.H., Dowlati A., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355:2542-2550.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
-
8
-
-
77649203360
-
Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: results of a west Japan thoracic oncology group trial (WJTOG0203)
-
Takeda K., Hida T., Sato T., Ando M., Seto T., Satouchi M., et al. Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: results of a west Japan thoracic oncology group trial (WJTOG0203). J Clin Oncol 2010, 28:753-760.
-
(2010)
J Clin Oncol
, vol.28
, pp. 753-760
-
-
Takeda, K.1
Hida, T.2
Sato, T.3
Ando, M.4
Seto, T.5
Satouchi, M.6
-
9
-
-
70350225538
-
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
-
Ciuleanu T., Brodowicz T., Zielinski C., Kim J.H., Krzakowski M., Laack E., et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 2009, 374:1432-1440.
-
(2009)
Lancet
, vol.374
, pp. 1432-1440
-
-
Ciuleanu, T.1
Brodowicz, T.2
Zielinski, C.3
Kim, J.H.4
Krzakowski, M.5
Laack, E.6
-
10
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F., Ciuleanu T., Stelmakh L., Cicenas S., Szczesna A., Juhasz E., et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 2010, 11:521-529.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
Cicenas, S.4
Szczesna, A.5
Juhasz, E.6
-
11
-
-
65549128316
-
Targeting the immune system in cancer
-
Chaudhuri D., Suriano R., Mittelman A., Tiwari R.K. Targeting the immune system in cancer. Curr Pharm Biotechnol 2009, 10:166-184.
-
(2009)
Curr Pharm Biotechnol
, vol.10
, pp. 166-184
-
-
Chaudhuri, D.1
Suriano, R.2
Mittelman, A.3
Tiwari, R.K.4
-
12
-
-
1542541479
-
Cancer vaccines: an old idea comes of age
-
Emens L.A., Jaffee E.M. Cancer vaccines: an old idea comes of age. Cancer Biol Ther 2003, 2:S161-S168.
-
(2003)
Cancer Biol Ther
, vol.2
-
-
Emens, L.A.1
Jaffee, E.M.2
-
13
-
-
59849122181
-
The cancer vaccine roller coaster
-
Goldman B., DeFrancesco L. The cancer vaccine roller coaster. Nat Biotechnol 2009, 27:129-139.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 129-139
-
-
Goldman, B.1
DeFrancesco, L.2
-
15
-
-
0036322920
-
Cancer vaccines and immunotherapy
-
Dermime S., Armstrong A., Hawkins R.E., Stern P.L. Cancer vaccines and immunotherapy. Br Med Bull 2002, 62:149-162.
-
(2002)
Br Med Bull
, vol.62
, pp. 149-162
-
-
Dermime, S.1
Armstrong, A.2
Hawkins, R.E.3
Stern, P.L.4
-
16
-
-
9744242007
-
Anticancer vaccination strategies
-
Nencioni A., Gruenbach F., Patrone F., Brossart P. Anticancer vaccination strategies. Ann Oncol 2004, 15(Suppl. 4):iv153-iv160.
-
(2004)
Ann Oncol
, vol.15
, Issue.SUPPL. 4
-
-
Nencioni, A.1
Gruenbach, F.2
Patrone, F.3
Brossart, P.4
-
17
-
-
0036623140
-
Immune escape of tumors: apoptosis resistance and tumor counterattack
-
Igney F.H., Krammer P.H. Immune escape of tumors: apoptosis resistance and tumor counterattack. J Leukoc Biol 2002, 71:907-920.
-
(2002)
J Leukoc Biol
, vol.71
, pp. 907-920
-
-
Igney, F.H.1
Krammer, P.H.2
-
19
-
-
31344453943
-
Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention
-
Whiteside T.L. Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention. Semin Cancer Biol 2006, 16:3-15.
-
(2006)
Semin Cancer Biol
, vol.16
, pp. 3-15
-
-
Whiteside, T.L.1
-
20
-
-
53449090440
-
Overcoming immunosuppressive mechanisms
-
Widen K., Mozaffari F., Choudhury A., Mellstedt H. Overcoming immunosuppressive mechanisms. Ann Oncol 2008, 19(Suppl. 7):vii241-vii247.
-
(2008)
Ann Oncol
, vol.19
, Issue.SUPPL. 7
-
-
Widen, K.1
Mozaffari, F.2
Choudhury, A.3
Mellstedt, H.4
-
21
-
-
40449133556
-
Early clinical trial experience with vaccine therapies in non-small-cell lung cancer
-
Ho C., Ochsenbein A.F., Gautschi O., Davies A.M. Early clinical trial experience with vaccine therapies in non-small-cell lung cancer. Clin Lung Cancer 2008, 9(Suppl. 1):S20-S27.
