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Volumn 125, Issue 1, 2012, Pages 263-270

Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: A meta-analysis and systematic review of the literature

Author keywords

Endometrial cancer; Fertility sparing; Hyperplasia with atypia; Meta analysis; Progestin

Indexed keywords

LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; MEGESTROL ACETATE; PROGESTERONE;

EID: 84858332285     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.11.043     Document Type: Review
Times cited : (125)

References (72)
  • 2
    • 0036181128 scopus 로고    scopus 로고
    • Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer
    • DOI 10.1097/00001703-200202000-00011
    • L. Elit, and H. Hirte Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer Curr Opin Obstet Gynecol 14 2002 67 73 (Pubitemid 34177910)
    • (2002) Current Opinion in Obstetrics and Gynecology , vol.14 , Issue.1 , pp. 67-73
    • Elit, L.1    Hirte, H.2
  • 3
    • 84858333362 scopus 로고    scopus 로고
    • Victorian Cancer Registry
    • Victorian Cancer Registry Australia: Cancer Council of Victoria http://www.cancervic.org.au/about-cancer/cancer-types/uterine-cancer
    • Australia: Cancer Council of Victoria
  • 5
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • DOI 10.1016/S0140-6736(08)60269-X, PII S014067360860269X
    • A.G. Renehan, and M. Tyson Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 371 2008 569 578 (Pubitemid 351232031)
    • (2008) The Lancet , vol.371 , Issue.9612 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 9
    • 0000706232 scopus 로고
    • Genesis of endometrial carcinoma
    • A. Hertig, and S. Sommers Genesis of endometrial carcinoma Cancer 2 1949 946
    • (1949) Cancer , vol.2 , pp. 946
    • Hertig, A.1    Sommers, S.2
  • 10
    • 0018601195 scopus 로고
    • The precursors of endometrial carcinoma
    • A. Sherman, and S. Brown The precursors of endometrial carcinoma Am J Obstet Gynecol 135 1979 947
    • (1979) Am J Obstet Gynecol , vol.135 , pp. 947
    • Sherman, A.1    Brown, S.2
  • 11
    • 0001697002 scopus 로고
    • Endometrial hyperplasia: Histologic classification and behavior
    • S. Huang, E. Amparo, and Y. Fu Endometrial hyperplasia: histologic classification and behavior Surg Pathol 1 1988 215
    • (1988) Surg Pathol , vol.1 , pp. 215
    • Huang, S.1    Amparo, E.2    Fu, Y.3
  • 12
    • 0021828824 scopus 로고
    • The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients
    • R. Kurman, P. Kaminski, and H. Norris The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients Cancer 56 1985 403
    • (1985) Cancer , vol.56 , pp. 403
    • Kurman, R.1    Kaminski, P.2    Norris, H.3
  • 13
    • 0001513523 scopus 로고
    • The significance of atypical endometrial hyperplasia
    • P. Campbell, and R. Barter The significance of atypical endometrial hyperplasia J Obstet Gynecol Br Commun 68 1961 668
    • (1961) J Obstet Gynecol Br Commun , vol.68 , pp. 668
    • Campbell, P.1    Barter, R.2
  • 14
    • 0013983353 scopus 로고
    • Treatment of persistent endometrial hyperplasia with progestins
    • W.B. Wentz Treatment of persistent endometrial hyperplasia with progestins Am J Obstet Gynecol 96 1966 999 1004
    • (1966) Am J Obstet Gynecol , vol.96 , pp. 999-1004
    • Wentz, W.B.1
  • 15
    • 0024536904 scopus 로고
    • The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia
    • A. Ferenczy, and M. Gelfand The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia Am J Obstet Gynecol 160 1989 126 131 (Pubitemid 19055273)
    • (1989) American Journal of Obstetrics and Gynecology , vol.160 , Issue.1 , pp. 126-131
    • Ferenczy, A.1    Gelfand, M.2
