Maternal quercetin intake during pregnancy results in an adapted iron homeostasis at adulthood

Toxicology

Volumn 290, Issue 2-3, 2011, Pages 350-358

  Vanhees, Kimberly ^a   Godschalk, Roger W ^a   Sanders, Anneke ^a   Van Waalwijk van Doorn Khosrovani, Sahar Barjesteh ^a   Van Schooten, Frederik J ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

DNA methylation; In utero exposure; Interleukins; Iron; Quercetin

Indexed keywords

BILIRUBIN; ERYTHROPOIETIN; GLOBIN; HEPCIDIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; IRON; QUERCETIN;

ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; FEMALE; FETUS DEVELOPMENT; GESTATIONAL AGE; IRON STORAGE; LIVER; MOUSE; NONHUMAN; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; UPREGULATION;

ANIMALIA; MUS;

EID: 84858620311     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.10.017     Document Type: Article

References (35)

1. Bothwell T.H. Iron requirements in pregnancy and strategies to meet them. Am. J. Clin. Nutr. 2000, 72:257S-264S.
2. Cao G., Sofic E., Prior R.L. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic. Biol. Med. 1997, 22:749-760.
3. Egert S., Wolffram S., Bosy-Westphal A., Boesch-Saadatmandi C., Wagner A.E., Frank J., Rimbach G., Mueller M.J. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J. Nutr. 2008, 138:1615-1621.
4. Ferrali M., Signorini C., Caciotti B., Sugherini L., Ciccoli L., Giachetti D., Comporti M. Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity. FEBS Lett. 1997, 416:123-129.
5. Gaj S., van Erk A., van Haaften R.I., Evelo C.T. Linking microarray reporters with protein functions. BMC Bioinform. 2007, 8:360.
6. Gambling L., Charania Z., Hannah L., Antipatis C., Lea R.G., McArdle H.J. Effect of iron deficiency on placental cytokine expression and fetal growth in the pregnant rat. Biol. Reprod. 2002, 66:516-523.
7. Gambling L., Czopek A., Andersen H.S., Holtrop G., Srai S.K., Krejpcio Z., McArdle H.J. Fetal iron status regulates maternal iron metabolism during pregnancy in the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 296:R1063-R1070.
8. Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematol. Am. Soc. Hematol. Educ. Program 2006, 29-35:507.
9. Godfrey K.M., Barker D.J. Fetal nutrition and adult disease. Am. J. Clin. Nutr. 2000, 71:1344S-1352S.
10. Hindmarsh P.C., Geary M.P., Rodeck C.H., Jackson M.R., Kingdom J.C. Effect of early maternal iron stores on placental weight and structure. Lancet 2000, 356:719-723.
11. Keller G., Lacaud G., Robertson S. Development of the hematopoietic system in the mouse. Exp. Hematol. 1999, 27:777-787.
12. Kingsley P.D., Malik J., Emerson R.L., Bushnell T.P., McGrath K.E., Bloedorn L.A., Bulger M., Palis J. " Maturational" globin switching in primary primitive erythroid cells. Blood 2006, 107:1665-1672.
13. Kitagawa S., Sakamoto H., Tano H. Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin. Chem. Pharm. Bull. (Tokyo) 2004, 52:999-1001.
14. Koury M.J., Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu. Rev. Nutr. 2004, 24:105-131.
15. Langie S.A., Kowalczyk P., Tudek B., Zabielski R., Dziaman T., Olinski R., van Schooten F.J., Godschalk R.W. The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets. Mutat. Res. 2010, 695:75-80.
16. Laughton M.J., Halliwell B., Evans P.J., Hoult J.R. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Biochem. Pharmacol. 1989, 38:2859-2865.
17. Maines M.D. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 1988, 2:2557-2568.
18. Mennen L.I., Walker R., Bennetau-Pelissero C., Scalbert A. Risks and safety of polyphenol consumption. Am. J. Clin. Nutr. 2005, 81:326S-329S.
19. Munoz M., Villar I., Garcia-Erce J.A. An update on iron physiology. World J. Gastroenterol. 2009, 15:4617-4626.
20. Ohgami R.S., Campagna D.R., McDonald A., Fleming M.D. The Steap proteins are metalloreductases. Blood 2006, 108:1388-1394.
21. Olivieri N.F., Brittenham G.M. Iron-chelating therapy and the treatment of thalassemia. Blood 1997, 89:739-761.
22. Palis J. Ontogeny of erythropoiesis. Curr. Opin. Hematol. 2008, 15:155-161.
23. Prater M.R., Laudermilch C.L., Liang C., Holladay S.D. Placental oxidative stress alters expression of murine osteogenic genes and impairs fetal skeletal formation. Placenta 2008, 29:802-808.
24. Ross J.A., Kasum C.M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu. Rev. Nutr. 2002, 22:19-34.
