Characterization of the humoral immune response in heparin-induced thrombocytopenia

American Journal of Hematology

Volumn 54, Issue 3, 1997, Pages 196-201

  Suh, Jang Soo ^a,b   Malik, Mohammad I ^c   Aster, Richard H ^a   Visentin, Gian Paolo ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b Kyungpook National University School of Medicine   (South Korea)

^c ST LUKE S MEDICAL CENTER   (United States)

Author keywords

Fc RII receptor; heparin; heparin ELISA; heparin induced thrombocytopenia thrombosis; isotyping; PF4; serotonin release assay

Indexed keywords

FC RECEPTOR; HEPARIN; IMMUNOGLOBULIN G; SEROTONIN; THROMBOCYTE FACTOR 4;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMORAL IMMUNITY; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOCYTOPENIA; THROMBOSIS;

AGED; AGED, 80 AND OVER; ANTIBODY FORMATION; FEMALE; HEPARIN; HUMANS; IMMUNOGLOBULIN ISOTYPES; MALE; MIDDLE AGED; PLATELET FACTOR 4; THROMBOCYTOPENIA; THROMBOSIS;

EID: 0030887879     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199703)54:3<196::AID-AJH4>3.0.CO;2-R     Document Type: Article

References (24)

1. Warkentin TE, Kelton JG: Heparin-induced thrombocytopenia. Prog Hemost Thromb 10:1-34, 1991.
2. Chong BH: Heparin-induced thrombocytopenia. Br J Haematol 89: 431-439, 1995.
3. Aster RH: Heparin-induced thrombocytopenia and thrombosis. N Engl J Med 332:1374-1376, 1995.
4. Kelton JG, Sheridan D, Santos A, et al: Heparin-induced thrombocytopenia: Laboratory studies. Blood 72:925-930, 1988.
5. Greinacher A, Michels I, Mueller-Eckhardt C: Heparin-associated thrombocytopenia: The antibody is not heparin specific. Thromb Haemosl 67:545-549, 1992.
6. Amiral J, Bridey F, Dreyfus M, et al: Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost (letter) 68:95-96, 1992.
7. Visentin GP, Ford SE, Scott JP, Aster RH: Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound endothelial cells. J Clin Invest 93:81-88, 1994.
8. Greinacher A, Potzsch B, Amiral J, Dummel V, Eichner A, Mueller-Eckhardt C: Heparin-associated thrombocytopenia: Isolation of the antibody and characterization of a multi molecular PF4-heparin complex as the major antigen. Thromb Haemost 71:247-51, 1994.
9. Kelton JG, Smith JW, Warkentin TE, Hayward CPM, Denomme GA, Horsewood P: Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4. Blood 83:3232-3239, 1994.
10. Amiral J, Bridey F, Wolf M: Antibodies to macromolecular platelet factor 4 heparin complexes in heparin-induced thrombocytopenia: A study of 44 cases. Thromb Haemost 73:31-28, 1995.
11. 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. Am J Clin Pathol 104:648-654, 1995.
12. Visentin GP, Malik M, Menden KA, Aster RH: A prospective study of the formation of antibodies reactive with heparin:PF4 complexes in patients treated with heparin. Blood 94 (Suppl l):80a, 1994 (abstract).
13. Burgess JK, Lindeman R, Chesterman CN, Chong BH: Single amino acid mutation of Fcγ receptor is associated with the development of heparin-induced thrombocytopenia. Br J Haematol 91:761-6, 1995.
14. Brandt JT, Isenhart CE, Osborne JM, Ahmed A, Anderson CL: On the role of platelet Fc-Gamma-RIIA phenotype in heparin-induced thrombocytopenia. Thromb Haemost 74:1564-1572, 1995.
15. Parren P, Warmerdam PAM, Boeije LCM, Arts J, Westerdaal NAC, Vlug A, Capel PJA, Aarden LA, van de Winkel JGJ: On the interaction of IgG subclasses with the low affinity FcγRIIA (CD32) on human monocytes, neutrophils and platelets. Analysis of a functional polymorphism to human IgG2. J Clin Invest 90:1537-1546, 1992.
16. Sheridan D, Carter C, Kelton JG: A diagnostic test for heparin-induced thrombocytopenia. Blood 67:27-30, 1986.
17. Woodman RC, Harker LA: Bleeding complications associated with cardiopulmonary bypass. Blood 76:1680-1697, 1990.
18. Jefferis R, Reimer CB, Skvaril F, de Lange G, Ling NR, Lowe J, Walker MR, Phillips DJ, Aloisio CH, Wells TW: Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: Results of an IUIS/WHO collaborative study. Immunol Lett 10:223-52, 1985.
19. Goldblatt D, van Etten L, van Milligen FJ, Aalberse RC, Turner MW: The role of pH in modified ELISA procedures used for the estimation of functional antibody affinity. J Immunol Methods. 166:281-5, 1993.
20. Szegedi A, Boros P, Chen J, Kaffina M, Bona C, Unkeless JC. An Fc gamma RIII (CD16)-specific autoantibody from a patient with progressive systemic sclerosis. Immunol Lett 35:69-76, 1993.
21. Amiral J, Wolf F, Fischer AM, Boyerneumann C, Vissac AM, Meyer D: Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia. Br J Haematol 92:954-959, 1996.
22. Cadroy Y, Amiral J, Raynaud H, Brunel P, Mazaleyrat A, Sauer M, Sie P: Evolution of antibodies anti-PF4/heparin in a patient with a history of heparin-induced thrombocytopenia reexposed to heparin. Thromb Haemost (letter) 71:247-51, 1994.
23. Arepally G, Poncz M, McKenzie SE, Cines D: Characterization of antibody subclass specificity and antigenic determinants in heparinassociated thrombocytopenia (HAT). Blood (abstract) 84:189a, 1994.
24. Gardyn J, Sorkin P, Kluger Y, Kabili S, Klausner JM, Zivelin A, Eldor A: Heparin-induced thrombocytopenia and fatal thrombosis in a patient with activated protein C resistance. Am J Hematol 50:292-295, 1995.