  • 16
    • 0031672319 scopus 로고    scopus 로고
    • Steroid receptor concentrations as a prognostic factor in atypical endometrial hyperplasia
    • B. Lindahl, and R. Willen Steroid receptor concentrations as a prognostic factor in atypical endometrial hyperplasia Anticancer Res 18 1998 3793
    • (1998) Anticancer Res , vol.18 , pp. 3793
    • Lindahl, B.1    Willen, R.2
  • 17
    • 77957340572 scopus 로고    scopus 로고
    • Complex atypical hyperplasia of the uterus: Characteristics and prediction of underlying carcinoma risk
    • M.M. Leitao, G. Han, L.X. Lee, R. Nadeem, N.R. Abu-Rustum, and C.L. Brown Complex atypical hyperplasia of the uterus: characteristics and prediction of underlying carcinoma risk Am J Obstet Gynecol 203 2010 349.e1 349.e6
    • (2010) Am J Obstet Gynecol , vol.203
    • Leitao, M.M.1    Han, G.2    Lee, L.X.3    Nadeem, R.4    Abu-Rustum, N.R.5    Brown, C.L.6
  • 18
    • 0029799612 scopus 로고    scopus 로고
    • Endometrial cancer
    • P. Rose Endometrial cancer N Engl J Med 335 1996 640 649
    • (1996) N Engl J Med , vol.335 , pp. 640-649
    • Rose, P.1
  • 20
    • 0023232969 scopus 로고
    • Surgical pathologic spread patterns of endometrial cancer. A gynecologic oncology group study
    • W.T. Creasman, C.P. Morrow, B.N. Bundy, H.D. Homesley, J.E. Graham, and P.B. Heller Surgical pathologic spread patterns of endometrial cancer: a Gynecologic Oncology Group Study Cancer 60 1987 2035 2041 (Pubitemid 17145924)
    • (1987) Cancer , vol.60 , Issue.8 SUPPL. , pp. 2035-2041
    • Creasman, W.T.1    Morrow, C.P.2    Bundy, B.N.3    Homesley, H.D.4    Graham, J.E.5    Heller, P.B.6
  • 21
    • 0029182276 scopus 로고
    • Pathologic indicators of prognosis in endometrial adenocarcinoma: Selected aspects emphasizing the GOG experience. Gynecologic Oncology Group
    • R.J. Zaino Pathologic indicators of prognosis in endometrial adenocarcinoma: selected aspects emphasizing the GOG experience. Gynecologic Oncology Group Pathol Annu 30 1995 1 28
    • (1995) Pathol Annu , vol.30 , pp. 1-28
    • Zaino, R.J.1
  • 22
    • 79951581746 scopus 로고    scopus 로고
    • Advances in the management of endometrial carcinoma
    • M.M. Leitao, and R.R. Barakat Advances in the management of endometrial carcinoma Gynecol Oncol 120 2011 489 492
    • (2011) Gynecol Oncol , vol.120 , pp. 489-492
    • Leitao, M.M.1    Barakat, R.R.2
  • 24
  • 27
    • 77952252742 scopus 로고    scopus 로고
    • Progestogen treatment options for early endometrial cancer
    • T.J. Cade, M.A. Quinn, R.M. Rome, and D. Neesham Progestogen treatment options for early endometrial cancer BJOG 117 2010 879 884
    • (2010) BJOG , vol.117 , pp. 879-884
    • Cade, T.J.1    Quinn, M.A.2    Rome, R.M.3    Neesham, D.4
  • 28
    • 65649153355 scopus 로고    scopus 로고
    • Efficacy of megestrol acetate (megace) in the treatment of patients with early endometrial adenocarcinoma: Our experiences with 21 patients
    • Z. Eftekhar, N. Izadi-Mood, F. Yarandi, H. Shojaei, Z. Rezaei, and S. Mohagheghi Efficacy of megestrol acetate (megace) in the treatment of patients with early endometrial adenocarcinoma: our experiences with 21 patients Int J Gynecol Cancer 19 2009 249 252
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 249-252
    • Eftekhar, Z.1    Izadi-Mood, N.2    Yarandi, F.3    Shojaei, H.4    Rezaei, Z.5    Mohagheghi, S.6
  • 30
    • 65649116161 scopus 로고    scopus 로고
    • Pregnancy outcomes using assisted reproductive technology after fertility-preserving therapy in patients with endometrial adenocarcinoma or atypical complex hyperplasia
