Syntheses and cell-based phenotypic screen of novel 7-amino pyrido[2,3-d]pyrimidine-6-carbonitrile derivatives as potential antiproliferative agents

Molecules

Volumn 17, Issue 3, 2012, Pages 2351-2366

  Yang, Tao ^a   He, Hong ^a   Ang, Wei ^b   Yang, Ying Hong ^b   Yang, Jian Zhong ^a   Lin, Yan Ni ^a   Yang, Hua Cheng ^b   Pi, Wei Yi ^a   Li, Zi Cheng ^b   Zhao, Ying Lan ^a   Luo, You Fu ^a   Wei, Yuquan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

7 Aminopyrido 2,3 d pyrimidin 6 carbonitrile derivatives; Anti tumor activity; Apoptosis; Cell based phenotypic screening; Structure activity relationship (SAR)

Indexed keywords

ANTINEOPLASTIC AGENT; NITRILE; PYRIMIDINE DERIVATIVE;

ARTICLE; CELL CYCLE; DRUG EFFECT; DRUG SCREENING; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; NITRILES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858973753     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17032351     Document Type: Article

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