N-vinylpyrrolidone dimer (VPD), a novel excipient for oral drugs: Repeat-dose oral toxicity in Sprague-Dawley rats

Toxicology Letters

Volumn 210, Issue 3, 2012, Pages 324-331

  Weber, S ^a   Halm, S ^a   Du Vall, M ^b   Whitney, K ^b   Blaich, G ^a   Bury, D ^a  

^a ABBOTT GMBH AND CO KG   (Germany)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Hepatocellular centrilobular hypertrophy; Hypertrophy of basophil chromophobe cells in pituitaries; Hypothalamic pituitary thyroid axis; Liver enzyme induction; Novel vehicle; Thyroid follicular cell hypertrophy

Indexed keywords

1 VINYL 2 PYRROLIDINONE; DIMER; EXCIPIENT; GLOBULIN; HEMOGLOBIN; SODIUM CHLORIDE; 2 PYRROLIDONE DERIVATIVE; N-VINYL-2-PYRROLIDINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOPHIL; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; DISEASE SEVERITY; ERYTHROCYTE; FEMALE; FLUID INTAKE; FOOD INTAKE; HEMATOCRIT; HISTOPATHOLOGY; HYPOPHYSIS FUNCTION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER HYPERTROPHY; LIVER WEIGHT; MALE; NONHUMAN; OVARY FOLLICLE CELL; PRIORITY JOURNAL; RAT; RELATIVE DENSITY; SALIVATION; THYROID FUNCTION; URINALYSIS; WEIGHT CHANGE; ANIMAL; DIMERIZATION; DOSE RESPONSE; DRUG EFFECT; EATING; LIVER; ORAL DRUG ADMINISTRATION; PATHOLOGY; SPRAGUE DAWLEY RAT; THYROID GLAND;

ANIMALIA; RATTUS; RODENTIA;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; EXCIPIENTS; FEMALE; LIVER; MALE; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; THYROID GLAND;

EID: 84858965318     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.02.002     Document Type: Article

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