Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies

FEBS Letters

Volumn 586, Issue 6, 2012, Pages 810-817

  Majumdar, Ritankar ^a   Railkar, Reema ^a   Dighe, Rajan R ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Agonist; Conformational change; Glycoprotein hormone and receptor; GPCR; Inverse agonist; Receptor activation

Indexed keywords

CYSTEINE; LUTEINIZING HORMONE RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PD1 37; SINGLE CHAIN FRAGMENT VARIABLE 13B1 ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANTIGEN BINDING; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EPITOPE MAPPING; HINGE REGION; HORMONE BINDING; PEPTIDE ANALYSIS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RECEPTOR UPREGULATION; STRUCTURE ANALYSIS; WILD TYPE;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; EPITOPES; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LH; RECEPTORS, THYROTROPIN; SINGLE-CHAIN ANTIBODIES;

EID: 84858698405     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.01.052     Document Type: Article

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