25. Sikkel E., Pasman S.A., Oepkes D., Kanhai H.H., Vandenbussche F.P. On the origin of amniotic fluid bilirubin. Placenta 2004, 25:463-468.
26. Skibola C.F., Smith M.T. Potential health impacts of excessive flavonoid intake. Free Radic. Biol. Med. 2000, 29:375-383.
27. Smyth G.K., Michaud J., Scott H.S. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 2005, 21:2067-2075.
28. Taher A., Sheikh-Taha M., Sharara A., Inati A., Koussa S., Ellis G., Dhillon A.P., Hoffbrand A.V. Safety and effectiveness of 100mg/kg/day deferiprone in patients with thalassemia major: a two-year study. Acta Haematol. 2005, 114:146-149.
29. Todaka E., Sakurai K., Fukata H., Miyagawa H., Uzuki M., Omori M., Osada H., Ikezuki Y., Tsutsumi O., Iguchi T., Mori C. Fetal exposure to phytoestrogens - the difference in phytoestrogen status between mother and fetus. Environ. Res. 2005, 99:195-203.
30. Vanhees K., de Bock L., Godschalk R.W., van Schooten F.J., van Waalwijk van Doorn-Khosrovani S.B. Prenatal exposure to flavonoids: implication for cancer risk. Toxicol. Sci. 2011, 120:59-67.
31. Vanhees K., Coort S., Ruijters E.J., Godschalk R.W., van Schooten F.J., van Waalwijk van Doorn-Khosrovani S.B. Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage. FASEB J. 2011, 25:797-807.
32. Vanhees K., Coort S., Ruijters E.J., Godschalk R.W., van Schooten F.J., van Doorn-Khosrovani S.B. Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage. FASEB J. 2011, 25:797-807.
33. Waterston R.H., Lindblad-Toh K., Birney E., Rogers J., Abril J.F., Agarwal P., Agarwala R., Ainscough R., Alexandersson M., An P., Antonarakis S.E., Attwood J., Baertsch R., Bailey J., Barlow K., Beck S., Berry E., Birren B., Bloom T., Bork P., Botcherby M., Bray N., Brent M.R., Brown D.G., Brown S.D., Bult C., Burton J., Butler J., Campbell R.D., Carninci P., Cawley S., Chiaromonte F., Chinwalla A.T., Church D.M., Clamp M., Clee C., Collins F.S., Cook L.L., Copley R.R., Coulson A., Couronne O., Cuff J., Curwen V., Cutts T., Daly M., David R., Davies J., Delehaunty K.D., Deri J., Dermitzakis E.T., Dewey C., Dickens N.J., Diekhans M., Dodge S., Dubchak I., Dunn D.M., Eddy S.R., Elnitski L., Emes R.D., Eswara P., Eyras E., Felsenfeld A., Fewell G.A., Flicek P., Foley K., Frankel W.N., Fulton L.A., Fulton R.S., Furey T.S., Gage D., Gibbs R.A., Glusman G., Gnerre S., Goldman N., Goodstadt L., Grafham D., Graves T.A., Green E.D., Gregory S., Guigo R., Guyer M., Hardison R.C., Haussler D., Hayashizaki Y., Hillier L.W., Hinrichs A., Hlavina W., Holzer T., Hsu F., Hua A., Hubbard T., Hunt A., Jackson I., Jaffe D.B., Johnson L.S., Jones M., Jones T.A., Joy A., Kamal M., Karlsson E.K., Karolchik D., Kasprzyk A., Kawai J., Keibler E., Kells C., Kent W.J., Kirby A., Kolbe D.L., Korf I., Kucherlapati R.S., Kulbokas E.J., Kulp D., Landers T., Leger J.P., Leonard S., Letunic I., Levine R., Li J., Li M., Lloyd C., Lucas S., Ma B., Maglott D.R., Mardis E.R., Matthews L., Mauceli E., Mayer J.H., McCarthy M., McCombie W.R., McLaren S., McLay K., McPherson J.D., Meldrim J., Meredith B., Mesirov J.P., Miller W., Miner T.L., Mongin E., Montgomery K.T., Morgan M., Mott R., Mullikin J.C., Muzny D.M., Nash W.E., Nelson J.O., Nhan M.N., Nicol R., Ning Z., Nusbaum C., O'Connor M.J., Okazaki Y., Oliver K., Overton-Larty E., Pachter L., Parra G., Pepin K.H., Peterson J., Pevzner P., Plumb R., Pohl C.S., Poliakov A., Ponce T.C., Ponting C.P., Potter S., Quail M., Reymond A., Roe B.A., Roskin K.M., Rubin E.M., Rust A.G., Santos R., Sapojnikov V., Schultz B., Schultz J., Schwartz M.S., Schwartz S., Scott C., Seaman S., Searle S., Sharpe T., Sheridan A., Shownkeen R., Sims S., Singer J.B., Slater G., Smit A., Smith D.R., Spencer B., Stabenau A., Stange-Thomann N., Sugnet C., Suyama M., Tesler G., Thompson J., Torrents D., Trevaskis E., Tromp J., Ucla C., Ureta-Vidal A., Vinson J.P., Von Niederhausern A.C., Wade C.M., Wall M., Weber R.J., Weiss R.B., Wendl M.C., West A.P., Wetterstrand K., Wheeler R., Whelan S., Wierzbowski J., Willey D., Williams S., Wilson R.K., Winter E., Worley K.C., Wyman D., Yang S., Yang S.P., Zdobnov E.M., Zody M.C., Lander E.S. Initial sequencing and comparative analysis of the mouse genome. Nature 2002, 420:520-562.
34. Weiss G. Iron metabolism in the anemia of chronic disease. Biochim. Biophys. Acta 2009, 1790:682-693.
35. Zhang Y., Li H., Zhao Y., Gao Z. Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury. Eur. J. Pharmacol. 2006, 535:263-269.