Endothelial cells and CMV dissemination

Future Microbiology

Volumn 7, Issue 4, 2012, Pages 441-444

  Gerna, Giuseppe ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

cytomegalovirus; endothelial cell; primary infection

Indexed keywords

ANGIOPOIETIN RECEPTOR; CRE RECOMBINASE; GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD TRANSFUSION; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CELL TRANSPORT; CELL TYPE; CONFERENCE PAPER; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE MODEL; ENDOTHELIUM CELL; EPITHELIUM CELL; FOLLOW UP; HOST; HUMAN; IMMUNE DEFICIENCY; INFORMATION PROCESSING; LEUKOCYTE; LIVER; MACROPHAGE; METHODOLOGY; MONOCYTE; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIMARY INFECTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SPLEEN; VASCULAR ENDOTHELIUM; VIREMIA; VIRUS LOAD; VIRUS REPLICATION;

ANIMALIA; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; MURINAE; MUS;

EID: 84858958390     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.12.12     Document Type: Conference Paper

References (19)

1. Sacher T, Andrassy J., Kalnins A et al. Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination. PLoS Pathog. 7, E1002366 (2011).
2. Fenner F. Mouse-pox: infectious ectromelia of mice; a review. J. Immunol. 63, 341-373 (1949).
3. Sacher T, Jordan S, Mohr CA et al. Conditional gene expression systems to study herpesvirus biology in vivo. Med. Microbiol. Immunol. 197, 269-276 (2008).
4. Gerna G, Parea M, Percivalle E et al. Human cytomegalovirus viraemia in HIV-1-seropositive patients at various clinical stages of infection. AIDS 4, 1027-1031 (1990).
5. van der Bij W, Torensma R, van Son WJ et al. Rapid immunodiagnosis of active cytomegalovirus infection by monoclonal antibody staining of blood leucocytes. J. Med. Virol. 25, 179-188 (1988).
6. Revello MG, Percivalle E, Zavattoni M, Parea M, Grossi P, Gerna G. Detection of human cytomegalovirus immediate early antigen in leukocytes as a marker of viremia in immunocompromised patients. J. Med. Virol. 29, 88-93 (1989).
7. Revello MG, Percivalle E, Di Matteo A, Morini F, Gerna G. Nuclear expression of the lower matrix protein of human cytomegalovirus in peripheral blood leukocytes of immunocompromised viraemic patients. J. Gen, Virol. 73, 437-442 (1992).
8. Gerna G, Revello MG, Percivalle E, Morini F. Comparison of different immunostaining techniques and monoclonal antibodies to the lower matrix phosphoprotein (pp65) for optimal quantitation of human cytomegalovirus antigenemia. J. Clin, Microbiol. 30, 1232-1237 (1992).
9. Revello MG, Percivalle E, Arbustini E, Pardi R, Sozzani S, GernaG. In vitro generation of human cytomegalovirus pp65 antigenemia, viremia, and leukoDNAemia. J. Clin. Invest. 101, 2686-2692 (1998). Documents for the first time the in vitro generation of pp65 antigenemia.
10. Revello MG, Baldanti F, Percivalle E et al. In vitro selection of human cytomegalovirus variants unable to transfer virus and virus products from infected cells to polymorphonuclear leukocytes and to grow in endothelial cells. J. Gen. Virol. 82, 1429-1438 (2001).
11. Gerna G, Percivalle E, Baldanti F et al. Human cytomegalovirus replicates abortively in polymorphonuclear leukocytes after transfer from infected endothelial cells via transient microfusion events. J. Virol. 74, 5629-5638 (2000).
12. Hahn G, Revello MG, Patrone M et al. Human cytomegalovirus ULI131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes. J. Virol. 78, 10023-10033 (2004). Erratum in: J. Virol. 83, 6323 (2009). The genetic determinants of endothelial cell tropism are identified in the UL131-128 locus.
13. Wang D, Shenk T. Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism. Proc. Natl Acad. Sci. USA 102, 18153-18158 (2005).
14. Ryckman BJ, Rainish BL, Chase MC et al. Characterization of human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells. J. Virol. 82, 60-70 (2008). Epithelial and endothelial cell tropism is mediated by a pentamer complex.
15. Macagno A, Bernasconi NL, Vanzetta F et al. Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex. J. Virol. 84, 1005-1013 (2010). Potent neutralizing human monoclonal antibodies directed to the UL131-128 locus products are isolated for the first time.
16. Revello MG, Gerna G. Human cytomegalovirus tropism for endothelial/epithelial cells: scientific background and clinical implications. Rev. Med. Virol. 20, 136-155 (2010).
17. Grefte A, van der Giessen M, van Son W, The TH. Circulating cytomegalovirus (CMV)-infected endothelial cells in patients with an active CMV infection. J. Infect. Dis. 167, 270-277 (1993).
18. Percivalle E, Revello MG, Vago L, Morini F, Gerna G. Circulating endothelial giant cells permissive for human cytomegalovirus (HCMV) are detected in disseminated HCMV infections with organ involvement. J. Clin. Invest. 92, 663-670 (1993).
19. Plachter B, Sinzger C, Jahn G. Cell types involved in replication and distribution of human cytomegalovirus. Adv. Virus Res. 46, 195-261 (1996).