-
1
-
-
34748820827
-
5T4-modified vaccinia Ankara: Progress in tumor-associated antigen-based immunotherapy
-
Amato RJ. 5T4-modified vaccinia Ankara: Progress in tumor-associated antigen-based immunotherapy. Expert Opin Biol. Ther. 7(9), 1463-1469 (2007)
-
(2007)
Expert Opin Biol. Ther.
, vol.7
, Issue.9
, pp. 1463-1469
-
-
Amato, R.J.1
-
3
-
-
32944473827
-
Viral vectors for cancer immunotherapy
-
Harrop R, Carrol MW. Viral vectors for cancer immunotherapy. Front. Biosci. 11, 804-817 (2006
-
(2006)
Front. Biosci.
, vol.11
, pp. 804-817
-
-
Harrop, R.1
Carrol, M.W.2
-
4
-
-
0028324131
-
Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma
-
Starzynska T, Marsh P, Schofield P et al. Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma. Br. J. Cancer 69, 899-902 (1994
-
(1994)
Br. J. Cancer
, vol.69
, pp. 899-902
-
-
Starzynska, T.1
Marsh, P.2
Schofield, P.3
-
5
-
-
27144440353
-
Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: A potential target for T-cell-based immunotherapy
-
Griffiths RW, Gilham DR, Dangoor A et al. Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: A potential target for T-cell-based immunotherapy. Br. J. Cancer 93(6), 670-677 (2005
-
(2005)
Br. J. Cancer
, vol.93
, Issue.6
, pp. 670-677
-
-
Griffiths, R.W.1
Gilham, D.R.2
Dangoor, A.3
-
6
-
-
22244468657
-
Embryonic expression of murine 5T4 oncofetal antigen is associated with morphogenetic events at implantation and in developing epithelia
-
Barrow KM, Ward CM, Rutter J, Ali S, Stern PL. Embryonic expression of murine 5T4 oncofetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev. Dyn. 233(4), 1535-1545 (2005
-
(2005)
Dev. Dyn.
, vol.233
, Issue.4
, pp. 1535-1545
-
-
Barrow, K.M.1
Ward, C.M.2
Rutter, J.3
Ali, S.4
Stern, P.L.5
-
7
-
-
0023818391
-
A 72 kD trophoblast glycoprotein defined by a monoclonal antibody
-
Hole N, Stern PL. A 72 kD trophoblast glycoprotein defined by a monoclonal antibody. Br. J. Cancer 57, 237-246 (1988
-
(1988)
Br. J. Cancer
, vol.57
, pp. 237-246
-
-
Hole, N.1
Stern, P.L.2
-
8
-
-
0025109257
-
Immunological distribution of 5T4 antigen in normal and malignant tissues
-
Southall P, Boxer G, Bagshaw K et al. Immunological distribution of 5T4 antigen in normal and malignant tissues. Br. J. Cancer 61, 89-95 (1990
-
(1990)
Br. J. Cancer
, vol.61
, pp. 89-95
-
-
Southall, P.1
Boxer, G.2
Bagshaw, K.3
-
9
-
-
77955849862
-
CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells
-
Southgate TD, McGinn OJ, Castro FV et al. CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells. PLoS ONE 5(4), e9982 (2010
-
(2010)
PLoS ONE
, vol.5
, Issue.4
-
-
Southgate, T.D.1
McGinn, O.J.2
Castro, F.V.3
-
10
-
-
0026442276
-
Non-replicating vaccinia vector efficiently expresses recombinant genes
-
Sutter G, Moss B. Non-replicating vaccinia vector efficiently expresses recombinant genes. Proc. Natl Acad. Sci. USA 89, 10847-10851 (1992
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 10847-10851
-
-
Sutter, G.1
Moss, B.2
-
11
-
-
33744478654
-
Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated
-
Harrop R, Ryan, MG, Myers KA et al. Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated. Cancer Immunol. Immunother. 55(9), 1081-1090 (2006
-
(2006)
Cancer Immunol. Immunother.
, vol.55
, Issue.9
, pp. 1081-1090
-
-
Harrop, R.1
Ryan, M.G.2
Myers, K.A.3
-
12
-
-
1842848097
-
Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors
-
Mulryan K, Ryan MG, Myers KA et al. Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors. Mol. Cancer Ther. 1, 1129-1137 (2002
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 1129-1137
-
-
Mulryan, K.1
Ryan, M.G.2
Myers, K.A.3
-
13
-
-
33745223435
-
Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: A Phase I/II trial
-
Harrop R, Connolly NB, Redchenko I et al. Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: A Phase I/II trial. Clin. Cancer Res. 12(11), 3416-3424 (2006
-
(2006)
Clin. Cancer Res.
, vol.12
, Issue.11
, pp. 3416-3424
-
-
Harrop, R.1
Connolly, N.B.2
Redchenko, I.3
-
14
-
-
42649138944
-
Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses
-
Harrop R, Drury N, Shingler W et al. Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses. Cancer Immunol. Immunother. 57(7), 977-986 (2008
-
(2008)
Cancer Immunol. Immunother.
