Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades

Gynecologic Oncology

Volumn 125, Issue 1, 2012, Pages 214-219

  Evans, J J ^a   Chitcholtan, K ^a   Dann, J M ^a   Guilford, P ^b   Harris, Gavin ^c   Lewis, L K ^a   Nagase, J ^a   Welkamp, A A W ^a,d   Zwerus, R ^a   Sykes, P H ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c CHRISTCHURCH HOSPITAL   (New Zealand)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Adrenomedullin; EGCG; Endometrial cancer; Natural compound; Resveratrol; Vascular endothelial growth factor

Indexed keywords

ADRENOMEDULLIN; COBALT CHLORIDE; EPIGALLOCATECHIN GALLATE; MESSENGER RNA; PEPTIDE; RESVERATROL; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER STAGING; CARCINOGENIC ACTIVITY; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SAMPLE; UPREGULATION;

ADENOCARCINOMA; ADRENOMEDULLIN; CASE-CONTROL STUDIES; CATECHIN; CELL LINE, TUMOR; COBALT; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM GRADING; RNA, MESSENGER; STILBENES; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84858339636     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.12.429     Document Type: Article

References (49)

1. J. Beltowski, and A. Jamroz Adrenomedullin-what do we know 10 years since its discovery? Pol J Pharmacol 56 2004 5 27 (Pubitemid 38515282)
2. J. López, and A. Martínez Cell and molecular biology of the multifunctional peptide, adrenomedullin Int Rev Cytol 221 2002 1 92 (Pubitemid 35429860)
3. J.B. Laoag-Fernandez, T. Otani, and T. Maruo Adrenomedullin expression in the human endometrium Endocrine 12 2000 15 19 (Pubitemid 30333805)
4. J.A. Maybin, S. Battersby, N. Hirani, L.L. Nikitenko, H.O. Critchley, and H.N. Jabbour The expression and regulation of adrenomedullin in the human endometrium: a candidate for endometrial repair Endocrinology 152 2011 2845 2856
5. L.J. Pearson, C. Rait, M.G. Nicholls, T.G. Yandle, and J.J. Evans Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II J Endocrinol 191 2006 179 188
6. V.A. Cameron, D.J. Autelitano, J.J. Evans, L.J. Ellmers, E.A. Espiner, M.G. Nicholls, and A.M. Richards Adrenomedullin expression in rat uterus is correlated with plasma estradiol Am J Physiol Endocrinol Metab 282 2002 E139 E146
7. M. Li, Y. Wu, and K.M. Caron Haploinsufficiency for adrenomedullin reduces pinopodes and diminishes uterine receptivity in mice Biol Reprod 79 2008 1169 1175
8. M. Nakamura, B. Han, O. Nunobiki, and K. Kakudo Adrenomedullin: a tumor progression factor via angiogenic control Curr Cancer Drug Targets 6 2006 635 643 (Pubitemid 44691005)
9. H. Kato, M. Shichiri, F. Marumo, and Y. Hirata Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells Endocrinology 138 1997 2615 2620 (Pubitemid 27215270)
10. L.L. Nikitenko, I.Z. MacKenzie, M.C. Rees, and R. Bicknell Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium Mol Hum Reprod 6 2000 811 819 (Pubitemid 30660613)
11. T. Tsuruda, J. Kato, K. Kitamura, K. Kuwasako, T. Imamura, Y. Koiwaya, T. Tsuji, K. Kangawa, and T. Eto Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes Hypertension 31 1998 505 510
12. M.K. Oehler, C. Norbury, S. Hague, M.C. Rees, and R. Bicknell Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth Oncogene 20 2001 2937 2945 (Pubitemid 33027761)
13. D. Ribatti, B. Nico, R. Spinazzi, A. Vacca, and G.G. Nussdorfer The role of adrenomedullin in angiogenesis Peptides 26 2005 1670 1675 (Pubitemid 41169764)
14. M.K. Oehler, S. Hague, M.C. Rees, and R. Bicknell Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis Oncogene 21 2002 2815 2821 (Pubitemid 34499378)
