Combined cardiac effects of cocaine and the anabolic steroid, nandrolone, in the rat

European Journal of Pharmacology

Volumn 398, Issue 2, 2000, Pages 263-272

  Phillis, Benjamin D ^a   Irvine, Rodney J ^a   Kennedy, Jennifer A ^b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b QUEEN ELIZABETH HOSPITAL   (Australia)

Author keywords

Cardiac hypertrophy; Cocaine; Deca durabolin; ECG (electrocardiogram); Nandrolone decanoate; Noradrenaline; Radiotelemetry

Indexed keywords

ANABOLIC AGENT; COCAINE; NANDROLONE DECANOATE; PHENTOLAMINE; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DRUG POTENTIATION; ELECTROCARDIOGRAM; HEART CONDUCTION; HEART FUNCTION; HEART HYPERTROPHY; HEART PERFUSION; HEART RATE; ISOLATED HEART; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANCE ABUSE; TELEMETRY;

ANABOLIC AGENTS; ANIMALS; AREA UNDER CURVE; BODY WEIGHT; CARDIOVASCULAR PHYSIOLOGY; CARDIOVASCULAR SYSTEM; COCAINE; CORONARY CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART; HEART RATE; MALE; MOTOR ACTIVITY; NANDROLONE; ORGAN SIZE; PERFUSION; RATS; RATS, WISTAR; TEMPERATURE;

EID: 0034674382     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00294-6     Document Type: Article

References (46)

