Brains have a gut feeling about fat storage: An overall inverse correlation between fat deposits and brain size in mammals is explained by neurons not burning fat

BioEssays

Volumn 34, Issue 4, 2012, Pages 275-276

  Speijer, Dave ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID;

ADIPOSE TISSUE; BODY WEIGHT; BRAIN; BRAIN SIZE; BRAIN TISSUE; CALORIC INTAKE; CARBOHYDRATE INTAKE; DIGESTIVE SYSTEM; ENERGY; FATTY ACID SYNTHESIS; GLUCONEOGENESIS; GLUCOSE INTAKE; HUMAN; LIFESPAN; LIPID STORAGE; MAMMAL; NERVE CELL; NOTE;

ADIPOSE TISSUE; ANIMALS; BIOLOGICAL EVOLUTION; BRAIN; FATS; HUMANS;

MAMMALIA;

EID: 84858284531     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201200002     Document Type: Note

References (12)

1. Navarrete A, van Schaik CP, Isler K. 2011. Energetics and the evolution of human brain size. Nature 480: 91-3.
2. Potts R. 2011. Evolution: big brains explained. Nature 480: 43-4.
3. Aiello LC, Wheeler P. 1995. The expensive-tissue hypothesis: the brain and the digestive system in human and primate evolution. Curr Anthropol 36: 199-221.
4. Yang SY, He XY, Schulz H. 1987. Fatty acid oxidation in rat brain is limited by the low activity of 3-ketoacyl-coenzyme A thiolase. J Biol Chem 262: 13027-32.
5. Speijer D. 2011. Oxygen radicals shaping evolution: why fatty acid catabolism leads to peroxisomes while neurons do without it. BioEssays 33: 88-94.
6. Weinman EO, Strisower EH, Chaikoff IL. 1957. Conversion of fatty acids to carbohydrate; application of isotopes to this problem and role of the Krebs cycle as a synthetic pathway. Physiol Rev 37: 252-72.
7. de Figueiredo LF, Schuster S, Kaleta C, Fell DA. 2008. Can sugars be produced from fatty acids? A test case for pathway analysis tools. Bioinformatics 24: 2615-21.
8. Moore A. 2011. A battle over brains: neonatal maturity hypothesis or grey ceiling for explaining brain size in mammals? BioEssays 33: 149-50.
9. Isler K, van Schaik CP. 2009. Why are there so few smart mammals (but so many smart birds)? Biol Lett 5: 125-9.
10. Wrangham R. 2009. Catching Fire: How Cooking Made Us Human. New York: Basic Books.
11. Perry GH, Dominy NJ, Claw KG, Lee AS, et al. 2007. Diet and the evolution of human amylase gene copy number variation. Nat Genet 39: 1256-60.
12. O'Rahilly S. 2009. Human genetics illuminates the paths to metabolic disease. Nature 462: 307-14.