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Volumn 19, Issue 2, 2012, Pages 88-92

Closed-loop artificial pancreas: Current studies and promise for the future

Author keywords

artificial pancreas; closed loop; control to range; low glucose suspend; sensor augmented pump

Indexed keywords

GLUCOSE;

EID: 84858280796     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/MED.0b013e3283514e6b     Document Type: Review
Times cited : (16)

References (53)
  • 1
    • 0142087597 scopus 로고    scopus 로고
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic retinopathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic retinopathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. JAMA 2003; 290:2159-2167.
    • (2003) JAMA , vol.290 , pp. 2159-2167
  • 2
    • 71749092532 scopus 로고    scopus 로고
    • Glycemic control in youth with diabetes: The SEARCH for diabetes in Youth Study
    • Pettiti DB, Klingensmith GJ, Bell RA, et al. Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth Study. J Pediatr 2009; 155:668-672.
    • (2009) J Pediatr , vol.155 , pp. 668-672
    • Pettiti, D.B.1    Klingensmith, G.J.2    Bell, R.A.3
  • 3
    • 0016185358 scopus 로고
    • Clinical control of diabetes by the artificial pancreas
    • Albisser AM, Leibel BS, Ewart TG, et al. Clinical control of diabetes by the artificial pancreas. Diabetes 1974; 23:397-404.
    • (1974) Diabetes , vol.23 , pp. 397-404
    • Albisser, A.M.1    Leibel, B.S.2    Ewart, T.G.3
  • 4
    • 0017338283 scopus 로고
    • The development of Biostator, a Glucose Controlled Insulin Infusion System (GCIIS)
    • Clemens AH, Chang PH, Myers RW. The development of Biostator, a Glucose Controlled Insulin Infusion System (GCIIS). Horm Metab Res 1977; Suppl 7:23-33
    • (1977) Horm Metab Res , Issue.SUPPL. 7 , pp. 23-33
    • Clemens, A.H.1    Chang, P.H.2    Myers, R.W.3
  • 5
    • 54849147700 scopus 로고    scopus 로고
    • Continuous glucose monitoring and intensive treatment of type 1 diabetes
    • JDRF CGM Study Group
    • JDRF CGM Study Group. Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med 2008; 359:1464-1476.
    • (2008) N Engl J Med , vol.359 , pp. 1464-1476
  • 6
    • 70449378190 scopus 로고    scopus 로고
    • Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes
    • JDRF CGM Study Group
    • JDRF CGM Study Group. Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes. Diabetes Care 2009; 32:1947-1953.
    • (2009) Diabetes Care , vol.32 , pp. 1947-1953
  • 7
    • 77954830051 scopus 로고    scopus 로고
    • Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes
    • The largest and longest clinical trial of sensor-augmented pump therapy to date (485 adults and children with type 1 diabtes studied for 1 year) demonstrated superiority of insulin pumps and continuous glucose monitoring to multiple daily injection regimens and routine blood glucose monitoring
    • Bergenstal RM, Tamborlane WV, Ahmann A, et al. Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med 2010; 363:311-320. The largest and longest clinical trial of sensor-augmented pump therapy to date (485 adults and children with type 1 diabtes studied for 1 year) demonstrated superiority of insulin pumps and continuous glucose monitoring to multiple daily injection regimens and routine blood glucose monitoring.
    • (2010) N Engl J Med , vol.363 , pp. 311-320
    • Bergenstal, R.M.1    Tamborlane, W.V.2    Ahmann, A.3
  • 8
    • 84856407738 scopus 로고    scopus 로고
    • Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 study
    • The pediatric cohort of the STAR3 clinical trial demonstrated improvement in A1c, reduction in hyperglycemic exposure, and reduction in glycemic variability using sensor-augmented pump therapy compared with multiple daily injections with routine glucose monitoring
    • Slover RH, Welsh JB, Criego A, et al. Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 study. Pediatr Diabetes 2012; 13:6-11. The pediatric cohort of the STAR3 clinical trial demonstrated improvement in A1c, reduction in hyperglycemic exposure, and reduction in glycemic variability using sensor-augmented pump therapy compared with multiple daily injections with routine glucose monitoring.
