Changes in human meibum lipid composition with age using nuclear magnetic resonance spectroscopy

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 1, 2012, Pages 475-482

  Borchman, Douglas ^a   Foulks, Gary N ^b   Yappert, Marta C ^a   Milliner, Sarah E ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; LIPID; LIPID HYDROPEROXIDE;

ADULT; AGE; AGED; ARTICLE; CHILD; FEMALE; HUMAN; INFANT; LIPID COMPOSITION; MALE; MEIBOMIAN GLAND; MEIBUM; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCHOOL CHILD; TEAR FILM; ADOLESCENT; AGING; CHEMISTRY; COMPARATIVE STUDY; METHODOLOGY; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; YOUNG ADULT;

EID: 84858814263     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8341     Document Type: Article

References (63)

1. Mantelli F, Tiberi E, Micera A, Lambiase A, Visintini F, Bonini S. MUC5AC over expression in tear film of neonates. Graefes Clin Exp Ophthalmol. 2007;245:1377-1381.
2. Isenberg SJ, Del Signore M, Chen A, Wei J, Guillon J. The lipid layer and stability of the preocular tear film in newborns and infants. Ophthalmology. 2003;110:1408-1411.
3. Bacher LF. Factors regulating eye blink rate in young infants. Optom Vis Sci. 2010;87:337-343.
4. Lawrenson JG, Birhah R, Murphy PJ. Tear-film lipid layer morphology and corneal sensation in the development of blinking in neonates and infants. J Anat. 2005;206:265-270.
5. Sforza C, Rango M, Galante D, Bresolin N, Ferrario VF. Spontaneous blinking in healthy persons: an optoelectronic study of eyelid motion. Ophthalmic Physiol Opt. 2008;28:345-353.
6. Cho P, Yap M. Age, gender, and tear break-up time. Optom Vis Sci. 1993;70:828-831.
7. Mohidin N, Bay TC, Yap M. Non-invasive tear break-up time in normal Malays. Clin Exp Optom. 2002;85:37-41.
8. Ozdemir M, Temizdemir H. Age- and sex- related tear function changes in normal population. Eye. 2010;24:79-83.
9. Maïssa C, Guillon M. Tear film dynamics and lipid layer characteristics- effect of age and sex. Contact Lens Anterior Eye. 2010;33: 176-182.
10. Sun WS, Baker RS, Chuke JC, Rouholiman BR. Age-related changes in human blinks. Invest Ophthalmol Vis Sci. 1997;38:92-99.
11. Lavezzo MM, Schellini SA, Padovani CR. Eye blink in newborn and preschool-age children. Acta Ophthalmol. 2008;86:275-278.
12. Craig J, Tomlinson A. Age and sex effects on the normal tear film. Adv Exp Med Biol. 1998;438:411-415.
13. Henderson JW, Prough WA. Influence of age, sex on flow of tears. Arch Ophthalmol. 1950;43:224-231.
14. Guillon M, Maïssa C. Tear film evaporation: effect of age and sex. Cont Lens Anterior Eye. 2010;33:171-175.
15. Cruz AA, Garcia DM, Pinto CT, Cehetti SP. Spontaneous eyeblink activity. Ocul Surf. 2011;9:29-41.
16. Foulks GN. The correlation between the tear film lipid layer and dry eye disease. Surv Ophthalmol. 2007;52:369-374.
17. Tsubota K, Hata S, Okusawa Y, Egami F, Ohtsuki T, Nakamori K. Quantitative videographic analysis of blinking in normal subjects and patients with dry eye. Arch Ophthalmol. 1996;114:715-720.
18. Tsubota K. Tear dynamics and dry eye. Prog Retin Eye Res. 1998; 17:565-596.
19. Tomlinson A, Khanal S. Assessment of tear film dynamics: quantification approach. Ocul Surf. 2005;3:81-95.
20. Borchman D, Foulks GN, Yappert MC. Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis. Exp Eye Res. 2010;91:246-256.
21. Oshima Y, Sato H, Zaghloul A, Foulks GN, Yappert MC, Borchman D. Characterization of human meibum lipid using Raman spectroscopy. Curr Eye Res. 2009;34:824-835.
