Effect of the single or combined administration of cocaine and testosterone on cardiovascular function and baroreflex activity in unanesthetized rats

Journal of Cardiovascular Pharmacology

Volumn 59, Issue 3, 2012, Pages 231-240

  Engi, Sheila A ^a,b   Cruz, Fábio C ^a   Leão, Rodrigo M ^a,b   Corrêa, Fernando M ^c   Planeta, Cleopatra S ^a,b   Crestani, Carlos C ^a,b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

abuse; anabolic steroids; cardiovascular; cocaine; hypertension; hypertrophy; vascular reactivity

Indexed keywords

COCAINE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; TESTOSTERONE; VASOACTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BODY WEIGHT; BRADYCARDIA; CARDIOTOXICITY; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; HEART HEMODYNAMICS; HEART RATE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; KIDNEY MASS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SYSTOLIC ARTERIAL PRESSURE;

ANIMALS; BAROREFLEX; BLOOD PRESSURE; COCAINE; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; MALE; NITROPRUSSIDE; PHENYLEPHRINE; RATS; RATS, WISTAR; TESTOSTERONE;

EID: 84858794992     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31823cc58b     Document Type: Article

References (58)

1. Kanayama G, Brower KJ, Wood RI, et al. Anabolic-androgenic steroid dependence: an emerging disorder. Addiction. 2009;104:1966-1978.
2. Goldstein RA, DesLauriers C, Burda A, et al. Cocaine: history, social implications, and toxicity: a review. Semin Diagn Pathol. 2009;26: 10-17.
3. UNODC. World Drug Report 2010. New York, NY: United Nations; 2010.
4. Arvary D, Pope HG, Jr. Anabolic-androgenic steroids as a gateway to opioid dependence. N Engl J Med. 2000;342:1532. (Pubitemid 30318288)
5. DuRant RH, Escobedo LG, Heath GW. Anabolic-steroid use, strength training, and multiple drug use among adolescents in the United States. Pediatrics. 1995;96:23-28.
6. DuRant RH, Rickert VI, Ashworth CS, et al. Use of multiple drugs among adolescents who use anabolic steroids. N Engl J Med. 1993; 328:922-926. (Pubitemid 23086644)
7. Maraj S, Figueredo VM, Lynn Morris D. Cocaine and the heart. Clin Cardiol. 2010;33:264-269.
8. van Amsterdam J, Opperhuizen A, Hartgens F. Adverse health effects of anabolic-androgenic steroids. Regul Toxicol Pharmacol. 2010;57:117-123.
9. Sullivan ML, Martinez CM, Gennis P, et al. The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis. 1998;41:1-15. (Pubitemid 28385246)
10. Kloner RA, Hale S, Alker K, et al. The effects of acute and chronic cocaine use on the heart. Circulation. 1992;85:407-419.
11. Isner JM, Estes NA III, Thompson PD, et al. Acute cardiac events temporally related to cocaine abuse. N Engl J Med. 1986;315:1438-1443. (Pubitemid 17051703)
12. Phillis BD, Irvine RJ, Kennedy JA. Combined cardiac effects of cocaine and the anabolic steroid, nandrolone, in the rat. Eur J Pharmacol. 2000; 398:263-272. (Pubitemid 30333354)
13. Togna GI, Togna AR, Graziani M, et al. Testosterone and cocaine: vascular toxicity of their concomitant abuse. Thromb Res. 2003;109: 195-201. (Pubitemid 36712908)
14. Tseng YT, Rockhold RW, Hoskins B, et al. Cardiovascular toxicities of nandrolone and cocaine in spontaneously hypertensive rats. Fundam Appl Toxicol. 1994;22:113-121. (Pubitemid 24073663)
15. Deck CC, Raya TE, Gaballa MA, et al. Baroreflex control of heart rate in rats with heart failure after myocardial infarction: effects of captopril. J Pharmacol Exp Ther. 1992;263:1424-1431. (Pubitemid 23157226)