1. Besse S., Assayag P., Latour C., Janmot C., Robert V., Delcayre C., Nahas G., Swynghedauw B. Molecular characteristics of cocaine-induced cardiomyopathy in rats. Eur. J. Pharmacol. 338:1997;123-129.
2. Billman G.E. Mechanisms responsible for the cardiotoxic effects of cocaine. FASEB J. 4:1990;2469-2475.
3. Billman G.E. Cocaine: a review of its toxic actions on cardiac function. Crit. Rev. Toxicol. 25:1995;113-132.
4. Billman G.E., Lappi M.D. Effects of cocaine on cardiac vagal tone before and during coronary artery occlusion: cocaine exacerbates the autonomic response to myocardial ischemia. J. Cardiovasc. Pharmacol. 22:1993;869-876.
5. Brickner M.E., Willard J.E., Eichhorn E.J., Black J., Grayburn P.A. Left ventricular hypertrophy associated with chronic cocaine abuse. Circulation. 84:1991;1130-1135.
6. Brockway B.P., Mills P.A., Azar S.H. A new method for continuous chronic measurement and recording of blood pressure, heart rate and activity in the rat via radiotelemetry. Clin. Exp. Hypertens., Part A: Theory Pract. 13:1991;885-895.
7. Chokshi S.K., Gal D., DeJesus S., Isner J.M. Cocaine produces vasoconstriction of human coronary arteries: in vitro studies using coronary arteries obtained from freshly explanted human hearts. J. Am. Coll. Cardiol. 15:1990;215A.
8. Clark W.G., Lipton J.M. Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants: II. Neurosci. Biobehav. Rev. 10:1986;153-220.
9. Cornish J.W., O'Brien C.P. Crack cocaine abuse: an epidemic with many public health consequences. Annu. Rev. Public Health. 17:1996;259-273.
10. Dafters R.I. Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4 methylendioxymethamphetamine (MDMA or "ecstasy") in rats. Psychopharmacology. 114:1994;505-508.
11. DuRant R.H., Rickert V.I., Ashworth C.S., Newman C., Slavens G. Use of multiple drugs among adolescents who use anabolic steroids. N. Engl. J. Med. 328:1993;922-926.
12. DuRant R.H., Escobedo L.G., Heath G.W. Anabolic steroid use, strength training and multiple drug use among adolescents in the United States. Pediatrics. 96:1995;23-28.
13. Gillis R.A., Hernandez Y.M., Erzouki H.K., Raczkowski V.F., Mandal A.K., Kuhn F.E., Dretchen K.L. Sympathetic nervous system mediated cardiovascular effects of cocaine are primarily due to a peripheral site of action of the drug. Drug Alcohol Depend. 37:1995;217-230.
14. Grossie J. Ca2+ dependent action of cocaine on K+ current in freshly dissociated dorsal root ganglia from rats. Am. J. Physiol. 265:1993;C674-C679.
15. Irvine R.J., White J.M., Chan R. The influence of restraint on blood pressure in the rat. J. Pharmacol. Toxicol. Methods. 38:1997;157-162.
16. Iversen L.L. The uptake of noradrenaline by the isolated perfused rat heart. Br. J. Pharmacol. 21:1963;523-537.
17. Javaid J.I., Davis J.M. Cocaine disposition in discrete regions of rat brain. Biopharm. Drug Dispos. 14:1993;357-364.
18. Kabas J.S., Blanchard S.M., Matsuyama Y. Cocaine mediated impairment of cardiac conduction in the dog: a potential mechanism for sudden death after cocaine. J. Pharmacol. Exp. Ther. 252:1990;185-191.
19. Karch S.B., Green S.G., Young S.N. Myocardial hypertrophy and coronary artery disease in male cocaine users. J. Forensic Sci. 40:1995;591-595.
20. Kashkin K.B., Kleber H.D. Hooked on hormones? An anabolic steroid addiction hypothesis. JAMA. 262:1989;3166-3170.
21. Kennedy L.T., Hanbauer I. Sodium sensitive cocaine binding to rat striatal membrane: possible relationship to dopamine uptake sites. J. Neurochem. 41:1983;172-178.
22. Kennedy M.C., Lawrence C. Anabolic steroid abuse and cardiac death. Med. J. Aust. 158:1993;346-348.
23. Kinson G.A., Layberry R.A., Hebert B. Influences of anabolic androgens on cardiac growth and metabolism in the rat. Can. J. Physiol. Pharmacol. 69:1991;1698-1704.
24. Kiritsy-Roy J.A., Halter J.B., Gordon S.M., Smith M.J., Terry L.C. Role of the CNS in haemodynamics and sympathoadrenal response to cocaine in rats. J. Pharmacol. Exp. Ther. 255:1990;154-160.
25. Koenig H., Goldstone A., Lu C. Testosterone-mediated sexual dimorphism of the rodent heart. Circ. Res. 50:1982;782-787.
26. Lange R.A., Cigarroa R.G., Yancy C.W., Wilard J.E., Popma J.J., Sills M.N., McBride W., Kim A.S., Hillis L.D. Cocaine induced coronary artery vasoconstriction. N. Engl. J. Med. 321:1989;1557-1562.
27. Lomax P., Daniel K.A. Cocaine and body temperature in the rat: effects of ambient temperature. Pharmacology. 40:1990;103-109.
28. Lomax P., Daniel K.A. Cocaine and body temperature: effects of exercise at high ambient temperature. Pharmacology. 46:1993;164-172.
29. Luke J.L., Farb A., Virmani R., Sample R.H. Sudden cardiac death during exercise in a weight lifter using anabolic-androgenic steroids: pathological and toxicological findings. J. Forensic Sci. 35:1990;1441-1447.
30. Marsh J.D., Lehmann M.H., Ritchie R.H., Gwathmey J.K., Green G.E., Schiebinger R.J. Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation. 98:1998;256-261.
31. McKillop G., Todd I.C., Ballantyne D. Increased left ventricular mass in a bodybuilder using anabolic steroids. Br. J. Sports Med. 20:1986;151-152.
32. Pan W.-J., Hedaya M.A. An animal model for simultaneous pharmacokinetic/pharmacodynamic investigations: application to cocaine. J. Pharmacol. Toxicol. Methods. 39:1998;1-8.
33. 2+ responsiveness of ferret myocardium. Br. J. Pharmacol. 101:1990;679-685.
34. Pitts D.K., Marwah J. Autonomic actions of cocaine. Can. J. Physiol. Pharmacol. 67:1989;1168-1176.
35. Pope H.G., Katz D.L. Psychiatric and medical effects of anabolic-androgenic steroid use. Arch. Gen. Psychiatry. 51:1994;375-382.
36. Reiter M. Calcium mobilisation and cardiac inotropic mechanisms. Pharmacol. Rev. 40:1988;189-218.
37. Salt P.J. Inhibition of noradrenaline uptake-2 in the isolated rat heart by steroids, clonidine and methoxylated phenylethylamines. Eur. J. Pharmacol. 20:1972;329-340.
38. Schwartz A.B., Janzen D., Jones R.T., Boyle W. Electrocardiographic and hemodynamic effects of intravenous cocaine in awake and anesthetized dog. J. Electrocardiol. 22(2):1989;159-166.
39. Shakalis A., Condouris G.A. Local anesthetic action of cocaine on nerves from adrenalectomized frogs. Arch. Int. Pharmacodyn. Ther. 166:1967;93-101.
40. Simkhovitch B.Z., Kloner R.A., Alker K.J., Giaconi J. Time course of direct cardiotoxic effects of high cocaine concentration in isolated rabbit heart. J. Cardiovasc. Pharmacol. 23:1994;509-516.
41. Stewart G., Rubin E., Thomas A.P. Inhibition by cocaine of excitation-contraction coupling in isolated cardiomyocytes. Am. J. Physiol. 260:1991;H50-H57.
42. Temesy-Armos P.N., Fraker T.D., Brewster P.S., Wilkerson R.D. The effects of cocaine on cardiac electrophysiology in conscious, unsedated dogs. J. Cardiovasc. Pharmacol. 19:1992;883-891.
43. Tseng Y.T., Rockhold R.W., Hoskins B., Ho I.K. Cardiovascular toxicities of nandrolone and cocaine in spontaneously hypertensive rats. Fundam. Appl. Toxicol. 22:1994;113-121.
44. Vitullo J.C., Karam R., Mekhail N., Wicker P., Engelmann G.l., Khairallah P.A. Cocaine-induced small vessel spasm in isolated rat hearts. Am. J. Pathol. 135:1989;85-91.
45. Wilkerson R.D. Cardiovascular effects of cocaine in conscious dogs: importance of fully functional autonomic and central nervous systems. J. Pharmacol. Exp. Ther. 246:1988;466-471.
46. Yesalis C.E., Kennedy N.J., Kopstein A.N., Bahrke M.S. Anabolic-androgenic steroid use in the Unite States. JAMA. 270:1993;1217-1221.