Incidence of isolated heparin-induced thrombocytopenia and risk of thrombosis by IgG-specific anti-PF4/heparin ELISA

Clinical and Applied Thrombosis/Hemostasis

Volumn 18, Issue 2, 2012, Pages 215-217

  Radaideh, Sofyan M ^a   Frenkel, Eugene P ^a   Dowell, Jonathan E ^a   Sarode, Ravindra ^b   Shen, Yu Min ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

heparins; thrombocytopenia; thrombosis

Indexed keywords

HEPARIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; THROMBIN INHIBITOR; THROMBOCYTE FACTOR 4; WARFARIN;

CARDIOVASCULAR RISK; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVIEW; THROMBOSIS;

ANTIBODY SPECIFICITY; ANTICOAGULANTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FALSE POSITIVE REACTIONS; FOLLOW-UP STUDIES; HEPARIN; HUMANS; IMMUNOGLOBULIN G; INCIDENCE; PLATELET FACTOR 4; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; RISK; SENSITIVITY AND SPECIFICITY; TEXAS; THROMBOPHILIA; THROMBOSIS; WARFARIN;

EID: 84858406742     PISSN: 10760296     EISSN: 19382723     Source Type: Journal    
DOI: 10.1177/1076029611423389     Document Type: Review

References (17)

1. Amiral J, Bridey F, Wolf M, et al. Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thromb Haemost. 1995 ; 73 (1). 21-28
2. Cines DB, Rauova L, Arepally G, et al. Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. J Clin Apher. 2007 ; 22 (1). 31-36 (Pubitemid 46407059)
3. Warkentin TE.. Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol. 2003 ; 121 (4). 535-555 (Pubitemid 36645375)
4. Zwicker JI, Uhl L, Huang WY, Shaz BH, Bauer KA.. Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2004 ; 2 (12). 2133-2137 (Pubitemid 40185772)
5. Altuntas F, Matevosyan K, Burner J, Shen YM, Sarode R.. Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia. Eur J Haematol. 2008 ; 80: 429-435 (Pubitemid 351503102)
6. Warkentin TE, Kelton JG.. A 14-year study of heparin-induced thrombocytopenia. Am J Med. 1996 ; 101 (5). 502-507 (Pubitemid 126335970)
7. Warkentin TE, Sheppard JI.. No significant improvement in diagnostic specificity of an anti-PF4/polyanion immunoassay with use of high heparin confirmatory procedure. J Thromb Haemost. 2006 ; 4 (1). 281-282
8. Arepally GM, Ortel TL.. Clinical practice. Heparin-induced thrombocytopenia. N Engl J Med. 2006 ; 355 (8). 809-817
9. Suh JS, Malik MI, Aster RH, Visentin GP.. Characterization of the humoral immune response in heparin-induced thrombocytopenia. Am J Hematol. 1997 ; 54 (3). 196-201 (Pubitemid 27148257)
10. Vun CM, Evans S, Chesterman CN.. Anti-PF4-heparin immunoglobulin G is the major class of heparin-induced thrombocytopenia antibody: findings of an enzyme-linked immunofiltration assay using membrane-bound hPF4-heparin. Br J Haematol. 2001 ; 112 (1). 69-75 (Pubitemid 32151152)
11. Lindhoff-Last E, Gerdsen F, Ackermann H, Bauersachs R.. Determination of heparin-platelet factor 4-IgG antibodies improves diagnosis of heparin-induced thrombocytopenia. Br J Haematol. 2001 ; 113 (4). 886-890 (Pubitemid 32634754)
12. Cuker A, Ortel TL.. ASH evidence-based guidelines: is the IgG-specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT?. Hematology Am Soc Hematol Educ Program. 2009 ;: 250-252
13. Bakchoul T, Giptner A, Najaoui A, Bein G, Santoso S, Sachs UJ.. Prospective evaluation of PF4/heparin immunoassays for the diagnosis of heparin-induced thrombocytopenia. J Thromb Haemost. 2009 ; 7 (8). 1260-1265
14. Lo GK, Sigouin CS, Warkentin TE.. What is the potential for overdiagnosis of heparin-induced thrombocytopenia?. Am J Hematol. 2007 ; 82 (12). 1037-1043 (Pubitemid 350209843)
15. Greinacher A, Juhl D, Strobel U, et al. Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes. J Thromb Haemost. 2007 ; 5 (8). 1666-1673 (Pubitemid 47091409)
16. Juhl D, Eichler P, Lubenow N, Strobel U, Wessel A, Greinacher A.. Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. Eur J Haematol. 2006 ; 76 (5). 420-426
17. Warkentin TE, Sheppard JA, Moore JC, Moore KM, Sigouin CS, Kelton JG.. Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: how much class do we need?. J Lab Clin Med. 2005 ; 146 (6). 341-346 (Pubitemid 41712020)