Coronary pressure-flow relations as basis for the understanding of coronary physiology

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 4, 2012, Pages 786-793

  van de Hoef, Tim P ^a   Nolte, Froukje ^a   Rolandi, M Cristina ^a   Piek, Jan J ^a   van den Wijngaard, Jeroen P H M ^a   Spaan, Jos A E ^a   Siebes, Maria ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Coronary blood flow; Coronary flow reserve; Fractional flow reserve; Functional stenosis severity; Microvascular resistance; Myocardial perfusion; Pressure flow relation

Indexed keywords

AUTOREGULATION; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; CORONARY FLOW RESERVE; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; FLOW MEASUREMENT; FLOW RATE; FRACTIONAL FLOW RESERVE; HEART FUNCTION; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HEMODYNAMICS; HUMAN; OXYGEN TENSION; PERFUSION WEIGHTED IMAGING; PRESSURE GRADIENT; PRIORITY JOURNAL; REVIEW;

BLOOD FLOW VELOCITY; CORONARY CIRCULATION; CORONARY STENOSIS; HEMODYNAMICS; HUMANS;

EID: 84858288249     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.07.025     Document Type: Review

References (85)

1. Tune J.D., Gorman M.W., Feigl E.O. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 2004, 97:404-415.
2. Restorff W.V., Holtz J., Bassenge E. Exercise induced augmentation of myocardial oxygen extraction in spite of normal coronary dilatory capacity in dogs. Pflugers Arch Eur J Phys 1977, 372:181-185.
3. Komaru T., Kanatsuka H., Shirato K. Coronary microcirculation - physiology and pharmacology. Pharmacol Ther 2000, 86:217-261.
4. Bassenge E., Heusch G. Endothelial and neuro-humoral control of coronary blood flow in health and disease. Rev Physiol Biochem Pharmacol 1990, 116:77-7165.
5. Scaramucci G.B. De motu cordis. Theoremata familiaria viros eruditos consulentia, de variis physico-medicis lucubrationibus juxta leges mecanicas 1695, 70-81. Apud Joannem Baptistam Bustum, Urbino, Italy.
6. Knaapen P., Camici P.G., Marques K.M., Nijveldt R., Bax J.J., Westerhof N., et al. Coronary microvascular resistance: methods for its quantification in humans. Basic Res Cardiol 2009, 104:485-498.
7. Plein S., Kozerke S., Suerder D., Luescher T.F., Greenwood J.P., Boesiger P., et al. High spatial resolution myocardial perfusion cardiac magnetic resonance for the detection of coronary artery disease. Eur Heart J 2008, 29:2148-2155.
8. Mosher P., Ross J., McFate P.A., Shaw R.F. Control of coronary blood flow by an autoregulatory mechanism. Circ Res 1964, 14:250-259.
9. 2 consumption and arterial pressure as independent determinants of coronary flow. Am J Physiol 1987, 252:H545-H553.
10. Drake-Holland A.J., Laird J.D., Noble M.I., Spaan J.A., Vergroesen I. Oxygen and coronary vascular resistance during autoregulation and metabolic vasodilation in the dog. J Physiol 1984, 348:285-299.
11. Feigl E.O., Neat G.W., Huang A.H. Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow. J Mol Cell Cardiol 1990, 22:375-390.
12. Tune J.D., Richmond K.N., Gorman M.W., Olsson R.A., Feigl E.O. Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise. Am J Physiol Heart Circ Physiol 2000, 278:H74-H84.
13. Duncker D., de Beer V., Merkus D. Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarction. Med Biol Eng Comput 2008, 46:485-497.
14. Vergroesen I., Kal J.E., Spaan J.A., Van Wezel H.B. Myocardial oxygen supply: demand ratio as reference for coronary vasodilatory drug effects in humans. Heart 1997, 78:117-126.
15. Cornelissen A.J.M., Dankelman J., VanBavel E., Spaan J.A.E. Balance between myogenic, flow-dependent, and metabolic flow control in coronary arterial tree: a model study. Am J Physiol Heart Circ Physiol 2002, 282:H2224-H2237.
16. Jones C.J., Kuo L., Davis M.J., Chilian W.M. Regulation of coronary blood flow: coordination of heterogeneous control mechanisms in vascular microdomains. Cardiovasc Res 1995, 29:585-596.
17. Jones C.J., Kuo L., Davis M.J., Chilian W.M. In vivo and in vitro vasoactive reactions of coronary arteriolar microvessels to nitroglycerin. Am J Physiol Heart Circ Physiol 1996, 271:H461-H468.
18. Siebes M. Intracoronary doppler-based techniques for stenosis appraisal. Coronary stenosis imaging, structure and physiology 2010, 377-400. PCR Publishing, Toulouse. J. Escaned, P.W. Serruys (Eds.).
