Effects of leucine supplementation and resistance exercise on dexamethasone-induced muscle atrophy and insulin resistance in rats

Nutrition

Volumn 28, Issue 4, 2012, Pages 465-471

  Nicastro, Humberto ^a   Zanchi, Nelo E ^a   Da Luz, Claudia R ^a   De Moraes, Wilson M A M ^a   Ramona, Pamella ^a   De Siqueira Filho, Mario A ^a   Chaves, Daniela F S ^a   Medeiros, Alessandra ^a,b   Brum, Patrícia C ^a   Dardevet, Dominique ^c,d   Lancha, Antonio H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c INRA and University of Auvergne   (France)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Branched chain amino acids; Glucocorticoid; Glucose transporter 4; Mammalian target of rapamycin; Muscle wasting

Indexed keywords

DEXAMETHASONE; DRINKING WATER; GLUCOSE; GLUCOSE TRANSPORTER 4; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOPROTEIN; S6 KINASE; SERINE; THREONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIET SUPPLEMENTATION; FAST MUSCLE; FEEDING; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE STRENGTH; NONHUMAN; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT; RESISTANCE TRAINING;

ANIMALS; BLOOD GLUCOSE; DEXAMETHASONE; DIETARY SUPPLEMENTS; GLUCOSE TRANSPORTER TYPE 4; HYPERGLYCEMIA; INSULIN RESISTANCE; LEUCINE; MALE; MOVEMENT; MUSCLE STRENGTH; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; RATS; RATS, WISTAR; RESISTANCE TRAINING; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

MAMMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84858293594     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2011.08.008     Document Type: Article

References (48)

