Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins

Human Pathology

Volumn 41, Issue 1, 2010, Pages 26-32

  Witkiewicz, Agnieszka K ^a   McConnell, Thomas ^b   Potoczek, Magdalena ^a   Emmons, Robert V B ^c   Kurman, Robert J ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endometrial carcinoma; Progestin

Indexed keywords

CD56 ANTIGEN; CD8 ANTIGEN; GESTAGEN; GRANZYME B; MEDROXYPROGESTERONE ACETATE; MEGESTROL; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; BENIGN TUMOR; CANCER GROWTH; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MORPHOLOGY; NATURAL KILLER CELL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TUMOR DIFFERENTIATION;

ADULT; ANTINEOPLASTIC AGENTS; BLOOD CELL COUNT; CARCINOMA, ENDOMETRIOID; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HUMANS; KILLER CELLS, NATURAL; PROGESTINS; T-LYMPHOCYTES, REGULATORY;

EID: 71049145735     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.06.012     Document Type: Article

References (37)

1. Clarke C.L., and Sutherland R.L. Progestin regulation of cellular proliferation. Endocr Rev 11 (1990) 266-301
2. Graham J.D., and Clarke C.L. Physiological action of progesterone in target tissues. Endocr Rev 18 (1997) 502-519
3. Decruze S.B., and Green J.A. Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. Int J Gynecol Cancer 17 (2007) 964-978
4. Ambros R.A., and Kurman R.J. Combined assessment of vascular and myometrial invasion as a model to predict prognosis in stage I endometrioid adenocarcinoma of the uterine corpus. Cancer 69 (1992) 1424-1431
5. Deligdisch L. Morphologic correlates of host response in endometrial carcinoma. Am J Reprod Immunol 2 (1982) 54-57
6. Kondratiev S., Sabo E., Yakirevich E., Lavie O., and Resnick M.B. Intratumoral CD8+ T lymphocytes as a prognostic factor of survival in endometrial carcinoma. Clin Cancer Res 10 (2004) 4450-4456
7. Ferguson A., Moore M., and Fox H. Expression of MHC products and leucocyte differentiation antigens in gynaecological neoplasms: an immunohistological analysis of the tumour cells and infiltrating leucocytes. Br J Cancer 52 (1985) 551-563
8. Garzetti G.G., Ciavattini A., Muzzioli M., et al. The relationship of clinical-pathologic status and adjuvant treatment with natural killer cell activity in stage I and II endometrial carcinoma. Acta Obstet Gynecol Scand 73 (1994) 652-657
9. Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4 (2003) 330-336
10. Piccirillo C.A., and Shevach E.M. Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin Immunol 16 (2004) 81-88
11. Sakaguchi S., Sakaguchi N., Shimizu J., et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 182 (2001) 18-32
12. Curiel T.J., Coukos G., Zou L., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10 (2004) 942-949
13. Nakamura T., Shima T., Saeki A., et al. Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer. Cancer Sci 98 (2007) 874-881
14. Zheng Y., and Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 8 (2007) 457-462
15. Giatromanolaki A., Bates G.J., Koukourakis M.I., et al. The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer. Gynecol Oncol 110 (2008) 216-221
16. Le Bouteiller P., and Piccinni M.P. Human NK cells in pregnant uterus: why there?. Am J Reprod Immunol 59 (2008) 401-406
17. Carlino C., Stabile H., Morrone S., et al. Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy. Blood 111 (2008) 3108-3115
18. Wheeler D.T., Bristow R.E., and Kurman R.J. Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol 31 (2007) 988-998
19. King A., Burrows T., and Loke Y.W. Human uterine natural killer cells. Nat Immun 15 (1996) 41-52
20. Trinchieri G. Biology of natural killer cells. Adv Immunol 47 (1989) 187-376
21. Trapani J.A., and Smyth M.J. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2 (2002) 735-747
22. Vitale M., Della Chiesa M., Carlomagno S., et al. NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor. Blood 106 (2005) 566-571
23. van den Heuvel M.J., Chantakru S., Xuemei X., et al. Trafficking of circulating pro-NK cells to the decidualizing uterus: regulatory mechanisms in the mouse and human. Immunol Invest 34 (2005) 273-293
24. van den Heuvel M.J., Xie X., Tayade C., et al. A review of trafficking and activation of uterine natural killer cells. Am J Reprod Immunol 54 (2005) 322-331
25. Okada H., Nakajima T., Sanezumi M., Ikuta A., Yasuda K., and Kanzaki H. Progesterone enhances interleukin-15 production in human endometrial stromal cells in vitro. J Clin Endocrinol Metab 85 (2000) 4765-4770
26. Sentman C.L., Meadows S.K., Wira C.R., and Eriksson M. Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone. J Immunol 173 (2004) 6760-6766
27. Albertsson P.A., Basse P.H., Hokland M., et al. NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity. Trends Immunol 24 (2003) 603-609
28. Coca S., Perez-Piqueras J., Martinez D., et al. The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma. Cancer 79 (1997) 2320-2328
29. Ishigami S., Natsugoe S., Tokuda K., et al. Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer 88 (2000) 577-583
30. Villegas F.R., Coca S., Villarrubia V.G., et al. Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer. Lung Cancer 35 (2002) 23-28
31. Mandelboim O., Malik P., Davis D.M., Jo C.H., Boyson J.E., and Strominger J.L. Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity. Proc Natl Acad Sci U S A 96 (1999) 5640-5644
32. Bulmer J.N., and Lash G.E. Human uterine natural killer cells: a reappraisal. Mol Immunol 42 (2005) 511-521
33. Crncic T.B., Laskarin G., Frankovic K.J., et al. Early pregnancy decidual lymphocytes beside perforin use Fas ligand (FasL) mediated cytotoxicity. J Reprod Immunol 73 (2007) 108-117
34. Kopcow H.D., Allan D.S., Chen X., et al. Human decidual NK cells form immature activating synapses and are not cytotoxic. Proc Natl Acad Sci U S A 102 (2005) 15563-15568
35. Ishitani A., Sageshima N., and Hatake K. The involvement of HLA-E and -F in pregnancy. J Reprod Immunol 69 (2006) 101-113
36. Woo Y.L., Sterling J., Crawford R., van der Burg S.H., Coleman N., and Stanley M. FOXP3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: poor correlation between different antibodies. J Clin Pathol 61 (2008) 969-971
37. Kasprzycka M., Zhang Q., Witkiewicz A., et al. Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes. J Immunol 181 (2008) 2506-2512