15. Y. Zhao, S. Hague, S. Manek, L. Zhang, R. Bicknell, and M.C. Rees PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium Oncogene 16 1998 409 415 (Pubitemid 28052295)
16. V. Ramachandran, T. Arumugam, R. Langley, R.F. Hwang, P. Vivas-Mejia, A.K. Sood, G. Lopez-Berestein, and C.D. Logsdon The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment PLoS One 4 2009 e7502
17. S. Cormier-Regard, S.V. Nguyen, and W.C. Claycomb Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes J Biol Chem 273 1998 17787 17792 (Pubitemid 28355122)
18. M. Nakayama, K. Takahashi, O. Murakami, K. Shirato, and S. Shibahara Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells Biochem Biophys Res Commun 243 1998 514 517 (Pubitemid 28414056)
19. M. Garayoa, A. Martinez, S. Lee, R. Pio, W.G. An, L. Neckers, J. Trepel, L.M. Montuenga, H. Ryan, R. Johnson, M. Gassmann, and F. Cuttitta Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis Mol Endocrinol 14 2000 848 862 (Pubitemid 32260498)
20. S.V. Nguyen, and W.C. Claycomb Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes Biochem Biophys Res Commun 265 1999 382 386
21. D.L. Hay, C.S. Walker, and D.R. Poyner Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges Endocr Relat Cancer 18 2011 C1 C14
22. J.M. Dann, J.J. Evans, D.R. Mason, and P.H. Sykes Regulation of vascular endothelial growth factor in endometrial tumour cells by resveratrol and EGCG Gynecol Oncol 113 2009 374 378
23. K.P. Bhat, and J.M. Pezzuto Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells Cancer Res 61 2001 6137 6144 (Pubitemid 32762550)
24. N.P. Tang, H. Li, Y.L. Qiu, G.M. Zhou, and J. Ma Tea consumption and risk of endometrial cancer: a metaanalysis Am J Obstet Gynecol 201 2009 605 e1-8
25. W. Li, P. Kessler, H. Yeger, J. Alami, A.E. Reeve, R. Heathcott, J. Skeen, and B.R. Williams A gene expression signature for relapse of primary wilms tumors Cancer Res 65 2005 2592 2601 (Pubitemid 40490057)
26. M.A. Frevel, T. Bakheet, A.M. Silva, J.G. Hissong, K.S. Khabar, and B.R. Williams p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts Mol Cell Biol 23 2003 425 436 (Pubitemid 36050538)
27. D.A. Budwit-Novotny, K.S. McCarty, E.B. Cox, J.T. Soper, D.G. Mutch, W.T. Creasman, J.L. Flowers, and K.S. McCarty Jr. Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody Cancer Res 46 1986 5419 5425 (Pubitemid 16008326)
28. K.S. McCarty Jr., L.S. Miller, E.B. Cox, J. Konrath, and K.S. McCarty Sr. Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies Arch Pathol Lab Med 109 1985 716 721 (Pubitemid 16237466)
29. L.K. Lewis, M.W. Smith, T.G. Yandle, A.M. Richards, and M.G. Nicholls Adrenomedullin(1-52) measured in human plasma by radioimmunoassay: plasma concentration, adsorption, and storage Clin Chem 44 1998 571 577 (Pubitemid 28141354)
30. O. Nunobiki, M. Nakamura, E. Taniguchi, H. Utsunomiya, I. Mori, Y. Tsubota, Y. Mabuchi, and K. Kakudo Adrenomedullin, Bcl-2 and microvessel density in normal, hyperplastic and neoplastic endometrium Pathol Int 59 2009 530 536
31. E. Zudaire, A. Martinez, and F. Cuttitta Adrenomedullin and cancer Regul Pept 112 2003 175 183 (Pubitemid 36351615)
32. E. Zudaire, A. Martinez, M. Garayoa, R. Pio, G. Kaur, M.R. Woolhiser, D.D. Metcalfe, W.A. Hook, R.P. Siraganian, T.A. Guise, J.M. Chirgwin, and F. Cuttitta Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis Am J Pathol 168 2006 280 291 (Pubitemid 43062580)
33. T. Ogita, E. Hashimoto, M. Yamasaki, T. Nakaoka, R. Matsuoka, Y. Kira, and T. Fujita Hypoxic induction of adrenomedullin in cultured human umbilical vein endothelial cells J Hypertens 19 2001 603 608 (Pubitemid 32280953)