16. Grassi G, Trevano FQ, Seravalle G, et al. Baroreflex function in hypertension: consequences for antihypertensive therapy. Prog Cardiovasc Dis. 2006;48:407-415. (Pubitemid 44250757)
17. Beutel A, Bergamaschi CT, Campos RR. Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats. J Steroid Biochem Mol Biol. 2005;93:43-48. (Pubitemid 40312732)
18. Trouve R, Nahas G, Latour C. Inhibition by cocaine of the baroreflex in the rat. Proc Soc Exp Biol Med. 1992;201:215-218.
19. Harrison DG, Freiman PC, Armstrong ML, et al. Alterations of vascular reactivity in atherosclerosis. Circ Res. 1987;61:74-80.
20. Panza JA, Casino PR, Kilcoyne CM, et al. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation. 1993;87:1468-1474. (Pubitemid 23133089)
21. Resstel LB, Tirapelli CR, Lanchote VL, et al. Chronic ethanol consumption alters cardiovascular functions in conscious rats. Life Sci. 2006;78: 2179-2187.
22. Ferrer M, Encabo A, Marin J, et al. Treatment with the anabolic steroid, nandrolone, reduces vasoconstrictor responses in rabbit arteries. Eur J Pharmacol. 1994;258:103-110. (Pubitemid 24174992)
23. Ferrer M, Encabo A, Marin J, et al. Chronic treatment with the anabolic steroid, nandrolone, inhibits vasodilator responses in rabbit aorta. Eur J Pharmacol. 1994;252:233-241. (Pubitemid 24051003)
24. Havranek EP, Nademanee K, Grayburn PA, et al. Endothelium-dependent vasorelaxation is impaired in cocaine arteriopathy. J Am Coll Cardiol. 1996;28:1168-1174. (Pubitemid 26376990)
25. Duysen EG, Li B, Carlson M, et al. Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice. Basic Clin Pharmacol Toxicol. 2008;103:514-521.
26. Head GA, McCarty R. Vagal and sympathetic components of the heart rate range and gain of the baroreceptor-heart rate reflex in conscious rats. J Auton Nerv Syst. 1987;21:203-213. (Pubitemid 18042281)
27. Grollman A, Harrison TR, Williams JR, Jr. The effects of various sterol derivatives on the blood pressure of the rat. J Pharmacol Exp Ther. 1940; 69:149-155.
28. Rosa F, Antequera R, Vasquez J, et al. Testosterone and nandrolone sensitization of brain anteroventral area of third ventricle to hypertonic NaCl-induced sympathetic response. Pharmacology. 2005;75:5-12. (Pubitemid 41491318)
29. Brecklin CS, Gopaniuk-Folga A, Kravetz T, et al. Prevalence of hypertension in chronic cocaine users. Am J Hypertens. 1998;11:1279-1283. (Pubitemid 28541041)
30. Gorlick DL, Kelley DB. The ontogeny of androgen receptors in the CNS of Xenopus laevis frogs. Brain Res. 1986;391:193-200. (Pubitemid 16110826)
31. Diano S, Naftolin F, Horvath TL. Gonadal steroids target ampa glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: a morphological and biochemical study. Endocrinology. 1997;138:778-789. (Pubitemid 27110932)
32. Pouliot WA, Handa RJ, Beck SG. Androgen modulates N-methyl-D-aspartate- mediated depolarization in CA1 hippocampal pyramidal cells. Synapse. 1996;23:10-19. (Pubitemid 26138643)
33. Kumai T, Tanaka M, Watanabe M, et al. Possible involvement of andro-gen in increased norepinephrine synthesis in blood vessels of spontaneously hypertensive rats. Jpn J Pharmacol. 1994;66:439-444.
34. Lara H, Galleguillos X, Arrau J, et al. Effect of castration and testosterone on norepinephrine storage and on the release of (3)Hnorepinephrine from rat vas deferens. Neurochem Int. 1985;7:667-674. (Pubitemid 15010640)
35. Michels G, Er F, Eicks M, et al. Long-term and immediate effect of testosterone on single T-type calcium channel in neonatal rat cardiomyo-cytes. Endocrinology. 2006;147:5160-5169. (Pubitemid 44790570)
