Emergence and characterization of neisseria gonorrhoeae isolates with decreased susceptibilities to ceftriaxone and cefixime in Canada: 2001-2010

Sexually Transmitted Diseases

Volumn 39, Issue 4, 2012, Pages 316-323

  Martin, Irene ^a   Sawatzky, Pam ^a   Allen, Vanessa ^b   Hoang, Linda ^c,d   Lefebvre, Brigitte ^e   Mina, Neil ^f   Wong, Tom ^g   Gilmour, Matthew ^a  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b PUBLIC HEALTH ONTARIO   (Canada)

^c BRITISH COLUMBIA CENTRE FOR DISEASE CONTROL   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e INSTITUT NATIONAL DE SANTÉ PUBLIQUE DU QUÉBEC   (Canada)

^f UNIVERSITY OF ALBERTA   (Canada)

^g PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CEFIXIME; CEFTRIAXONE; CEPHALOSPORIN; CIPROFLOXACIN; SPECTINOMYCIN;

ADOLESCENT; ADULT; AGAR DILUTION; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; CANADA; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC TRAIT; HUMAN; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MULTILOCUS SEQUENCE TYPING; NEISSERIA GONORRHOEAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PREVALENCE;

ADOLESCENT; ADULT; CANADA; CEFIXIME; CEFTRIAXONE; DRUG RESISTANCE, MICROBIAL; FEMALE; GONORRHEA; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEISSERIA GONORRHOEAE; SENTINEL SURVEILLANCE; YOUNG ADULT;

EID: 84858705834     PISSN: 01485717     EISSN: 15374521     Source Type: Journal    
DOI: 10.1097/OLQ.0b013e3182401b69     Document Type: Article

References (30)

1. World Health Organization (WHO). Emergence of multi-drug resistant Neisseria gonorrhoeae-Threat of global rise in untreatable sexually transmitted infections. 2011. Available at: http://whqlibdoc. who.int/hq/2011/WHO-RHR-11.14- eng.pdf. Accessed May 6, 2011.
2. Public Health Agency of Canada, Centre for Communicable Diseases and Infection Control, Community Acquired Infections Division. STI Data Tables. 2009. Available at: http://www.phac-aspc.gc. ca/std-mts/sti-its-tab/gonorrhea- pts-eng.php. Accessed November 30, 2010.
3. Barry PM, Klausner JD. The use of cephalosporins for gonorrhea: The impending problem of resistance. Expert Opin Pharmacother 2009; 10:555-577.
4. Akasaka S, Muratani T, Yamada Y, et al. Emergence of cephemand aztreonam-high-resistant Neisseria gonorrhoeae that does not produce-lactamase. J Infect Chemother 2001; 7:49-50. (Pubitemid 32377858)
5. Unemo M, Golparian D, Syversen G, et al. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. Euro Surveill. 2010; 15:pii 19721. Available at: http://www.eurosurveillance. org/ViewArticle.aspx?Articleld-19721.
6. Ison CA, Hussey J, Sankar KN, et al. Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010. Euro Surveill. 2011; 16:pii 19833. Available at: http://www. eurosurveillance.org/ViewArticle.aspx?Articled-19833.
7. Tapsall J, Read P, Carmody C, et al. Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods. J Med Microbiol 2009; 58:683-687.
8. Unemo M, Golparian D, Hestner A. Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010. Euro Surveill 2011; 16:pii 19792. Available at: http://www. eurosurveillance.org/ViewArticle.aspx? Articleld-19792.
9. Ohnishi M, Saika T, Hoshina S, et al. Ceftriaxone-resistant Neisseria gonorrhoeae, Japan. Emerg Infect Dis 2011; 17:148-149.
10. Whiley DM, Limnios EA, Ray S, et al. Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone Antimicrob Agents Chemother 2007; 51:3111-3116. (Pubitemid 350067516)
11. Osaka K, Takakura T, Narukawa K, et al. Analysis of amino acid sequences of penicillin-binding protein 2 in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime and ceftriaxone. J Infect Chemother 2008; 14:195-203. (Pubitemid 351875924)
12. Zhao S, Duncan M, Tomberg J, et al. Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother 2009; 53: 3744-3751.
13. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: 20th informational supplement M100-S20. Wayne, PA: Clinical and Laboratory Standards Institute; 2010.
14. Hendry AT, Stewart IO. Auxanographic grouping and typing of Neisseria gonorrhoeae. Can J Microbiol 1979; 25:512-521. (Pubitemid 9172464)
15. Dillon JR, Bezanson GS, Yeung KH. Basic techniques. In: Dillon JR, Nasim A, Nestmann ER, eds. Recombinant DNA Methodology. New York, NY: John Wiley and Sons, 1985:1-114.
16. Martin IMC, Ison CA, Aanensen DM, et al. Rapid sequencebased identification of gonococcal transmission clusters in a large metropolitan area. J Infect Dis 2004; 189:1497-1505. (Pubitemid 38552358)
17. Ito M, Deguchi T, Mizutani K, et al. Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in central Japan. Antimicrob Agents Chemother 2005; 49:137-143. (Pubitemid 40065784)
18. Mavroidi A, Tzouvelekis LS, Kyriakis KP, et al. Multidrugresistant strains of Neisseria gonorrhoeae in Greece. Antimicrob Agents Chemother 2001; 45:2651-2654. (Pubitemid 32801927)
19. Ropp PA, Hu M, Olesky M, et al. Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother 2002; 46:769-777. (Pubitemid 34162507)
20. Liao M, Bell K, Gu W, et al. Clusters of circulating Neisseria gonorrhoeae strains and association with antimicrobial resistance in Shanghai. J Antimicrob Chemother 2008; 61:478-487. (Pubitemid 351321118)
21. Whiley D, Bates J, Limnios A, et al. Use of a novel screening PCR indicates presence of Neisseria gonorrhoeae isolates with a mosaic penA gene sequence in Australia. Pathology 2007; 39: 445-446. (Pubitemid 47221473)
22. Allen VG, Farrell DJ, Rebbapragada A, et al. Molecular Analysis of Antimicrobial Resistance Mechanisms in Neisseria gonorrhoeae from Ontario, Canada Antimicrob Agents Chemother 2011; 55:703-712.
23. Saitou N, Nei M. The neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol Biol Evol 1987; 4:406-425.
24. Nei M, Kumar S. Molecular evolution and phylogenetics. New York, NY: Oxford University Press, 2000.
25. Tamura K, Dudley J, Nei M, et al. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 2007; 24:1596-1599. (Pubitemid 47236692)
26. Whiley DM, Goire N, Lambert SB, et al. Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillinbinding protein 2. J Antimicrob Chemother 2010; 65:1615-1618.
27. Golparian D, Hellmark B, Fredlund H, et al. Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden. Sex Transm Infect 2010; 86:454-460.
28. Pandori M, Barry PM, Wu A, et al. Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. Antimicrob Agents Chemother 2009; 53:4032-4034.
29. Tapsall JW, Ray S, Limnios A. Characteristics and population dynamics of mosaic penA allele-containing Neisseria gonorrhoeae isolates collected in Sydney, Australia, in 2007-2008. Antimicrob Agents Chemother 2010; 54:554-556.
30. Chisholm SA, Mouton JW, Lewis DA, Nichols T, Ison CA, Livermore DM. Cephalosporin MIC creep among gonococci: Time for a pharmacodynamic rethink? J Antimicrob Chemother 2010; 65:2141-2148.