22. Borchman D, Foulks GN, Yappert MC. Confirmation of changes in human meibum lipid infrared spectra with age using principal component analysis. Curr Eye Res. 2010;35:778-786.
23. Borchman D, Foulks GN, Yappert MC, et al. Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction. Invest Ophthalmol Vis Sci. 2011;52:3805-3817.
24. Borchman D, Foulks GN, Yappert MC, Tang D, Ho DV. Temperature- induced conformational changes in human tear lipids hydrocarbon chains. Biopolymers Biospectrosc. 2007;87:124-133.
25. Borchman D, Foulks GN, Yappert MC, Tang D, Ho DV. Spectroscopic evaluation of human tear lipids. Chem Phys Lipids. 2007; 147:87-102.
26. Tiffany JM. Refractive index of meibomian and other lipids. Curr Eye Res. 1986;5:887-889.
27. Ashraf Z, Pasha U, Greenstone V, et al. Quantification of human sebum on skin and human meibum on the eye lid margin using sebum tape, spectroscopy and chemical analysis. Curr Eye Res. 2011;36:553-562.
28. Borchman D, Foulks GN, Yappert MC, et al. Physical changes in human meibum with age as measured by infrared spectroscopy. Ophthalmic Res. 2010;244:34-42.
29. Foulks GN, Borchman D, Yappert MC, Sung-Hye K, McKay JW. Topical azithromycin therapy of meibomian gland dysfunction: clinical response and lipid alterations. Cornea. 2010;29:781-788.
30. Foulks GN, Borchman D. Meibomian gland dysfunction: the past, the present, the future. Eye Contact Lens. 2010;36:249-253.
31. Huang L, Grami V, Marrero Y, et al. Human lens phospholipid changes with age and cataract. Invest Ophthalmol Vis Sci. 2005; 46:1682-1689.
32. Estrada R, Puppato A, Borchman D, Yappert MC. Re-evaluation of the phospholipid composition in membranes of adult human lenses by 31-P NMR and MALDI-MS. Biochim Biophys Acta. 2010; 1798:303-311.
33. Ferguson-Yankey S, Borchman D, Taylor KG, DuPre DB, Yappert MC. Conformational studies of sphingolipids by NMR spectroscopy: I, dihydrosphingomyelin. Biochim Biophys Acta. 2000;1467:307-325.
34. Borchman D, Byrdwell WC, Yappert MC. Regional and age-dependent differences in the phospholipid composition of human lens membranes. Invest Ophthalmol Vis Sci. 1994;35:3938-3942.
35. Byrdwell WC, Borchman D, Porter RA, Taylor KG, Yappert MC. Separation and characterization of the unknown phospholipid in human lens membranes. Invest Ophthalmol Vis Sci. 1994;35: 4333-4343.
36. Merchant TE, Lass JH, Meneses P, Greiner JV, Glonek T. Human crystalline lens phospholipid analysis with age. Invest Ophthalmol Vis Sci. 1991;32:549-555.
37. Tulloch AP. Solvent effects on the nuclear magnetic resonance spectra of methyl hydroxysterates. J Am Oil Chem Soc. 1966;43: 670-674.
38. Verardo G, Pagani E, Geatti P. A thorough study of the surface wax of apple fruits. Anal Biochem. 2003;376:659-667.
39. Frost DJ, Barzilay J. Proton magnetic resonance identification of nonconjugated cis-unsaturated fatty acids and esters. Anal Chem. 1971;43:1316-1318.
40. Scano P, Marincola FC, Locci E, Lai A. 1H and 13C NMR studies of melon and head blubber of the striped dolphin (Stenella coeruleoalba). Lipids. 2006;41:1039-1048.
41. Tulloch AP. Beeswax: structure of the esters and their component hydroxyl acids and diols. Chem Phys Lipids. 1971;6:235-265.
42. Wineburg JP, Swern D. NMR chemical shift reagents in structural determination of lipid derivatives: II, methyl petroselinate and methyl oleate. J Am Oil Chem Soc. 1971;49:267-273.