-
(2008)
Clin Lung Cancer
, vol.9
, Issue.SUPPL. 1
-
-
Ho, C.1
Ochsenbein, A.F.2
Gautschi, O.3
Davies, A.M.4
-
22
-
-
27644457376
-
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
-
Thomas D.A., Massague J. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 2005, 8:369-380.
-
(2005)
Cancer Cell
, vol.8
, pp. 369-380
-
-
Thomas, D.A.1
Massague, J.2
-
23
-
-
65249138393
-
Myeloid-derived suppressor cells: linking inflammation and cancer
-
Ostrand-Rosenberg S., Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 2009, 182:4499-4506.
-
(2009)
J Immunol
, vol.182
, pp. 4499-4506
-
-
Ostrand-Rosenberg, S.1
Sinha, P.2
-
24
-
-
34848906252
-
A comparison and critical analysis of preclinical anticancer vaccination strategies
-
Kochenderfer J.N., Gress R.E. A comparison and critical analysis of preclinical anticancer vaccination strategies. Exp Biol Med (Maywood) 2007, 232:1130-1141.
-
(2007)
Exp Biol Med (Maywood)
, vol.232
, pp. 1130-1141
-
-
Kochenderfer, J.N.1
Gress, R.E.2
-
25
-
-
77952540334
-
Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results
-
Cluff C.W. Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv Exp Med Biol 2009, 667:111-123.
-
(2009)
Adv Exp Med Biol
, vol.667
, pp. 111-123
-
-
Cluff, C.W.1
-
26
-
-
70349416505
-
Vaccines for the treatment of non-small cell lung cancer: a renewed anticancer strategy
-
Gridelli C., Rossi A., Maione P., Ferrara M.L., Castaldo V., Sacco P.C. Vaccines for the treatment of non-small cell lung cancer: a renewed anticancer strategy. Oncologist 2009, 14:909-920.
-
(2009)
Oncologist
, vol.14
, pp. 909-920
-
-
Gridelli, C.1
Rossi, A.2
Maione, P.3
Ferrara, M.L.4
Castaldo, V.5
Sacco, P.C.6
-
27
-
-
0035883073
-
Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression
-
Sotomayor E.M., Borrello I., Rattis F.M., Cuenca A.G., Abrams J., Staveley-O'Carroll K., et al. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood 2001, 98:1070-1077.
-
(2001)
Blood
, vol.98
, pp. 1070-1077
-
-
Sotomayor, E.M.1
Borrello, I.2
Rattis, F.M.3
Cuenca, A.G.4
Abrams, J.5
Staveley-O'Carroll, K.6
-
28
-
-
9144261696
-
Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication
-
van Mierlo G.J., Boonman Z.F., Dumortier H.M., den Boer A.T., Fransen M.F., Nouta J., et al. Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication. J Immunol 2004, 173:6753-6759.
-
(2004)
J Immunol
, vol.173
, pp. 6753-6759
-
-
van Mierlo, G.J.1
Boonman, Z.F.2
Dumortier, H.M.3
den Boer, A.T.4
Fransen, M.F.5
Nouta, J.6
-
29
-
-
34548249596
-
An international, randomized, phase III trial of bacillus Calmette-Guerin (BCG) plus allogeneic melanoma vaccine (MCV) or placebo after complete resection of melanoma metastatic to regional or distant sites
-
[abstract 8508]
-
Morton D.L., Mozzillo N., Thompson J.F., Kelley M.C., Faries M., Wagner J., et al. An international, randomized, phase III trial of bacillus Calmette-Guerin (BCG) plus allogeneic melanoma vaccine (MCV) or placebo after complete resection of melanoma metastatic to regional or distant sites. J Clin Oncol 2007, 25(18S). [abstract 8508].
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Morton, D.L.1
Mozzillo, N.2
Thompson, J.F.3
Kelley, M.C.4
Faries, M.5
Wagner, J.6
-
30
-
-
59349103735
-
Recent advances in cancer vaccines: an overview
-
Itoh K., Yamada A., Mine T., Noguchi M. Recent advances in cancer vaccines: an overview. Jpn J Clin Oncol 2009, 39:73-80.