, vol.57
, Issue.7
, pp. 977-986
-
-
Harrop, R.1
Drury, N.2
Shingler, W.3
-
15
-
-
34547652648
-
Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses
-
Harrop R, Drury N, Shingler W et al. Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses. Clin. Cancer Res. 13(15 Pt 1), 4487-4494 (2007
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.15 PART 1
, pp. 4487-4494
-
-
Harrop, R.1
Drury, N.2
Shingler, W.3
-
16
-
-
68549110430
-
Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4
-
Elkord E, Dangoor A, Burt DJ et al. Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4). Cancer Immunol. Immunother. 58(10), 1657-1667 (2009
-
(2009)
Cancer Immunol. Immunother.
, vol.58
, Issue.10
, pp. 1657-1667
-
-
Elkord, E.1
Dangoor, A.2
Burt, D.J.3
-
17
-
-
67449085969
-
Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-a
-
Hawkins RE, MacDermott C, Shablak A et al. Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-a. J. Immunother. 3(4), 424-429 (2009
-
(2009)
J. Immunother.
, vol.3
, Issue.4
, pp. 424-429
-
-
Hawkins, R.E.1
MacDermott, C.2
Shablak, A.3
-
18
-
-
68449100522
-
Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): A Phase 2 trial
-
This study demonstrated that MVA-5T4 was well tolerated both alone and in combination, and induced an increased immune response in patients
-
Amato RJ, Shingler W, Goonewardena M et al. Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): A Phase 2 trial. J. Immunother. 32(7), 765-772 (2009). This study demonstrated that MVA-5T4 was well tolerated both alone and in combination, and induced an increased immune response in patients.
-
(2009)
J. Immunother.
, vol.32
, Issue.7
, pp. 765-772
-
-
Amato, R.J.1
Shingler, W.2
Goonewardena, M.3
-
19
-
-
60549106426
-
Phase II trial of modified vaccinia Ankara (MVA) virus expressing 5T4 and high dose interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma
-
MVA-5T4 was safely combined with high-dose IL-2
-
Kaufman HL, Taback B, Sherman W et al. Phase II trial of modified vaccinia Ankara (MVA) virus expressing 5T4 and high dose interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma. J. Transl Med. 7, 2 (2009). MVA-5T4 was safely combined with high-dose IL-2.
-
(2009)
J. Transl Med.
, vol.7
, pp. 2
-
-
Kaufman, H.L.1
Taback, B.2
Sherman, W.3
-
20
-
-
58149354757
-
Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering tumor antigen 5T4 (TroVax) administered with interleukin 2: A Phase II trial
-
MVA-5T4 plus IL-2 was found to be well tolerated and to induce an immune response in renal cell cancer patients, leading to the Phase III TRIST clinical trial
-
Amato R, Shingler W, Naylor S et al. Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering tumor antigen 5T4 (TroVax) administered with interleukin 2: A Phase II trial. Clin. Cancer Res. 14(22), 7504-7510 (2008). MVA-5T4 plus IL-2 was found to be well tolerated and to induce an immune response in renal cell cancer patients, leading to the Phase III TRIST clinical trial.
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.22
, pp. 7504-7510
-
-
Amato, R.1
Shingler, W.2
Naylor, S.3
-
21
-
-
48549088424
-
Vaccination of prostate cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax): A Phase 2 trial
-
Amato RJ, Drury N, Naylor S et al. Vaccination of prostate cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax): A Phase 2 trial. J. Immunother. 31(6), 577-585 (2008
-
(2008)
J. Immunother.
, vol.31
, Issue.6
, pp. 577-585
-
-
Amato, R.J.1
Drury, N.2
Naylor, S.3
-
22
-
-
78349284842
-
Vaccination of metastatic renal cancer patients with MVA-5T4: A randomized, double-blind, placebo-controlled Phase III study
-
Phase III trial confirming that MVA-5T4 produced immune response activity, and established the need for improved patient selection to maximize clinical benefit
-
Amato RJ, Hawkins RE, Kaufman HL et al. Vaccination of metastatic renal cancer patients with MVA-5T4: A randomized, double-blind, placebo-controlled Phase III study. Cancer Res. 16(22), 5539-5547 (2010). Phase III trial confirming that MVA-5T4 produced immune response activity, and established the need for improved patient selection to maximize clinical benefit.
-
(2010)
Cancer Res.
, vol.16
, Issue.22
, pp. 5539-5547
-
-
Amato, R.J.1
Hawkins, R.E.2
Kaufman, H.L.3
-
23
-
-
33846181370
-
Sunitinib versus interferon-A in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon-a in metastatic renal-cell carcinoma. N. Engl. J. Med. 256(2), 115-124 (2007
-
(2007)
N. Engl. J. Med.
, vol.256
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
24
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
Huang S, Houston P. Targeting mTOR signaling for cancer therapy. Curr. Opin Pharmacol. 3(4), 371-377 (2003
-
(2003)
Curr. Opin Pharmacol.
, vol.3
, Issue.4
, pp. 371-377
-
-
Huang, S.1
Houston, P.2
-
25
-
-
34249779568
-
Temsirolimus, interferon-A, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P et al. Temsirolimus, interferon-a, or both for advanced renal-cell carcinoma. N. Engl. J. Med. 356(22), 2271-2281 (2007)
-
(2007)
N. Engl. J. Med.
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
26
-
-
79959699551
-
MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients
-
Harrop R, Shingler WH, McDonald M et al. MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients. Cancer Immunol. Immunother. 60, 829-837 (2011)
-
(2011)
Cancer Immunol. Immunother.
, vol.60
, pp. 829-837
-
-
Harrop, R.1
Shingler, W.H.2
McDonald, M.3
|