34. B. Kaur, F.W. Khwaja, E.A. Severson, S.L. Matheny, D.J. Brat, and E.G. Van Meir Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis Neuro Oncol 7 2005 134 153 (Pubitemid 40590514)
35. S. Frede, P. Freitag, T. Otto, C. Heilmaier, and J. Fandrey The proinflammatory cytokine interleukin 1beta and hypoxia cooperatively induce the expression of adrenomedullin in ovarian carcinoma cells through hypoxia inducible factor 1 activation Cancer Res 65 2005 4690 4697 (Pubitemid 40740805)
36. S. Fernandez-Sauze, C. Delfino, K. Mabrouk, C. Dussert, O. Chinot, P.M. Martin, F. Grisoli, L. Ouafik, and F. Boudouresque Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors Int J Cancer 108 2004 797 804 (Pubitemid 38112605)
37. J. Elkas, A. Armstrong, J. Pohl, F. Cuttitta, A. Martinez, and K. Gray Modulation of endometrial steroid receptors and growth regulatory genes by tamoxifen Obstet Gynecol 95 2000 697 703 (Pubitemid 30210054)
38. J. Liu, R. Butzow, C. Hyden-Granskog, and R. Voutilainen Expression of adrenomedullin in human ovaries, ovarian sex cord-stromal tumors and cultured granulosa-luteal cells Gynecol Endocrinol 25 2009 96 103
39. J. Michelsen, H. Thiesson, S. Walter, P.D. Ottosen, O. Skott, and B.L. Jensen Tissue expression and plasma levels of adrenomedullin in renal cancer patients Clin Sci (Lond) 111 2006 61 70 (Pubitemid 44023412)
40. S. Buyukberber, I. Sari, C. Camci, N.M. Buyukberber, A. Sevinc, and H.M. Turk Adrenomedullin expression does not correlate with survival in lung cancer Med Oncol 24 2007 245 249 (Pubitemid 350135978)
41. J.L. Deville, C. Bartoli, C. Berenguer, S. Fernandez-Sauze, I. Kaafarani, C. Delfino, F. Fina, S. Salas, X. Muracciole, J. Mancini, E. Lechevallier, P.M. Martin, D. Figarella-Branger, L. Ouafik, and L. Daniel Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma Int J Cancer 125 2009 2307 2315
42. L.L. Nikitenko, S.B. Fox, S. Kehoe, M.C. Rees, and R. Bicknell Adrenomedullin and tumour angiogenesis Br J Cancer 94 2006 1 7 (Pubitemid 43088532)
43. O. Casanovas, D.J. Hicklin, G. Bergers, and D. Hanahan Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors Cancer Cell 8 2005 299 309 (Pubitemid 41443415)
44. G. Bergers, and D. Hanahan Modes of resistance to anti-angiogenic therapy Nat Rev Cancer 8 2008 592 603
45. R. Pio, A. Martinez, E.J. Unsworth, J.A. Kowalak, J.A. Bengoechea, P.F. Zipfel, T.H. Elsasser, and F. Cuttitta Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners J Biol Chem 276 2001 12292 12300
46. K. Marutsuka, K. Hatakeyama, Y. Sato, A. Yamashita, A. Sumiyoshi, and Y. Asada Immunohistological localization and possible functions of adrenomedullin Hypertens Res 26 2003 S33 S40 Suppl. (Pubitemid 36372314)
47. I. Kaafarani, S. Fernandez-Sauze, C. Berenguer, O. Chinot, C. Delfino, C. Dussert, P. Metellus, F. Boudouresque, K. Mabrouk, F. Grisoli, D. Figarella-Branger, P.M. Martin, and L. Ouafik Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice FASEB J 23 2009 3424 3435
48. D. Guidolin, G. Albertin, R. Spinazzi, E. Sorato, A. Mascarin, D. Cavallo, M. Antonello, and D. Ribatti Adrenomedullin stimulates angiogenic response in cultured human vascular endothelial cells: involvement of the vascular endothelial growth factor receptor 2 Peptides 29 2008 2013 2023
49. E. Sivridis, A. Giatromanolaki, K.C. Gatter, A.L. Harris, and M.I. Koukourakis Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma Cancer 95 2002 1055 1063 (Pubitemid 34925357)