Haplotype polymorphism in the alpha-2B-adrenergic receptor gene influences response inhibition in a large chinese sample

Neuropsychopharmacology

Volumn 37, Issue 5, 2012, Pages 1115-1121

  Lei, Xuemei ^a,b   Chen, Chuansheng ^b   He, Qinghua ^c   Moyzis, Robert ^d   Xue, Gui ^a,c   Chen, Chunhui ^a   Cao, Zhongyu ^a   Li, Jin ^a   Li, He ^a   Zhu, Bi ^a   Zhang, Mingxia ^a   Li, Jun ^a   Dong, Qi ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ADRA2B gene; haplotype; norepinephrine neurotransmission system; response inhibition; stop signal task

Indexed keywords

ALANINE; ALPHA 2B ADRENERGIC RECEPTOR; GUANINE; NORADRENALIN;

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; MENTAL DISEASE; NEUROTRANSMISSION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ANALYSIS OF VARIANCE; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INHIBITION (PSYCHOLOGY); INTELLIGENCE; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REACTION TIME; RECEPTORS, ADRENERGIC, ALPHA-2; SIGNAL DETECTION, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84858340522     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.266     Document Type: Article

References (55)

1. Alderson RM, Rapport MD, Kofler MJ (2007). Attention-deficit/ hyperactivity disorder and behavioral inhibition: A meta-analytic review of the stop-signal paradigm. J Abnorm Child Psychol 35: 745-758.
2. Aron AR, Dowson JH, Sahakian BJ, Robbins TW (2003). Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry 54: 1465-1468.
3. Aron AR, Durston S, Eagle DM, Logan GD, Stinear CM, Stuphorn V (2007). Converging evidence for a fronto-basalganglia network for inhibitory control of action and cognition. J Neurosci 27: 11860-11864.
4. Aron AR, Poldrack RA (2005). The cognitive neuroscience of response inhibition: Relevance for genetic research in attentiondeficit/ hyperactivity disorder. Biol Psychiatry 57: 1285-1292.
5. Aron AR, Poldrack RA (2006). Cortical and subcortical contributions to Stop signal response inhibition: Role of the subthalamic nucleus. J Neurosci 26: 2424-2433.
6. Aron AR, Robbins TW, Poldrack RA (2004). Inhibition and the right inferior frontal cortex. Trends Cognitive Sci 8: 170-177.
7. Aston-Jones G, Cohen JD (2005). An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance. Ann Rev Neurosci 28: 403-450.
8. Aston-Jones G, Gold JI (2009). How we say no: Norepinephrine, inferior frontal gyrus, and response inhibition. Biol Psychiatry 65: 548-549.
9. Band GP, van der Molen MW, Logan GD (2003). Horse-race model simulations of the stop-signal procedure. Acta Psychologica 112: 105-142.
10. Beck AT (1990). Beck Anxiety Inventory Manual. Psychological Corporation: San Antonio, TX.
11. Beck AT, Steer RA, Ball R, Ranieri W (1996). Comparison of Beck depression inventories -IA and -II in psychiatric outpatients. J Personality Assess 67: 588-597.
12. Belfer I, Buzas B, Hipp H, Phillips G, Taubman J, Lorincz I et al (2005). Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. J Hum Genet 50: 12-20.
13. Bymaster FP, Katner JS, Nelson DL, Hemrick-Luecke SK, Threlkeld PG, Heiligenstein JH et al (2002). Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: A potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27: 699-711.
14. Cayla C, Heinonen P, Viikari L, Schaak S, Snapir A, Bouloumie A et al (2004). Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2Badrenergic receptor gene. Biochem Pharmacol 67: 469-478.
15. Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2005). The neuropsychology of obsessive compulsive disorder: The importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 29: 399-419.
16. Chamberlain SR, Del Campo N, Dowson J, Muller U, Clark L, Robbins TW et al (2007). Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder. Biol Psychiatry 62: 977-984.
17. Chamberlain SR, Hampshire A, Muller U, Rubia K, Del Campo N, Craig K et al (2009). Atomoxetine modulates right inferior frontal activation during inhibitory control: A pharmacological functional magnetic resonance imaging study. Biol Psychiatry 65: 550-555.
18. Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006). Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311: 861-863.
19. Chamberlain SR, Robbins TW, Winder-Rhodes S, Muller U, Sahakian BJ, Blackwell AD et al (2011). Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery. Biol Psychiatry 69: 1192-1203.
20. Chamberlain SR, Sahakian BJ (2007). The neuropsychiatry of impulsivity. Curr Opin Psychiatry 20: 255-261.
21. Chen C, Chen C, Moyzis R, Dong Q, He Q, Zhu B et al (2011). Sex modulates the associations between the COMT gene and personality traits. Neuropsychopharmacology 36: 1593-1598.
22. Cheon KA, Cho DY, Koo MS, Song DH, Namkoong K (2009). Association between homozygosity of a G allele of the alpha-2aadrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. Biol Psychiatry 65: 564-570.
23. Congdon E, Mumford JA, Cohen JR, Galvan A, Aron AR, Xue G et al (2010). Engagement of large-scale networks is related to individual differences in inhibitory control. Neuroimage 53: 653-663.
24. Cousijn H, Rijpkema M, Qin S, van Marle HJ, Franke B, Hermans EJ et al (2010). Acute stress modulates genotype effects on amygdala processing in humans. Proc Natl Acad Sci USA 107: 9867-9872.
