Influence of the eye-associated lymphoid tissue (EALT) on inflammatory ocular surface disease

Ocular Surface

Volumn 3, Issue 4, 2005, Pages S180-S186

  Knop, Erich ^a   Knop, Nadja ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Eye associated lymphoid tissue (EALT); Inflammation; Mucosa associated lymphoid tissue (MALT); Mucosal immune system

Indexed keywords

CELL ADHESION MOLECULE; MATRIX METALLOPROTEINASE;

ANTIGEN PRESENTATION; ARTICLE; EYE ASSOCIATED LYMPHOID TISSUE; EYE INFLAMMATION; HUMAN; IMMUNOMODULATION; LEUKOCYTE; LYMPHOCYTE FUNCTION; LYMPHOID CELL; LYMPHOID TISSUE; MUCOSAL IMMUNITY; OCULAR SURFACE DISEASE; UPREGULATION; WOUND;

EID: 84949116556     PISSN: 15420124     EISSN: 19375913     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Kessing SV. A quantitative normal anatomical study. Acta Ophthalmol (Copenh) 1968; Suppl 95:1-133
2. Osterlind G. An investigation into the presence of lymphatic tissue in the human conjunctiva, and its biological and clinical importance. Acta Ophthalmol (Copenh) 1944; Suppl. 23:1-79
3. Allansmith MR, Greiner JV, Baird RS. Number of inflammatory cells in the normal conjunctiva. Am J Ophthalmol 1978;86:250-9
4. Franklin RM, Kenyon KR, Tomasi TB, Jr. Immunohistologic studies of human lacrimal gland: localization of immunoglobulins, secretory component and lactoferrin. J Immunol 1973;110:984-92
5. Wieczorek R, Jakobiec FA, Sacks EH, Knowles DM. The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions. Ophthalmology 1988;95:100-9
6. Knop E, Knop N. The role of eye-associated lymphoid tissue in corneal immune protection. J Anat 2005;206:271-85
7. Knop E, Knop N. [Eye-associated lymphoid tissue (EALT) is continuously spread throughout the ocular surface from the lacrimal gland to the lacrimal drainage system]. Ophthalmologe 2003;100:929-42
8. Knop N, Knop E. Conjunctiva-associated lymphoid tissue in the human eye. Invest Ophthalmol Vis Sci 2000;41:1270-9
9. Knop E, Knop N. Lacrimal drainage associated lymphoid tissue (LDALT): A part of the human mucosal immune system. Invest Ophthalmol Vis Sci 2001;42:566-74
10. Paulsen FP, Paulsen JI, Thale AB, et al. Organized mucosaassociated lymphoid tissue in human naso-lacrimal ducts. Adv Exp Med Biol 2002;506:873-6
11. Knop E, Knop N. A functional unit for ocular surface immune defense formed by the lacrimal gland, conjunctiva and lacrimal drainage system. Adv Exp Med Biol 2002;506:835-44
12. Gowans JL. The recirculation of lymphocytes from blood to lymph in the rat. J Physiol 1959;146:54
13. Kraehenbuhl JP, Neutra MR. Molecular and cellular basis of immune protection of mucosal surfaces. Physiol Rev 1992;72:853-79
14. Knop E, Knop N. Lymphocyte homing in the mucosal immune system to the eye-associated lymphoid tissue (EALT), in Zierhut M, Sullivan DA, Stern ME, (eds). Immunology of the ocular surface and tearfilm. Amsterdam, Swets & Zeitlinger, 2004, pp 35-72
15. Dua HS, Gomes JA, Jindal VK, et al. Mucosa specific lymphocytes in the human conjunctiva, corneoscleral limbus and lacrimal gland. Curr Eye Res 1994;13:87-93
16. Hingorani M, Metz D, Lightman SL. Characterisation of the normal conjunctival leukocyte population. Exp Eye Res 1997;64:905-12
17. Sacks EH, Wieczorek R, Jakobiec FA, Knowles DM. Lymphocytic subpopulations in the normal human conjunctiva. A monoclonal antibody study. Ophthalmology 1986;93:1276-83
18. Sack RA, Conradi L, Krumholz D, Beaton A, Sathe S, Morris C. Membrane array characterization of 80 chemokines, cytokines, and growth factors in open- and closed-eye tears: angionenin and other defense system constituents. Invest Ophthalmol Vis Sci 2005;46(4):1228-38.
19. Mougneau E, Hugues S, Glaichenhaus N. Antigen presentation by dendritic cells in vivo. J Exp Med 2002;196:1013-16
20. Dana MR. Corneal antigen-presenting cells: diversity, plasticity, and disguise. The Cogan Lecture. Invest Ophthalmol Vis Sci 2004;45:722-7
21. Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, Bandeira A. On the ontogeny and physiology of regulatory T cells. Immunol Rev 2001;182:5-17
22. Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A 2002;99:351-8
23. Sullivan DA. Immunology of the lacrimal gland and tear film. Dev Ophthalmol 1999;30:39-53
24. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immuno 1994;12:991-1045
25. Pflugfelder SC. Tear fluid influence on the ocular surface. Adv Exp Med Biol 1998;438:611-7
26. McGill J. Conjunctival cytokines in ocular allergy. Clin Exp Allergy 2000;30:1355-7
27. Baudouin C, Haouat N, Brignole F, et al. Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens. Br J Ophthalmol 1992;76:545-9
28. Brignole F, Pisella PJ, Goldschild M, et al. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest Ophthalmol Vis Sci 2000;41:1356-63
29. Mircheff AK, Xie J, Qian L, Hamm-Alvarez SF. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol 2002;21:435-42
30. Stern ME, Beuerman RW, Fox RI, et al. A unified theory of the role of the ocular surface in dry eye. Adv Exp Med Biol 1998;438:643-51
31. Gao J, Morgan G, Tieu D, et al. ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjogrens syndrome-like MRL/lpr mice. Exp Eye Res 2004;78:823-35
32. Stern ME, Gao J, Schwalb TA, et al. Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest Ophthalmol Vis Sci 2002;43:2609-14
33. Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behaviour. Annu Rev Cell Devel Biol 2001;17:463-516
34. Afonso AA, Sobrin L, Monroy DC, et al. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci 1999;40:2506-12
35. Konttinen YT, Halinen S, Hanemaaijer R, et al. Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjogren's syndrome. Matrix Biol 1998;17:335-47
36. Garrana RM, Zieske JD, Assouline M, Gipson IK. Matrix metalloproteinases in epithelia from human recurrent corneal erosion. Invest Ophthalmol Vis Sci 1999;40:1266-70
37. Smith VA, Rishmawi H, Hussein H, Easty DL. Tear film MMP accumulation and corneal disease. Br J Ophthalmol 2001;85:147-53
38. Meller D, Li DQ, Tseng SC. Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1beta and tumor necrosis factor-alpha. Invest Ophthalmol Vis Sci 2000;41:2922-9
39. Kumagai N, Yamamoto K, Fukuda K, et al. Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. J Allergy Clin Immunol 2002;110:489-91
40. Jones DT, Monroy D, Ji Z, Pflugfelder SC. Alterations of ocular surface gene expression in Sjogren's syndrome. Adv Exp Med Biol 1998;438:533-6
41. Pflugfelder SC, Jones D, Ji Z, et al. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999;19:201-11
42. MacDonald TT, Bajaj-Elliott M, Pender SL. T cells orchestrate intestinal mucosal shape and integrity. Immunol Today 1999;20:505-10
43. Sall K, Stevenson OD, Mundorf TK, Reis BL. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 2000;107:631-39