Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion

Journal of Biological Chemistry

Volumn 287, Issue 13, 2012, Pages 10013-10020

  Lo, Dorothy ^a   Dai, Mu Shui ^b   Sun, Xiao Xin ^b   Zeng, Shelya X ^a   Lu, Hua ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCEROUS CELLS; DOXORUBICIN; GTP BINDING; GTP-BINDING PROTEINS; KNOCK OUTS; MOLECULAR MECHANISM; MOUSE EMBRYONIC FIBROBLASTS; MYCOPHENOLIC ACIDS; NUCLEOLAR PROTEINS; POLYUBIQUITINATION; PROTEASOMAL DEGRADATION; TEMPERATURE-SENSITIVE; UBIQUITIN; UBIQUITIN MOLECULES; UBIQUITINATION; WILD TYPES;

CELL CULTURE; CELLS; DEGRADATION;

PROTEINS;

DOXORUBICIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSINE; MYCOPHENOLIC ACID; NUCLEOSTEMIN; PROTEASOME; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FIBROBLAST CULTURE; GENE INACTIVATION; HALF LIFE TIME; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STABILITY; UBIQUITINATION; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CARRIER PROTEINS; CELL LINE; CELL NUCLEUS; EMBRYO, MAMMALIAN; FIBROBLASTS; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; MICE; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MDM2; UBIQUITIN; UBIQUITINATION;

ANIMALIA;

EID: 84858980187     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.335141     Document Type: Article

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