Family-based association study of early growth response gene 3 with child bipolar i disorder

Journal of Affective Disorders

Volumn 138, Issue 3, 2012, Pages 387-396

  Gallitano, Amelia L ^a   Tillman, Rebecca ^b   Dinu, Valentin ^c   Geller, Barbara ^b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Child bipolar I disorder; Early growth response gene 3; Environment; Family Based Association Test; Immediate early gene; Stress

Indexed keywords

EARLY GROWTH RESPONSE FACTOR; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 2; EARLY GROWTH RESPONSE FACTOR 3; EARLY GROWTH RESPONSE FACTOR 4; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; BIPOLAR I DISORDER; CHILD; CLINICAL ARTICLE; FAMILY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; MALE; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; BIPOLAR DISORDER; CHILD; EARLY GROWTH RESPONSE PROTEIN 3; EARLY GROWTH RESPONSE TRANSCRIPTION FACTORS; FAMILY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84858285171     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.01.011     Document Type: Article

References (60)

1. J.C. Barrett, B. Fry, J. Maller, and M.J. Daly Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 2005 263 265 (Pubitemid 40202029)
2. H.R. Bird, G. Canino, M. Rubio-Stipec, and J.C. Ribera Further measures of the psychometric properties of the Children's Global Assessment Scale Archives of General Psychiatry 44 1987 821 824 (Pubitemid 17152884)
3. H.R. Bird, M.S. Gould, and B. Staghezza Aggregating data from multiple informants in child psychiatry epidemiological research Journal of the American Academy of Child and Adolescent Psychiatry 31 1992 78 85
4. P.F. Buckley, A. Pillai, and K.R. Howell Brain-derived neurotrophic factor: findings in schizophrenia Current Opinion in Psychiatry 24 2011 122 127
5. R.G. Fahmy, C.R. Dass, L.Q. Sun, C.N. Chesterman, and L.M. Khachigian Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth Nature Medicine 9 2003 1026 1032 (Pubitemid 37021782)
6. E.W. Fish, D. Shahrokh, R. Bagot, C. Caldji, T. Bredy, M. Szyf, and M.J. Meaney Epigenetic programming of stress responses through variations in maternal care Annals of the New York Academy of Sciences 1036 2004 167 180 (Pubitemid 40576094)
7. K.A. Frazer, D.G. Ballinger, D.R. Cox, D.A. Hinds, L.L. Stuve, R.A. Gibbs, J.W. Belmont, A. Boudreau, P. Hardenbol, S.M. Leal, S. Pasternak, D.A. Wheeler, T.D. Willis, F. Yu, H. Yang, C. Zeng, Y. Gao, H. Hu, W. Hu, C. Li, W. Lin, S. Liu, H. Pan, X. Tang, J. Wang, W. Wang, J. Yu, B. Zhang, Q. Zhang, H. Zhao, H. Zhao, J. Zhou, S.B. Gabriel, R. Barry, B. Blumenstiel, A. Camargo, M. Defelice, M. Faggart, M. Goyette, S. Gupta, J. Moore, H. Nguyen, R.C. Onofrio, M. Parkin, J. Roy, E. Stahl, E. Winchester, L. Ziaugra, D. Altshuler, Y. Shen, Z. Yao, W. Huang, X. Chu, Y. He, L. Jin, Y. Liu, Y. Shen, W. Sun, H. Wang, Y. Wang, Y. Wang, X. Xiong, L. Xu, M.M. Waye, S.K. Tsui, H. Xue, J.T. Wong, L.M. Galver, J.B. Fan, K. Gunderson, S.S. Murray, A.R. Oliphant, M.S. Chee, A. Montpetit, F. Chagnon, V. Ferretti, M. Leboeuf, J.F. Olivier, M.S. Phillips, S. Roumy, C. Sallee, A. Verner, T.J. Hudson, P.Y. Kwok, D. Cai, D.C. Koboldt, R.D. Miller, L. Pawlikowska, P. Taillon-Miller, M. Xiao, L.C. Tsui, W. Mak, Y.Q. Song, P.K. Tam, Y. Nakamura, T. Kawaguchi, T. Kitamoto, T. Morizono, A. Nagashima, Y. Ohnishi, A. Sekine, T. Tanaka, T. Tsunoda, P. Deloukas, C.P. Bird, M. Delgado, E.T. Dermitzakis, R. Gwilliam, S. Hunt, J. Morrison, D. Powell, B.E. Stranger, P. Whittaker, D.R. Bentley, M.J. Daly, P.I. de