Chiral metabonomics: 1H NMR-based enantiospecific differentiation of metabolites in human urine via direct cosolvation with β-cyclodextrin

Analytical Chemistry

Volumn 84, Issue 6, 2012, Pages 2868-2874

  Pérez Trujillo, Míriam ^a   Lindon, John C ^b   Parella, Teodor ^a   Keun, Hector C ^b   Nicholson, Jeremy K ^b   Athersuch, Toby J ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; BIOFLUIDS; CHIRAL DRUGS; DERIVATIZATIONS; DIASTEREOISOMERS; DIRECT DIFFERENTIATION; DRUG METABOLISMS; ENANTIO-DIFFERENTIATION; ENANTIOSPECIFIC; H NMR SPECTROSCOPY; HUMAN URINE; METABOLIC PROFILING; METABONOMICS; MICROBIAL SOURCES; MINIMAL SAMPLE; MOLECULAR CHIRALITY; PHARMACEUTICAL INDUSTRY; POTENTIAL VALUES; PRE-TREATMENT; REGULATORY AUTHORITIES;

BIOMOLECULES; BODY FLUIDS; CARBOXYLATION; CHIRALITY; ENANTIOMERS; MAMMALS; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

METABOLISM;

BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CHEMISTRY; ECONOMICS; HUMAN; METABOLISM; METABOLOMICS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; TIME; URINE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETA-CYCLODEXTRINS; HUMANS; IBUPROFEN; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; STEREOISOMERISM; TIME FACTORS;

EID: 84858728447     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac203291d     Document Type: Article

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