    • (2012) Pediatr Diabetes , vol.13 , pp. 6-11
    • Slover, R.H.1    Welsh, J.B.2    Criego, A.3
  • 9
    • 84873075493 scopus 로고    scopus 로고
    • A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children (4 to <10 year DLDs)
    • Diabetes Research in Children Network Study Group. (in press)
    • Diabetes Research in Children Network Study Group. A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children (4 to <10 year DLDs). Diabetes Care (in press).
    • Diabetes Care
  • 10
    • 84858287882 scopus 로고    scopus 로고
    • Feasibility of continuous glucose monitoring in infants and toddlers with type 1 diabetes
    • Diabetes Research in Children Network Study Group
    • Diabetes Research in Children Network Study Group. Feasibility of continuous glucose monitoring in infants and toddlers with type 1 diabetes. Diabetes 2011; 60 (Supp 1):A335.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
  • 11
    • 0027998781 scopus 로고
    • Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial
    • Diabetes Control and Complications Trial Research Group
    • Diabetes Control and Complications Trial Research Group. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. J Pediatr 1994; 125:177-188.
    • (1994) J Pediatr , vol.125 , pp. 177-188
  • 12
    • 0030840380 scopus 로고    scopus 로고
    • Incidence and predictive criteria of nocturnal hypoglycemia in young children with insulin-dependent diabetes mellitus
    • DOI 10.1016/S0022-3476(97)70197-5
    • Porter PA, Keating B, Byrne G, Jones TW. Incidence and predictive criteria of nocturnal hypoglycemia in young children with insulin-dependent diabetes mellitus. J Pediatr 1997; 130:366-372. (Pubitemid 27492679)
    • (1997) Journal of Pediatrics , vol.130 , Issue.3 , pp. 366-372
    • Porter, P.A.1    Keating, B.2    Byrne, G.3    Jones, T.W.4
  • 14
    • 20544452543 scopus 로고    scopus 로고
    • Response to nocturnal alarms using a real-time glucose sensor
    • Buckingham B, Block J, Burdick J, et al. Response to nocturnal alarms using a real-time glucose sensor. Diabetes Technol Ther 2005; 7:440-447.
    • (2005) Diabetes Technol Ther , vol.7 , pp. 440-447
    • Buckingham, B.1    Block, J.2    Burdick, J.3
  • 15
    • 59249094292 scopus 로고    scopus 로고
    • Duration of nocturnal hypoglycemia prior to seizures
    • Buckingham B, Wilson DM, Lecher T, et al. Duration of nocturnal hypoglycemia prior to seizures. Diabetes Care 2008; 31:2110-2112.
    • (2008) Diabetes Care , vol.31 , pp. 2110-2112
    • Buckingham, B.1    Wilson, D.M.2    Lecher, T.3
  • 16
    • 84857423158 scopus 로고    scopus 로고
    • Usage and effectiveness of the low glucose suspend feature of the Medtronic Paradigm Veo insulin pump
    • Data from over 900 patients over almost 50 000 patient-days of real-world use in the ambulatory setting provides compelling evidence for the safety and efficacy of sensor-augmented pump therapy with a low-glucose suspend feature: hypoglycemia was reduced without a deterioration in overall glucose control
    • Agrawal P, Welsh JB, Kannard B, et al. Usage and effectiveness of the low glucose suspend feature of the Medtronic Paradigm Veo insulin pump. J Diabetes Sci Technol 2011; 5:1137-1141. Data from over 900 patients over almost 50 000 patient-days of real-world use in the ambulatory setting provides compelling evidence for the safety and efficacy of sensor-augmented pump therapy with a low-glucose suspend feature: hypoglycemia was reduced without a deterioration in overall glucose control.