43. KE PJ, Ackman RG. N.M.R. determination of wax esters in marine lipids. Anal Chem Acta. 1974;69:253-258.
44. Purcell JM, Morris SG, Susi H. Proton magnetic resonance spectra of unsaturated fatty acids. Anal Chem. 1966;38:588-592.
45. Johnson LF, Shoolery JN. Determination of unsaturation and average molecular weight of natural fats by nuclear magnetic resonance. Anal Chem. 1962;34:1136-1139.
46. Glass CA, Dutton HJ. Determination of beta-olefinic methyl groups in esters of fatty acids by nuclear magnetic resonance. Anal Chem. 1964;36:2401-2404.
47. Robosky LC, Wade K, Woolson D, et al. Quantitative evaluation of sebum lipid components with nuclear magnetic resonance. J Lipid Res. 2008;49:686-692.
48. Shrestha RK, Borchman D, Foulks GN, Yappert MC. Analysis of the composition of lipid in human meibum from normal infants, children, adolescents, adults and adults with meibomian gland dysfunction using 1H-NMR spectroscopy. Invest Ophthalmol Vis Sci. 2011;52:7350-7358.
49. Guillén MD, Ruiz A. Oxidation process of oils with high content of linoleic acyl groups and formation of toxic hydroperoxy- and hydroxyalkenals: a study by 1H nuclear magnetic resonance. J Sci Food Agric. 2005;85:2413-2420.
50. Haywood RM, Claxson AW, Hawkes GE, et al. Detection of aldehydes and their conjugated hydroperoxydiene precursors in thermally-stressed culinary oils and fats: investigations using high resolution proton NMR spectroscopy. Free Radic Res. 1995;22:441-482.
51. Chew CKS, Hykin PG, Jansweijer C, Dikstein S, Bron AJ. The casual level of meibomian lipids in humans. Curr Eye Res. 1993;12:255-259.
52. Borchman D, Yappert MC. Lipids and the ocular lens. J Lipid Res. 2010;51:2473-2488.
53. Byrdwell CW, Borchman D. Liquid chromatography/mass spectrometric characterization of the unknown phospholipid of human lens membranes. Ophthalmic Res. 1997;29:191-206.
54. Deeley JM, Mitchell TW, Wei X, et al. Human lens lipids differ markedly from those of commonly used experimental animals. Biochim Biophys Acta. 2008;1781:288-298.
55. Witting LA. Lipid peroxidation in vivo. J Am Oil Chem Soc. 1965; 42:908-913.
56. Oborina EM, Yappert MC. Effect of sphingomyelin versus dipalmitoylphosphatidylcholine on the extent of lipid oxidation. Chem Phys Lipids. 2003;123:223-232.
57. Lamba OP, Lal S, Yappert MC, Borchman D. Spectroscopic detection of lipid peroxidation products and structural changes in a sphingomyelin model system. Biochem Biophys Acta. 1991;1081: 181-187.
58. Borchman D, Ozaki Y, Lamba OP, Byrdwell WC, Yappert MC. Age and regional structural characterization of clear human lens lipid membranes by infrared and near-infrared Raman spectroscopies. Biospectroscopy. 1996;2:113-123.
59. Borchman D, Lamba OP, Yappert MC. Structural characterization of lipid membranes from clear and cataractous human lenses. Exp Eye Res. 1993;57:199-208.
60. Paterson CA, Zeng J, Husseini Z, et al. Calcium ATPase activity and membrane structure in clear and cataractous human lenses. Curr Eye Res. 1997;16:333-338.
61. Huang L, Grami V, Marrero Y, et al. Human lens phospholipid changes with age and cataract. Invest Ophthalmol Vis Sci. 2005; 46:1682-1689.
62. Borchman D, Tang D, Yappert MC. Lipid composition, membrane structure relationships in lens and muscle sarcoplasmic reticulum membranes. Biospectroscopy. 1999;5:151-167.
63. Borchman D, Giblin FJ, Yappert MC, et al. Impact of aging and hyperbaric oxygen in vivo on guinea pig lens lipid and nuclear light scatter. Invest Ophthalmol Vis Sci. 2000;41:3061-3073.