Bakker, J. Barrett, Y.R. Chretien, J. Maller, S. McCarroll, N. Patterson, I. Pe'er, A. Price, S. Purcell, D.J. Richter, P. Sabeti, R. Saxena, S.F. Schaffner, P.C. Sham, P. Varilly, D. Altshuler, L.D. Stein, L. Krishnan, A.V. Smith, M.K. Tello-Ruiz, G.A. Thorisson, A. Chakravarti, P.E. Chen, D.J. Cutler, C.S. Kashuk, S. Lin, G.R. Abecasis, W. Guan, Y. Li, H.M. Munro, Z.S. Qin, D.J. Thomas, G. McVean, A. Auton, L. Bottolo, N. Cardin, S. Eyheramendy, C. Freeman, J. Marchini, S. Myers, C. Spencer, M. Stephens, P. Donnelly, L.R. Cardon, G. Clarke, D.M. Evans, A.P. Morris, B.S. Weir, T. Tsunoda, J.C. Mullikin, S.T. Sherry, M. Feolo, A. Skol, H. Zhang, C. Zeng, H. Zhao, I. Matsuda, Y. Fukushima, D.R. Macer, E. Suda, C.N. Rotimi, C.A. Adebamowo, I. Ajayi, T. Aniagwu, P.A. Marshall, C. Nkwodimmah, C.D. Royal, M.F. Leppert, M. Dixon, A. Peiffer, R. Qiu, A. Kent, K. Kato, N. Niikawa, I.F. Adewole, B.M. Knoppers, M.W. Foster, E.W. Clayton, J. Watkin, R.A. Gibbs, J.W. Belmont, D. Muzny, L. Nazareth, E. Sodergren, G.M. Weinstock, D.A. Wheeler, I. Yakub, S.B. Gabriel, R.C. Onofrio, D.J. Richter, L. Ziaugra, B.W. Birren, M.J. Daly, D. Altshuler, R.K. Wilson, L.L. Fulton, J. Rogers, J. Burton, N.P. Carter, C.M. Clee, M. Griffiths, M.C. Jones, K. McLay, R.W. Plumb, M.T. Ross, S.K. Sims, D.L. Willey, Z. Chen, H. Han, L. Kang, M. Godbout, J.C. Wallenburg, P. L'Archeveque, G. Bellemare, K. Saeki, H. Wang, D. An, H. Fu, Q. Li, Z. Wang, R. Wang, A.L. Holden, L.D. Brooks, J.E. McEwen, M.S. Guyer, V.O. Wang, J.L. Peterson, M. Shi, J. Spiegel, L.M. Sung, L.F. Zacharia, F.S. Collins, K. Kennedy, R. Jamieson, and J. Stewart A second generation human haplotype map of over 3.1 million SNPs Nature 449 2007 851 861 (Pubitemid 47598626)
8. A. Gallitano-Mendel, Y. Izumi, K. Tokuda, C.F. Zorumski, M.P. Howell, L.J. Muglia, D.F. Wozniak, and J. Milbrandt The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty Neuroscience 148 2007 633 643 (Pubitemid 47418369)
9. B. Geller, M. Williams, B. Zimerman, and J. Frazier Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) 1996 Washington University St. Louis, MO
10. B. Geller, B. Zimerman, M. Williams, K. Bolhofner, J.L. Craney, M.P. DelBello, and C. Soutullo Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections Journal of the American Academy of Child and Adolescent Psychiatry 40 2001 450 455 (Pubitemid 32242529)
11. B. Geller, J.L. Craney, K. Bolhofner, M.J. Nickelsburg, M. Williams, and B. Zimerman Two-year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype The American Journal of Psychiatry 159 2002 927 933 (Pubitemid 34586936)
12. B. Geller, B. Zimerman, M. Williams, M.P. Delbello, K. Bolhofner, J.L. Craney, J. Frazier, L. Beringer, and M.J. Nickelsburg DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls Journal of Child and Adolescent Psychopharmacology 12 2002 11 25 (Pubitemid 34461530)
13. B. Geller, J.A. Badner, R. Tillman, S.L. Christian, K. Bolhofner, and E.H. Cook Jr. Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype The American Journal of Psychiatry 161 2004 1698 1700 (Pubitemid 39201469)