    • (2011) J Diabetes Sci Technol , vol.5 , pp. 1137-1141
    • Agrawal, P.1    Welsh, J.B.2    Kannard, B.3
  • 17
    • 82555164135 scopus 로고    scopus 로고
    • Insulin pump therapy with automated insulin suspension in response to hypoglycemia: Reduction in nocturnal hypoglycemia in those at greatest risk
    • Choudhary P, Shin J, Wang Y, et al. Insulin pump therapy with automated insulin suspension in response to hypoglycemia: reduction in nocturnal hypoglycemia in those at greatest risk. Diabetes Care 2011; 34:2023-2025.
    • (2011) Diabetes Care , vol.34 , pp. 2023-2025
    • Choudhary, P.1    Shin, J.2    Wang, Y.3
  • 18
    • 80055028578 scopus 로고    scopus 로고
    • Prevention of hypoglycemia by using low glucose suspend function in sensor-augmented pump therapy
    • A crossover study of sensor-augmented pump therapy with low-glucose suspend feature in 21 children with type 1 diabetes demonstrated efficacy (reduction of hypoglycemia episodes and time spent in hypoglycemia) and safety (no deterioration in average glucose levels) over a 6-week course
    • Danne T, Kordonouri O, Holder M, et al. Prevention of hypoglycemia by using low glucose suspend function in sensor-augmented pump therapy. Diabetes Technol Ther 2011; 13:1129-1134. A crossover study of sensor-augmented pump therapy with low-glucose suspend feature in 21 children with type 1 diabetes demonstrated efficacy (reduction of hypoglycemia episodes and time spent in hypoglycemia) and safety (no deterioration in average glucose levels) over a 6-week course.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 1129-1134
    • Danne, T.1    Kordonouri, O.2    Holder, M.3
  • 19
    • 77955652578 scopus 로고    scopus 로고
    • Real-Time hypoglycemia prediction suite using continuous glucose monitoring: A safety net for the artificial pancreas
    • Dassau E, Cameron F, Lee H, et al. Real-Time hypoglycemia prediction suite using continuous glucose monitoring: a safety net for the artificial pancreas. Diabetes Care 2010; 33:1249-1254.
    • (2010) Diabetes Care , vol.33 , pp. 1249-1254
    • Dassau, E.1    Cameron, F.2    Lee, H.3
  • 20
    • 77954939888 scopus 로고    scopus 로고
    • Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension
    • Using an array of five different prediction algorithms and a voting scheme to suspend basal insulin delivery when a predetermined number of algorithms predicted incipient hypoglycemia, this study demonstrated prevention of up to 75% of hypoglycemic episodes
    • Buckingham B, Chase HP, Dassau E, et al. Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension. Diabetes Care 2010; 33:1013-1017. Using an array of five different prediction algorithms and a voting scheme to suspend basal insulin delivery when a predetermined number of algorithms predicted incipient hypoglycemia, this study demonstrated prevention of up to 75% of hypoglycemic episodes.
    • (2010) Diabetes Care , vol.33 , pp. 1013-1017
    • Buckingham, B.1    Chase, H.P.2    Dassau, E.3
  • 21
    • 58449094833 scopus 로고    scopus 로고
    • Preventing hypoglycemia using predictive alarm algorithms and insulin pump suspension
    • Buckingham B, Cobry E, Clinton P, et al. Preventing hypoglycemia using predictive alarm algorithms and insulin pump suspension. Diabetes Technol Ther 2009; 11:93-97.
    • (2009) Diabetes Technol Ther , vol.11 , pp. 93-97
    • Buckingham, B.1    Cobry, E.2    Clinton, P.3
  • 22
    • 38949150087 scopus 로고    scopus 로고
    • Detection of a meal using continuous glucose monitoring: Implications for an artificial beta-cell
    • DOI 10.2337/dc07-1293
    • Dassau E, Bequette BW, Buckingham BA, Doyle FJ 3rd. Detection of a meal using continuous glucose monitoring: implications for an artificial beta-cell. Diabetes Care 2008; 31:295-300. (Pubitemid 351213339)
    • (2008) Diabetes Care , vol.31 , Issue.2 , pp. 295-300
    • Dassau, E.1    Bequette, B.W.2    Buckingham, B.A.3    Doyle III, F.J.4
  • 23
    • 77953039088 scopus 로고    scopus 로고
    • Control to range for diabetes: Functionality and modular architecture
    • Kovatchev B, Patek S, Dassau E, et al. Control to range for diabetes: functionality and modular architecture. J Diabetes Sci Technol 2009; 3:1058-1065.
