Hepatoprotective activity of Nelsonia canescens (Lam.) spreng on acute hepatotoxicity induced by paracetamol

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue SUPPL.1, 2012, Pages 107-112

  Dasgupta, Bedabati ^a   Kalita, Jogen Chandra ^a   Chowdhury, Arudyuti ^b   Kotoky, Jibon ^c  

^a GAUHATI UNIVERSITY   (India)

^b SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

^c IASST   (India)

Author keywords

Hepatoprotective; Nelsonia canescens (Lam.) spreng; Paracetamol; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; FLAVONOID; GAMMA GLUTAMYLTRANSFERASE; NELSONIA CANESCENS EXTRACT; PARACETAMOL; PHENOL DERIVATIVE; PLANT EXTRACT; SILYMARIN; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGIC SKIN REACTION; LETHALITY; LIVER PROTECTION; LIVER TOXICITY; MALE; MEDICINAL PLANT; MORPHOLOGY; MOUSE; NELSONIA CANESCENS; NONHUMAN; PHYTOCHEMISTRY;

EID: 84858966010     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Guyton AC, Hall JE. A Text Book of Medical Physiology. 9th ed. Bangalore: W.B. Sauders Company; 1996. p. 883-88.
2. Handa SS, Sharma A, Chakraborty KK. Natural products and plants as liver protecting drugs. Fitoterapia 1986; LVII (5): 307-351.
3. Adhikari BS, Babu MM, Saklani PL, Rawat GS. Medicinal plants diversity and their conservation status in Wildlife Institute of India (WII) campus, Dehradun. Ethnobotanical Leaflets 2010; 14: 46-83.
4. Focho DA, Ndam WT and Fonge BA. Medicinal plants of Aguambu - Bamumbu in the Lebialem highlands, southwest province of Cameroon. Afr J Pharma Pharmacol 2009; 3(1): 001-13.
5. Ngamo TSL, Ngassoum MB, Mapongmestsem PM, Noudjou WF, Malaisse F, Haubruge E et al. Use of essential oils of aromatic plants as protectant of grains during storage. Agricultural Journal 2007; 2(2): 204-09.
6. Owoyele VB, Oloriegbe YY, Balogun EA, Soladoye AO. Analgesic and anti-inflammatory properties of Nelsonia canescens leaf extract. J Ethnopharmacol 2005; 99(1): 153-56.
7. Sofowora A. Screening plants for bioactive agents, In: Medicinal plant and Traditional Medicine in Africa. 2nd ed. Ibadan: Spectrum Books Ltd.; 1993. p. 289.
8. Evans WC. An overview of drugs having antihepatotoxic and oral hypoglycaemic activities. In: Trease and Evans, Pharmacognosy, 14th ed. U.K.: Sanders Company Ltd.; 1996. p. 119-59.
9. Haughton PJ, Raman A. Laboratory handbook for the fractionation of natural extracts. 1st ed. USA: Clapman and Hall; 1998. p. 22-52.
10. Handa SS, Sharma A. Hepatoprotective activity of andrographolide from Andrographis paniculata against carbon tertrachloride. Ind J Med Res 1990; 92: 276-83.
11. Gilani AH and Janbaz KH. Preventive and curative effects of Berberis aristata fruit extract on paracetamol and CCl4induced hepatotoxicity. Phytotherapy Res 2003; 9(7): 489-94.
12. Subramoniam A, Evans DA, Rajasekharan S, Pushpangadan P. Hepatoprotective activity of Trichopus zeylanicus extract against paracetamol- induced hepatic damage in rats. Ind J Exp Biol 1998; 36: 385-89.
13. Sharma A, Singh RT, Sehgal V, Handa SS. Antihepatotoxic activity of some plants used in herbal formulations. Fitoterapia 1991; LXII (2): 131-38.
14. Galigher AE and Kozoff EN. Essentials of practical microtechnique. 2nd ed. New York; Lea and Finger; 1976. p. 210-16.
15. Khan IA and Khanum A. Fundamentals of biostatistics. 1st ed. India; Ukaaz Publishers; 1994. p. 112-30.
16. Yoko A, Koyama T, Miyagic C, Miyahira M, Inomata C, Kinoshita S et al. Free radical scavenging and hepatoprotective action of the medicinal herb, Crassocephalum crepietioides from Okinowa Islands. Biol Pharm Bull 2005; 28: 19-24.
17. Guzy J, Chovanova Z, Marekova M, Chavkova Z, Tomechova V, Mojzisova G et al. Effect of quercetin on paracetamol induced rat liver mitochondria dysfunction. Biologia Bratislava 2004; 59(3): 399-03.