-
(2009)
Jpn J Clin Oncol
, vol.39
, pp. 73-80
-
-
Itoh, K.1
Yamada, A.2
Mine, T.3
Noguchi, M.4
-
31
-
-
34748815649
-
GSK's antigen-specific cancer immunotherapy programme: pilot results leading to Phase III clinical development
-
Brichard V.G., Lejeune D. GSK's antigen-specific cancer immunotherapy programme: pilot results leading to Phase III clinical development. Vaccine 2007, 25(Suppl. 2):B61-71.
-
(2007)
Vaccine
, vol.25
, Issue.SUPPL. 2
-
-
Brichard, V.G.1
Lejeune, D.2
-
32
-
-
8744223031
-
Targeting dendritic cells with antigen-containing liposomes: antitumour immunity
-
Altin J.G., van Broekhoven C.L., Parish C.R. Targeting dendritic cells with antigen-containing liposomes: antitumour immunity. Expert Opin Biol Ther 2004, 4:1735-1747.
-
(2004)
Expert Opin Biol Ther
, vol.4
, pp. 1735-1747
-
-
Altin, J.G.1
van Broekhoven, C.L.2
Parish, C.R.3
-
33
-
-
34547661985
-
L-BLP25: a peptide vaccine strategy in non small cell lung cancer
-
Sangha R., Butts C. L-BLP25: a peptide vaccine strategy in non small cell lung cancer. Clin Cancer Res 2007, 13:S4652-S4654.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Sangha, R.1
Butts, C.2
-
34
-
-
34848831575
-
The B7 family and cancer therapy: costimulation and coinhibition
-
Zang X., Allison J.P. The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res 2007, 13:5271-5279.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5271-5279
-
-
Zang, X.1
Allison, J.P.2
-
35
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
-
Wolchok J.D., Neyns B., Linette G., Negrier S., Lutzky J., Thomas L., et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 2010, 11:155-164.
-
(2010)
Lancet Oncol
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
Negrier, S.4
Lutzky, J.5
Thomas, L.6
-
36
-
-
49649114804
-
Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger R., Rotem-Yehudar R., Slama G., Landes S., Kneller A., Leiba M., et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 2008, 14:3044-3051.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
Landes, S.4
Kneller, A.5
Leiba, M.6
-
37
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer J.R., Drake C.G., Wollner I., Powderly J.D., Picus J., Sharfman W.H., et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010, 28:3167-3175.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
-
38
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
Curran M.A., Montalvo W., Yagita H., Allison J.P. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A 2010, 107:4275-4280.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
39
-
-
68549135290
-
Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
-
Higano C.S., Schellhammer P.F., Small E.J., Burch P.A., Nemunaitis J., Yuh L., et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer 2009, 115:3670-3679.
-
(2009)
Cancer
, vol.115
, pp. 3670-3679
-
-
Higano, C.S.1
Schellhammer, P.F.2
Small, E.J.3
Burch, P.A.4
Nemunaitis, J.5
Yuh, L.6
-
40
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
Kantoff P.W., Higano C.S., Shore N.D., Berger E.R., Small E.J., Penson D.F., et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010, 363:411-422.
-
(2010)
N Engl J Med
, vol.363
, pp. 411-422
-
-
Kantoff, P.W.1
Higano, C.S.2
Shore, N.D.3
Berger, E.R.4
Small, E.J.5
Penson, D.F.6
-
41
-
-
46749085802
-
An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial
-
Wood C., Srivastava P., Bukowski R., Lacombe L., Gorelov A.I., Gorelov S., et al. An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial. Lancet 2008, 372:145-154.
-
(2008)
Lancet
, vol.372
, pp. 145-154
-
-
Wood, C.1
Srivastava, P.2
Bukowski, R.3
Lacombe, L.4
Gorelov, A.I.5
Gorelov, S.6
-
42
-
-
70349638579
-
Idiotype vaccine therapy (BiovaxID) in follicular lymphoma in first complete remission: phase III clinical trial results
-
[abstract 2]
-
Schuster S.J., Neelapu S.S., Gause B.L., Muggia F.M., Gockerman J.P., Sotomayor E.M., et al. Idiotype vaccine therapy (BiovaxID) in follicular lymphoma in first complete remission: phase III clinical trial results. J Clin Oncol 2009, 17(18S). [abstract 2].