19. Siebes M., Verhoeff B.J., Meuwissen M., de Winter R.J., Spaan J.A., Piek J.J. Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions. Circulation 2004, 109:756-762.
20. Smith S.C., Feldman T.E., Hirshfeld J.W., Jacobs A.K., Kern M.J., King S.B., et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (ACC/AHA/SCAI writing committee to update the 2001 guidelines for percutaneous coronary intervention). J Am Coll Cardiol 2006, 47:e1-e121.
21. Wijns W., Kolh P., Danchin N., Di Mario C., Falk V., Folliguet T., et al. Guidelines on myocardial revascularization: The task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2010, 31:2501-2555.
22. Heusch G. Adenosine and maximum coronary vasodilation in humans: myth and misconceptions in the assessment of coronary reserve. Basic Res Cardiol 2010, 105:1-5.
23. Gould K.L. Quantification of coronary artery stenosis in vivo. Circ Res 1985, 57:341-353.
24. Hoffman J.I.E. Maximal coronary flow and the concept of coronary vascular reserve. Circulation 1984, 70:153-159.
25. Kern M.J., Bach R.G., Mechem C.J., Caracciolo E.A., Aguirre F.V., Miller L.W., et al. Variations in normal coronary vasodilatory reserve stratified by artery, gender, heart transplantation and coronary artery disease. J Am Coll Cardiol 1996, 28:1154-1160.
26. Kern M.J., Lerman A., Bech J.W., De Bruyne B., Eeckhout E., Fearon W.F., et al. Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation 2006, 114:1321-1341.
27. Hoffman J.I.E. Problems of coronary flow reserve. Ann Biomed Eng 2000, 28:884-896.
28. Uren N.G., Camici P.G., Melin J.A., Bol A., de Bruyne B., Radvan J., et al. Effect of aging on myocardial perfusion reserve. J Nucl Med 1995, 36:2032-2036.
29. Rajappan K., Rimoldi O.E., Dutka D.P., Ariff B., Pennell D.J., Sheridan D.J., et al. Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries. Circulation 2002, 105:470-476.
30. Baumgart D., Haude M., Goerge G., Ge J., Vetter S., Dagres N., et al. Improved assessment of coronary stenosis severity using the relative flow velocity reserve. Circulation 1998, 98:40-46.
31. Ince C., Ashruf J.F., Avontuur J.A., Wieringa P.A., Spaan J.A., Bruining H.A. Heterogeneity of the hypoxic state in rat heart is determined at capillary level. Am J Physiol 1993, 264:H294-H301.
32. Austin R.E., Aldea G.S., Coggins D.L., Flynn A.E., Hoffman J.I. Profound spatial heterogeneity of coronary reserve. Discordance between patterns of resting and maximal myocardial blood flow. Circ Res 1990, 67:319-331.
33. Hoffman J.I. Heterogeneity of myocardial blood flow. Basic Res Cardiol 1995, 90:103-111.
34. Young D.F., Cholvin N.R., Kirkeeide R.L., Roth A.C. Hemodynamics of arterial stenoses at elevated flow rates. Circ Res 1977, 41:99-107.
35. Pijls N.H.J., van Son J.A., Kirkeeide R.L., de Bruyne B., Gould K.L. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. Circulation 1993, 87:1354-1367.
36. Hanley F.L., Messina L.M., Grattan M.T., Hoffman J.I.E. The effect of coronary inflow pressure on coronary vascular resistance in the isolated dog heart. Circ Res 1984, 54:760-772.
37. Marcus M., Chilian W., Kanatsuka H., Dellsperger K., Eastham C., Lamping K. Understanding the coronary circulation through studies at the microvascular level. Circulation 1990, 82:1-7.
38. Spaan J.A., Piek J.J., Hoffman J.I., Siebes M. Physiological basis of clinically used coronary hemodynamic indices. Circulation 2006, 113:446-455.
39. Claessens T.E., Van Herck P.L., Matthys K.S., Segers P., Vrints C.J., Verdonck P.R. Influence of zero flow pressure on fractional flow reserve. Biomech Model Mechanobiol 2004, 3:48-55.
40. Fokkema D.S., VanTeeffelen J.W., Dekker S., Vergroesen I., Reitsma J.B., Spaan J.A. Diastolic time fraction as a determinant of subendocardial perfusion. Am J Physiol Heart Circ Physiol 2005, 288:H2450-H2456.
41. Siebes M., Chamuleau S.A., Meuwissen M., Piek J.J., Spaan J.A. Influence of hemodynamic conditions on fractional flow reserve: parametric analysis of underlying model. Am J Physiol Heart Circ Physiol 2002, 283:H1462-H1470.
42. van den Wijngaard J.P., Kolyva C., Siebes M., Dankelman J., van Gemert M.J., Piek J.J., et al. Model prediction of subendocardial perfusion of the coronary circulation in the presence of an epicardial coronary artery stenosis. Med Biol Eng Comput 2008, 46:421-432.