25. Crassous PA, Blaise R, Marquette A, Snapir A, Scheinin M, Paris H et al (2010). Identification of a novel 12-nucleotide insertion polymorphism in the promoter region of ADRA2B: Full linkage with the 9-nucleotide deletion in the coding region and influence on transcriptional activity. Biochem Pharmacol 79: 407-412.
26. da Silva TL, Pianca TG, Roman T, Hutz MH, Faraone SV, Schmitz M et al (2008). Adrenergic alpha2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type. J Neural Transm 115: 341-345.
27. de Quervain DJ, Kolassa IT, Ertl V, Onyut PL, Neuner F, Elbert T et al (2007). A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nat Neurosci 10: 1137-1139.
28. Eason MG, Kurose H, Holt BD, Raymond JR, Liggett SB (1992). Simultaneous coupling of alpha 2-adrenergic receptors to two Gproteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. J Biol Chem 267: 15795-15801.
29. Easton N, Marshall F, Fone K, Marsden C (2007). Atomoxetine produces changes in cortico-basal thalamic loop circuits: Assessed by phMRI BOLD contrast. Neuropharmacology 52: 812-826.
30. Gibbs AA, Naudts KH, Azevedo RT, David AS (2010). Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance. Eur Neuropsychopharmacol 20: 272-275.
31. Gong Y (1992). The Manual of Wechsler Adult Intelligence Scale Revised in China. Hunan Medical University Press: Changsh Hunan, China.
32. He Q, Xue G, Chen C, Lu Z, Dong Q, Lei X et al (2010). Serotonin transporter gene-linked polymorphic region (5-HTTLPR) influences decision making under ambiguity and risk in a large Chinese sample. Neuropharmacology 59: 518-526.
33. Heinonen P, Koulu M, Pesonen U, Karvonen MK, Rissanen A, Laakso M et al (1999). Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J Clin Endocrinol Metabol 84: 2429-2433.
34. Li J, Chen C, He Q, Li H, Moyzis RK, Xue G et al (2011). Neurotensin receptor 1 gene (NTSR1) polymorphism is associated with working memory. PLoS One 6: E17365.
35. Li X, Liang Z, Kleiner M, Lu ZL (2010). RTbox: A device for highly accurate response time measurements. Behav Res Methods 42: 212-225.
36. Lijffijt M, Kenemans JL, Verbaten MN, van Engeland H (2005). A meta-analytic review of stopping performance in attentiondeficit/ hyperactivity disorder: Deficient inhibitory motor control? J Abnormal Psychol 114: 216-222.
37. Lipszyc J, Schachar R (2010). Inhibitory control and psychopathology: A meta-analysis of studies using the stop signal task. J Int Neuropsychol Soc 16: 1064-1076.
38. Logan GD, Cowan WB (1984). On the ability to inhibit thought and action: A theory of an act of control. Psychol Rev 91: 295-327.
39. Logan GD, Schachar RJ, Tannock R (1997). Impulsivity and inhibitory control. Psychol Sci 8: 60-64.
40. Lomasney JW, Lorenz W, Allen LF, King K, Regan JW, Yang-Feng TL et al (1990). Expansion of the alpha 2-adrenergic receptor family: Cloning and characterization of a human alpha 2- adrenergic receptor subtype, the gene for which is located on chromosome 2. Proc Natl Acad Sci USA 87: 5094-5098.
41. Nackley AG, Shabalina SA, Tchivileva IE, Satterfield K, Korchynskyi O, Makarov SS et al (2006). Human catechol-Omethyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314: 1930-1933.
42. Pattij T, Vanderschuren LJ (2008). The neuropharmacology of impulsive behaviour. Trends Pharmacol Sci 29: 192-199.
43. Polanczyk G, Zeni C, Genro JP, Guimaraes AP, Roman T, Hutz MH et al (2007). Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 64: 218-224.
44. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D et al (2007). PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Human Genet 81: 559-575.
45. Rasch B, Spalek K, Buholzer S, Luechinger R, Boesiger P, Papassotiropoulos A et al (2009). A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. Proc Natl Acad Sci USA 106: 19191-19196.
46. Robinson ES, Eagle DM, Mar AC, Bari A, Banerjee G, Jiang X et al (2008). Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat. Neuropsychopharmacology 33: 1028-1037.
47. Scheinin M, Lomasney JW, Hayden-Hixson DM, Schambra UB, Caron MG, Lefkowitz RJ et al (1994). Distribution of alpha 2- adrenergic receptor subtype gene expression in rat brain. Brain research. Mol Brain Res 21: 133-149.
48. Small KM, Brown KM, Forbes SL, Liggett SB (2001). Polymorphic deletion of three intracellular acidic residues of the alpha 2Badrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. J Biol Chem 276: 4917-4922.
49. Tavares A, Handy DE, Bogdanova NN, Rosene DL, Gavras H (1996). Localization of alpha 2A- and alpha 2B-adrenergic receptor subtypes in brain. Hypertension 27(3 Part 1): 449-455.
50. Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ (2004). Modafinil improves cognition and response inhibition in adult attention-deficit/ hyperactivity disorder. Biol Psychiatry 55: 1031-1040.
51. Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003). Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology 165: 260-269.
52. Urner M, van Wingen G, Franke B, Rijpkema M, Fernandez G, Tendolkar I (2011). Genetic variation of the alpha2b-adrenoceptor affects neural correlates of successful emotional memory formation. Hum Brain Mapp 21: 21171.
53. Verbruggen F, Logan GD (2008). Response inhibition in the stopsignal paradigm. Trends Cogn Sci 12: 418-424.
54. Xue G, Aron AR, Poldrack RA (2008). Common neural substrates for inhibition of spoken and manual responses. Cerebral Cortex 18: 1923-1932.
55. Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R et al (2007). Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci USA 104: 20552-20557.