-
(2009)
J Clin Oncol
, vol.17
, Issue.18 S
-
-
Schuster, S.J.1
Neelapu, S.S.2
Gause, B.L.3
Muggia, F.M.4
Gockerman, J.P.5
Sotomayor, E.M.6
-
43
-
-
70350135349
-
A phase III multi-institutional randomized study of immunization with the gp100:209-217 (210M) peptide followed by high-dose IL-2 compared with high-dose IL-2 alone in patients with metastatic melanoma
-
[abstract CRA9011]
-
Schwartzentruber D.J., Lawson D., Richards J., Conry R.M., Miller D., Triesman J., et al. A phase III multi-institutional randomized study of immunization with the gp100:209-217 (210M) peptide followed by high-dose IL-2 compared with high-dose IL-2 alone in patients with metastatic melanoma. J Clin Oncol 2009, 27(18S). [abstract CRA9011].
-
(2009)
J Clin Oncol
, vol.27
, Issue.18 S
-
-
Schwartzentruber, D.J.1
Lawson, D.2
Richards, J.3
Conry, R.M.4
Miller, D.5
Triesman, J.6
-
44
-
-
78449263060
-
Randomized phase III trial comparing postoperative adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation in stage II (T3-T4N0M0) melanoma: final results of study EORTC 18961
-
[abstract 8505]
-
Eggermont A.M., Suciu S., Rutkowski P., Marsden J., Testori A., Corrie P., et al. Randomized phase III trial comparing postoperative adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation in stage II (T3-T4N0M0) melanoma: final results of study EORTC 18961. J Clin Oncol 2010, 28(15s). [abstract 8505].
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Eggermont, A.M.1
Suciu, S.2
Rutkowski, P.3
Marsden, J.4
Testori, A.5
Corrie, P.6
-
45
-
-
40449114433
-
Unmet need in lung cancer: can vaccines bridge the gap?
-
Kim J., Raz D., Jablons D. Unmet need in lung cancer: can vaccines bridge the gap?. Clin Lung Cancer 2008, 9(Suppl. 1):S6-S12.
-
(2008)
Clin Lung Cancer
, vol.9
, Issue.SUPPL. 1
-
-
Kim, J.1
Raz, D.2
Jablons, D.3
-
46
-
-
84941944867
-
Intratumoral administration of adenoviral interleukin 7 gene-modified dendritic cells augments specific antitumor immunity and achieves tumor eradication
-
Miller P.W., Sharma S., Stolina M., Butterfield L.H., Luo J., Lin Y., et al. Intratumoral administration of adenoviral interleukin 7 gene-modified dendritic cells augments specific antitumor immunity and achieves tumor eradication. Hum Gene Ther 2000, 11:53-65.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 53-65
-
-
Miller, P.W.1
Sharma, S.2
Stolina, M.3
Butterfield, L.H.4
Luo, J.5
Lin, Y.6
-
47
-
-
70349249620
-
Lung cancer-associated tumor antigens and the present status of immunotherapy against non-small-cell lung cancer
-
Yasumoto K., Hanagiri T., Takenoyama M. Lung cancer-associated tumor antigens and the present status of immunotherapy against non-small-cell lung cancer. Gen Thorac Cardiovasc Surg 2009, 57:449-457.
-
(2009)
Gen Thorac Cardiovasc Surg
, vol.57
, pp. 449-457
-
-
Yasumoto, K.1
Hanagiri, T.2
Takenoyama, M.3
-
49
-
-
33750586798
-
Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer
-
Nemunaitis J., Dillman R.O., Schwarzenberger P.O., Senzer N., Cunningham C., Cutler J., et al. Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer. J Clin Oncol 2006, 24:4721-4730.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4721-4730
-
-
Nemunaitis, J.1
Dillman, R.O.2
Schwarzenberger, P.O.3
Senzer, N.4
Cunningham, C.5
Cutler, J.6
-
50
-
-
0022617915
-
Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness
-
Rook A.H., Kehrl J.H., Wakefield L.M., Roberts A.B., Sporn M.B., Burlington D.B., et al. Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J Immunol 1986, 136:3916-3920.
-
(1986)
J Immunol
, vol.136
, pp. 3916-3920
-
-
Rook, A.H.1
Kehrl, J.H.2
Wakefield, L.M.3
Roberts, A.B.4
Sporn, M.B.5
Burlington, D.B.6
-
51
-
-
0033854184
-
Immunization with TGF-beta antisense oligonucleotide-modified autologous tumor vaccine enhances the antitumor immunity of MBT-2 tumor-bearing mice through upregulation of MHC class I and Fas expressions
-
Tzai T.S., Shiau A.L., Liu L.L., Wu C.L. Immunization with TGF-beta antisense oligonucleotide-modified autologous tumor vaccine enhances the antitumor immunity of MBT-2 tumor-bearing mice through upregulation of MHC class I and Fas expressions. Anticancer Res 2000, 20:1557-1562.