    • A.R. Han, Y.-S. Kwon, D.Y. Kim, J.H. Kim, Y.M. Kim, and Y.T. Kim Pregnancy outcomes using assisted reproductive technology after fertility-preserving therapy in patients with endometrial adenocarcinoma or atypical complex hyperplasia Int J Gynecol Cancer 19 2009 147 151
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 147-151
    • Han, A.R.1    Kwon, Y.-S.2    Kim, D.Y.3    Kim, J.H.4    Kim, Y.M.5    Kim, Y.T.6
  • 31
    • 0034885881 scopus 로고    scopus 로고
    • Medroxyprogesterone acetate therapy for patients with adenocarcinoma of the endometrium who wish to preserve the uterus-usefulness and limitations
    • M. Imai, T. Jobo, R. Sato, M. Kawaguchi, and H. Kuramoto Medroxyprogesterone acetate therapy for patients with adenocarcinoma of the endometrium who wish to preserve the uterus-usefulness and limitations Eur J Gynaecol Oncol 22 2001 217 220 (Pubitemid 32757874)
    • (2001) European Journal of Gynaecological Oncology , vol.22 , Issue.3 , pp. 217-220
    • Imai, M.1    Jobo, T.2    Sato, R.3    Kawaguchi, M.4    Kuramoto, H.5
  • 34
    • 72749112756 scopus 로고    scopus 로고
    • Outcomes of conservative therapy for young women with early endometrial adenocarcinoma
    • Y. Mao, X. Wan, Y. Chen, W. Lv, and X. Xie Outcomes of conservative therapy for young women with early endometrial adenocarcinoma Fertil Steril 93 2010 283 285
    • (2010) Fertil Steril , vol.93 , pp. 283-285
    • Mao, Y.1    Wan, X.2    Chen, Y.3    Lv, W.4    Xie, X.5
  • 35
    • 33847298630 scopus 로고    scopus 로고
    • Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium
    • T. Minaguchi, S. Nakagawa, Y. Takazawa, T. Nei, K. Horie, and T. Fujiwara Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium Cancer Lett 248 2007 112 122
    • (2007) Cancer Lett , vol.248 , pp. 112-122
    • Minaguchi, T.1    Nakagawa, S.2    Takazawa, Y.3    Nei, T.4    Horie, K.5    Fujiwara, T.6
  • 36
    • 22544470875 scopus 로고    scopus 로고
    • Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger
    • DOI 10.1111/j.1525-1438.2005.00129.x
    • T. Ota, M. Yoshida, M. Kimura, and K. Kinoshita Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger Int J Gynecol Cancer 15 2005 657 662 (Pubitemid 41022904)
    • (2005) International Journal of Gynecological Cancer , vol.15 , Issue.4 , pp. 657-662
    • Ota, T.1    Yoshida, M.2    Kimura, M.3    Kinoshita, K.4
  • 37
    • 0030797584 scopus 로고    scopus 로고
    • Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40
    • DOI 10.1016/S0029-7844(97)00297-4, PII S0029784497002974
    • T.C. Randall, and R.J. Kurman Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40 Obstet Gynecol 90 1997 434 440 (Pubitemid 27357938)
    • (1997) Obstetrics and Gynecology , vol.90 , Issue.3 , pp. 434-440
    • Randall, T.C.1    Kurman, R.J.2
  • 38
    • 57349177747 scopus 로고    scopus 로고
    • Fertility-sparing treatment in young women with endometrial cancer or atypical complex hyperplasia: A prospective single-institution experience of 21 cases
    • M. Signorelli, G. Caspani, C. Bonazzi, V. Chiappa, P. Perego, and C. Mangioni Fertility-sparing treatment in young women with endometrial cancer or atypical complex hyperplasia: a prospective single-institution experience of 21 cases BJOG 116 2009 114 118
    • (2009) BJOG , vol.116 , pp. 114-118
    • Signorelli, M.1    Caspani, G.2    Bonazzi, C.3    Chiappa, V.4    Perego, P.5    Mangioni, C.6
  • 40
    • 34447335590 scopus 로고    scopus 로고
    • Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer
    • DOI 10.1093/humrep/dem088
    • K. Yamazawa, M. Hirai, A. Fujito, H. Nishi, F. Terauchi, and H. Ishikura Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer Hum Reprod 22 2007 1953 1958 (Pubitemid 47062765)