    • (2009) J Diabetes Sci Technol , vol.3 , pp. 1058-1065
    • Kovatchev, B.1    Patek, S.2    Dassau, E.3
  • 24
    • 0347624612 scopus 로고    scopus 로고
    • Modeling beta-Cell Insulin Secretion - Implications for Closed-Loop Glucose Homeostasis
    • DOI 10.1089/152091503322640999
    • Steil GM, Rebrin K, Janowski R, et al. Modeling beta-cell insulin secretion: implications for closed-loop glucose homeostasis. Diabetes Technol Ther 2003; 5:953-964. (Pubitemid 38009933)
    • (2003) Diabetes Technology and Therapeutics , vol.5 , Issue.6 , pp. 953-964
    • Steil, G.M.1    Rebrin, K.2    Janowski, R.3    Darwin, C.4    Saad, M.F.5
  • 25
    • 1642452596 scopus 로고    scopus 로고
    • Closed-loop insulin delivery - The path to physiological glucose control
    • DOI 10.1016/j.addr.2003.08.011
    • Steil GM, Panteleon AE, Rebrin K. Closed-loop insulin delivery-the path to physiological glucose control. Adv Drug Deliv Rev 2004; 56:125-144. (Pubitemid 38114927)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.2 , pp. 125-144
    • Steil, G.M.1    Panteleon, A.E.2    Rebrin, K.3
  • 27
    • 67650850418 scopus 로고    scopus 로고
    • Model predictive control of type 1 diabetes: An in silico trial
    • Magni L, Raimondo DM, Bossi L, et al. Model predictive control of type 1 diabetes: an in silico trial. J Diabetes Sci Technol 2007; 1:804-812.
    • (2007) J Diabetes Sci Technol , vol.1 , pp. 804-812
    • Magni, L.1    Raimondo, D.M.2    Bossi, L.3
  • 28
    • 0032962321 scopus 로고    scopus 로고
    • A model-based algorithm for blood glucose control in type I diabetic patients
    • DOI 10.1109/10.740877
    • Parker RS, Doyle FJ, Peppas NA. A model-based algorithm for blood glucose control in type 1 diabetic patients. IEEE Trans Biomed Eng 1999; 46:148-157. (Pubitemid 29058920)
    • (1999) IEEE Transactions on Biomedical Engineering , vol.46 , Issue.2 , pp. 148-157
    • Parker, R.S.1    Doyle, F.J.2    Peppas, N.A.3
  • 29
    • 78049498460 scopus 로고    scopus 로고
    • Zone model predictive control: A strategy to minimize hyper- and hypoglycemic events
    • Grosman B, Dassau E, Zisser HC, et al. Zone model predictive control: a strategy to minimize hyper- and hypoglycemic events. J Diabetes Sci Technol 2010; 4:961-975.
    • (2010) J Diabetes Sci Technol , vol.4 , pp. 961-975
    • Grosman, B.1    Dassau, E.2    Zisser, H.C.3
  • 30
    • 78049505191 scopus 로고    scopus 로고
    • Proposed clinical application for tuning fuzzy logic controller of artificial pancreas utilizing a personalization factor
    • Mauseth R, Wang Y, Dassau E, et al. Proposed clinical application for tuning fuzzy logic controller of artificial pancreas utilizing a personalization factor. J Diabetes Sci Technol 2010; 4:913-922.