-
(2000)
Anticancer Res
, vol.20
, pp. 1557-1562
-
-
Tzai, T.S.1
Shiau, A.L.2
Liu, L.L.3
Wu, C.L.4
-
52
-
-
77958590905
-
Correlation of immune responses and survival in a phase II study of belagenpumatucel-L in non-small cell lung cancer
-
[abstract 3013]
-
Fakhrai H., Tong A., Nemunaitis J., Shawler D.L. Correlation of immune responses and survival in a phase II study of belagenpumatucel-L in non-small cell lung cancer. J Clin Oncol 2009, 27(15S). [abstract 3013].
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Fakhrai, H.1
Tong, A.2
Nemunaitis, J.3
Shawler, D.L.4
-
53
-
-
79957765086
-
-
NCT00676507. Phase III Lucanix™ vaccine therapy in advanced non-small cell lung cancer (NSCLC) following front-line chemotherapy (STOP trial). [updated 25.03.2011]
-
NCT00676507. Phase III Lucanix™ vaccine therapy in advanced non-small cell lung cancer (NSCLC) following front-line chemotherapy (STOP trial). [updated 25.03.2011]. http://www.clinicaltrials.gov/ct2/show/NCT00676507?term=STOP+belagenpumatucel&rank=1.
-
-
-
-
54
-
-
1642447060
-
The role of EGFR inhibitors in nonsmall cell lung cancer
-
Ciardiello F., De Vita F., Orditura M., Tortora G. The role of EGFR inhibitors in nonsmall cell lung cancer. Curr Opin Oncol 2004, 16:130-135.
-
(2004)
Curr Opin Oncol
, vol.16
, pp. 130-135
-
-
Ciardiello, F.1
De Vita, F.2
Orditura, M.3
Tortora, G.4
-
55
-
-
32544443644
-
Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis
-
Nakamura H., Kawasaki N., Taguchi M., Kabasawa K. Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis. Thorax 2006, 61:140-145.
-
(2006)
Thorax
, vol.61
, pp. 140-145
-
-
Nakamura, H.1
Kawasaki, N.2
Taguchi, M.3
Kabasawa, K.4
-
56
-
-
33847323129
-
Epidermal growth factor receptor mutations in lung cancer
-
Sharma S.V., Bell D.W., Settleman J., Haber D.A. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 2007, 7:169-181.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 169-181
-
-
Sharma, S.V.1
Bell, D.W.2
Settleman, J.3
Haber, D.A.4
-
57
-
-
0031775979
-
A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial
-
Gonzalez G., Crombet T., Catala M., Mirabal V., Hernandez J.C., Gonzalez Y., et al. A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial. Ann Oncol 1998, 9:431-435.
-
(1998)
Ann Oncol
, vol.9
, pp. 431-435
-
-
Gonzalez, G.1
Crombet, T.2
Catala, M.3
Mirabal, V.4
Hernandez, J.C.5
Gonzalez, Y.6
-
58
-
-
41149159650
-
Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer
-
Neninger Vinageras E., de la Torre A., Osorio Rodriguez M., Catala Ferrer M., Bravo I., Mendoza del Pino M., et al. Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer. J Clin Oncol 2008, 26:1452-1458.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1452-1458
-
-
Neninger Vinageras, E.1
de la Torre, A.2
Osorio Rodriguez, M.3
Catala Ferrer, M.4
Bravo, I.5
Mendoza del Pino, M.6
-
59
-
-
77649229271
-
Clinical development and perspectives of CIMAvax EGF, Cuban vaccine for non-small-cell lung cancer therapy
-
Rodriguez P.C., Rodriguez G., Gonzalez G., Lage A. Clinical development and perspectives of CIMAvax EGF, Cuban vaccine for non-small-cell lung cancer therapy. MEDICC Rev 2010, 12:17-23.
-
(2010)
MEDICC Rev
, vol.12
, pp. 17-23
-
-
Rodriguez, P.C.1
Rodriguez, G.2
Gonzalez, G.3
Lage, A.4
-
60
-
-
79957670787
-
-
NCT00516685. Vaccine therapy in treating patients with non-small cell lung cancer (NSCLC) stages IIIB/IV. [updated 29.01.2009].
-
NCT00516685. Vaccine therapy in treating patients with non-small cell lung cancer (NSCLC) stages IIIB/IV. [updated 29.01.2009]. http://www.clinicaltrials.gov/ct2/show/NCT00516685?term=EGF+vaccine&rank=1.
