Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase

Parasitology

Volumn 139, Issue 4, 2012, Pages 497-505

  Manneck, Theresia ^a,b   Keiser, Jennifer ^a,b   Müller, Joachim ^c  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

affinity chromatography; drug target; enolase; glycolysis; isothermal microcalorimetry; mefloquine; metabolic inhibition; Schistosoma mansoni

Indexed keywords

BINDING PROTEIN; BROMOPYRUVIC ACID; COMPLEMENTARY DNA; ENOLASE; FLUORIDE SODIUM; GLUCOSE; MEFLOQUINE; MENADIONE; MESSENGER RNA; POLYPEPTIDE; PYRUVIC ACID DERIVATIVE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ARTICLE; BINDING AFFINITY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; GLYCOLYSIS; MASS SPECTROMETRY; MICROCALORIMETRY; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHISTOSOMA MANSONI;

ANIMALS; ANTHELMINTICS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, AFFINITY; DRUG DELIVERY SYSTEMS; GLYCOLYSIS; MEFLOQUINE; PARASITIC SENSITIVITY TESTS; PHOSPHOPYRUVATE HYDRATASE; SCHISTOSOMA MANSONI;

ESCHERICHIA COLI; SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 84858844711     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182011002204     Document Type: Article

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