14. B. Geller, R. Tillman, J.L. Craney, and K. Bolhofner Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype Archives of General Psychiatry 61 2004 459 467 (Pubitemid 38620844)
15. B. Geller, R. Tillman, K. Bolhofner, B. Zimerman, N.A. Strauss, and P. Kaufmann Controlled, blindly rated, direct-interview family study of a prepubertal and early-adolescent bipolar I disorder phenotype: morbid risk, age at onset, and comorbidity Archives of General Psychiatry 63 2006 1130 1138 (Pubitemid 44498392)
16. B. Geller, R. Tillman, K. Bolhofner, and B. Zimerman Child bipolar I disorder: prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome Archives of General Psychiatry 65 2008 1125 1133
17. D.J. Gerber, D. Hall, T. Miyakawa, S. Demars, J.A. Gogos, M. Karayiorgou, and S. Tonegawa Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit Proceedings of the National Academy of Sciences of the United States of America 100 2003 8993 8998 (Pubitemid 36899211)
18. E.S. Gershon, N. Alliey-Rodriguez, and C. Liu After GWAS: searching for genetic risk for schizophrenia and bipolar disorder The American Journal of Psychiatry 168 2011 253 256
19. J. Gonzalez-Maeso, T. Yuen, B.J. Ebersole, E. Wurmbach, A. Lira, M. Zhou, N. Weisstaub, R. Hen, J.A. Gingrich, and S.C. Sealfon Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex Journal of Neuroscience 23 2003 8836 8843 (Pubitemid 37210895)
20. B.F. Grant, F.S. Stinson, D.S. Hasin, D.A. Dawson, S.P. Chou, W.J. Ruan, and B. Huang Prevalence, correlates, and comorbidity of bipolar I disorder and axis I and II disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions The Journal of Clinical Psychiatry 66 2005 1205 1215 (Pubitemid 41546498)
21. A.Y. Guo, J. Sun, P. Jia, and Z. Zhao A novel microRNA and transcription factor mediated regulatory network in schizophrenia BMC Systems Biology 4 2010 10
22. D.R. Hanson, and I.I. Gottesman Theories of schizophrenia: a genetic-inflammatory-vascular synthesis BMC Medical Genetics 6 2005 7
23. S. Hippenmeyer, N.A. Shneider, C. Birchmeier, S.J. Burden, T.M. Jessell, and S. Arber A role for neuregulin1 signaling in muscle spindle differentiation Neuron 36 2002 1035 1049 (Pubitemid 36044506)
24. K.R. Jessen, and R. Mirsky Signals that determine Schwann cell identity Journal of Anatomy 200 2002 367 376 (Pubitemid 34498531)
25. M.W. Jones, M.L. Errington, P.J. French, A. Fine, T.V. Bliss, S. Garel, P. Charnay, B. Bozon, S. Laroche, and S. Davis A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories Nature Neuroscience 4 2001 289 296 (Pubitemid 32194877)
26. A.L. Jones, B.J. Mowry, M.P. Pender, and J.M. Greer Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis? Immunology and Cell Biology 83 2005 9 17 (Pubitemid 40179396)
27. T. Kato Molecular genetics of bipolar disorder and depression Psychiatry and Clinical Neurosciences 61 2007 3 19 (Pubitemid 46089400)
28. S.H. Kim, J.Y. Song, E.J. Joo, K.Y. Lee, Y.M. Ahn, and Y.S. Kim EGR3 as a potential susceptibility gene for schizophrenia in Korea American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 153B 2010 1355 1360
29. C. Kyogoku, M. Yanagi, K. Nishimura, D. Sugiyama, A. Morinobu, M. Fukutake, K. Maeda, O. Shirakawa, T. Kuno, and S. Kumagai Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population Psychiatry Research 185 2011 16 19
30. N.M. Laird, and C. Lange Family-based designs in the age of large-scale gene-association studies Nature Reviews Genetics 7 2006 385 394