    • (2007) Human Reproduction , vol.22 , Issue.7 , pp. 1953-1958
    • Yamazawa, K.1    Hirai, M.2    Fujito, A.3    Nishi, H.4    Terauchi, F.5    Ishikura, H.6    Shozu, M.7    Isaka, K.8
  • 41
    • 27144530030 scopus 로고    scopus 로고
    • Reevaluating the safety of fertility-sparing hormonal therapy for early endometrial cancer
    • DOI 10.1016/j.ygyno.2005.06.018, PII S0090825805004208
    • Y.-C. Yang, C.-C. Wu, C.-P. Chen, C.-L. Chang, and K.-L. Wang Reevaluating the safety of fertility-sparing hormonal therapy for early endometrial cancer Gynecol Oncol 99 2005 287 293 (Pubitemid 41502832)
    • (2005) Gynecologic Oncology , vol.99 , Issue.2 , pp. 287-293
    • Yang, Y.-C.1    Wu, C.-C.2    Chen, C.-P.3    Chang, C.-L.4    Wang, K.-L.5
  • 42
    • 70949093183 scopus 로고    scopus 로고
    • Fertility-preserving treatment in young women with well-differentiated endometrial carcinoma and severe atypical hyperplasia of endometrium
    • M. Yu, J.-x. Yang, M. Wu, J.-h. Lang, Z. Huo, and K. Shen Fertility-preserving treatment in young women with well-differentiated endometrial carcinoma and severe atypical hyperplasia of endometrium Fertil Steril 92 2009 2122 2124
    • (2009) Fertil Steril , vol.92 , pp. 2122-2124
    • Yu, M.1    Yang, J.-X.2    Wu, M.3    Lang, J.-H.4    Huo, Z.5    Shen, K.6
  • 43
    • 79952118889 scopus 로고    scopus 로고
    • Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: A systematic review and metaanalysis
    • I.D. Gallos, M. Shehmar, S. Thangaratinam, T.K. Papapostolou, A. Coomarasamy, and J.K. Gupta Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: a systematic review and metaanalysis Am J Obstet Gynecol 203 2010 547.e1 547.e10
    • (2010) Am J Obstet Gynecol , vol.203
    • Gallos, I.D.1    Shehmar, M.2    Thangaratinam, S.3    Papapostolou, T.K.4    Coomarasamy, A.5    Gupta, J.K.6
  • 44
    • 31944433149 scopus 로고    scopus 로고
    • Fertility-preserving treatment in young women with endometrial cancer
    • DOI 10.1159/000089974
    • C. Böing, and R. Kimmig Fertility-preserving treatment in young women with endometrial cancer Gynakol Geburtshilfliche Rundsch 46 2006 25 33 (Pubitemid 43189793)
    • (2006) Gynakologisch-geburtshilfliche Rundschau , vol.46 , Issue.1-2 , pp. 25-33
    • Boing, C.1    Kimmig, R.2
  • 45
    • 70350668592 scopus 로고    scopus 로고
    • The fertility-sparing treatment in patients with endometrial atypical hyperplasia and early endometrial cancer: A debated therapeutic option
    • A. Gadducci, N. Spirito, E. Baroni, R. Tana, and A.R. Genazzani The fertility-sparing treatment in patients with endometrial atypical hyperplasia and early endometrial cancer: a debated therapeutic option Gynecol Endocrinol 25 2009 683 691
    • (2009) Gynecol Endocrinol , vol.25 , pp. 683-691
    • Gadducci, A.1    Spirito, N.2    Baroni, E.3    Tana, R.4    Genazzani, A.R.5
  • 48
    • 34347340589 scopus 로고    scopus 로고
    • Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins
    • DOI 10.1097/PAS.0b013e31802d68ce, PII 0000047820070700000002
    • D.T. Wheeler, R.E. Bristow, and R.J. Kurman Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins Am J Surg Pathol 31 2007 988 998 (Pubitemid 47012294)
    • (2007) American Journal of Surgical Pathology , vol.31 , Issue.7 , pp. 988-998
    • Wheeler, D.T.1    Bristow, R.E.2    Kurman, R.J.3
  • 49
    • 77749258716 scopus 로고    scopus 로고
    • Prognostic significance of estrogen and progesterone receptor expression in LNG-IUS (Mirena) treatment of endometrial hyperplasia: An immunohistochemical study
    • E. Akesson, I.D. Gallos, R. Ganesan, R. Varma, and J.K. Gupta Prognostic significance of estrogen and progesterone receptor expression in LNG-IUS (Mirena) treatment of endometrial hyperplasia: an immunohistochemical study Acta Obstet Gynecol Scand 89 2010 393 398
