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Volumn 8, Issue 3, 2012, Pages 231-237

Evaluation of MVA-5T4 as a novel immunotherapeutic vaccine in colorectal, renal and prostate cancer

Author keywords

cancer vaccines; colorectal cancer; MVA 5T4; prostate cancer; renal cell carcinoma; TroVax

Indexed keywords

FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MODIFIED VACCINIA VIRUS ANKARA 5T4 VACCINE; PLACEBO; RECOMBINANT ALPHA INTERFERON; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 2; SUNITINIB;

EID: 84858392112     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.12.7     Document Type: Review
Times cited : (13)

References (26)
  • 1
    • 34748820827 scopus 로고    scopus 로고
    • 5T4-modified vaccinia Ankara: Progress in tumor-associated antigen-based immunotherapy
    • Amato RJ. 5T4-modified vaccinia Ankara: Progress in tumor-associated antigen-based immunotherapy. Expert Opin Biol. Ther. 7(9), 1463-1469 (2007)
    • (2007) Expert Opin Biol. Ther. , vol.7 , Issue.9 , pp. 1463-1469
    • Amato, R.J.1
  • 3
    • 32944473827 scopus 로고    scopus 로고
    • Viral vectors for cancer immunotherapy
    • Harrop R, Carrol MW. Viral vectors for cancer immunotherapy. Front. Biosci. 11, 804-817 (2006
    • (2006) Front. Biosci. , vol.11 , pp. 804-817
    • Harrop, R.1    Carrol, M.W.2
  • 4
    • 0028324131 scopus 로고
    • Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma
    • Starzynska T, Marsh P, Schofield P et al. Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma. Br. J. Cancer 69, 899-902 (1994
    • (1994) Br. J. Cancer , vol.69 , pp. 899-902
    • Starzynska, T.1    Marsh, P.2    Schofield, P.3
  • 5
    • 27144440353 scopus 로고    scopus 로고
    • Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: A potential target for T-cell-based immunotherapy
    • Griffiths RW, Gilham DR, Dangoor A et al. Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: A potential target for T-cell-based immunotherapy. Br. J. Cancer 93(6), 670-677 (2005
    • (2005) Br. J. Cancer , vol.93 , Issue.6 , pp. 670-677
    • Griffiths, R.W.1    Gilham, D.R.2    Dangoor, A.3
  • 6
    • 22244468657 scopus 로고    scopus 로고
    • Embryonic expression of murine 5T4 oncofetal antigen is associated with morphogenetic events at implantation and in developing epithelia
    • Barrow KM, Ward CM, Rutter J, Ali S, Stern PL. Embryonic expression of murine 5T4 oncofetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev. Dyn. 233(4), 1535-1545 (2005
    • (2005) Dev. Dyn. , vol.233 , Issue.4 , pp. 1535-1545
    • Barrow, K.M.1    Ward, C.M.2    Rutter, J.3    Ali, S.4    Stern, P.L.5
  • 7
    • 0023818391 scopus 로고
    • A 72 kD trophoblast glycoprotein defined by a monoclonal antibody
    • Hole N, Stern PL. A 72 kD trophoblast glycoprotein defined by a monoclonal antibody. Br. J. Cancer 57, 237-246 (1988
    • (1988) Br. J. Cancer , vol.57 , pp. 237-246
    • Hole, N.1    Stern, P.L.2
  • 8
    • 0025109257 scopus 로고
    • Immunological distribution of 5T4 antigen in normal and malignant tissues
    • Southall P, Boxer G, Bagshaw K et al. Immunological distribution of 5T4 antigen in normal and malignant tissues. Br. J. Cancer 61, 89-95 (1990
    • (1990) Br. J. Cancer , vol.61 , pp. 89-95
    • Southall, P.1    Boxer, G.2    Bagshaw, K.3
  • 9
    • 77955849862 scopus 로고    scopus 로고
    • CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells
    • Southgate TD, McGinn OJ, Castro FV et al. CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells. PLoS ONE 5(4), e9982 (2010
    • (2010) PLoS ONE , vol.5 , Issue.4
    • Southgate, T.D.1    McGinn, O.J.2    Castro, F.V.3
  • 10
    • 0026442276 scopus 로고
    • Non-replicating vaccinia vector efficiently expresses recombinant genes
