The frpB1 gene of Helicobacter pylori is regulated by iron and encodes a membrane protein capable of binding haem and haemoglobin

FEBS Letters

Volumn 586, Issue 6, 2012, Pages 875-879

  Carrizo Chávez, Miguel Angel ^a   Cruz Castanẽda, Areli ^a   Olivares Trejo, José De Jesús ^a  

^a UNIVERSIDAD AUTÓNOMA DE LA CIUDAD DE MÉXICO   (Mexico)

Author keywords

Haem; Haemoglobin; Helicobacter pylori; Iron regulation; Membrane receptor

Indexed keywords

HEME; HEMOGLOBIN; IRON; MEMBRANE PROTEIN; PROTEIN FRPB1; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BINDING AFFINITY; CELL GROWTH; CONTROLLED STUDY; FRPB1 GENE; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC REGULATION; HELICOBACTER PYLORI; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION;

BACTERIAL OUTER MEMBRANE PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HELICOBACTER PYLORI; HEME; HEMOGLOBINS; HUMANS; IRON; PROTEIN BINDING;

HELICOBACTER PYLORI;

EID: 84858703401     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.02.015     Document Type: Article

References (17)

1. Mackenzie, E.L., Iwasakik, K. and Tsuju, Y. (2008) Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid. Redox Signal. 10, 997-1030. (Pubitemid 351451707)
2. Carniel, E., Mazigh, D. and Mollaret, H.H. (1987) Expression of iron-regulated proteins in Yersinia species and their relation to virulence. Infect. Immun. 55, 277-280. (Pubitemid 17220402)
3. Otto, B.R., Verweij-van Vught, A.M. and MacLaren, D.M. (1992) Transferrins and Heme-compounds as iron sources for pathogenic bacteria. Crit. Rev. Microbiol. 18, 217-223.
4. Genco, C. and Dixon, D. (2001) Emerging strategies in microbial haem capture. Mol. Microbiol. 39, 1-11. (Pubitemid 32057671)
5. Moeck, G.S. and Coulton, J.W. (1998) TonB-dependent iron acquisition: mechanisms of siderophore-mediated active transport. Mol. Microbiol. 28, 675-681. (Pubitemid 28234378)
6. Simpson, W., Olczak, T. and Genco, C.A. (2000) Characterization and expression of HmuR, a TonB-dependent hemglobin receptor of Porphyromonas gingivalis. J. Bacteriol. 182, 5737-5748.
7. Hoffmann, H., Hornef, M., Schubert, S. and Roggenkamp, A. (2001) Distribution of the outer membrane haem receptor protein ChuA in environmental and human isolates of Escherichia coli. Int. J. Med. Microbiol. 291, 227-230. (Pubitemid 32818133)
8. Schmitt, M.P. (1997) Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin. J. Bacteriol. 179, 838-845.
9. Ochsner, A., Johnson, Z. and Vasil, L. (2000) Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa. Microbiology 146, 185-198. (Pubitemid 30066320)
10. Worst, D.J., Otto, B.R. and de Graaff, J. (1995) Iron-repressible outer membrane proteins of Helicobacter pylori involved in heme uptake. Infect. Immun. 63, 4161-4165.
11. Gonzalez-Lopez, M.A. and Olivares-Trejo, J.J. (2009) The gene frpB2 of Helicobacter pylori encodes an hemoglobin-binding protein involved in iron acquisition. Biometals 22, 889-894.
12. Merrell, D.S., Goodrich, M.L., Otto, G., Tompkins, L.S. and Falkow, S. (2003) PHregulated gene expression of the gastric pathogen Helicobacter pylori. Infect. Immun. 71, 3529-3539. (Pubitemid 36637582)
13. Worst, D.J., Maaskant, J., Vandenbroucke-Grauls, C.M.J.E. and Kusters, J.G. (1999) Multiple haem-utiIization loci in Helicobacter pylori. Microbiology 145, 681-688.
14. Sambrook, M. and Russell, M. (2001) Molecular Cloning: A Laboratory Manual, 3rd ed, Cold Spring Harbor Laboratory Press.
15. Cruz-Castaneda, A. and Olivares-Trejo, J.J. (2008) Ehhmbp45 is a novel hemoglobin-binding protein identified in Entamoeba histolytica. FEBS Lett. 582, 2806-2810.
16. Cruz-Castañeda, A., López-Casamichana, M. and Olivares-Trejo, J.J. (2011) Entamoeba histolytica secretes two haem-binding proteins to scavenge haem. Biochem. J. 15, 105-111.
17. Létoffé, S., Delepelaire, O. and Wandersman, C. (2008) Functional differences between heme permeases: Serratia marcescens HemTUV permease exhibits a narrower substrate specificity (restricted to heme) than the Escherichia coli Dpp ABCDF peptide-heme permease. J. Bacteriol. 190, 1866-1870. (Pubitemid 351355309)