Physical changes in human meibum with age as measured by infrared spectroscopy

Ophthalmic Research

Volumn 44, Issue 1, 2010, Pages 34-42

  Borchman, Douglas ^a   Foulks, Gary N ^a,b   Yappert, Marta C ^b   Kakar, Shelly ^a   Podoll, Nathan ^a   Rychwalski, Paul ^a   Schwietz, Eric ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Aging; Human meibum; Infrared spectroscopy; Lipids; Tears

Indexed keywords

HYDROCARBON; LIPID;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CHILD; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRY EYE; FEMALE; HUMAN; INFRARED SPECTROSCOPY; LACRIMAL FLUID; LIPID COMPOSITION; MALE; MEIBUM; PHASE TRANSITION; PRESCHOOL CHILD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHOOL CHILD; SECRETIONS; SEX DIFFERENCE; TEMPERATURE SENSITIVITY; AGING; CHEMISTRY; LIPID METABOLISM; MEIBOMIAN GLAND; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SEX RATIO; VERY ELDERLY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; HYDROCARBONS; LIPID METABOLISM; LIPIDS; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; PHASE TRANSITION; SEX DISTRIBUTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEARS;

EID: 76549135326     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000283606     Document Type: Article

References (44)

1. Chew CK, Hykin PG, Jansweijer C, Dikstein S, Tiffany JM, Bron AJ: The casual level of meibomian lipids in humans. Curr Eye Res 1993; 12: 255-259.
2. Korb DR, Baron DF, Herman JP, Finnemore VM, Exford JM, Hermosa JL, Leahy CD, Glonek T, Greiner JV: Tear film lipid layer thickness as a function of blinking. Cornea 1994; 13: 354-359.
3. Creech JL, Do LT, Fatt I, Radke CJ: In vivo tear-film thickness determination and implications for tear-film stability. Curr Eye Res 1998; 17: 1058-1066.
4. King-Smith PE, Fink BA, Hill RM, Koelling KW, Tiffany JM: The thickness of the tear film. Curr Eye Res 2005; 29: 357-368.
5. Radke CJ: Comments on 'The thickness of the tear film'. Curr Eye Res 2005; 30: 1131-1132.
6. McDonald JE : Surface phenomena of tear films. Trans Am Ophthalmol Soc 1968; 66: 905-939.
7. Haberich FJ: Der präorneale Träenfilm (PKTF). Dtsch Opt Ztg 1981; 24-33.
8. Van Haeringen NJ: Clinical biochemistry of tears. Surv Ophthalmol 1981; 26: 84-96.
9. Wolff E: Muco-cutaneous function of the lid margin and the distribution of the tear fluid. Trans Ophthalmol Soc UK 1946; 66: 291-308.
10. Craig JP, Blades K, Patel S: Tear lipid layer structure and stability following expression of the meibomian glands. Ophthalmic Physiol Optics 1995; 15: 569-574.
11. Craig JP, Tomlinson A: Importance of the lipid layer in human tear film stability and evaporation. Optom Vis Sci 1997; 74: 8-13.
12. Mathers WD, Lane JA, Sutphin JE, et al: Model for ocular tear film function. Cornea 1996; 15: 110-119.
13. Mathers W: Evaporation from the ocular surface. Exp Eye Res 2004; 78: 389-394.
14. Butovich IA, Millar TJ, Ham BM: Understanding and analyzing meibomian lipids - A review. Curr Eye Res 2008; 33: 405-420.
15. Mathers WD, Lane JA: Meibomian gland lipid, evaporation, and tear film stability; in Sullivan DA, Dartt DA, Meneray MA (eds): Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. New York, Plenum Press, 1998, pp 349-360.
16. Craig JP, Tomlinson A: Age and gender effects on the tear film; in Sullivan DA, Dartt DA, Meneray MA (eds): Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. New York, Plenum Press, 1998, pp 411-415.
17. Rolando M, Refojo MF: Tear evaporimeter for measuring water evaporation from the tear film under controlled conditions in humans. Exp Eye Res 1983; 36: 25-33.
18. Tomlinson A, Giesbrecht C: The ageing tear film. Br J Contact Lens Assoc 1993; 16: 67-69.
19. Nicolaides N, Santos EC: The di- and tri-esters of the lipids of steer and human meibomian glands. Lipids 1985; 20: 454-467.
20. Borchman D, Foulks GN, Yappert MC, Ho DV: Temperature-induced conformational changes in human tear lipids hydrocarbon chains. Biopolymers 2007; 87: 124-133.
