The Effect of Pharmacotherapy on Suicide Rates in Bipolar Patients

CNS Neuroscience and Therapeutics

Volumn 18, Issue 3, 2012, Pages 238-242

  Rihmer, Zoltan ^a   Gonda, Xenia ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Affective disorder; Antidepressants; Antipsychotics; Bipolar disorder; Lithium; Suicide

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; CARBAMAZEPINE; CLOZAPINE; GABAPENTIN; LAMOTRIGINE; LITHIUM; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RISPERIDONE; SERTINDOLE; TOPIRAMATE; VALPROATE SEMISODIUM; VALPROIC ACID;

BIPOLAR DEPRESSION; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; COGNITIVE THERAPY; DRUG EFFICACY; FOLLOW UP; HOSPITALIZATION; HUMAN; LIFESTYLE MODIFICATION; LONG TERM CARE; MAJOR DEPRESSION; MANIA; MENTAL PATIENT; PSYCHOPHARMACOTHERAPY; REVIEW; RISK FACTOR; SCHIZOPHRENIA; SUICIDAL BEHAVIOR; SUICIDAL IDEATION; SUICIDE ATTEMPT; TREATMENT OUTCOME;

ANTIDEPRESSIVE AGENTS; BIPOLAR DISORDER; HUMANS; LITHIUM; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; SUICIDE, ATTEMPTED;

EID: 84858286920     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2011.00261.x     Document Type: Review

References (40)

