Conjunctiva-associated lymphoid tissue (CALT) reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Liang, Hong ^a,b,c,d   Baudouin, Christophe ^a,b,c,d,e,f   Labbe, Antoine ^a,b,c,d,f   Riancho, Luisa ^a,b,c   Brignole Baudouin, Françoise ^a,b,c,d,e,g  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c CNRS   (France)

^d CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^f LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^g FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALKONIUM CHLORIDE; BIMATOPROST; CD45 ANTIGEN; LATANOPROST; PROSTAGLANDIN DERIVATIVE; TAFLUPROST; TRAVOPROST; BENZALKONIUM; EYE DROPS; MUCIN 5AC; PRESERVATIVE; PROSTAGLANDIN;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONFOCAL MICROSCOPY; CONJUNCTIVA ASSOCIATED LYMPHOID TISSUE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; FROZEN SECTION; GOBLET CELL; HEMATOPOIETIC CELL; IMMUNOHISTOLOGY; IMPRESSION CYTOLOGY; IN VIVO STUDY; INFLAMMATORY CELL; LYMPHOID TISSUE; MORPHOLOGY; NONHUMAN; PROTEIN EXPRESSION; RABBIT; ANIMAL; CHEMICALLY INDUCED DISORDER; CONJUNCTIVA; CONJUNCTIVITIS; DOSE RESPONSE; GLAUCOMA; MALE; METABOLISM; PATHOLOGY;

ORYCTOLAGUS CUNICULUS;

ANIMALS; ANTIGENS, CD45; BENZALKONIUM COMPOUNDS; CONJUNCTIVA; CONJUNCTIVITIS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLAUCOMA; LYMPHOID TISSUE; MALE; MUCIN 5AC; OPHTHALMIC SOLUTIONS; PRESERVATIVES, PHARMACEUTICAL; PROSTAGLANDINS; RABBITS;

EID: 84858629622     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033913     Document Type: Article

References (31)