    • (2010) Acta Obstet Gynecol Scand , vol.89 , pp. 393-398
    • Akesson, E.1    Gallos, I.D.2    Ganesan, R.3    Varma, R.4    Gupta, J.K.5
  • 51
    • 33645881678 scopus 로고    scopus 로고
    • The management of endometrial hyperplasia: An evaluation of current practice
    • T.J. Clark, D. Neelakantan, and J.K. Gupta The management of endometrial hyperplasia: an evaluation of current practice Eur J Obstet Gynecol Reprod Biol 125 2006 259 264
    • (2006) Eur J Obstet Gynecol Reprod Biol , vol.125 , pp. 259-264
    • Clark, T.J.1    Neelakantan, D.2    Gupta, J.K.3
  • 52
    • 20444477040 scopus 로고    scopus 로고
    • Is levonorgestrel intrauterine system effective for treatment of early endometrial cancer? Report of four cases and review of the literature
    • DOI 10.1016/j.ygyno.2004.10.031, PII S0090825804008868
    • K.K. Dhar, T. NeedhiRajan, M. Koslowski, and R.P. Woolas Is levonorgestrel intrauterine system effective for treatment of early endometrial cancer? Report of four cases and review of the literature Gynecol Oncol 97 2005 924 927 (Pubitemid 40824667)
    • (2005) Gynecologic Oncology , vol.97 , Issue.3 , pp. 924-927
    • Dhar, K.K.1    NeedhiRajan, T.2    Koslowski, M.3    Woolas, R.P.4
  • 53
    • 0035204026 scopus 로고    scopus 로고
    • Metabolic effects associated with high-dose continuous megestrol acetate administration in the treatment of endometrial pathology
    • DOI 10.1007/s004040000154
    • M. Guven, Y. Dikmen, M.C. Terek, A.A. Ozsaran, I.M. Itil, and Y. Erhan Metabolic effects associated with high-dose continuous megestrol acetate administration in the treatment of endometrial pathology Arch Gynecol Obstet 265 2001 183 186 (Pubitemid 33116839)
    • (2001) Archives of Gynecology and Obstetrics , vol.265 , Issue.4 , pp. 183-186
    • Guven, M.1    Dikmen, Y.2    Terek, M.C.3    Ozsaran, A.A.4    Itil, I.M.5    Erhan, Y.6
  • 54
    • 2042465026 scopus 로고    scopus 로고
    • Risk of progression in complex and atypical endometrial hyperplasia: Clinicopathologic analysis in cases with and without progestogen treatment
    • DOI 10.1111/j.1048-891x.2004.014220.x
    • L.C. Horn, U. Schnurrbusch, K. Bilek, B. Hentschel, and J. Einenkel Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment Int J Gynecol Cancer 14 2004 348 353 (Pubitemid 38533908)
    • (2004) International Journal of Gynecological Cancer , vol.14 , Issue.2 , pp. 348-353
    • Horn, L.-C.1    Schnurrbusch, U.2    Bilek, K.3    Hentschel, B.4    Einenkel, J.5
  • 55
    • 55949096482 scopus 로고    scopus 로고
    • Serial histologic observation of endometrial adenocarcinoma treated with high-dose progestin until complete disappearance of carcinomatous foci-review of more than 25 biopsies from five patients
    • S. Kamoi, Y. Ohaki, O. Mori, K. Kurose, M. Fukunaga, and T. Takeshita Serial histologic observation of endometrial adenocarcinoma treated with high-dose progestin until complete disappearance of carcinomatous foci-review of more than 25 biopsies from five patients Int J Gynecol Cancer 18 2008 1305 1314
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 1305-1314
    • Kamoi, S.1    Ohaki, Y.2    Mori, O.3    Kurose, K.4    Fukunaga, M.5    Takeshita, T.6
  • 56
    • 38049085766 scopus 로고    scopus 로고
    • Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of rapamycin are associated with progesterone refractory endometrial hyperplasia
    • M.R. Milam, P.T. Soliman, L.H. Chung, K.M. Schmeler, R.L.J. Bassett, and R.R. Broaddus Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of rapamycin are associated with progesterone refractory endometrial hyperplasia Int J Gynecol Cancer 18 2008 146 151