31. P. Lichtenstein, B.H. Yip, C. Bjork, Y. Pawitan, T.D. Cannon, P.F. Sullivan, and C.M. Hultman Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study Lancet 373 2009 234 239
32. D.A. Liebermann, and B. Hoffman Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation Leukemia 16 2002 527 541 (Pubitemid 34449730)
33. B.C. Liu, J. Zhang, L. Wang, X.W. Li, Y. Wang, J. Ji, F.P. Yang, C.L. Wan, L.H. Gao, Y.F. Xu, G.Y. Feng, L. He, X.Z. Zhao, and G. He No association between EGR gene family polymorphisms and schizophrenia in the Chinese population Prog Neuropsychopharmacol Biological Psychiatry 34 2010 506 509
34. W. Maier Common risk genes for affective and schizophrenic psychoses European Archives of Psychiatry and Clinical Neuroscience 258 Suppl. 2 2008 37 40 (Pubitemid 351758759)
35. M. Manchia, C.C. Zai, A. Squassina, J.B. Vincent, V. De Luca, and J.L. Kennedy Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes European Neuropsychopharmacology 20 2010 663 670
36. H.A. Mansour, M.E. Talkowski, J. Wood, K.V. Chowdari, L. McClain, K. Prasad, D. Montrose, A. Fagiolini, E.S. Friedman, M.H. Allen, C.L. Bowden, J. Calabrese, R.S. El-Mallakh, M. Escamilla, S.V. Faraone, M.D. Fossey, L. Gyulai, J.M. Loftis, P. Hauser, T.A. Ketter, L.B. Marangell, D.J. Miklowitz, A.A. Nierenberg, J. Patel, G.S. Sachs, P. Sklar, J.W. Smoller, N. Laird, M. Keshavan, M.E. Thase, D. Axelson, B. Birmaher, D. Lewis, T. Monk, E. Frank, D.J. Kupfer, B. Devlin, and V.L. Nimgaonkar Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia Bipolar Disorders 11 2009 701 710
37. F. Mathieu, S. Miot, B. Etain, M.A. El Khoury, F. Chevalier, F. Bellivier, M. Leboyer, B. Giros, and E.T. Tzavara Association between the PPP3CC gene, coding for the calcineurin gamma catalytic subunit, and bipolar disorder Behavioral and Brain Functions 4 2008 2
38. P.O. McGowan, A. Sasaki, A.C. D'Alessio, S. Dymov, B. Labonte, M. Szyf, G. Turecki, and M.J. Meaney Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse Nature Neuroscience 12 2009 342 348
39. S. Mexal, M. Frank, R. Berger, C.E. Adams, R.G. Ross, R. Freedman, and S. Leonard Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers Brain Research. Molecular Brain Research 139 2005 317 332 (Pubitemid 41317945)
40. J. Milbrandt A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor Science 238 1987 797 799 (Pubitemid 18005238)
41. P.R. Mittelstadt, and J.D. Ashwell Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression Molecular and Cellular Biology 18 1998 3744 3751 (Pubitemid 28287896)
42. T. Miyakawa, L.M. Leiter, D.J. Gerber, R.R. Gainetdinov, T.D. Sotnikova, H. Zeng, M.G. Caron, and S. Tonegawa Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia Proceedings of the National Academy of Sciences of the United States of America 100 2003 8987 8992 (Pubitemid 36899210)
43. H.W. Moises, T. Zoega, and I. Gottesman The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia BMC Psychiatry 2 2002 8
44. K.J. O'Donovan, W.G. Tourtellotte, J. Millbrandt, and J.M. Baraban The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience Trends in Neuroscience 22 1999 167 173 (Pubitemid 29166785)
45. M.C. O'Donovan, N.J. Craddock, and M.J. Owen Genetics of psychosis; insights from views across the genome Human Genetics 126 2009 3 12
