Contribution of voltage-dependent K + channels to metabolic control of coronary blood flow

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 4, 2012, Pages 912-919

  Berwick, Zachary C ^a   Dick, Gregory M ^b   Moberly, Steven P ^a   Kohr, Meredith C ^a   Sturek, Michael ^a   Tune, Johnathan D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Coronary; Exercise; K V channels; Metabolic syndrome; Swine

Indexed keywords

AMINOPYRIDINE; POTASSIUM CHANNEL KV1.5; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA PRESSURE; ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; EXERCISE; HEART MUSCLE OXYGEN CONSUMPTION; METABOLIC REGULATION; METABOLIC SYNDROME X; NONHUMAN; OXYGEN SUPPLY; PHENOTYPE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VENOUS OXYGEN TENSION;

4-AMINOPYRIDINE; ANIMALS; BLOTTING, WESTERN; CORONARY CIRCULATION; CORONARY VESSELS; ELECTROPHYSIOLOGY; HEMODYNAMICS; MYOCARDIUM; OXYGEN CONSUMPTION; PHYSICAL EXERTION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SWINE;

SUIDAE;

EID: 84858276501     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.07.004     Document Type: Article

References (52)

1. Duncker D.J., Bache R.J. Regulation of coronary blood flow during exercise. Physiol Rev 2008, 88:1009-1086.
2. Tune J.D., Gorman M.W., Feigl E.O. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 2004, 97:404-415.
3. Dick G.M., Tune J.D. Role of potassium channels in coronary vasodilation. Exp Biol Med (Maywood) 2010, 235:10-22.
4. Dick G.M., Bratz I.N., Borbouse L., Payne G.A., Dincer U.D., Knudson J.D., et al. Voltage-dependent K+ channels regulate the duration of reactive hyperemia in the canine coronary circulation. Am J Physiol Heart Circ Physiol 2008, 294:H2371-H2381.
5. Saitoh S., Zhang C., Tune J.D., Potter B., Kiyooka T., Rogers P.A., et al. Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow. Arterioscler Thromb Vasc Biol 2006, 26:2614-2621.
6. Bender S.B., Tune J.D., Borbouse L., Long X., Sturek M., Laughlin M.H. Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood) 2009, 234:683-692.
7. Berwick Z.C., Payne G.A., Lynch B., Dick G.M., Sturek M., Tune J.D. Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels. Microcirculation 2010, 17:600-607.
8. Berwick Z.C., Dick G.M., Tune J.D. Heart of the matter: coronary dysfunction in metabolic syndrome. J Mol Cell Cardiol 2011.
9. Borbouse L., Dick G.M., Payne G.A., Payne B.D., Svendsen M.C., Neeb Z.P., et al. Contribution of BKCa channels to local metabolic coronary vasodilation: effects of metabolic syndrome. Am J Physiol Heart Circ Physiol 2010, 298:H966-H973.
10. Knudson J.D., Dincer U.D., Bratz I.N., Sturek M., Dick G.M., Tune J.D. Mechanisms of coronary dysfunction in obesity and insulin resistance. Microcirculation 2007, 14:317-338.
11. Setty S., Sun W., Tune J.D. Coronary blood flow regulation in the prediabetic metabolic syndrome. Basic Res Cardiol 2003, 98:416-423.
12. Zhang C., Knudson J.D., Setty S., Araiza A., Dincer U.D., Kuo L., et al. Coronary arteriolar vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors. Am J Physiol Heart Circ Physiol 2005, 288:H2154-H2162.
13. Long X., Mokelke E.A., Neeb Z.P., Alloosh M., Edwards J.M., Sturek M. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Pharmacol Exp Ther 2010, 335:781-787.
14. Mokelke E.A., Dietz N.J., Eckman D.M., Nelson M.T., Sturek M. Diabetic dyslipidemia and exercise affect coronary tone and differential regulation of conduit and microvessel K+ current. Am J Physiol Heart Circ Physiol 2005, 288:H1233-H1241.
15. Pirat B., Bozbas H., Simsek V., Yildirir A., Sade L.E., Gursoy Y., et al. Impaired coronary flow reserve in patients with metabolic syndrome. Atherosclerosis 2008, 201:112-116.
16. Schindler T.H., Cardenas J., Prior J.O., Facta A.D., Kreissl M.C., Zhang X.L., et al. Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function. J Am Coll Cardiol 2006, 47:1188-1195.
17. Teragawa H., Morita K., Shishido H., Otsuka N., Hirokawa Y., Chayama K., et al. Impaired myocardial blood flow reserve in subjects with metabolic syndrome analyzed using positron emission tomography and N-13 labeled ammonia. Eur J Nucl Med Mol Imaging 2010, 37:368-376.