21. Borchman D, Foulks GN, Yappert MC, Tang D, Ho DV: Spectroscopic evaluation of human tear lipids. Chem Phys Lipids 2007; 147: 87-102.
22. Kilp H, Schmid E, Kirchner L, Pohl A: Tear film observation by reflecting microscopy and differential interference contrast microscopy; in Holly FJ (ed): The Preocular Tear Film in Health, Disease and Contact Lens Wear. Lubbock, The Dry Eye Institute, 1986, pp 564-569.
23. Kóa Z, Debreczeny M, Szalontai B: Separable contributions of ordered and disordered lipid fatty acyl chain segments to vCH 2 bands in model and biological membranes: a Fourier transform infrared spectroscopic study. Biospectroscopy 1999; 5: 169-178.
24. Borchman D, Yappert MC, Herrell P: Structural characterization of human lens membrane lipid by infrared spectroscopy. Invest Ophthalmol Vis Sci 1991; 32: 2404-2416.
25. Borchman D, Tang D, Yappert MC: Lipid composition, membrane structure relationships in lens and muscle sarcoplasmic reticulum membranes Biospectroscopy 1999; 5: 151-167.
26. Borchman D, Yappert MC, Afzal M: Lens lipids and maximum lifespan. Exp Eye Res 2004; 79: 761-768.
27. Borchman D, Cenedella RI, Lamba OP: Role of cholesterol in the structural order of lens membrane lipids. Exp Eye Res 1996; 62: 191-197. (Pubitemid 26140104)
28. Moore DJ, Wyrwa M, Reboulleau CP, Mendelsohn R: Quantitative IR studies of acyl chain conformational order in fatty acid homogeneous membranes of live cells of Acholeplasma laidlawii B. Biochemistry 1993; 32: 6281-6287.
29. Popova AV, Hincha DK: Intermolecular interactions in dry and rehydrated pure and mixed bilayers of phosphatidylcholine and digalactosyldiacylglycerol: a Fourier transform infrared spectroscopy study. Biophys J 2003; 85: 1682-1690.
30. Casal HL, Mantsch HH: Polymorphic phase behaviour of phospholipid membranes studied by infrared spectroscopy. Biochim Biophys Acta 1984; 779: 381-401.
31. Mantsch HH, McElhaney RN: Phospholipid phase transitions in model and biological membranes as studied by infrared spectroscopy. Chem Phys Lipids 1991; 57: 213-226.
32. Mendelsohn R, Moore DJ: Vibrational spectroscopic studies of lipid domains in biomembranes and model systems. Chem Phys Lipids 1998; 96: 141-157.
33. Geiser MH, Bonvin M, Quibel O: Corneal and retinal temperatures under various ambient conditions: a model and experimental approach. Klin Monatsbl Augenheilkd 2004; 221: 311-314.
34. Brown SI, Dervichian DG: The oils of the meibomian glands. Physical and surface characteristics. Arch Ophthalmol 1969; 82: 537-540.
35. Linton RG, Curnow DH, Riley WJ: The meibomian glands: an investigation into the secretion and some aspects of the physiology. Br J Ophthalmol 1961; 45: 718-723.
36. Terada O, Chiba K, Senoo T, Obara Y: Ocular surface temperature of meibomian gland dysfunction patients and the melting point of meibomian gland secretions. Nippon Ganka Gakkai Zasshi 2004; 108: 690-693.
37. Ong BL, Larke JR: Meibomian gland dysfunction: some clinical, biochemical and physical observations. Ophthalmic Physiol Opt 1990; 10: 144-148.
38. Tiffany JM: Refractive index of meibomian and other lipids. Curr Eye Res 1986; 5: 887-889.
39. Nagymihalyi A, Dikstein S, Tiffany JM: The influence of eyelid temperature on the delivery of meibomian oil. Exp Eye Res 2004; 78: 367-370.
40. Holly FJ: Formation and rupture of the tear film. Exp Eye Res 1973; 15: 515-525.
41. Glasgow BJ, Abduragimov AR, Farahbakhsh ZT, Faull KF, Hubbell WL: Tear lipocalins bind a broad array of lipid ligands. Curr Eye Res 1995; 14: 363-372.
42. Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ: Binding studies of tear lipocalin: the role of the conserved tryptophan in maintaining structure, stability and ligand affinity. Biochim Biophys Acta 1999; 1433: 307-320.
43. Nagyova B, Tiffany JM: Components responsible for the surface tension of human tears. Curr Eye Res 1999; 19: 4-11.
44. Millar TJ, Mudgil P, Butovich IA, Palaniappan CK: Adsorption of human tear lipocalin to human meibomian lipid films. Invest Ophthalmol Vis Sci 2009; 50,140-151.