46. S.D. Patel, H. Le-Niculescu, D.L. Koller, S.D. Green, D.K. Lahiri, F.J. McMahon, J.I. Nurnberger Jr.; and A.B. Niculescu 3rd Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 153B 2010 850 877
47. R. Poirier, H. Cheval, C. Mailhes, S. Garel, P. Charnay, S. Davis, and S. Laroche Distinct functions of egr gene family members in cognitive processes Frontiers in Neuroscience 2 2008 47 55
48. S.M. Purcell, N.R. Wray, J.L. Stone, P.M. Visscher, M.C. O'Donovan, P.F. Sullivan, and P. Sklar Common polygenic variation contributes to risk of schizophrenia and bipolar disorder Nature 460 2009 748 752
49. D.S. Roberts, Y. Hu, I.V. Lund, A.R. Brooks-Kayal, and S.J. Russek Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons Journal of Biological Chemistry 281 2006 29431 29435 (Pubitemid 44536950)
50. E. Senba, and T. Ueyama Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat Neuroscience Research 29 1997 183 207 (Pubitemid 27520819)
51. D. Shaffer, M.S. Gould, J. Brasic, P. Ambrosini, P. Fisher, H. Bird, and S. Aluwahlia A children's global assessment scale (CGAS) Archives of General Psychiatry 40 1983 1228 1231 (Pubitemid 13015019)
52. H. Stefansson, E. Sigurdsson, V. Steinthorsdottir, S. Bjornsdottir, T. Sigmundsson, S. Ghosh, J. Brynjolfsson, S. Gunnarsdottir, O. Ivarsson, T.T. Chou, O. Hjaltason, B. Birgisdottir, H. Jonsson, V.G. Gudnadottir, E. Gudmundsdottir, A. Bjornsson, B. Ingvarsson, A. Ingason, S. Sigfusson, H. Hardardottir, R.P. Harvey, D. Lai, M. Zhou, D. Brunner, V. Mutel, A. Gonzalo, G. Lemke, J. Sainz, G. Johannesson, T. Andresson, D. Gudbjartsson, A. Manolescu, M.L. Frigge, M.E. Gurney, A. Kong, J.R. Gulcher, H. Petursson, and K. Stefansson Neuregulin 1 and susceptibility to schizophrenia American Journal of Human Genetics 71 2002 877 892 (Pubitemid 135750519)
53. P.F. Sullivan The psychiatric GWAS consortium: big science comes to psychiatry Neuron 68 2010 182 186
54. G.W. Tam, R. Redon, N.P. Carter, and S.G. Grant The role of DNA copy number variation in schizophrenia Biological Psychiatry 66 2009 1005 1012
55. J. Tang, L. Xiao, C. Shu, G. Wang, Z. Liu, X. Wang, H. Wang, and X. Bai Association of the brain-derived neurotrophic factor gene and bipolar disorder with early age of onset in mainland China Neuroscience Letters 433 2008 98 102
56. I.C. Weaver, N. Cervoni, F.A. Champagne, A.C. D'Alessio, S. Sharma, J.R. Seckl, S. Dymov, M. Szyf, and M.J. Meaney Epigenetic programming by maternal behavior Nature Neuroscience 7 2004 847 854 (Pubitemid 38989508)
57. I.C. Weaver, A.C. D'Alessio, S.E. Brown, I.C. Hellstrom, S. Dymov, S. Sharma, M. Szyf, and M.J. Meaney The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes Journal of Neuroscience 27 2007 1756 1768 (Pubitemid 46280071)
58. J. Wozniak, S.V. Faraone, E. Mick, M. Monuteaux, A. Coville, and J. Biederman A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidity Psychological Medicine 2009 1 10
59. K. Yamada, D.J. Gerber, Y. Iwayama, T. Ohnishi, H. Ohba, T. Toyota, J. Aruga, Y. Minabe, S. Tonegawa, and T. Yoshikawa Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia Proceedings of the National Academy of Sciences of the United States of America 104 2007 2815 2820 (Pubitemid 46327962)
60. K. Yamagata, W.E. Kaufmann, A. Lanahan, M. Papapavlou, C.A. Barnes, K.I. Andreasson, and P.F. Worley Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268 Learning and Memory 1 1994 140 152 (Pubitemid 2143751)