43. de Bruyne B., Bartunek J., Sys S.U., Pijls N.H., Heyndrickx G.R., Wijns W. Simultaneous coronary pressure and flow velocity measurements in humans. Feasibility, reproducibility, and hemodynamic dependence of coronary flow velocity reserve, hyperemic flow versus pressure slope index, and fractional flow reserve. Circulation 1996, 94:1842-1849.
44. Meuwissen M., Siebes M., Chamuleau S.A.J., Verhoeff B.-J., Henriques J.P.S., Spaan J.A.E., et al. Role of fractional and coronary flow reserve in clinical decision making in intermediate coronary lesions. Interv Cardiol 2009, 1:237-255.
45. Meuwissen M., Chamuleau S.A.J., Siebes M., Schotborgh C.E., Koch K.T., de Winter R.J., et al. Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions. Circulation 2001, 103:184-187.
46. Meuwissen M., Siebes M., Chamuleau S.A., van Eck-Smit B.L., Koch K.T., de Winter R.J., et al. Hyperemic stenosis resistance index for evaluation of functional coronary lesion severity. Circulation 2002, 106:441-446.
47. Meuwissen M., Chamuleau S.A., Siebes M., de Winter R.J., Koch K.T., Dijksman L.M., et al. The prognostic value of combined intracoronary pressure and blood flow velocity measurements after deferral of percutaneous coronary intervention. Catheter Cardiovasc Interv 2008, 71:291-297.
48. Topol E.J., Nissen S.E. Our preoccupation with coronary luminology. The dissociation between clinical and angiographic findings in ischemic heart disease. Circulation 1995, 92:2333-2342.
49. Tonino P.A., Fearon W.F., De Bruyne B., Oldroyd K.G., Leesar M.A., Ver Lee P.N., et al. Angiographic versus functional severity of coronary artery stenoses in the fame study: fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol 2010, 55:2816-2821.
50. Manka R., Vitanis V., Boesiger P., Flammer A.J., Plein S., Kozerke S. Clinical feasibility of accelerated, high spatial resolution myocardial perfusion imaging. JACC Cardiovasc Imaging 2010, 3:710-717.
51. Lockie T., Ishida M., Perera D., Chiribiri A., De Silva K., Kozerke S., et al. High-resolution magnetic resonance myocardial perfusion imaging at 3.0-tesla to detect hemodynamically significant coronary stenoses as determined by fractional flow reserve. J Am Coll Cardiol 2011, 57:70-75.
52. Algranati D., Kassab G.S., Lanir Y. Why is the subendocardium more vulnerable to ischemia? A new paradigm. Am J Physiol Heart Circ Physiol 2011, 300:H1090-H1100.
53. Bache R.J., Cobb F.R. Effect of maximal coronary vasodilation on transmural myocardial perfusion during tachycardia in the awake dog. Circ Res 1977, 41:648-653.
54. Hoffman J.I. Transmural myocardial perfusion. Prog Cardiovasc Dis 1987, 29:429-464.
55. Hoffman J.I., Spaan J.A. Pressure-flow relations in coronary circulation. Physiol Rev 1990, 70:331-390.
56. Kaneko N., Matsuda R., Toda M., Shimamoto K. Three-dimensional reconstruction of the human capillary network and the intramyocardial micronecrosis. Am J Physiol Heart Circ Physiol 2011, 300:H754-H761.
57. Spaan J.A., ter Wee R., van Teeffelen J.W., Streekstra G., Siebes M., Kolyva C., et al. Visualisation of intramural coronary vasculature by an imaging cryomicrotome suggests compartmentalisation of myocardial perfusion areas. Med Biol Eng Comput 2005, 43:431-435.
58. Wusten B., Buss D.D., Deist H., Schaper W. Dilatory capacity of the coronary circulation and its correlation to the arterial vasculature in the canine left ventricle. Basic Res Cardiol 1977, 72:636-650.
59. Spaan J.A.E. Coronary blood flow. Mechanics, distribution, and control 1991, Kluwer, Dordrecht.
60. Chilian W. Microvascular pressures and resistances in the left ventricular subepicardium and subendocardium. Circ Res 1991, 69:561-570.
61. Kajiya F., Tsujioka K., Goto M., Wada Y., Chen X.L., Nakai M., et al. Functional characteristics of intramyocardial capacitance vessels during diastole in the dog. Circ Res 1986, 58:476-485.
62. Hiramatsu O., Goto M., Yada T., Kimura A., Chiba Y., Tachibana H., et al. In vivo observations of the intramural arterioles and venules in beating canine hearts. J Physiol (Lond) 1998, 509:619-628.