    • Sutter G, Moss B. Non-replicating vaccinia vector efficiently expresses recombinant genes. Proc. Natl Acad. Sci. USA 89, 10847-10851 (1992
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 10847-10851
    • Sutter, G.1    Moss, B.2
  • 11
    • 33744478654 scopus 로고    scopus 로고
    • Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated
    • Harrop R, Ryan, MG, Myers KA et al. Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated. Cancer Immunol. Immunother. 55(9), 1081-1090 (2006
    • (2006) Cancer Immunol. Immunother. , vol.55 , Issue.9 , pp. 1081-1090
    • Harrop, R.1    Ryan, M.G.2    Myers, K.A.3
  • 12
    • 1842848097 scopus 로고    scopus 로고
    • Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors
    • Mulryan K, Ryan MG, Myers KA et al. Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors. Mol. Cancer Ther. 1, 1129-1137 (2002
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 1129-1137
    • Mulryan, K.1    Ryan, M.G.2    Myers, K.A.3
  • 13
    • 33745223435 scopus 로고    scopus 로고
    • Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: A Phase I/II trial
    • Harrop R, Connolly NB, Redchenko I et al. Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: A Phase I/II trial. Clin. Cancer Res. 12(11), 3416-3424 (2006
    • (2006) Clin. Cancer Res. , vol.12 , Issue.11 , pp. 3416-3424
    • Harrop, R.1    Connolly, N.B.2    Redchenko, I.3
  • 14
    • 42649138944 scopus 로고    scopus 로고
    • Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses
    • Harrop R, Drury N, Shingler W et al. Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses. Cancer Immunol. Immunother. 57(7), 977-986 (2008
    • (2008) Cancer Immunol. Immunother. , vol.57 , Issue.7 , pp. 977-986
    • Harrop, R.1    Drury, N.2    Shingler, W.3
  • 15
    • 34547652648 scopus 로고    scopus 로고
    • Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses
    • Harrop R, Drury N, Shingler W et al. Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses. Clin. Cancer Res. 13(15 Pt 1), 4487-4494 (2007
    • (2007) Clin. Cancer Res. , vol.13 , Issue.15 PART 1 , pp. 4487-4494
    • Harrop, R.1    Drury, N.2    Shingler, W.3
  • 16
    • 68549110430 scopus 로고    scopus 로고
    • Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4
    • Elkord E, Dangoor A, Burt DJ et al. Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4). Cancer Immunol. Immunother. 58(10), 1657-1667 (2009
    • (2009) Cancer Immunol. Immunother. , vol.58 , Issue.10 , pp. 1657-1667
    • Elkord, E.1    Dangoor, A.2    Burt, D.J.3
  • 17
    • 67449085969 scopus 로고    scopus 로고
    • Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-a
    • Hawkins RE, MacDermott C, Shablak A et al. Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-a. J. Immunother. 3(4), 424-429 (2009
    • (2009) J. Immunother. , vol.3 , Issue.4 , pp. 424-429
    • Hawkins, R.E.1    MacDermott, C.2    Shablak, A.3
  • 18
    • 68449100522 scopus 로고    scopus 로고
    • Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): A Phase 2 trial
    • This study demonstrated that MVA-5T4 was well tolerated both alone and in combination, and induced an increased immune response in patients
    • Amato RJ, Shingler W, Goonewardena M et al. Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): A Phase 2 trial. J. Immunother. 32(7), 765-772 (2009). This study demonstrated that MVA-5T4 was well tolerated both alone and in combination, and induced an increased immune response in patients.
    • (2009) J. Immunother. , vol.32 , Issue.7 , pp. 765-772
    • Amato, R.J.1    Shingler, W.2    Goonewardena, M.3
  • 19
    • 60549106426 scopus 로고    scopus 로고
    • Phase II trial of modified vaccinia Ankara (MVA) virus expressing 5T4 and high dose interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma
    • MVA-5T4 was safely combined with high-dose IL-2