1. Baudouin C, Hamard P, Liang H, Creuzot-Garcher C, Bensoussan L, et al. (2004) Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term. Ophthalmology 111: 2186-2192.
2. Baudouin C, Liang H, Bremond-Gignac D, Hamard P, Hreiche R, et al. (2005) CCR 4 and CCR 5 expression in conjunctival specimens as differential markers of T(H)1/T(H)2 in ocular surface disorders. J Allergy Clin Immunol 116: 614-619.
3. Baudouin C, Liang H, Hamard P, Riancho L, Creuzot-Garcher C, et al. (2008) The ocular surface of glaucoma patients treated over the long term expresses inflammatory markers related to both T-helper 1 and T-helper 2 pathways. Ophthalmology 115: 109-115.
4. Martone G, Frezzotti P, Tosi GM, Traversi C, Mittica V, et al. (2009) An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. Am J Ophthalmol 147: 725-735.
5. Baudouin C, Labbe A, Liang H, Pauly A, Brignole-Baudouin F, (2010) Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res 29: 312-334.
6. Gerberick GF, Cruse LW, Ryan CA, Hulette BC, Chaney JG, et al. (2002) Use of a B cell marker (B220) to discriminate between allergens and irritants in the local lymph node assay. Toxicol Sci 68: 420-8.
7. Willis CM, Stephens CJ, Wilkinson JD, (1990) Differential effects of structurally unrelated chemical irritants on the density and morphology of epidermal CD1+ cells. J Invest Dermatol 95: 711-716.
8. Knop E, Knop N, (2005) Influence of the eye-associated lymphoid tissue (EALT) on inflammatory ocular surface disease. Ocul Surf 3: S180-186.
9. Knop E, Knop N, (2005) Ultrastructural anatomy of CALT follicles in the rabbit reveals characteristics of M-cells, germinal centres and high endothelial venules. J Anat 207: 409-426.
10. Franklin RM, Remus LE, (1984) Conjunctival-associated lymphoid tissue: evidence for a role in the secretory immune system. Invest Ophthalmol Vis Sci 25: 181-187.
11. Knop N, Knop E, (2010) Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT). Dev Ophthalmol 45: 23-39.
12. Banerjee S, Figueiredo FC, Easty DL, Dick AD, Nicholls SM, (2003) Development of organised conjunctival leucocyte aggregates after corneal transplantation in rats. Br J Ophthalmol 87: 1515-1522.
13. Steven P, Rupp J, Hüttmann G, Koop N, Lensing C, et al. (2008) Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue. Invest Ophthalmol Vis Sci 49: 1512-1517.
14. Liang H, Baudouin C, Dupas B, Brignole-Baudouin F, (2010) Live conjunctiva-associated lymphoid tissue analysis in rabbit under inflammatory stimuli using in vivo confocal microscopy. Invest Ophthalmol Vis Sci 51: 1008-1015.
15. Alagöz G, Bayer A, Boran C, Serin D, Kükner A, et al. (2008) Comparison of ocular surface side effects of topical travoprost and bimatoprost. Ophthalmologica 222: 161-167.
16. Konstas AG, Katsimbris JM, Lallos N, Boukaras GP, Jenkins JN, et al. (2005) Latanoprost 0.005% versus bimatoprost 0.03% in primary open-angle glaucoma patients. Ophthalmology 112: 262-266.
17. Liang H, Brignole-Baudouin F, Rabinovich-Guilatt L, Mao Z, Riancho L, et al. (2008) Reduction of quaternary ammonium-induced ocular surface toxicity by emulsions: an in vivo study in rabbits. Mol Vis 14: 204-216.
18. Ichijima H, Petroll WM, Jester JV, Cavanagh HD, (1992) Confocal microscopic studies of living rabbit cornea treated with benzalkonium chloride. Cornea 11: 221-225.
19. Liang H, Baudouin C, Labbé A, Pauly A, Martin C, et al. (2006) In vivo confocal microscopy and ex vivo flow cytometry: new tools for assessing ocular inflammation applied to rabbit lipopolysaccharide-induced conjunctivitis. Mol Vis 12: 1392-1402.
20. Uter W, Lessmann H, Geier J, Schnuch A, (2008) Is the irritant benzalkonium chloride a contact allergen? A contribution to the ongoing debate from a clinical perspective. Contact Derm 58: 359-63.
21. Baudouin C, Riancho L, Warnet JM, Brignole F, (2007) In vitro studies of antiglaucomatous prostaglandin analogues: travoprost with and without benzalkonium chloride and preserved latanoprost. Invest Ophthalmol Vis Sci 48: 4123-4128.
22. Brasnu E, Brignole-Baudouin F, Riancho L, Guenoun JM, Warnet JM, et al. (2008) In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line. Curr Eye Res 33: 303-312.
23. Liang H, Baudouin C, Pauly A, Brignole-Baudouin F, (2008) Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride. Br J Ophthalmol 92: 1275-1282.
24. De Saint Jean M, Brignole F, Bringuier AF, Bauchet A, Feldmann G, et al. (1999) Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci 40: 619-630.
25. Debbasch C, Pisella PJ, De Saint Jean M, Rat P, Warnet JM, et al. (2001) Mitochondrial activity and glutathione injury in apoptosis induced by unpreserved and preserved beta-blockers on Chang conjunctival cells. Invest Ophthalmol Vis Sci 42: 2525-2533.
26. Pauly A, Meloni M, Brignole-Baudouin F, Warnet J M, Baudouin C, (2009) Multiple endpoint analysis of the 3D-reconstituted corneal epithelium after treatment with benzalkonium chloride: early detection of toxic damage. Invest Ophthalmol Vis Sci 50: 1644-1652.
27. Peebo BB, Fagerholm P, Traneus-Rockert C, Lagali N, (2010) Cellular-level characterization of lymph vessels in live, unlabeled corneas by in vivo confocal microscopy. Invest Ophthalmol Vis Sci 51: 830-835.
28. Patel DV, McGhee CN, (2009) In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: a review. Br J Ophthalmol 93: 853-860.
29. Seo Kyoung Yul, Han Soo Jung, Cha Hye-Ran, Seo Sang-Uk, Song Joo-Hye, et al. (2010) Eye mucosa: an efficient vaccine delivery route for inducing protective immunity. J Immunol 185: 3610-3619.
30. Liang H, Baudouin C, Faure MO, Lambert G, Brignole-Baudouin F, (2009) Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay. Mol Vis 15: 1690-1699.
31. Malvitte L, Montange T, Vejux A, Baudouin C, Bron AM, et al. (2007) Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs. Br J Ophthalmol 91: 29-32.