63. Yada T., Hiramatsu O., Kimura A., Tachibana H., Chiba Y., Lu S., et al. Direct in vivo observation of subendocardial arteriolar response during reactive hyperemia. Circ Res 1995, 77:622-631.
64. Spaan J.A., Breuls N.P., Laird J.D. Diastolic-systolic coronary flow differences are caused by intramyocardial pump action in the anesthetized dog. Circ Res 1981, 49:584-593.
65. Spaan J.A.E. Mechanical determinants of myocardial perfusion. Basic Res Cardiol 1995, 90:89-102.
66. Westerhof N., Boer C., Lamberts R.R., Sipkema P. Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev 2006, 86:1263-1308.
67. Krams R., Sipkema P., Zegers J., Westerhof N. Contractility is the main determinant of coronary systolic flow impediment. Am J Physiol 1989, 257:H1936-H1944.
68. Van Winkle D.M., Swafford A.N., Downey J.M. Subendocardial coronary compression in beating dog hearts is independent of pressure in the ventricular lumen. Am J Physiol 1991, 261:H500-H505.
69. Krams R., Sipkema P., Westerhof N. Varying elastance concept may explain coronary systolic flow impediment. Am J Physiol 1989, 257:H1471-H1479.
70. Algranati D., Kassab G.S., Lanir Y. Mechanisms of myocardium-coronary vessel interaction. Am J Physiol Heart Circ Physiol 2010, 298:H861-H873.
71. Merkus D., Kajiya F., Vink H., Vergroesen I., Dankelman J., Goto M., et al. Prolonged diastolic time fraction protects myocardial perfusion when coronary blood flow is reduced. Circulation 1999, 100:75-81.
72. Hautvast G.L.T.F., Chiribiri A., Lockie T., Breeuwer M., Nagel E., Plein S. Quantitative analysis of transmural gradients in myocardial perfusion magnetic resonance images. Magn Reson Med 2011, 66:1477-1487.
73. Karamitsos T.D., Leccisotti L., Arnold J.R., Recio-Mayoral A., Bhamra-Ariza P., Howells R.K., et al. Relationship between regional myocardial oxygenation and perfusion in patients with coronary artery disease: insights from cardiovascular magnetic resonance and positron emission tomography. Circ Cardiovasc Imaging 2010, 3:32-40.
74. Downey J.M., Kirk E.S. Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ Res 1975, 36:753-760.
75. Verhoeff B.J., Siebes M., Meuwissen M., Atasever B., Voskuil M., de Winter R.J., et al. Influence of percutaneous coronary intervention on coronary microvascular resistance index. Circulation 2005, 111:76-82.
76. Gregg D.E., Green H.D. Registration and interpretation of normal phasic inflow into a left coronary artery by an improved differential manometric method. Am J Physiol 1940, 130:114-125.
77. Bellamy R.F. Diastolic coronary artery pressure-flow relations in the dog. Circ Res 1978, 43:92-101.
78. Klocke F.J., Mates R.E., Canty J.M., Ellis A.K. Coronary pressure-flow relationships. Controversial issues and probable implications. Circ Res 1985, 56:310-323.
79. Spaan J.A. Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance. Circ Res 1985, 56:293-309.
80. Chilian W.M., Marcus M.L. Coronary venous outflow persists after cessation of coronary arterial inflow. Am J Physiol 1984, 247:H984-H990.
81. Messina L.M., Hanley F.L., Uhlig P.N., Baer R.W., Grattan M.T., Hoffman J.I. Effects of pressure gradients between branches of the left coronary artery on the pressure axis intercept and the shape of steady state circumflex pressure-flow relations in dogs. Circ Res 1985, 56:11-19.
82. van den Wijngaard J.P., Schulten H., van Horssen P., ter Wee R.D., Siebes M., Post M.J., et al. Porcine coronary collateral formation in the absence of a pressure gradient remote of the ischemic border zone. Am J Physiol Heart Circ Physiol 2011, 5:H1930-H1937.
83. Sezer M., Nisanci Y., Umman B., Yilmaz E., Erzengin F., Ozsaruhan O. Relationship between collateral blood flow and microvascular perfusion after reperfused acute myocardial infarction. Jpn Heart J 2003, 44:855-863.
84. Piek J.J., van Liebergen R.A., Koch K.T., Peters R.J., David G.K. Clinical, angiographic and hemodynamic predictors of recruitable collateral flow assessed during balloon angioplasty coronary occlusion. J Am Coll Cardiol 1997, 29:275-282.
85. van Liebergen R.A., Piek J.J., Koch K.T., de Winter R.J., Schotborgh C.E., Lie K.I. Quantification of collateral flow in humans: a comparison of angiographic, electrocardiographic and hemodynamic variables. J Am Coll Cardiol 1999, 33:670-677.