1. Rihmer Z. Suicide risk in mood disorders. Curr Opin Psychiatry 2007;20:17-22.
2. Rihmer Z. Prediction and prevention of suicide in bipolar disorders. Clin Neuropsychiatry 2005;2:48-54.
3. Akiskal H. Targeting suicide prevention to modifiable risk factors: Has bipolar II been overlooked? Acta Psychiatr Scand 2007;116:395-402.
4. Tondo L, Lepri B, Baldessarini RJ. Suicidal risks among 2826 Sardinian major affective disorder patients. Acta Psychiatr Scand 2007;116:419-428.
5. Valtonen HM, Suominen K, Haukka J, Mantere O, Leppamaki S, Arvilommi P, Isometsa ET. Differences in incidence of suicide attempts during phases of bipolar I and II disorders. Bipolar Disord 2008;10:588-596.
6. Tondo L, Lepri B, Baldessarini RJ. Suicidal status during antidepressant treatment in 789 Sardinian patients with major affective disorder. Acta Psychiatr Scand 2008;118:106-115.
7. Tondo L, Baldessarini RJ, Hennen J, et al. Suicide attempts in major affective disorder patients with comorbid substance use disorders. J Clin Psychiatry 1999;60(Suppl 2):63-69; discussion 75-6, 113-6.
8. Isometsa ET, Henriksson MM, Aro HM, Lonnqvist JK. Suicide in bipolar disorder in Finland. Am J Psychiatry 1994;151:1020-1024.
9. Bowden CL. Pharmacological treatment of bipolar disorder: A review. In: Maj M, Akiskal HS, Lopez-Ibor J, Sartorius N, editors. Bipolar Disorder. Chichester: John Wiley and Sons, 2002;191-221.
10. Goodwin FK. Anticonvulsant therapy and suicide risk in affective disorders. J Clin Psychiatry 1999;60(Suppl 2):89-93; discussion 111-6.
11. Goodwin FK, Jamison KR. Manic-depressive illness. New York: Oxford University Press, 1990.
12. Henry C, Sorbara F, Lacoste J, Gindre C, Leboyer M. Antidepressant-induced mania in bipolar patients: Identification of risk factors. J Clin Psychiatry 2001;62:249-255.
13. Mundo E, Cattaneo E, Russo M, Altamura AC. Clinical variables related to antidepressant-induced mania in bipolar disorder. J Affect Disord 2006;92:227-230.
14. Baldessarini RJ, Tondo L, Davis P, Pompili M, Goodwin FK, Hennen J. Decreased risk of suicides and attempts during long-term lithium treatment: A meta-analytic review. Bipolar Disord 2006;8:625-639.
15. Ahrens B, Muller-Oerlinghausen B. Does lithium exert an independent antisuicidal effect? Pharmacopsychiatry 2001;34:132-136.
16. Guzzetta F, Tondo L, Centorrino F, Baldessarini RJ. Lithium treatment reduces suicide risk in recurrent major depressive disorder. J Clin Psychiatry 2007;68:380-383.
17. Lauterbach E, Felber W, Muller-Oerlinghausen B, et al. Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: A randomised, placebo-controlled, 1-year trial. Acta Psychiatr Scand 2008;118:469-479.
18. Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N. Lithium levels in drinking water and risk of suicide. Br J Psychiatry 2009;194:464-465; discussion 46.
19. Angst F, Stassen HH, Clayton PJ, Angst J. Mortality of patients with mood disorders: Follow-up over 34-38 years. J Affect Disord 2002;68:167-181.
20. Thies-Flechtner K, Muller-Oerlinghausen B, Seibert W, Walther A, Greil W. Effect of prophylactic treatment on suicide risk in patients with major affective disorders. Data from a randomized prospective trial. Pharmacopsychiatry 1996;29:103-107.
21. Yerevanian BI, Koek RJ, Mintz J. Lithium, anticonvulsants and suicidal behavior in bipolar disorder. J Affect Disord 2003;73:223-228.
22. Yerevanian BI, Koek RJ, Mintz J. Bipolar pharmacotherapy and suicidal behavior. Part I: Lithium, divalproex and carbamazepine. J Affect Disord 2007;103:5-11.
23. Goodwin FK, Fireman B, Simon GE, Hunkeler EM, Lee J, Revicki D. Suicide risk in bipolar disorder during treatment with lithium and divalproex. JAMA 2003;290:1467-1473.
24. Sondergard L, Lopez AG, Andersen PK, Kessing LV. Mood-stabilizing pharmacological treatment in bipolar disorders and risk of suicide. Bipolar Disord 2008;10:87-94.
25. Collins JC, McFarland BH. Divalproex, lithium and suicide among Medicaid patients with bipolar disorder. J Affect Disord 2008;107:23-28.
26. Marangell LB, Dennehy EB, Wisniewski SR, et al. Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: Findings from STEP-BD. J Clin Psychiatry 2008;69:916-922.
27. Rihmer Z, Gonda X, Tondo L. Lithium and suicidal behavior in patients with bipolar disorder. J Clin Psychiatry 2008;69:1831-1832.
28. Tohen M, Greil W, Calabrese JR, et al. Olanzapine versus lithium in the maintenance treatment of bipolar disorder: A 12-month, randomized, double-blind, controlled clinical trial. Am J Psychiatry 2005;162:1281-1290.
29. Yatham LN, Kennedy SH, Schaffer A, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: Update 2009. Bipolar Disord 2009;11:225-255.
30. Young AH, McElroy S, Chang W, Olausson B, Paulsson B, Brecher M. Placebo-controlled study with acute and continuation phase of quetiapine in adults with bipolar depression (EMBOLDEN I). Eur Neuropsychopharmacol 2008;18:S371.
31. Benazzi F. How could antidepressants worsen unipolar depression? Psychother Psychosom 2003;72:107-108; author reply 9.
32. Rihmer Z, Akiskal H. Do antidepressants t(h)reat(en) depressives? Toward a clinically judicious formulation of the antidepressant-suicidality FDA advisory in light of declining national suicide statistics from many countries. J Affect Disord 2006;94:3-13.
33. Yerevanian BI, Koek RJ, Mintz J. Bipolar pharmacotherapy and suicidal behavior Part 3: Impact of antipsychotics. J Affect Disord 2007;103:23-28.
34. Yerevanian BI, Koek RJ, Mintz J, Akiskal HS. Bipolar pharmacotherapy and suicidal behavior Part 2. The impact of antidepressants. J Affect Disord 2007;103:13-21.
35. Thomas SH, Drici MD, Hall GC, et al. Safety of sertindole versus risperidone in schizophrenia: Principal results of the sertindole cohort prospective study (SCoP). Acta Psychiatr Scand 2010;122:345-355.
36. Fountoulakis KN, Gonda X, Siamouli M, Rihmer Z. Psychotherapeutic intervention and suicide risk reduction in bipolar disorder: A review of the evidence. J Affect Disord 2009;113:21-29.
37. Bauer MS. Psychosocial interventions for bipolar disorder: A review. In: Maj M, Akiskal HS, Lopez-Ibor J, Sartorius N, editors. Bipolar Disorder. Chichester: John Wiley and Sons, 2002;281-313.
38. Colom F, Vieta E. Treatment adherence in bipolar patients. Clin Appr Bipol Disord 2002;1:49-56.
39. Lam DH, Watkins ER, Hayward P, et al. A randomized controlled study of cognitive therapy for relapse prevention for bipolar affective disorder: Outcome of the first year. Arch Gen Psychiatry 2003;60:145-152.
40. Rucci P, Frank E, Kostelnik B, et al. Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapy. Am J Psychiatry 2002;159:1160-1164.