1. Nicastro H., Artioli G.G., Costa Ados S., Solis M.Y., da Luz C.R., Blachier F., Lancha A.H. An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids 2011, 40:287-300.
2. Zanchi N.E., Nicastro H., Lancha A.H. Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies. Nutr Metab (Lond) 2008, 5:20.
3. Baptista I.L., Leal M.L., Artioli G.G., Aoki M.S., Fiamoncini J., Turri A.O., et al. Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases. Muscle Nerve 2010, 41:800-808.
4. Marzani B., Balage M., Venien A., Astruc T., Papet I., Dardevet D., Mosoni L. Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats. J Nutr 2008, 138:2205-2211.
5. Rieu I., Balage M., Sornet C., Debras E., Ripes S., Rochon-Bonhomme C., Pouyet C., et al. Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats. Nutrition 2007, 23:323-331.
6. Combaret L., Dardevet D., Rieu I., Pouch M.N., Bechet D., Taillandier D., et al. A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle. J Physiol 2005, 569:489-499.
7. De Bandt J.P., Cynober L. Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr 2006, 136:308S-313S.
8. da Silva P.M., Zoppi C.C., Filiputti E., Silveira L.R., Quesada I., Boschero A.C., Carneiro E.M. Preliminary report: leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats. Metabolism 2010, 59:911-913.
9. Filiputti E., Rafacho A., Araujo E.P., Silveira L.R., Trevisan A., Batista T.M., et al. Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway. Metabolism 2010, 59:635-644.
10. Little J.P., Phillips S.M. Resistance exercise and nutrition to counteract muscle wasting. Appl Physiol Nutr Metab 2009, 34:817-828.
11. Phillips S.M. Physiologic and molecular bases of muscle hypertrophy and atrophy: impact of resistance exercise on human skeletal muscle (protein and exercise dose effects). Appl Physiol Nutr Metab 2009, 34:403-410.
12. Linderman J.K., Gosselink K.L., Booth F.W., Mukku V.R., Grindeland R.E. Resistance exercise and growth hormone as countermeasures for skeletal muscle atrophy in hindlimb-suspended rats. Am J Physiol Regul Integr Comp Physiol 1994, 267:R365-R371.
13. Adams G.R., Haddad F., Bodell P.W., Tran P.D., Baldwin K.M. Combined isometric, concentric, and eccentric resistance exercise prevents unloading-induced muscle atrophy in rats. J Appl Physiol 2007, 103:1644-1654.
14. Haddad F., Adams G.R., Bodell P.W., Baldwin K.M. Isometric resistance exercise fails to counteract skeletal muscle atrophy processes during the initial stages of unloading. J Appl Physiol 2006, 100:433-441.
15. Dupont-Versteegden E.E., Fluckey J.D., Knox M., Gaddy D., Peterson C.A. Effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats. J Appl Physiol 2006, 101:202-212.
16. Fluckey J.D., Dupont-Versteegden E.E., Montague D.C., Knox M., Tesch P., Peterson C.A., Gaddy-Kurten D. A rat resistance exercise regimen attenuates losses of musculoskeletal mass during hindlimb suspension. Acta Physiol Scand 2002, 176:293-300.
17. Gualano B., Ugrinowitsch C., Neves M., Lima F.R., Pinto A.L., Laurentino G., et al. Vascular occlusion training for inclusion body myositis: a novel therapeutic approach. J Vis Exp 2010, 5:1894.
18. Pereira L.O., Lancha A.H. Effect of insulin and contraction up on glucose transport in skeletal muscle. Prog Biophys Mol Biol 2004, 84:1-27.
19. Gualano B., de Salles Painneli V., Roschel H., Artioli G.G., Junior M.N., Lucia de Sa Pinto A., et al. Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Med Sci Sports Exerc 2011, 43:770-778.
20. Zanchi N.E., Filho M.A., Felitti V., Nicastro H., Lorenzeti F.M., Lancha A.H. Glucocorticoids: extensive physiological actions modulated through multiple mechanisms of gene regulation. J Cell Physiol 2010, 224:311-315.
21. Bernal-Mizrachi C., Weng S., Feng C., Finck B.N., Knutsen R.H., Leone T.C., et al. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med 2003, 9:1069-1075.
22. Giorgino F., Almahfouz A., Goodyear L.J., Smith R.J. Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo. J Clin Invest 1993, 91:2020-2030.
23. Clarke B.A., Drujan D., Willis M.S., Murphy L.O., Corpina R.A., Burova E., et al. The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metab 2007, 6:376-385.
24. Gilson H., Schakman O., Combaret L., Lause P., Grobet L., Attaix D., et al. Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology 2007, 148:452-460.
25. Hasselgren P.O. Glucocorticoids and muscle catabolism. Curr Opin Clin Nutr Metab Care 1999, 2:201-205.
