From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists

Journal of Medicinal Chemistry

Volumn 55, Issue 6, 2012, Pages 2574-2584

  Barth, Martine ^a   Bondoux, Michel ^a   Luccarini, Jean Michel ^a   Peyrou, Vincent ^a   Dodey, Pierre ^a   Pruneau, Didier ^a   Massardier, Christine ^a   Paquet, Jean Luc ^a  

^a Laboratoires Fournier SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHOXY N,2,6 TRIMETHYL N [2 [2 [4 (1 METHYL 4 PIPERIDINYL) 1 PIPERAZINYL] 2 OXOETHOXY]ETHYL]BENZENESULFONAMIDE BISTRIFLUOROACETATE; ANTINOCICEPTIVE AGENT; BRADYKININ B1 RECEPTOR ANTAGONIST; BRADYKININ B2 RECEPTOR ANTAGONIST; DICLOFENAC; IMIDAZOLINE DERIVATIVE; MORPHINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHRONIC INFLAMMATION; CHRONIC PAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; CELL LINE; CERCOPITHECUS AETHIOPS; CRICETINAE; CRICETULUS; HUMANS; HYPERALGESIA; IMIDAZOLINES; MALE; MICE; PAIN MEASUREMENT; PIPERAZINES; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B1; RECEPTOR, BRADYKININ B2; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84858714103     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2016057     Document Type: Article

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