36. Melon PG, Boyd CJ, McVey S, et al. Effects of active chronic cocaine use on cardiac sympathetic neuronal function assessed by carbon-11-hydroxyephedrine. J Nucl Med. 1997;38:451-456. (Pubitemid 27376902)
37. Beveridge TJ, Smith HR, Nader MA, et al. Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function. Neurosci Lett. 2004;370:201-205. (Pubitemid 39370879)
38. Dampney RA. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev. 1994;74:323-364. (Pubitemid 24127645)
39. Avakian EV, LeRoy M, St John-Allan K, et al. Effect of chronic cocaine administration and cocaine withdrawal on coronary flow rate and heart rate responses to epinephrine and cocaine in isolated perfused rat hearts. Life Sci. 1990;46:1569-1574. (Pubitemid 20179838)
40. Iversen LL, Salt PJ. Inhibition of catecholamine uptake-2 by steroids in the isolated rat heart. Br J Pharmacol. 1970;40:528-530.
41. Smith TL, Callahan M, Williams D, et al. Tachyphylaxis in cardiovascular responses to cocaine in conscious rats. J Cardiovasc Pharmacol. 1993;21:272-278. (Pubitemid 23027604)
42. Pagel PS, Tessmer JP, Warltier DC. Systemic and coronary hemody-namic effects of repetitive cocaine administration in conscious dogs. J Cardiovasc Pharmacol. 1994;24:443-453. (Pubitemid 24260525)
43. Goldstein DS. Arterial baroreflex sensitivity, plasma catecholamines, and pres-sor responsiveness in essential hypertension. Circulation. 1983;68:234-240.
44. Tang EH, Vanhoutte PM. Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch. 2010;459:995-1004.
45. Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta. 1999;1411:273-289. (Pubitemid 29221955)
46. Siegel AJ, Sholar MB, Mendelson JH, et al. Cocaine-induced erythrocy-tosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects. Arch Intern Med. 1999;159:1925-1929.
47. Moritz F, Monteil C, Isabelle M, et al. Role of reactive oxygen species in cocaine-induced cardiac dysfunction. Cardiovasc Res. 2003;59: 834-843. (Pubitemid 38366239)
48. Bernini G, Versari D, Moretti A, et al. Vascular reactivity in congenital hypogonadal men before and after testosterone replacement therapy. J Clin Endocr Metab. 2006;91:1691-1697.
49. Kang SM, Jang Y, Kim JY, et al. Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease. Am J Cardiol. 2002;89:862-864. (Pubitemid 34241469)
50. Malkin CJ, Jones RD, Jones TH, et al. Effect of testosterone on ex vivo vascular reactivity in man. Clin Sci (Lond). 2006;111:265-274. (Pubitemid 44599873)
51. McCredie RJ, McCrohon JA, Turner L, et al. Vascular reactivity is impaired in genetic females taking high-dose androgens. J Am Coll Cardiol. 1998;32:1331-1335.
52. Perusquia M, Stallone JN. Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites. Am J Physiol Heart Circ Physiol. 2010;298:H1301-H1307.
53. Balopole DC, Hansult CD, Dorph D. Effect of cocaine on food intake in rats. Psychopharmacology. 1979;64:121-122. (Pubitemid 9227059)
54. Tsunoda K, Yamaguchi Y, Taguchi T, et al. Cardiovascular effects of dihydrotestosterone in rats. Leg Med (Tokyo). 1999;1:95-104.
55. Marsh JD, Lehmann MH, Ritchie RH, et al. Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation. 1998;98:256-261. (Pubitemid 28337617)
56. Trifunovic B, Norton GR, Duffield MJ, et al. An androgenic steroid decreases left ventricular compliance in rats. Am J Physiol. 1995;268: H1096-H1105.
57. Pan WJ, Hedaya MA. Cocaine and alcohol interactions in the rat: effect on cocaine pharmacokinetics and pharmacodynamics. J Pharm Sci. 1999;88:459-467. (Pubitemid 29180772)
58. Kicman AT. Pharmacology of anabolic steroids. Br J Pharmacol. 2008; 154:502-521. (Pubitemid 351744954)