    • (2010) J Diabetes Sci Technol , vol.4 , pp. 913-922
    • Mauseth, R.1    Wang, Y.2    Dassau, E.3
  • 31
    • 80053387073 scopus 로고    scopus 로고
    • Automatic learning algorithm for the MD-logic artificial pancreas system
    • Miller S, Nimri R, Atlas E, et al. Automatic learning algorithm for the MD-logic artificial pancreas system. Diabetes Technol Ther 2011; 13:983-990.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 983-990
    • Miller, S.1    Nimri, R.2    Atlas, E.3
  • 32
    • 27744588950 scopus 로고    scopus 로고
    • A novel insulin delivery algorithm in rats with type 1 diabetes: The fading memory proportional-derivative method
    • DOI 10.1111/j.1525-1594.2005.29096.x
    • Gopakumaran B, Duman HM, Overholser DP, et al. A novel insulin delivery algorithm in rats with type 1 diabetes: the fading memory proportional- derivative method. Artif Organs 2005; 29:599-607. (Pubitemid 41602836)
    • (2005) Artificial Organs , vol.29 , Issue.8 , pp. 599-607
    • Gopakumaran, B.1    Duman, H.M.2    Overholser, D.P.3    Federiuk, I.F.4    Quinn, M.J.5    Wood, M.D.6    Ward, W.K.7
  • 33
    • 77952996672 scopus 로고    scopus 로고
    • A feasibility study of bihormonal closed-loop blood glucose control using dual subcutaneous infusion of insulin and glucagon in ambulatory diabetic swine
    • El-Khatib FH, Jiang J, Damiano ER. A feasibility study of bihormonal closed-loop blood glucose control using dual subcutaneous infusion of insulin and glucagon in ambulatory diabetic swine. J Diabetes Sci Technol 2009; 3:789-803.
    • (2009) J Diabetes Sci Technol , vol.3 , pp. 789-803
    • El-Khatib, F.H.1    Jiang, J.2    Damiano, E.R.3
  • 34
    • 33845521334 scopus 로고    scopus 로고
    • Feasibility of automating insulin delivery for the treatment of type 1 diabetes
    • DOI 10.2337/db06-0419
    • Steil GM, Rebrin K, Darwin C, et al. Feasibility of automating insulin delivery for the treatment of type 1 diabetes. Diabetes 2006; 55:3344-3350. (Pubitemid 44923591)
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3344-3350
    • Steil, G.M.1    Rebrin, K.2    Darwin, C.3    Hariri, F.4    Saad, M.F.5
  • 35
    • 48649083317 scopus 로고    scopus 로고
    • Fully automated closed-loop insulin delivery vs. semi-automated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas
    • Weinzimer SA, Steil GM, Swan KL, et al. Fully automated closed-loop insulin delivery vs. semi-automated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas. Diabetes Care 2008; 31:934-939.
    • (2008) Diabetes Care , vol.31 , pp. 934-939
    • Weinzimer, S.A.1    Steil, G.M.2    Swan, K.L.3
  • 36
    • 79955164375 scopus 로고    scopus 로고
    • Physiologic insulin delivery with insulin feedback: A control systems perspective
    • Epub 2010 Aug 2
    • Palerm CC. Physiologic insulin delivery with insulin feedback: a control systems perspective. Comput Methods Programs Biomed 2011; 102:130-137; Epub 2010 Aug 2.
    • (2011) Comput Methods Programs Biomed , vol.102 , pp. 130-137
    • Palerm, C.C.1
  • 37
    • 79955670667 scopus 로고    scopus 로고
    • The effect of insulin feedback on closed loop glucose control
    • Steil GM, Palerm CC, Kurtz N, et al. The effect of insulin feedback on closed loop glucose control. J Clin Endocrinol Metab 2011; 96:1402-1408.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1402-1408
    • Steil, G.M.1    Palerm, C.C.2    Kurtz, N.3
  • 38
    • 84873061508 scopus 로고    scopus 로고
    • Effect of insulin feedback algorithm on closed-loop blood glucose control
    • Abstract
    • Ruiz JL, Sherr JL, Cengiz E, et al. Effect of insulin feedback algorithm on closed-loop blood glucose control [Abstract]. Diabetes Technol Soc 2011; A163.
