Niflumic acid inhibits goblet cell degranulation in a guinea pig asthma model

Allergology International

Volumn 61, Issue 1, 2012, Pages 133-142

  Kondo, Mitsuko ^a   Nakata, Junko ^a   Arai, Naoki ^a   Izumo, Takehiro ^a   Tagaya, Etsuko ^a   Takeyama, Kiyoshi ^a   Tamaoki, Jun ^a   Nagai, Atsushi ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Calcium activated chloride channel; Degranulation; Goblet cells; MUC5AC; Niflumic acid

Indexed keywords

HISTAMINE; INTERLEUKIN 13; NIFLUMIC ACID; OVALBUMIN; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL SWELLING; CONTROLLED STUDY; DEGRANULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOCYTOSIS; GOBLET CELL; GOBLET CELL METAPLASIA; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; MALE; METAPLASIA; MORPHOLOGY; MUCUS; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; TRACHEA; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84858321712     PISSN: 13238930     EISSN: 14401592     Source Type: Journal    
DOI: 10.2332/allergolint.11-OA-0307     Document Type: Article

References (30)

1. Aikawa T, Shimura S, Sasaki H, Ebina M, Takishima T. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest 1992;101:916-21.
2. - channel 1 (CaCC1) gene in the asthmatic airway. Am J Respir Crit Care Med 2002;165:1132-6.
3. Nakanishi A, Morita S, Iwashita H et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci U S A 2001;98:5175-80.
4. Long AJ, Sypek JP, Askew R et al. Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation. Am J Respir Cell Mol Biol 2006;35:357-65.
5. Wills-Karp M, Luyimbazi J, Xu X et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-61.
6. Yoshisue H, Puddicombe SM, Wilson SJ et al. Characterization of ciliated bronchial epithelium 1, a ciliated cellassociated gene induced during mucociliary differentiation. Am J Respir Cell Mol Biol 2004;31:491-500.
7. Nakano T, Inoue H, Fukuyama S et al. Niflumic acid suppresses interleukin-13-induced asthma phenotypes. Am J Respir Crit Care Med 2006;173:1216-21.
8. Endo Y, Isono K, Kondo M, Tamaoki J, Nagai A. Interleukin-9 and Interleukin-13 augment UTP-induced Cl ion transport via hCLCA1 expression in a human bronchial epithelial cell line. Clin Exp Allergy 2007;37:219-24.
9. Leverkoehne I, Gruber AD. The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells. J Histochem Cytochem 2002;50:829-38.
10. Tokuyama K, Kuo HP, Rohde JA, Barnes PJ, Rogers DF. Neural control of goblet cell secretion in guinea pig airways. Am J Physiol 1990;259:L108-15.
11. Takeyama K, Tamaoki J, Nakata J, Konno K. Effect of oxitropium bromide on histamine-induced airway goblet cell secretion. Am J Respir Crit Care Med 1996;154:231-6.
12. Kondo M, Tamaoki J, Takeyama K, Nakata J, Nagai A. Interleukin-13 induces goblet cell differentiation in primary cell culture from guinea pig tracheal epithelium. Am J Respir Cell Mol Biol 2002;27:536-41.
13. Griffiths-Johnson DA, Karol MH. Validation of a noninvasive technique to assess development of airway hyperreactivity in an animal model of immunologic pulmonary hypersensitivity. Toxicology 1991;65:283-94.
14. Nakata J, Tamaoki J, Takeyama K et al. [Effect of heparin on airway goblet cell secretion in sensitized guinea pigs]. Nihon Kokyuki Gakkai Zasshi 1998;36:845-50 (in Japanese).
15. Chen Y, Zhao YH, Wu R. Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates. Am J Respir Cell Mol Biol 2001;25:409-17.
16. 2+-mobilizing receptors for ATP and UTP. Cell Calcium 1995;17:111-9.
17. Davis CW. Regulation of mucin secretion from in vitro cellular models. Novartis Found Symp 2002;248:113-25.
18. Tamaoki J, Nakata J, Takeyama K, Chiyotani A, Konno K. Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes. J Allergy Clin Immunol 1997;99:233-8.
19. Liu YC, Khawaja AM, Rogers DF. Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlu-kast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. Br J Pharmacol 1998;124:563-71.
20. Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010;363:2233-47.
21. Tamaoki J, Kondo M, Kuroda H et al. Validity and safety of sputum induction by inhaled uridine 5'-triphosphate. Am J Respir Crit Care Med 2001;164:378-81.
22. Bertrand CA, Danahay H, Poll CT, Laboisse C, Hopfer U, Bridges RJ. Niflumic acid inhibits ATP-stimulated exocytosis in a mucin-secreting epithelial cell line. Am J Physiol Cell Physiol 2004;286:C247-55.
23. Gibson A, Lewis AP, Affleck K, Aitken AJ, Meldrum E, Thompson N. Hclca1 and mCLCA3 are secreted nonintegral membrane proteins and therefore are not ion channels. J Biol Chem 2005;280:27205-12.
24. Hamann M, Gibson A, Davies N et al. Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents. J Physiol 2009;587:2255-74.
25. - channels in Xenopus oocytes. Mol Pharmacol 1990;37:720-4.
26. Tissot M, Roch-Arveiller M, Fontagne J, Giroud JP. Effects of niflumic acid on polyphosphoinositide and oxidative metabolism in polymorphonuclear leukocytes from healthy and thermally injured rats. Inflammation 1992; 16:645-57.
27. Shimizu T, Shimizu S, Hattori R, Majima Y. A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats. J Allergy Clin Immunol 2003; 112:119-25.
28. Plog S, Mundhenk L, Klymiuk N, Gruber AD. Genomic, tissue expression, and protein characterization of pCLCA1, a putative modulator of cystic fibrosis in the pig. J Histochem Cytochem 2009;57:1169-81.
29. Hauber HP, Bergeron C, Tsicopoulos A et al. Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis. Can Respir J 2005;12:143-6.
30. Winpenny JP, Marsey LL, Sexton DW. The CLCA gene family: putative therapeutic target for respiratory diseases. Inflamm Allergy Drug Targets 2009;8:146-60.