-
-
-
-
61
-
-
0347364737
-
Melanoma associated antigen (MAGE)-A3 expression in Stages I and II non-small cell lung cancer: results of a multi-center study
-
Sienel W., Varwerk C., Linder A., Kaiser D., Teschner M., Delire M., et al. Melanoma associated antigen (MAGE)-A3 expression in Stages I and II non-small cell lung cancer: results of a multi-center study. Eur J Cardiothorac Surg 2004, 25:131-134.
-
(2004)
Eur J Cardiothorac Surg
, vol.25
, pp. 131-134
-
-
Sienel, W.1
Varwerk, C.2
Linder, A.3
Kaiser, D.4
Teschner, M.5
Delire, M.6
-
62
-
-
42549106307
-
Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC)
-
[abstract 7554]
-
Vansteenkiste J., Zielinski H., Linder A., Dahabre J., Esteban E., Malinowski W., et al. Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC). J Clin Oncol 2007, 25(18S). [abstract 7554].
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Vansteenkiste, J.1
Zielinski, H.2
Linder, A.3
Dahabre, J.4
Esteban, E.5
Malinowski, W.6
-
63
-
-
79957688506
-
-
NCT00480025. GSK1572932A antigen-specific cancer immunotherapeutic as adjuvant therapy in patients with non-small cell lung cancer (MAGRIT trial). [updated 24.03.2011].
-
NCT00480025. GSK1572932A antigen-specific cancer immunotherapeutic as adjuvant therapy in patients with non-small cell lung cancer (MAGRIT trial). [updated 24.03.2011]. http://www.clinicaltrials.gov/ct2/show/NCT00480025?term=MAGE-A3&rank=8.
-
-
-
-
64
-
-
1142286444
-
MUC1 immunobiology: from discovery to clinical applications
-
Vlad A.M., Kettel J.C., Alajez N.M., Carlos C.A., Finn O.J. MUC1 immunobiology: from discovery to clinical applications. Adv Immunol 2004, 82:249-293.
-
(2004)
Adv Immunol
, vol.82
, pp. 249-293
-
-
Vlad, A.M.1
Kettel, J.C.2
Alajez, N.M.3
Carlos, C.A.4
Finn, O.J.5
-
65
-
-
0037031255
-
Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions
-
Grinstead J.S., Koganty R.R., Krantz M.J., Longenecker B.M., Campbell A.P. Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions. Biochemistry 2002, 41:9946-9961.
-
(2002)
Biochemistry
, vol.41
, pp. 9946-9961
-
-
Grinstead, J.S.1
Koganty, R.R.2
Krantz, M.J.3
Longenecker, B.M.4
Campbell, A.P.5
-
66
-
-
17644401665
-
MUC1 mucin-mediated regulation of human T cells
-
Agrawal B., Longenecker B.M. MUC1 mucin-mediated regulation of human T cells. Int Immunol 2005, 17:391-399.
-
(2005)
Int Immunol
, vol.17
, pp. 391-399
-
-
Agrawal, B.1
Longenecker, B.M.2
-
67
-
-
33748055445
-
MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
-
Raina D., Ahmad R., Kumar S., Ren J., Yoshida K., Kharbanda S., et al. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J 2006, 25:3774-3783.
-
(2006)
EMBO J
, vol.25
, pp. 3774-3783
-
-
Raina, D.1
Ahmad, R.2
Kumar, S.3
Ren, J.4
Yoshida, K.5
Kharbanda, S.6
-
68
-
-
42049108198
-
MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1
-
Shen Q., Rahn J.J., Zhang J., Gunasekera N., Sun X., Shaw A.R., et al. MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1. Mol Cancer Res 2008, 6:555-567.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 555-567
-
-
Shen, Q.1
Rahn, J.J.2
Zhang, J.3
Gunasekera, N.4
Sun, X.5
Shaw, A.R.6
-
69
-
-
0031914321
-
Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
-
Agrawal B., Krantz M.J., Reddish M.A., Longenecker B.M. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nat Med 1998, 4:43-49.
-
(1998)
Nat Med
, vol.4
, pp. 43-49
-
-
Agrawal, B.1
Krantz, M.J.2
Reddish, M.A.3
Longenecker, B.M.4
-
70
-
-
15644365913
-
MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients
-
Guddo F., Giatromanolaki A., Koukourakis M.I., Reina C., Vignola A.M., Chlouverakis G., et al. MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients. J Clin Pathol 1998, 51:667-671.
