The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: U-NGAL, u-KIM1 and u-LFABP

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 72, Issue 2, 2012, Pages 137-142

  Nielsen, Stine E ^a   Rossing, Kasper ^a   Hess, Georg ^b   Zdunek, Dietmar ^c   Jensen, Berit R ^a   Parving, Hans Henrik ^d,e   Rossing, Peter ^a  

^a STENO DIABETES CENTER   (Denmark)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

^d Rigshospitalet   (Denmark)

^e AARHUS UNIVERSITY   (Denmark)

Author keywords

Albuminuria; Diabetes mellitus; Kidney tubules; Nephrology; Proximal; Renin angiotensin system

Indexed keywords

ALBUMIN; BENDROFLUMETHIAZIDE; CREATININE; FATTY ACID BINDING PROTEIN; IRBESARTAN; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

ADULT; ARTICLE; BLOOD PRESSURE MONITORING; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DISEASE DURATION; DRUG EFFECT; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; KIDNEY TUBULE DISORDER; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ACUTE-PHASE PROTEINS; AGED; DIABETIC NEPHROPATHIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY ACID-BINDING PROTEINS; FEMALE; HUMANS; KIDNEY TUBULES; LIPOCALINS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; RECEPTORS, VIRUS; RENIN-ANGIOTENSIN SYSTEM;

EID: 84858377872     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2011.645055     Document Type: Article

References (19)

1. Parving H-H, Mauer M, Ritz E. Diabetic nephropathy. In: Brenner BM, editor. Brenner & Rector's The kidney, 8th edn. Boston, MA: WB Saunders; 2008. pp. 1265-98.
2. Rossing P, Hommel E, Smidt UM, Parving H-H. Reduction in albuminuria predicts a beneficial effect on diminishing the progression of human diabetic nephropathy during antihy-pertensive treatment. Diabetologia 1994;37:511-6. (Pubitemid 24133655)
3. Gilbert RE, Cooper ME. The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int 1999;56:1627-37. (Pubitemid 29518163)
4. Kelly DJ, Cox AJ, Tolcos M, Cooper ME, Wilkinson-Berka JL, Gilbert RE. Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats. Kidney Int 2002;61:31-9. (Pubitemid 34075128)
5. Kelly DJ, Stein-Oakley A, Zhang Y, Wassef L, Maguire J, Koji T, Thomson N, Wilkinson-Berka JL, Gilbert RE. Fas-induced apoptosis is a feature of progressive iabetic nephropathy in transgenic (mRen-2)27 rats: attenuation with renin-angiotensin blockade. Nephrology (Carlton) 2004;9:7-13. (Pubitemid 38230524)
6. Nielsen SE, Sugaya T, Tarnow L, Lajer M, Schjoedt KJ, Astrup AS, Baba T, Parving HH, Rossing P. Tubular and glomerular injury in diabetes and the impact of ACE inhibition. Diabetes Care 2009;32:1684-8.
7. Waanders F, Vaidya VS, van GH, Leuvenink H, Damman K, Hamming I, Bonventre JV, Vogt L, Navis G. Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial. Am J Kidney Dis 2009;53:16-25.
8. Bolignano D, Donato V, Coppolino G, Campo S, Buemi A, Lacquaniti A, Buemi M. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 2008;52:595-605.
9. Kamijo A, Sugaya T, Hikawa A, Okada M, Okumura F, Yaman-ouchi M, Honda A, Okabe M, Fujino T, Hirata Y, Omata M, Kaneko R, Fujii H, Fukamizu A, Kimura K. Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules. Am J Pathol 2004;165:1243-55. (Pubitemid 39297730)
10. van Timmeren MM, van den Heuvel MC, Bailly V, Bakker SJ, van GH, Stegeman CA. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol 2007;212: 209-17. (Pubitemid 46852099)
11. Rossing K, Schjoedt KJ, Jensen BR, Boomsma F, Parving H-H. Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbu-minuria. Kidney Int 2005;68:1190-8. (Pubitemid 43246436)
12. Bröchner-Mortensen J, Rödbro P. Selection of routine method for determination of glomerular filtration rate in adult patients. Scand J Clin Lab Invest 1976;36:35-45.
13. Nakamura T, Sugaya T, Koide H. Angiotensin II receptor antagonist reduces urinary liver-type fatty acid-binding protein levels in patients with diabetic nephropathy and chronic renal failure. Diabetologia 2007;50:490-2.
14. Nielsen SE, Schjoedt KJ, Astrup AS, Tarnow L, Lajer M, Hansen PR, Parving HH, Rossing P. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM1) in patients with diabetic nephropathy: a cross-sectional study and the effects of lisinopril. Diabet Med 2010;27:1144-50.
15. Maatman RG, van de Westerlo EM, van Kuppevelt TH, Veerkamp JH. Molecular identification of the liver-and the heart-type fatty acid-binding proteins in human and rat kidney. Use of the reverse transcriptase polymerase chain reaction. Biochem J 1992;288 (Pt 1):285-90.
16. Ding H, He Y, Li K, Yang J, Li X, Lu R, Gao W. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy. Clin Immunol 2007;123:227-34. (Pubitemid 46613869)
17. Kelly DJ, Cox AJ, Tolcos M, Cooper ME, Wilkinson-Berka JL, Gilbert RE. Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats. Kidney Int 2002;61:31-9. (Pubitemid 34075128)
18. Izuhara Y, Nangaku M, Inagi R, Tominaga N, Aizawa T, Kurokawa K, van Ypersele de SC, Miyata T. Renoprotec-tive properties of angiotensin receptor blockers beyond blood pressure lowering. J Am Soc Nephrol 2005;16: 3631-41. (Pubitemid 46211284)
19. Wagener G, Lee HT. In Reply to'Instability of urinary NGAL during long-term storage'and'NGAL and cardiac surgery-associated acute kidney injury'. Am J Kidney Dis 2009;53:566.