Synthetic cannabinoid use: Recognition and management

Journal of Psychiatric Practice

Volumn 18, Issue 2, 2012, Pages 86-93

  Castellanos, Daniel ^a   Thornton, Gabriel ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

abuse; adolescents; physical effects; psychoactive effects; synthetic cannabinoids

Indexed keywords

ANANDAMIDE; BENZODIAZEPINE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABIS; NEUROLEPTIC AGENT; SYNTHETIC CANNABINOID; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGITATION; ANXIETY; AROMATHERAPY; ARTICLE; BEHAVIOR DISORDER; CANNABIS ADDICTION; COGNITIVE DEFECT; DISEASE EXACERBATION; DRUG ABUSE; DRUG EFFECT; DRUG INTOXICATION; DRUG MARKETING; DRUG URINE LEVEL; HUMAN; HYDRATION; MOOD CHANGE; PANIC; PATIENT MONITORING; PSYCHOSIS; SMOKING; SYMPTOM;

ADOLESCENT; ADULT; CANNABINOIDS; HUMANS; MARIJUANA ABUSE; PSYCHOTIC DISORDERS; YOUNG ADULT;

EID: 84858831460     PISSN: 15274160     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pra.0000413274.09305.9c     Document Type: Article

References (52)

1. European Monitoring Centre for Drugs and Drug Addiction. Understanding the 'Spice' phenomenon, 2009 (available at: Www.emcdda.europa.eu/attachements. cfm /att-80086-EN-SpiceThematicpaperfinalversion.pdf, doi: 10.2810/27063, accessed January 21, 2012).
2. Pertwee RG. Pharmacological actions of cannabinoids. In: Abood ME, Pertwee RG. Cannabinoids. Berlin: Springer; 2005: 1-51.
3. Pertwee RG. Cannabinoid pharmacology: The first 66 years. Br J Pharmacol 2006;147:S163-71.
4. Pacher P, Bátkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006;58:389-462.
5. Uchiyama N, Kikura-Hanajiri R, Kawahara N, et al. Identification of a cannabinoid analog as a new type of designer drug in a herbal product. Chem Pharm Bull (Tokyo) 2009;57:439-41.
6. Uchiyama N, Kawahara M, Kikura-Hanajiri R, et al. Identification of a cannabimimetic indole as a designer drug in a herbal product. Forensic Toxicol 2009;27:61-6.
7. Uchiyama N, Kawahara M, Kikura-Hanajiri R, et al. Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylindoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products. Forensic Toxicol 2011;29:25-37.
8. Hudson S, Ramsey J, King L, et al. Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in "herbal high" products. J Anal Toxicol 2010;34:252-60.
9. Banerji S, Deutsch CM, Bronstein AC. Spice ain't so nice. Clin Toxicol 2010;48:632 (abstract 137) (available at http://informahealthcare.com/doi/pdf/ 10.3109/15563650.2 010.493290, accessed January 27, 2012).
10. American Association of Poison Control Centers. Fake marijuana spurs more than 4,500 calls to U.S. Poison Centers. May 12, 2011 (available at: Www.aapcc.org/dnn/Portals/0 /prrel/updatedk2-may112011.pdf, accessed Janu ary 21, 2012).
11. Schneir AB, Cullen J, Ly BT. "Spice" girls: Synthetic cannabinoid intoxication. J Emerg Med 2011;40:296-9.
12. American Association of Poison Control Centers. Synthetic marijuana data, updated September 8, 2011 (available at www.aapcc.org/dnn/Portals/0/ Synthetic%20Marijuana%20 Data%20for%20Website%209.08.2011.pdf, accessed Janu -ary 27, 2012).
13. Griffiths P, Sedefov R, Gallegos A, et al. How globalisation and market innovation challenge how we think about and respond to drug use: 'Spice' a case study. Addiction 2009; 105:951-3.
14. Dresen S, Ferreiros N, Pütz M, et al. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J Mass Spectrom 2010;45: 1186-94.
15. Hu X, Primack BA, Barnett TE, et al. College students and use of K2: An emerging drug of abuse in young persons. Subst Abuse Treat Prev Policy 2011;6:16.
16. United States Drug Enforcement Administration. Chemi -cals used in "Spice" and "K2" type products under Federal control and regulation for additional 6 months. February 29, 2012 (available at www.justice.gov/dea/pubs /pressrel/ pr022912.html, accessed February 29, 2012).
17. Vandrey R, Dunn KE, Fry JA, et al. A survey study to characterize use of Spice products (synthetic cannabinoids). Drug Alcohol Depend 2012;120:238-41.
18. Bebarta VS, Varney S, Sessions D, et al. Spice: A new "legal" herbal mixture abused by young active duty military personnel. Clin Toxicol 2010;48:632 (abstract 138) (available at: Http://informahealthcare.com/doi/pdf/ 10 3109/15563650.2010.493290, accessed January 27, 2012).
19. Castellanos D, Singh S, Thornton G, et al. Synthetic cannabinoid use: A case series of adolescents. J Adolesc Health 2011;49:347-9.
20. Every-Palmer S. Synthetic cannabinoid JWH-018 and psychosis: An explorative study. Drug Alcohol Depend 2011; 117:152-7.
21. Johnson LA, Johnson RL, Alfonzo C. Spice: A legal marijuana equivalent. Mil Med 2011;176:718-20.
22. Zimmermann US, Winkelmann PR, Pilhatsch M, et al. Withdrawal phenomena and dependence syndrome after the consumption of "Spice Gold." Dtsch Arztebl Int 2009; 106:464-7.
23. Müller H, Sperling W, Köhrmann M, et al. The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes. Schizophr Res 2010;118:309-10.
24. Vearrier D, Osterhoudt KC. A teenager with agitation: Higher than she should have climbed. Pediatr Emerg Care 2010;26:462-5.