    • (2011) Diabetes Technol Soc
    • Ruiz, J.L.1    Sherr, J.L.2    Cengiz, E.3
  • 39
    • 82555167939 scopus 로고    scopus 로고
    • Effect of adjuvant injected pramlintide on closed-loop automated insulin delivery
    • Weinzimer SA, Sherr JL, Cengiz E, et al. Effect of adjuvant injected pramlintide on closed-loop automated insulin delivery. Diabetes 2011; 60 (Supp 1):A253.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Weinzimer, S.A.1    Sherr, J.L.2    Cengiz, E.3
  • 40
    • 84873064107 scopus 로고    scopus 로고
    • Glucose control using closed loop insulin delivery during nights with or without antecedent afternoon exercise
    • Weinzimer SA, Sherr JL, Cengiz E, et al. Glucose control using closed loop insulin delivery during nights with or without antecedent afternoon exercise. Diabetes 2011; 60 (Supp 1):A42.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Weinzimer, S.A.1    Sherr, J.L.2    Cengiz, E.3
  • 41
    • 77249157244 scopus 로고    scopus 로고
    • Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: A phase 2 randomised crossover trial
    • Hovorka R, Allen JM, Elleri D, et al. Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. Lancet 2010; 375:743-751.
    • (2010) Lancet , vol.375 , pp. 743-751
    • Hovorka, R.1    Allen, J.M.2    Elleri, D.3
  • 42
    • 79954457764 scopus 로고    scopus 로고
    • Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: Crossover randomised controlled studies
    • Two small crossover studies that showed improvements in overnight blood glucose levels (time within target and time spent hypoglycemic) with a closed-loop compared with open-loop system, after two types of mealtime challenges, one including a large meal with alcohol to simulate 'eating out'
    • Hovorka R, Kumareswaran K, Harris J, et al. Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies. BMJ 2011; 342:1855-1864. Two small crossover studies that showed improvements in overnight blood glucose levels (time within target and time spent hypoglycemic) with a closed-loop compared with open-loop system, after two types of mealtime challenges, one including a large meal with alcohol to simulate 'eating out'.
    • (2011) BMJ , vol.342 , pp. 1855-1864
    • Hovorka, R.1    Kumareswaran, K.2    Harris, J.3
  • 43
    • 79951699957 scopus 로고    scopus 로고
    • Closed-loop insulin delivery during pregnancycomplicated by type1 diabetes
    • Murphy HR, Elleri D, Allen JM, et al. Closed-loop insulin delivery during pregnancycomplicated by type1 diabetes. Diabetes Care 2011; 34:406-411.
    • (2011) Diabetes Care , vol.34 , pp. 406-411
    • Murphy, H.R.1    Elleri, D.2    Allen, J.M.3
  • 44
    • 82555199427 scopus 로고    scopus 로고
    • Safety and efficacy of 24-h closed-loop insulin delivery in well controlled pregnant women with type 1 diabetes: A randomized crossover case series
    • Murphy HR, Kumareswaran K, Elleri D, et al. Safety and efficacy of 24-h closed-loop insulin delivery in well controlled pregnant women with type 1 diabetes: a randomized crossover case series. Diabetes Care 2011; 34:2527-2529.
    • (2011) Diabetes Care , vol.34 , pp. 2527-2529
    • Murphy, H.R.1    Kumareswaran, K.2    Elleri, D.3
  • 45
    • 79953021776 scopus 로고    scopus 로고
    • Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: Summary of the results
    • This study demonstrated that an MPC-based closed-loop system achieved superior overnight glucose control, with more time in target and less hypoglycemia, compared with an open-loop system; of note, the design and initial testing of the algorithm was accomplished entirely in silico
    • Kovatchev B, Cobelli C, Renard E, et al. Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results. J Diabetes Sci Technol 2010; 4:1374-1381. This study demonstrated that an MPC-based closed-loop system achieved superior overnight glucose control, with more time in target and less hypoglycemia, compared with an open-loop system; of note, the design and initial testing of the algorithm was accomplished entirely in silico.
    • (2010) J Diabetes Sci Technol , vol.4 , pp. 1374-1381
    • Kovatchev, B.1    Cobelli, C.2    Renard, E.3
  • 46
    • 77954901769 scopus 로고    scopus 로고
    • MD-logic artificial pancreas system: A pilot study in adults with type 1 diabetes
    • Atlas E, Nimri R, Miller S, et al. MD-logic artificial pancreas system: a pilot study in adults with type 1 diabetes. Diabetes Care 2010; 33:1072-1076.
