Drug encapsulation in pectin hydrogel beads- a systematic study of simulated digestion media

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 3, Issue SUPPL. 5, 2011, Pages 292-299

  Cabrera, Juan Carlos ^a   Cambier, Pierre ^a   van Cutsem, Pierre ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Digestion; Encapsulation; Hydrogel; Pectin

Indexed keywords

CALCIUM; CHITOSAN; OLIGOMER; PANCREATIN; PECTIN; POLYETHYLENEIMINE; POLYGALACTURONASE;

ARTICLE; DIGESTION; ENCAPSULATION; FECES; HYDROGEL; IN VITRO STUDY; INTESTINE; POLYMERIZATION;

EID: 84858306816     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Mishra MU, Khandare JN. Evaluation of Tamarind seed polysaccharide as biodegradable carrier for colon specific drug delivery. Int J Pharm Pharm Sci 2011;3(1): 139-42
2. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J of Pharm Pharm Sci 2003;6(1):33-66.
3. Aurora J, Talwar N, Pathak V. Colonic drug delivery challenges an opportunities-An overview. Eur Gastroenterol Rev 2006;1:1-6.
4. Awasthi R. Selection of pectin as pharmaceutical excipient on the basis of rheological behavior. Int J Pharm Pharm Sci 2011;3(1): 229-31
5. Liners F, Letesson JJ, Didembourg C, Van Cutsem P. Monoclonal Antibodies against Pectin: Recognition of a Conformation Induced by Calcium. Plant Physiol 1989;91(4):1419-24.
6. Saito D, Nakaji S, Fukuda S, Shimoyama T, Sakamoto J, Sugawara K. Comparison of the amount of pectin in the human terminal ileum with the amount of orally administered pectin. Nutrition 2005;21:914-9.
7. Bourgeois S, Gernet M, Pradeau D, Andremont A, Fattal E. Evaluation of critical formulation parameters influencing the bioactivity of beta-lactamases entrapped in pectin beads. Int J Pharm 2006;324(1):2-9.
8. Bourgeois S, Laham A, Besnard M, Andremont A, Fattal E. In vitro and in vivo evaluation of pectin beads for the colon delivery of beta-lactamases. J Drug Target 2005; 13 (5):277-84.
9. Platt D, Raz A. Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin. J Natl Cancer Ins 1992;84(6):438-42.
10. Eliaz I, Hotchkiss AT, Fishman ML, Rode D. The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother Res 2006;20: 859-64
11. Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R, Raz A. Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst 2002;94(24):1854-62.
12. Glinsky VV, Raz A. Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydr Res, 2009;344:1788-91.
13. Olano-Martin E, Rimbach GH, Gibson GR, Rastall RA. Pectin and pectic-oligosaccharides induce apoptosis in in vitro human colonic adenocarcinoma cells. Anticancer Res 2003;23(1A):341-6.
14. Jackson CL, Dreaden TM, Theobald LK, Tran NM, Beal TL, Eid M, Gao MY, Shirley RB, Stoffel MT, Kumar M, Mohnen D. Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology 2007;17(8):805-19.
15. Hotchkiss AT, Olano-Martin E, Grace WE, Gibson GR, Rastall RA. Pectic oligosaccharides as prebiotics. In: Eggleston G, Cote GL, editors. Oligosaccharides in food and agriculture. ACS symposium series, 849. American Chemical Society, Washington; 2003. p54-62.
16. Ganan M, Collins M, Rastall R, Hotchkiss AT, Chau HK, Carrascosa AV, Martinez-Rodriguez AJ. Inhibition by pectic oligosaccharides of the invasion of undifferentiated and differentiated Caco-2 cells by Campylobacter jejuni. Int J Food Microbiol 2009;137(2-3):181-5.
17. Rhoades J, Manderson K, Wells A, Hotchkiss AT, Gibson GR, Formentin K, Beer M, Rastall RA. Oligosaccharide-mediated inhibition of the adhesion of pathogenic Escherichia coli strains to human gut epithelial cells in vitro. J Food Prot 2008;71(11):2272-7.
18. Ridley BL, O'Neill MA, Mohnen DA. Pectins: structure, biosynthesis, and oligogalacturonide-related signaling. Phytochemistry 2001;57(6):929-67.
19. Messiaen J, Van Cutsem P. Defense gene transcription in carrot cells treated with oligogalacturonides. Plant Cell Physiol 1993;34(7):93-116.
20. Cabrera JC, Boland A, Cambier P, Frettinger P, Van Cutsem P. Chitosan oligosaccharides modulate the supramolecular conformation and the biological activity of oligogalacturonides in Arabidopsis. Glycobiology 2010;20(6):775-86.
21. Decreux A, Thomas A, Spies B, Brasseur R, Van Cutsem P, Messiaen J. In vitro characterization of the homogalacturonan binding domain of the wall-associated kinase WAK1 using site-directed mutagenesis. Phytochemistry 2006;67:1068-79
22. Dongowski G, Anger H. Metabolism of pectin in the gastrointestinal tract. In: Visser J, Voragen AGJ, editors. Pectins and pectinases, Proceedings of an International Symposium. Progress in Biotechnology 1996;(14). p659-66
23. Munjeri O, Collett JH, Fell JT. Hydrogel beads based on amidated pectins for colon-specific drug delivery: The role of chitosan in modifying drug release. J Control Release 1997;46(3):273-8.
24. Chang KLB, Lin J. Swelling behavior and the release of protein from chitosan-pectin composite particles. Carbohydr Polym 2000;43(2):163-9.
25. Atyabi F, Inanloo K, Dinarvand R. Bovine serum albumin-loaded pectinate beads as colonic peptide delivey system: Preparation and in vitro characterization. Drug Deliv 2005;12(6):367-75.
26. The United States Pharmacopoeia XXIV and NF XIX, Amer Pharmaceut Assoc, Washington, DC, 2000
27. Hotchkiss AT, El-Bahtimy K, Fishman ML. Analysis of Pectin Structure by HPAEC-PAD. In: Linskens H-F, Jackson JF editors. Plant Cell Wall Analysis, Modern Methods of Plant Analysis, Springer-Verlag, Berlin, Vol. 17, 1996. p129-46.
28. Cabrera JC, Boland A, Messiaen J, Cambier P, Van Cutsem P. Egg box conformation of oligogalacturonides: The time-dependent stabilization of the elicitor-active conformation increases its biological activity. Glycobiology 2008;18(6):473-82
29. Dongowski G, Lorenz A, Anger H. Degradation of pectins with different degrees of esterification by Bacteroides thetaiotaomicron isolated from human gut flora. Appl Environ Microbiol 2000;66: 1321-7.
30. Park Y, Kim SH, Matalon S, Wang N-HL, Franses EI. Effect of phosphate salts concentrations, supporting electrolytes, and calcium phosphate salt precipitation on the pH of phosphate buffer solutions. Fluid Phase Equilib 2009;278:76-84.