26. Waddell D.S., Baehr L.M., van den Brandt J., Johnsen S.A., Reichardt H.M., Furlow J.D., Bodine S.C. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am J Physiol Endocrinol Metab 2008, 295:E785-E797.
27. Falduto M.T., Czerwinski S.M., Hickson R.C. Glucocorticoid-induced muscle atrophy prevention by exercise in fast-twitch fibers. J Appl Physiol 1990, 69:1058-1062.
28. Nicastro H., Gualano B., de Moraes W.M.A.M., de Salles Painelli V., da Luz C.R., dos Santos Costa A., et al. Effects of creatine supplementation on muscle wasting and glucose homeostasis in rats treated with high dose of dexamethasone. Amino Acids 2011, (in press).
29. Crozier S.J., Kimball S.R., Emmert S.W., Anthony J.C., Jefferson L.S. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 2005, 135:376-382.
30. Wirth O., Gregory E.W., Cutlip R.G., Miller G.R. Control and quantitation of voluntary weight-lifting performance of rats. J Appl Physiol 2003, 95:402-412.
31. Zanchi N.E., Lira F.S., Seelaender M., Lancha A.H. Experimental chronic low-frequency resistance training produces skeletal muscle hypertrophy in the absence of muscle damage and metabolic stress markers. Cell Biochem Funct 2010, 28:232-238.
32. Zanchi N.E., Lira F.S., de Siqueira Filho M.A., Rosa J.C., de Oliveira Carvalho C.R., Seelaender M., et al. Chronic low frequency/low volume resistance training reduces pro-inflammatory cytokine protein levels and TLR4 mRNA in rat skeletal muscle. Eur J Appl Physiol 2010, 109:1095-1102.
33. Lira F.S., Koyama C.H., Yamashita A.S., Rosa J.C., Zanchi N.E., Batista M.L., Seelaender M.C. Chronic exercise decreases cytokine production in healthy rat skeletal muscle. Cell Biochem Funct 2009, 27:458-461.
34. Fry A.C. The role of resistance exercise intensity on muscle fibre adaptations. Sports Med 2004, 34:663-679.
35. Kauvar D.S., Baer D.G., Walters T.J. Influence of systemic hypotension on skeletal muscle ischemia-reperfusion injury after 4-hour tourniquet application. J Surg Educ 2007, 64:273-277.
36. Adami G.F., Cordera R., Andraghetti G., Camerini G.B., Marinari G.M., Scopinaro N. Changes in serum ghrelin concentration following biliopancreatic diversion for obesity. Obes Res 2004, 12:684-687.
37. de Salles Painelli V., Gualano B., Artioli G.G., de Sa Pinto A.L., Bonfa E., Lancha Junior A.H., Lima F.R. The possible role of physical exercise on the treatment of idiopathic inflammatory myopathies. Autoimmun Rev 2009, 8:355-359.
38. Kennedy J.W., Hirshman M.F., Gervino E.V., Ocel J.V., Forse R.A., Hoenig S.J., et al. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes 1999, 48:1192-1197.
39. Thorell A., Hirshman M.F., Nygren J., Jorfeldt L., Wojtaszewski J.F., Dufresne S.D., et al. Exercise and insulin cause GLUT-4 translocation in human skeletal muscle. Am J Physiol Endocrinol Metab 1999, 277:E733-E741.
40. Terzis G., Spengos K., Mascher H., Georgiadis G., Manta P., Blomstrand E. The degree of p70 S6k and S6 phosphorylation in human skeletal muscle in response to resistance exercise depends on the training volume. Eur J Appl Physiol 2010, 110:835-843.
41. Zanchi N.E., Lancha A.H. Mechanical stimuli of skeletal muscle: implications on mTOR/p70s6k and protein synthesis. Eur J Appl Physiol 2008, 102:253-263.
42. Terzis G., Georgiadis G., Stratakos G., Vogiatzis I., Kavouras S., Manta P., et al. Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects. Eur J Appl Physiol 2008, 102:145-152.
43. Apro W., Blomstrand E. Influence of supplementation with branched-chain amino acids in combination with resistance exercise on p70S6 kinase phosphorylation in resting and exercising human skeletal muscle. Acta Physiol (Oxf) 2010, 200:237-248.
44. Pellegrino M.A., D'Antona G., Bortolotto S., Boschi F., Pastoris O., Bottinelli R., et al. Clenbuterol antagonizes glucocorticoid-induced atrophy and fibre type transformation in mice. Exp Physiol 2004, 89:89-100.
45. Nicastro H., Artioli G.G., Dos Santos Costa A., Solis M.Y., da Luz C.R., Blachier F., Lancha A.H. An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids 2011, 40:287-300.
46. Rieu I., Balage M., Sornet C., Giraudet C., Pujos E., Grizard J., et al. Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 2006, 575:305-315.
47. Dardevet D., Rieu I., Fafournoux P., Sornet C., Combaret L., Bruhat A., et al. Leucine: a key amino acid in ageing-associated sarcopenia?. Nutr Res Rev 2003, 16:61-70.
48. Balage M., Dupont J., Mothe-Satney I., Tesseraud S., Mosoni L., Dardevet D. Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. J Nutr Biochem 2010, 22:219-226.