18. Nazareth WM, Sethi JK, McLean AE. Effect of paracetamol on mitochondrial membrane function in rat liver slices. Biochem Pharmacol 1991; 42: 931-36.
19. Tanaka E, Terada M, Misawa S. Cytochrome P-450 2E1: its clinical and toxicological role. J Clin Ther 2000; 25: 165-75.
20. Venkatakrishnan K, Von Moltke LL and Greenblatt DJ. Human cytochrome P-450 mediating phenecetin-O-deethylation in vitro: validation of the high affinity component as an index of CYP 1A2 activity. J Pharm Sci 1988; 87: 1502-507.
21. Chen W, Koenig LL, Thompson SJ, Peter RM, Rettie AE, Trager WF et al. Oxidation of acetaminophen to its toxic quinine imine and nontoxic catechol metabolites by baculovirus- expressed and purified human cytochrome P-450 2E1 and 2A6. Chem Res Toxicol 1998; 11: 295-01.
22. Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD. Involvement of human cytochrome P-450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos 2000; 28: 1397-400.
23. Ray SD, Mumaw VR, Raj RR, Fariss MW. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther 1996; 279: 1470-483.
24. Adamson GM, Harman AW. Oxidative stress in cultured hepatocytes exposed to acetaminophen. Biochem Pharmacol 1993; 45: 2289-294.
25. Gardner PR, Gardner AM, Martin LA, and Salzman AL. Nitric oxide dioxygenase: An enzymic function for flavohemoglobin. Proc Natl Acad Sci, USA. 1998; 95:10378-0383.
26. Kamiyama T, Sato C, Liu J, Tajiri K, Miyakawa H, Marumo F. Role of lipid peroxidation in acetaminophen-induced hepatotoxicity: Comparison with carbon tetrachloride. Toxicol Lett 1993; 66: 7-12.
27. Salas VM, Corcoran GB. Calcium-dependent DNA damage and adenosine 30 50-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury. Hepatology 1997; 25 (6): 1432-1438.
28. Rao GMP, Rao G, Ramnarayan K, Srinivasan KK. Effect of hepatogard on paracetamol induced liver injury in male albino rats. Indian Drugs 1992; 30: 40-47.
29. Plaa GL and Hewitt WR. Quantitative evaluation of indices of hepatotoxicity, In: Toxicology of the liver. 1st ed. New York: Raven Press; 1982. p. 103-20.
30. Pimple BP, Kadam PV, Badgujar NS, Bafna AR, Patil MJ. Protective effect of Tamarindus indica Linn. against paracetamol induced hepatotoxicity in rats. Ind J Pharm Sc 2007; 69(6): 827-31.
31. Malathi R and Gomez MP. Hepatoprotective effect of methanolic leaves extracts of Tylophrora asthmatica against paracetamol induced liver damage in rats. J Pharmacol Toxicol 2007; 2(8): 737-42.
32. Oyagbemi AA, Odetola AA. Hepatoprotective effects of ethanolic extract of Cnidoscolus aconitifolius on paracetamol-induced hepatic damage in rats. Pakistan J Biol Sci 2010; 13(4): 164-69.
33. Sheeba Rani M, Emmanual S, Raja Sreekanth M, Ignasimuthu S. Evaluation of in vivo antioxidant and hepatoprotective activity of Cassia occidentalis Linn. against paracetamol induced liver toxicity in rats. Int J Pharmacy Pharm Sci 2010; 2(3): 67-70.
34. Moss DW, Butterworth PJ. Enzymology and Medicine. London: Pitman Medical; 1974. p.139.
35. Drotman RB, Lawhorn GT. Serum enzymes as indicators of chemical induced liver damage. Drug Chem Toxicol 1978; 1: 163-71.
36. Muriel P, Garciapiña T, Pérez-Alvarez V, Mourelle M. Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J Appl Toxicol 1992; 12: 439-42.
37. Noorani AA, Mulla K, Patil SD. Hepatoprotective effect of Rimonabant against ethanol induced liver damage in albino wistar rats. JSSR. 2010; 1(1): 25-29.
38. Recknagel RO. Carbon tetrachloride hepatotoxicity. Pharmacol Rev 1967; 19: 145-08.
39. Sawadogo WR, Meda A, Lamein CE, Kiendrebeogo M, Guissou IP, Nacoulma OG. Phenolic Content and Antioxidant Activity of Six Acanthaceae from Burkina Faso. J Biol Sci 2006; 6 (2): 249-52.
40. Pal A, Banerjee B, Banerjee T, Masih M, Pal K. Hepatoprotective activity of Chenopodium album Linn. plant against paracetamol induced hepatic injury in rats. Int J Pharm Pharm Sci 2011; 3(3): 55-57.