-
(1998)
J Clin Pathol
, vol.51
, pp. 667-671
-
-
Guddo, F.1
Giatromanolaki, A.2
Koukourakis, M.I.3
Reina, C.4
Vignola, A.M.5
Chlouverakis, G.6
-
71
-
-
77951791725
-
MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients
-
Macdermed D.M., Khodarev N.N., Pitroda S.P., Edwards D.C., Pelizzari C.A., Huang L., et al. MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients. BMC Med Genomics 2010, 3:16.
-
(2010)
BMC Med Genomics
, vol.3
, pp. 16
-
-
Macdermed, D.M.1
Khodarev, N.N.2
Pitroda, S.P.3
Edwards, D.C.4
Pelizzari, C.A.5
Huang, L.6
-
72
-
-
36749058906
-
Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer
-
Woenckhaus M., Merk J., Stoehr R., Schaeper F., Gaumann A., Wiebe K., et al. Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer. Hum Pathol 2008, 39:126-136.
-
(2008)
Hum Pathol
, vol.39
, pp. 126-136
-
-
Woenckhaus, M.1
Merk, J.2
Stoehr, R.3
Schaeper, F.4
Gaumann, A.5
Wiebe, K.6
-
73
-
-
0034012454
-
Natural autoantibody to MUC1 is a prognostic indicator for non-small cell lung cancer
-
Hirasawa Y., Kohno N., Yokoyama A., Kondo K., Hiwada K., Miyake M. Natural autoantibody to MUC1 is a prognostic indicator for non-small cell lung cancer. Am J Respir Crit Care Med 2000, 161:589-594.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 589-594
-
-
Hirasawa, Y.1
Kohno, N.2
Yokoyama, A.3
Kondo, K.4
Hiwada, K.5
Miyake, M.6
-
74
-
-
50349090322
-
A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV non-small cell lung cancer
-
Ramlau R., Quoix E., Rolski J., Pless M., Lena H., Levy E., et al. A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV non-small cell lung cancer. J Thorac Oncol 2008, 3:735-744.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 735-744
-
-
Ramlau, R.1
Quoix, E.2
Rolski, J.3
Pless, M.4
Lena, H.5
Levy, E.6
-
75
-
-
51349133571
-
Randomized phase IIb trial evaluating the therapeutic vaccine TG4010(MVA-MUC1-IL2) as an adjunct to chemotherapy in patients with advanced non-small cell lung cancer (NSCLC)
-
[abstract 8023]
-
Ramlau R., Westeel V., Papai Z., Riviere A., Madroszyk A., Koralewski P., et al. Randomized phase IIb trial evaluating the therapeutic vaccine TG4010(MVA-MUC1-IL2) as an adjunct to chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2008, 26(15S). [abstract 8023].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Ramlau, R.1
Westeel, V.2
Papai, Z.3
Riviere, A.4
Madroszyk, A.5
Koralewski, P.6
-
76
-
-
70350573808
-
Biomarkers associated with clinical outcome in advanced non-small cell lung cancer patients treated with TG4010
-
[abstract 3027]
-
Acres B., Quoix E., Ramlau R., Lacoste G., Marie Bastien B., Tavernaro A., et al. Biomarkers associated with clinical outcome in advanced non-small cell lung cancer patients treated with TG4010. J Clin Oncol 2009, 27(15S). [abstract 3027].
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Acres, B.1
Quoix, E.2
Ramlau, R.3
Lacoste, G.4
Marie Bastien, B.5
Tavernaro, A.6
-
77
-
-
79957788316
-
-
NCT00415818. Immunotherapy with TG4010 in patients with advanced non-small cell lung cancer. [updated 02.09.2010].
-
NCT00415818. Immunotherapy with TG4010 in patients with advanced non-small cell lung cancer. [updated 02.09.2010]. http://www.clinicaltrials.gov/ct2/show/NCT00415818?term=TG4010&rank=1.
-
-
-
-
78
-
-
79957770535
-
-
Transgene. TG4010(MVA-MUC-1-IL2). [accessed 29.03.2011].
-
Transgene. TG4010(MVA-MUC-1-IL2). [accessed 29.03.2011]. http://transgene.fr/.
-
-
-
-
79
-
-
0032127618
-
Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses
-
Guan H.H., Budzynski W., Koganty R.R., Krantz M.J., Reddish M.A., Rogers J.A., et al. Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses. Bioconjug Chem 1998, 9:451-458.
-
(1998)
Bioconjug Chem
, vol.9
, pp. 451-458
-
-
Guan, H.H.1
Budzynski, W.2
Koganty, R.R.3
Krantz, M.J.4
Reddish, M.A.5
Rogers, J.A.6
-
80
-
-
22144483806
-
Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers
-
North S., Butts C. Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers. Expert Rev Vaccines 2005, 4:249-257.