    • Kaufman HL, Taback B, Sherman W et al. Phase II trial of modified vaccinia Ankara (MVA) virus expressing 5T4 and high dose interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma. J. Transl Med. 7, 2 (2009). MVA-5T4 was safely combined with high-dose IL-2.
    • (2009) J. Transl Med. , vol.7 , pp. 2
    • Kaufman, H.L.1    Taback, B.2    Sherman, W.3
  • 20
    • 58149354757 scopus 로고    scopus 로고
    • Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering tumor antigen 5T4 (TroVax) administered with interleukin 2: A Phase II trial
    • MVA-5T4 plus IL-2 was found to be well tolerated and to induce an immune response in renal cell cancer patients, leading to the Phase III TRIST clinical trial
    • Amato R, Shingler W, Naylor S et al. Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering tumor antigen 5T4 (TroVax) administered with interleukin 2: A Phase II trial. Clin. Cancer Res. 14(22), 7504-7510 (2008). MVA-5T4 plus IL-2 was found to be well tolerated and to induce an immune response in renal cell cancer patients, leading to the Phase III TRIST clinical trial.
    • (2008) Clin. Cancer Res. , vol.14 , Issue.22 , pp. 7504-7510
    • Amato, R.1    Shingler, W.2    Naylor, S.3
  • 21
    • 48549088424 scopus 로고    scopus 로고
    • Vaccination of prostate cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax): A Phase 2 trial
    • Amato RJ, Drury N, Naylor S et al. Vaccination of prostate cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax): A Phase 2 trial. J. Immunother. 31(6), 577-585 (2008
    • (2008) J. Immunother. , vol.31 , Issue.6 , pp. 577-585
    • Amato, R.J.1    Drury, N.2    Naylor, S.3
  • 22
    • 78349284842 scopus 로고    scopus 로고
    • Vaccination of metastatic renal cancer patients with MVA-5T4: A randomized, double-blind, placebo-controlled Phase III study
    • Phase III trial confirming that MVA-5T4 produced immune response activity, and established the need for improved patient selection to maximize clinical benefit
    • Amato RJ, Hawkins RE, Kaufman HL et al. Vaccination of metastatic renal cancer patients with MVA-5T4: A randomized, double-blind, placebo-controlled Phase III study. Cancer Res. 16(22), 5539-5547 (2010). Phase III trial confirming that MVA-5T4 produced immune response activity, and established the need for improved patient selection to maximize clinical benefit.
    • (2010) Cancer Res. , vol.16 , Issue.22 , pp. 5539-5547
    • Amato, R.J.1    Hawkins, R.E.2    Kaufman, H.L.3
  • 23
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon-A in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon-a in metastatic renal-cell carcinoma. N. Engl. J. Med. 256(2), 115-124 (2007
    • (2007) N. Engl. J. Med. , vol.256 , Issue.2 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 24
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang S, Houston P. Targeting mTOR signaling for cancer therapy. Curr. Opin Pharmacol. 3(4), 371-377 (2003
    • (2003) Curr. Opin Pharmacol. , vol.3 , Issue.4 , pp. 371-377
    • Huang, S.1    Houston, P.2
  • 25
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon-A, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P et al. Temsirolimus, interferon-a, or both for advanced renal-cell carcinoma. N. Engl. J. Med. 356(22), 2271-2281 (2007)
    • (2007) N. Engl. J. Med. , vol.356 , Issue.22 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 26
    • 79959699551 scopus 로고    scopus 로고
    • MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients
    • Harrop R, Shingler WH, McDonald M et al. MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients. Cancer Immunol. Immunother. 60, 829-837 (2011)
    • (2011) Cancer Immunol. Immunother. , vol.60 , pp. 829-837
    • Harrop, R.1    Shingler, W.H.2    McDonald, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.