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 146-151
    • Milam, M.R.1    Soliman, P.T.2    Chung, L.H.3    Schmeler, K.M.4    Bassett, R.L.J.5    Broaddus, R.R.6
  • 57
    • 78650396679 scopus 로고    scopus 로고
    • Levonorgestrel-releasing intrauterine system (LNG-IUS) as an effective treatment option for endometrial hyperplasia: A 15-year follow-up study
    • G. Scarselli, G. Bargelli, G.L. Taddei, M. Marchionni, E. Peruzzi, and A. Pieralli Levonorgestrel-releasing intrauterine system (LNG-IUS) as an effective treatment option for endometrial hyperplasia: a 15-year follow-up study Fertil Steril 95 2011 420 422
    • (2011) Fertil Steril , vol.95 , pp. 420-422
    • Scarselli, G.1    Bargelli, G.2    Taddei, G.L.3    Marchionni, M.4    Peruzzi, E.5    Pieralli, A.6
  • 58
    • 34248679208 scopus 로고    scopus 로고
    • Conservative management of atypical endometrial hyperplasia and early invasive carcinoma with intrauterine levonorgestrel: A progesterone receptor study
    • W.A.A. Tjalma, D. Janssens, D. Wildemeersch, C. Colpaert, and K. Watty Conservative management of atypical endometrial hyperplasia and early invasive carcinoma with intrauterine levonorgestrel: a progesterone receptor study Eur J Cancer Suppl 2 2004 93 94
    • (2004) Eur J Cancer Suppl , vol.2 , pp. 93-94
    • Tjalma, W.A.A.1    Janssens, D.2    Wildemeersch, D.3    Colpaert, C.4    Watty, K.5
  • 60
    • 47849096862 scopus 로고    scopus 로고
    • The effectiveness of a levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of endometrial hyperplasia - A long-term follow-up study
    • R. Varma, H. Soneja, K. Bhatia, R. Ganesan, T. Rollason, and T.J. Clark The effectiveness of a levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of endometrial hyperplasia-a long-term follow-up study Eur J Obstet Gynecol Reprod Biol 139 2008 169 175
    • (2008) Eur J Obstet Gynecol Reprod Biol , vol.139 , pp. 169-175
    • Varma, R.1    Soneja, H.2    Bhatia, K.3    Ganesan, R.4    Rollason, T.5    Clark, T.J.6
  • 61
    • 1642417350 scopus 로고    scopus 로고
    • Nuclear morphometric changes and therapy monitoring in patients with endometrial hyperplasia: A study comparing effects of intrauterine levonorgestrel and systemic medroxyprogesterone
    • DOI 10.1016/j.ygyno.2003.07.002, PII S0090825803005031
    • A.B. Vereide, M. Arnes, B. Straume, J.M. Maltau, and A. Ørbo Nuclear morphometric changes and therapy monitoring in patients with endometrial hyperplasia: a study comparing effects of intrauterine levonorgestrel and systemic medroxyprogesterone Gynecol Oncol 91 2003 526 533 (Pubitemid 38388145)
    • (2003) Gynecologic Oncology , vol.91 , Issue.3 , pp. 526-533
    • Vereide, A.B.1    Arnes, M.2    Straume, B.3    Maltau, J.M.4    Orbo, A.5
  • 62
    • 34248667285 scopus 로고    scopus 로고
    • Management of patients with non-atypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system: Long-term follow-up
    • DOI 10.1016/j.maturitas.2006.12.004, PII S0378512206004038
    • D. Wildemeersch, D. Janssens, K. Pylyser, N. De Wever, G. Verbeeck, and M. Dhont Management of patients with non-atypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system: long-term follow-up Maturitas 57 2007 210 213 (Pubitemid 46771029)
    • (2007) Maturitas , vol.57 , Issue.2 , pp. 210-213
    • Wildemeersch, D.1    Janssens, D.2    Pylyser, K.3    De Wever, N.4    Verbeeck, G.5    Dhont, M.6    Tjalma, W.7
  • 63
    • 71049145735 scopus 로고    scopus 로고
    • Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins
    • A.K. Witkiewicz, T. McConnell, M. Potoczek, R.V.B. Emmons, and R.J. Kurman Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins Hum Pathol 41 2010 26 32
    • (2010) Hum Pathol , vol.41 , pp. 26-32
    • Witkiewicz, A.K.1    McConnell, T.2    Potoczek, M.3    Emmons, R.V.B.4    Kurman, R.J.5
  • 64
    • 0029823306 scopus 로고    scopus 로고
    • Models for estimating the number of unpublished studies
    • DOI 10.1002/(SICI)1097-0258(19961215)15:23<2493::AID-SIM381>3.0. CO;2-C
    • L. Gleser, and I. Olkin Models for estimating the number of unpublished studies Stat Med 15 1996 2493 2507 (Pubitemid 26413809)
    • (1996) Statistics in Medicine , vol.15 , Issue.23 , pp. 2493-2507
    • Gleser, L.J.1    Olkin, I.2
  • 65
    • 70349768936 scopus 로고    scopus 로고
    • The effect of the levonorgestrel releasing intrauterine system on endometrial hyperplasia: An Australian study and systematic review
    • M.J. Buttini, S.J. Jordan, and P.M. Webb The effect of the levonorgestrel releasing intrauterine system on endometrial hyperplasia: an Australian study and systematic review Aust N Z J Obstet Gynaecol 49 2009 316 322
    • (2009) Aust N Z J Obstet Gynaecol , vol.49 , pp. 316-322
    • Buttini, M.J.1    Jordan, S.J.2    Webb, P.M.3
  • 67
    • 56449099764 scopus 로고    scopus 로고
    • Stage IV endometrial cancer after failed conservative management: A case report
    • R. Kothari, and L. Seamon Stage IV endometrial cancer after failed conservative management: a case report Gynecol Oncol 111 2008 579 582
    • (2008) Gynecol Oncol , vol.111 , pp. 579-582
    • Kothari, R.1    Seamon, L.2
  • 68
    • 54349105362 scopus 로고    scopus 로고
    • Endometrioid adenocarcinoma after insertion of a levonorgestrel-releasing intrauterine system
    • R. Flemming, and S. Sathiyathasan Endometrioid adenocarcinoma after insertion of a levonorgestrel-releasing intrauterine system J Minim Invasive Gynecol 15 2008 771 773
    • (2008) J Minim Invasive Gynecol , vol.15 , pp. 771-773
    • Flemming, R.1    Sathiyathasan, S.2
  • 69
    • 0036923050 scopus 로고    scopus 로고
    • Endometrial adenocarcinoma following the insertion of a Mirena IUCD
    • DOI 10.1006/gyno.2002.6817
    • K. Jones, and M. Georgiou Endometrial adenocarcinoma following the insertion of a Mirena IUCD Gynecol Oncol 87 2002 216 218 (Pubitemid 36044091)
    • (2002) Gynecologic Oncology , vol.87 , Issue.2 , pp. 216-218
    • Jones, K.1    Georgiou, M.2    Hyatt, D.3    Spencer, T.4    Thomas, H.5
  • 70
    • 78649907114 scopus 로고    scopus 로고
    • Conservative treatment of early endometrial cancer: Preliminary results of a pilot study
    • G. Laurelli, G. Di Vagno, C. Scaffa, S. Losito, M. Del Giudice, and S. Greggi Conservative treatment of early endometrial cancer: preliminary results of a pilot study Gynecol Oncol 120 2011 43 46
    • (2011) Gynecol Oncol , vol.120 , pp. 43-46
    • Laurelli, G.1    Di Vagno, G.2    Scaffa, C.3    Losito, S.4    Del Giudice, M.5    Greggi, S.6
  • 71
    • 84858332273 scopus 로고    scopus 로고
    • Multi-institutional study identifying predictors of response to progestin treatment of complex atypical hyperplasia or grade 1 endometrial adenocarcinoma
    • K. Penner, and O. Dorigo Multi-institutional study identifying predictors of response to progestin treatment of complex atypical hyperplasia or grade 1 endometrial adenocarcinoma Gynecol Oncol 111 2008 379
    • (2008) Gynecol Oncol , vol.111 , pp. 379
    • Penner, K.1    Dorigo, O.2
  • 72
    • 37249013214 scopus 로고    scopus 로고
    • U.s. National Institutes Of Health
    • U.S. National Institutes of Health ClinicalTrials.gov clinicaltrials.gov
    • ClinicalTrials.gov


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.