-
(2005)
Expert Rev Vaccines
, vol.4
, pp. 249-257
-
-
North, S.1
Butts, C.2
-
81
-
-
0034789572
-
Phase I study of the BLP25 (MUC1 peptide) liposomal vaccine for active specific immunotherapy in stage IIIB/IV non-small-cell lung cancer
-
[discussion 8]
-
Palmer M., Parker J., Modi S., Butts C., Smylie M., Meikle A., et al. Phase I study of the BLP25 (MUC1 peptide) liposomal vaccine for active specific immunotherapy in stage IIIB/IV non-small-cell lung cancer. Clin Lung Cancer 2001, 3:49-57. [discussion 8].
-
(2001)
Clin Lung Cancer
, vol.3
, pp. 49-57
-
-
Palmer, M.1
Parker, J.2
Modi, S.3
Butts, C.4
Smylie, M.5
Meikle, A.6
-
82
-
-
27244449289
-
Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
-
Butts C., Murray N., Maksymiuk A., Goss G., Marshall E., Soulieres D., et al. Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer. J Clin Oncol 2005, 23:6674-6681.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6674-6681
-
-
Butts, C.1
Murray, N.2
Maksymiuk, A.3
Goss, G.4
Marshall, E.5
Soulieres, D.6
-
83
-
-
65349149403
-
A multi-centre phase IIB randomized controlled study of BLP25 liposome vaccine (L-BLP25 or Stimuvax) for active specific immunotherapy of non-small cell lung cancer (NSCLC): updated survival analysis
-
[abstract B1-01]
-
Butts C., Maksymiuk A., Goss G., Soulieres D., Marshall E., Cormier Y., et al. A multi-centre phase IIB randomized controlled study of BLP25 liposome vaccine (L-BLP25 or Stimuvax) for active specific immunotherapy of non-small cell lung cancer (NSCLC): updated survival analysis. J Thorac Oncol 2007, 2(Suppl. 4):S332-S333. [abstract B1-01].
-
(2007)
J Thorac Oncol
, vol.2
, Issue.SUPPL. 4
-
-
Butts, C.1
Maksymiuk, A.2
Goss, G.3
Soulieres, D.4
Marshall, E.5
Cormier, Y.6
-
84
-
-
77953393492
-
Long-term safety of BLP25 liposome vaccine (L-BLP25) in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC)
-
Abstract 3055
-
Butts C., Anderson H., Maksymiuk A., Vergidis D., Soulieres D., Cormier Y., et al. Long-term safety of BLP25 liposome vaccine (L-BLP25) in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC). J Clin Oncol 2009, 27(15S). Abstract 3055.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Butts, C.1
Anderson, H.2
Maksymiuk, A.3
Vergidis, D.4
Soulieres, D.5
Cormier, Y.6
-
85
-
-
78649235731
-
A multicenter open-label study to assess the safety of a new formulation of BLP25 liposome vaccine (L-BLP25) in patients with unresectable stage III non-small-cell lung cancer
-
Butts C., Murray N., Smith C.J., Ellis P.M., Jasas K., Maksymiuk A., et al. A multicenter open-label study to assess the safety of a new formulation of BLP25 liposome vaccine (L-BLP25) in patients with unresectable stage III non-small-cell lung cancer. Clin Lung Cancer 2010, 11:391-395.
-
(2010)
Clin Lung Cancer
, vol.11
, pp. 391-395
-
-
Butts, C.1
Murray, N.2
Smith, C.J.3
Ellis, P.M.4
Jasas, K.5
Maksymiuk, A.6
-
86
-
-
79957719050
-
-
NCT00409188. Cancer vaccine study for unresectable stage III non-small cell lung cancer (START trial). [updated 23.02.2011].
-
NCT00409188. Cancer vaccine study for unresectable stage III non-small cell lung cancer (START trial). [updated 23.02.2011]. http://www.clinicaltrials.gov/ct2/show/NCT00409188?term=00409188&rank=1.
-
-
-
-
87
-
-
79957698692
-
-
NCT01015443. Cancer vaccine study for stage III, unresectable, non-small cell lung cancer (NSCLC) in the Asian population (INSPIRE trial). [updated 03.02.2011].
-
NCT01015443. Cancer vaccine study for stage III, unresectable, non-small cell lung cancer (NSCLC) in the Asian population (INSPIRE trial). [updated 03.02.2011]. http://clinicaltrials.gov/ct2/show/NCT01015443.
-
-
-
|