Anti-apoptotic effects of SERPIN B3 and B4 via STAT6 activation in macrophages after infection with Toxoplasma gondii

Korean Journal of Parasitology

Volumn 50, Issue 1, 2012, Pages 1-6

  Song, Kyoung Ju ^a,b   Ann, Hye Jin ^a   Nam, Ho Woo ^a  

^a The Catholic University of Korea   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Anti apoptosis; B4; Macrophage; SERPIN B3; STAT6; Toxoplasma gondii

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SERINE PROTEINASE INHIBITOR; SERPIN B3; SERPIN B4; SMALL INTERFERING RNA; STAT6 PROTEIN; STAUROSPORINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL LINE; CELL STRAIN THP 1; CONTROLLED STUDY; DNA FRAGMENTATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MACROPHAGE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ANTIGENS, NEOPLASM; APOPTOSIS; CELL LINE; DNA FRAGMENTATION; HUMANS; MACROPHAGES; MICE; MICE, INBRED BALB C; SERPINS; STAT6 TRANSCRIPTION FACTOR; TOXOPLASMA; TOXOPLASMOSIS;

EUKARYOTA; TOXOPLASMA GONDII;

EID: 84858971696     PISSN: 00234001     EISSN: 17380006     Source Type: Journal    
DOI: 10.3347/kjp.2012.50.1.1     Document Type: Article

References (25)

1. Dubey JP. Toxoplasmosis-a waterborne zoonosis. Vet Parasitol 2004; 126: 57-72.
2. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animal to humans. Int J Parasitol 2000; 30: 1217-1258.
3. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet 2004; 363: 1965-1976.
4. Reiner NE. Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection. Immunol Today 1994; 15: 374-381.
5. Hall BF, Webster P, Ma AK, Joiner KA, Andrew NW. Desialylation of lysosomal membrane glycoproteins by Trypanosoma cruzi: a role for the surface neuraminidase in facilitating parasite entry into the host cell cytoplasm. J Exp Med 1992; 176: 313-325.
6. Rittig MG, Bogdan C. Leishmania-host cell interaction: complexities and alteration views. Parasitol Today 2000; 16: 292-297.
7. Butcher BA Kim L, Johnson PF, Denker EY. Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kB. J Immunol 2001; 167: 2193-2201.
8. Bogdan C, Rollinghof F M. How do protozoan parasites survive inside macrophages? Parasitol Today 1999; 15: 22-28.
9. Liider CG, Gross U, Lopes ME. Intracellular protozoan parasites and apoptosis: diverse strategies to modulate parasite-host interactions. Trends Parasitol 2001; 17: 480-486.
10. Goebel S, Gross U, Liider C. Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression. J Cell Sci 2001; 114: 3495-3505.
11. Carmen JC, Hardi L, Sinai AP. Toxoplasma gondii inhibits ultraviolet light-induced apoptosis through multiple interactions with the mitochondrion-dependent programmed cell death pathway. Cell Microbiol 2006; 8:301-315.
12. Duke RC, Cohen JJ. IL-2 addiction: Withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res 1986; 5: 289-299.
13. Ahn HJ, Kim JY, Ryu KJ, Nam HW. STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemo-kine ligands and B clade serine protease inhibitors in macro-phage. Parasitol Res 2009; 105: 1445-1453.
14. Takeda A, Kajiya A, Iwasawa A, Nakamura Y, Hibino T. Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor mediated apoptosis. J Biol Chem 2002; 383: 1231-1236.
15. Tonnetti L, Netzel-Arnett S, Darnell GA Hayes T, Buzza MS, An-glin IE, Suhrbier A Antalis TM. SerpinB2 protection of retino-blastoma protein from calpain enhances tumor cell survival. Cancer Res 2008; 68: 5648-5657.
16. Jacobson MD, Weil M, Raf FMC. Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death. J Cell Biol 1996; 133: 1041-1051.
17. Butcher BA Denkers EY. Mechanism of entry determines the ability oiToxoplasma gondii to inhibit macrophage proinflammatory cytokine production. Infect Immun 2002; 70: 5216-5224.
18. Lüder CG, Algner M, Lang C, Bleicher N, Groβ U. Reduced expression of the inducible nitric oxide synthethase after infection with Toxoplasma gondii facilitates parasite replication in activated murine macrophages. Int J parasitol 2003; 33: 833-844.
19. Bladder IJ, Manger ID, Boothroyd JC. Microarray analysis reveals previously unknown changes in Toxoplasma goniiii-infected human cells. J Biol Chem 2001; 276(26): 24223-24231.
20. Saeji JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 2007; 445(7125): 324-327.
21. McGettrick AF, Barnes RC, Worrall DM. SCCA2 inhibits TNF-me-diated apoptosis in transfected HeLa cells. Eur J Biochem 2001; 268: 5868-5875.
22. Suminami Y, Nagashima S, Vujanovic NL, Hirabayashi K Kato H, Whiteside TL. Inhibition of apoptosis in human tumour cells by the tumour associated serpin, SCC antigen-1. Br J Cancer 2000; 82: 981-989.
23. Gan H, Newman GW, Remold HG. Plasminogen activator inhibitor type2 prevents programmed cell death of human macrophages infected with Mycobacterium avium, serovar 4. J Immunol 1995; 155: 1304-1315.
24. Tewari M, Telford WG, Miller RA, Dixit VM. CrmA a poxvirus-encoded serpin, inhibits cytotoxicT-lymphocyte mediated apoptosis. J Biol Chem 1995; 270: 22705-22708.
25. Enari M, Hug H, Nagata S. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 1995; 375: 78-81.