25. Young AC, Schwarz E, Medina G, et al. Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation. Am J Emerg Med Jul 28, 2011 [Epub ahead of print].
26. Hurst D, Loeffler GH, McLay RN. Synthetic cannabis induced psychosis: A case-series. Proceedings from the Annual Meeting of the American Psychiatric Association, 2011, May 14-18, 2011; Honolulu, Hawaii (Washington, DC: American Psychiatric Association, 2011: NR02-39).
27. Navy.mil website (official website of the United States Navy). New policy prohibits use of alternative substances. July 12, 2009 (available at www.navy.mil/search/display asp?story-id=46856, accessed January 27, 2012).
28. Marines.mil website (official website of United States Marine Corps). Marine Forces Pacific bans spice, salvia as drugs. December 10, 2009 (available at www.marines.mil /unit/mcasyuma/Pages/20091210Spice.aspx, accessed January 27, 2012).
29. Af.mil (official Website of the United States Air Force). Air Force officials ban use and possession of spice, mood-altering substances. June 18, 2010 (available at www.af.mil /news/story.asp?id=123209754, accessed January 27, 2012).
30. Every-Palmer S. Warning: Legal synthetic cannabinoidreceptor agonists such as JWH-018 may precipitate psychosis in vulnerable individuals. Addiction 2010;105: 1959-60.
31. Auwärter V, Dresen S, Weinmann W, et al. Spice and other herbal blends: Harmless incense or cannabinoid designer drugs? J Mass Spectrom 2009;44:832-7.
32. Donnelly MT. Health advisory: K2 synthetic marijuana use among teenagers and young adults in Missouri. Missouri Department of Health and Senior Services March 5, 2010 (available at: Http://health.mo.gov/emergencies/ ert/alertsadvisories/pdf/HAd3-5-2010.pdf, accessed January 28, 2012).
33. Rodgman C, Kinzie E, Leimbach E. Bad mojo: Use of the new marijuana substitute leads to more and more ED visits for acute psychosis. Am J Emerg Med 2011;29:232.
34. Ellsworth H, Stellpflug SJ. Déjà vu, another designer drug: Synthetic cannabinoids. American College Emer gency Physicians Toxicology Section Newsletter, March 2011 (available at: Http://acep3.wsol.net/Content aspx?id=77201, accessed January 28, 2012).
35. Benford DM, Caplan JP. Psychiatric sequelae of spice, K2, and synthetic cannabinoid receptor agonists. Psycho -somatics 2011;52:295.
36. Simmons JR, Skinner CG, Williams J, et al. Intoxication from smoking "spice." Ann Emerg Med 2011; 57:187-8.
37. Van Der Veer N, Friday J. Persistent psychosis following the use of Spice. Schizophr Res 2011;130:285-6.
38. Pierre JM. Cannabis, synthetic cannabinoids, and psychosis risk: What the evidence says. Curr Psychiatr 2011;10:49-58.
39. Vardakou I, Pistos C, Spiliopoulou Ch. Spice drugs as a new trend: Mode of action, identification and legislation. Toxicol Lett 2010;197:157-62.
40. Miami Herald. 'Incense' makers thwart bid to weed out fake pot, June 27, 2011 (available at: Http://story.floridastatesman. com/index.php/ct/9/cid/ 257b7bc7aa875450/id/46 403512, accessed January 28, 2012).
41. Redwood Toxicology Laboratory. Synthetic cannabinoid drug testing, 2011 (available at www.redwoodtoxicology com/services/synthetic-cannabinoid-testing. html, accessed January 28, 2012).
42. NMS Labs. K2, Spice, and other synthetic cannabinoids testing (available at www.nmslabs.com/services-forensic-K2-testing, accessed January 28, 2012).
43. Bendiner and Schlesinger, Inc. Synthetic cannabinoids testing (K2, Spice) (available at www.bendinerlab.com /index.htm, accessed January 28, 2012).
44. Dominion Diagnostics. Synthetic cannabinoids (available at www.dominiondiagnostics.com/labservices/testcatalog php, accessed January 28, 2012).
45. ExperTox. Synthetic cannabinoids, 2011 (available at http://www.expertox. com/html/resources/protocols.php, accessed January 28, 2012).
46. MEDTOX Diagnostics Inc. Synthetic cannabinoids (available at: Www.medtox.com/resources/images/5883.pdf, accessed January 28, 2012).
47. Quest Diagnostics. Synthetic cannabinoid metabolite (available at http://www.questdiagnostics.com/hcp/testmenu/ jsp/showTestMenu.jsp?fn=90824. html&labCode=M IA, accessed January 28, 2012
48. Atlantic Diagnostic Laboratories. K2/Spice testing (available at adllab.net/article001.php, accessed January 28, 2012).
49. Avee Laboratories. Synthetic cannabinoids-K2/Spice (available at www.avee.com/sandbox/index.php?option=com-content&view=article&id= 64&Itemid=76, accessed January 28, 2012).
50. Sterling Reference Laboratories. Spice/synthetic marijuana (available at sterlingreflabs.com/docs/SRL-Testing-Menu-06-11.pdf, accessed on January 28, 2012).
51. US Drug Testing Laboratories. Synthetic cannabinoids (available at www.usdtl.com/articles/USDTL-syntheticcannabinoid-urine-test-stems-from- increasing-illicituse/ 786.html, accessed January 28, 2012).
52. National Institute on Drug Abuse. InfoFacts. Treatment approaches for drug addiction. National Institute on Drug Abuse, September 2009 (available at www.nida.nih.gov /Infofacts/TreatMeth.html, accessed January 28,2012).