    • (2010) Diabetes Care , vol.33 , pp. 1072-1076
    • Atlas, E.1    Nimri, R.2    Miller, S.3
  • 47
    • 74249093844 scopus 로고    scopus 로고
    • Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery
    • Renard E, Place J, Cantwell M, et al. Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery. Diabetes Care 2010; 33:121-127.
    • (2010) Diabetes Care , vol.33 , pp. 121-127
    • Renard, E.1    Place, J.2    Cantwell, M.3
  • 48
    • 77952987107 scopus 로고    scopus 로고
    • A bihormonal closed-loop artificial pancreas for type 1 diabetes
    • This study in 11 adult patients with type 1 diabetes demonstrated the feasibility of a two-hormone closed-loop system, with insulin and glucagon, using two infusion pumps and two separate controller algorithms
    • El-Khatib FH, Russell SJ, Nathan DM, et al. A bihormonal closed-loop artificial pancreas for type 1 diabetes. Transl Med 2010; 2:27ra27. This study in 11 adult patients with type 1 diabetes demonstrated the feasibility of a two-hormone closed-loop system, with insulin and glucagon, using two infusion pumps and two separate controller algorithms.
    • (2010) Transl Med , vol.2
    • El-Khatib, F.H.1    Russell, S.J.2    Nathan, D.M.3
  • 49
    • 77956071742 scopus 로고    scopus 로고
    • Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes
    • Castle JR, Engle JM, El Youssef J, et al. Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes. Diabetes Care 2010; 33:1282-1287.
    • (2010) Diabetes Care , vol.33 , pp. 1282-1287
    • Castle, J.R.1    Engle, J.M.2    El Youssef, J.3
  • 50
    • 69949146908 scopus 로고    scopus 로고
    • In silico preclinical trials: A proof of concept in closed-loop control of type 1 diabetes
    • Kovatchev BP, Breton M, Man CD, Cobelli C. In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes. J Diabetes Sci Technol 2009; 3:44-55.
    • (2009) J Diabetes Sci Technol , vol.3 , pp. 44-55
    • Kovatchev, B.P.1    Breton, M.2    Man, C.D.3    Cobelli, C.4
  • 51
    • 62249085411 scopus 로고    scopus 로고
    • In silico evaluation platform for artificial pancreatic beta-cell development: A dynamic simulator for closed-loop control with hardware-in-the-loop
    • Dassau E, Palerm CC, Zisser H, et al. In silico evaluation platform for artificial pancreatic beta-cell development: a dynamic simulator for closed-loop control with hardware-in-the-loop. Diabetes Technol Ther 2009; 11:187-194.
    • (2009) Diabetes Technol Ther , vol.11 , pp. 187-194
    • Dassau, E.1    Palerm, C.C.2    Zisser, H.3
  • 52
    • 77953067473 scopus 로고    scopus 로고
    • Identification of intraday metabolic profiles during closed-loop glucose control in individuals with type 1 diabetes
    • Kanderian SS, Weinzimer SA, Voskanyan G, Steil GM. Identification of intraday metabolic profiles during closed-loop glucose control in individuals with type 1 diabetes. J Diabetes Sci Technol 2009; 3:1047-1057.
    • (2009) J Diabetes Sci Technol , vol.3 , pp. 1047-1057
    • Kanderian, S.S.1    Weinzimer, S.A.2    Voskanyan, G.3    Steil, G.M.4
  • 53
    • 77954679388 scopus 로고    scopus 로고
    • Simulation environment to evaluate closed-loop insulin delivery systems in type 1 diabetes
    • Wilinska ME, Chassin LJ, Acerini CL, et al. Simulation environment to evaluate closed-loop insulin delivery systems in type 1 diabetes. J Diabetes Sci Technol 2010; 4:132-144.
    • (2010) J Diabetes Sci Technol , vol.4 , pp. 132-144
    • Wilinska, M.E.1    Chassin, L.J.2    Acerini, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.