Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats

Kidney International

Volumn 61, Issue 1, 2002, Pages 31-39

  Kelly, Darren J ^a   Cox, Alison J ^a   Tolcos, Mary ^a   Cooper, Mark E ^a   Wilkinson Berka, Jennifer L ^a   Gilbert, Richard E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cell death; Diabetic nephropathy; Growth factors; Renoprotection; Transgenic rats; Tubulointerstitial disease

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CANCER GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; MESSENGER RNA; PERINDOPRIL; SINGLE STRANDED DNA; STREPTOZOCIN; VALSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STREPTOZOCIN DIABETES;

EID: 0036149122     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00088.x     Document Type: Article

References (45)

1. The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?
2. Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis
3. Fas-dependent fratricidal apoptosis is a mechanism of tubular epithelial cell deletion in chronic renal failure
4. Involvement of Fas-dependent apoptosis in renal tubular epithelial cell deletion in chronic renal failure
5. Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat
6. Role of transforming growth factor beta in diabetic nephropathy
7. Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities
8. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation
9. The combination of epidermal growth factor and transforming growth factor-beta induces novel phenotypic changes in mouse liver stem cell lines
10. The effect of angiotensin converting enzyme inhibition on diabetic nephropathy
11. Proteinuria predicts end-stage renal failure in non-diabetic chronic nephropathies
12. Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis
13. Expression of transforming growth factor-beta and type IV collagen in the renal tubulointerstitium in experimental diabetes: Effects of angiotensin converting enzyme inhibition
14. Transforming growth factor beta 1 and renal injury following subtotal nephrectomy in the rat. Role of the renin-angiotensin system
15. Delayed treatment with enalapril halts tubulointerstitial fibrosis in rats with obstructive nephropathy
16. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene
17. A new model of progressive diabetic renal impairment in the transgenic (mRen-2) 27 rat
18. Vascular endothelial growth factor and its receptors in control and diabetic rat eyes
19. Cytotoxicity and apoptosis in human renal allografts: Identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA
20. Fundamentals of quantitative autoradiography by computer densitometry for in situ hybridization, with emphasis on 33P
21. Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin
22. Structural-functional correlations in renal disease. II. The correlations
23. Epidermal growth factor and the kidney
24. The transforming growth factor-beta family
25. Metabolism and effects of epidermal growth factor and related growth factors in mammals
26. Urinary excretion of human epidermal growth factor in the various stages of diabetic nephropathy
27. Expression of epidermal growth factor and its receptor in normal and diseased human kidney: An immunohistochemical and in situ hybridization study
28. Expression and distribution of epidermal growth factor in acute and chronic renal allograft rejection
29. Changes in gene expression after temporary renal ischemia
30. Ureteral obstruction decreases renal prepro-epidermal growth factor and Tamm-Horsfall expression
31. Increased epidermal growth factor in experimental diabetes related kidney growth in rats
32. Epidermal growth factor accelerates renal repair in mercuric chloride nephrotoxicity
33. Epidermal growth factor accelerates renal tissue repair in a model of gentamicin nephrotoxicity in rats
34. Epidermal growth factor accelerates functional recovery from ischaemic acute tubular necrosis in the rat: Role of the epidermal growth factor receptor
35. Obstructive nephropathy in the neonatal rat is attenuated by epidermal growth factor
36. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis
37. Transforming growth factor beta in tissue fibrosis
38. Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors
39. Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells
40. Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: Involvement of reactive oxygen intermediates
41. Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture
42. Epidermal growth factor is a potent inhibitor of renin secretion
43. Gene expression of the reninangiotensin system in human kidney
44. Pathological expression of renin and angiotensin II in the renal tubule after subtotal nephrectomy. Implications for the pathogenesis of tubulointerstitial fibrosis
45. ANG II is a mitogen for a murine cell line isolated from medullary thick ascending limb of Henle's loop