18. Borbouse L., Dick G.M., Payne G.A., Berwick Z.C., Neeb Z.P., Alloosh M., et al. Metabolic syndrome reduces the contribution of K+ channels to ischemic coronary vasodilation. Am J Physiol Heart Circ Physiol 2010, 298:H1182-H1189.
19. Burnham M.P., Johnson I.T., Weston A.H. Reduced Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels from arteries of Type 2 diabetic Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol 2006, 290:H1520-H1527.
20. Borbouse L., Dick G.M., Asano S., Bender S.B., Dincer U.D., Payne G.A., et al. Impaired function of coronary BK(Ca) channels in metabolic syndrome. Am J Physiol Heart Circ Physiol 2009, 297:H1629-H1637.
21. Lu T., Wang X.L., He T., Zhou W., Kaduce T.L., Katusic Z.S., et al. Impaired arachidonic acid-mediated activation of large-conductance Ca2+-activated K+ channels in coronary arterial smooth muscle cells in Zucker diabetic fatty rats. Diabetes 2005, 54:2155-2163.
22. Heaps C.L., Jeffery E.C., Laine G.A., Price E.M., Bowles D.K. Effects of exercise training and hypercholesterolemia on adenosine activation of voltage-dependent K+ channels in coronary arterioles. J Appl Physiol 2008, 105:1761-1771.
23. Heaps C.L., Tharp D.L., Bowles D.K. Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles. Am J Physiol Heart Circ Physiol 2005, 288:H568-H576.
24. Bratz I.N., Swafford A.N., Kanagy N.L., Dick G.M. Reduced functional expression of K(+) channels in vascular smooth muscle cells from rats made hypertensive with N{omega}-nitro-L-arginine. Am J Physiol Heart Circ Physiol 2005, 289:H1284-H1290.
25. Li H., Chai Q., Gutterman D.D., Liu Y. Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells. Am J Physiol Heart Circ Physiol 2003, 285:H1213-H1219.
26. Liu Y., Terata K., Rusch N.J., Gutterman D.D. High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries. Circ Res 2001, 89:146-152.
27. Liu Y., Gutterman D.D. The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation. Vascul Pharmacol 2002, 38:43-49.
28. Dyson M.C., Alloosh M., Vuchetich J.P., Mokelke E.A., Sturek M. Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet. Comp Med 2006, 56:35-45.
29. Sturek M., Alloosh M., Wenzel J., Byrd J.P., Edwards J.M., Lloyd P.G., et al. Ossabaw island miniature swine: cardiometabolic syndrome assessment. Swine in the laboratory: surgery, anesthesia, imaging and experimental techniques 2007, 397-402. CRC Press, Boca Raton. Second Edition. M.M. Swindle (Ed.).
30. Feigl E.O., Neat G.W., Huang A.H. Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow. J Mol Cell Cardiol 1990, 22:375-390.
31. Bratz I.N., Dick G.M., Tune J.D., Edwards J.M., Neeb Z.P., Dincer U.D., et al. Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome. Am J Physiol Heart Circ Physiol 2008, 294:H2489-H2496.
32. Thorneloe K.S., Chen T.T., Kerr P.M., Grier E.F., Horowitz B., Cole W.C., et al. Molecular composition of 4-aminopyridine-sensitive voltage-gated K(+) channels of vascular smooth muscle. Circ Res 2001, 89:1030-1037.
33. Rogers P.A., Dick G.M., Knudson J.D., Focardi M., Bratz I.N., Swafford A.N., et al. H2O2-induced redox-sensitive coronary vasodilation is mediated by 4-aminopyridine-sensitive K+ channels. Am J Physiol Heart Circ Physiol 2006, 291:H2473-H2482.
34. Berg T. The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats. Eur J Pharmacol 2003, 466:301-310.
35. Ko E.A., Park W.S., Firth A.L., Kim N., Yuan J.X., Han J. Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases. Prog Biophys Mol Biol 2010, 103:95-101.
36. Cox R.H. Changes in the expression and function of arterial potassium channels during hypertension. Vascul Pharmacol 2002, 38:13-23.
37. Yang Y., Jones A.W., Thomas T.R., Rubin L.J. Influence of sex, high-fat diet, and exercise training on potassium currents of swine coronary smooth muscle. Am J Physiol Heart Circ Physiol 2007, 293:H1553-H1563.
38. Yen M.H., Lee S.H., Ho S.T. Effects of 4-aminopyridine on cat blood pressure in relation to the sympathetic nervous system. Eur J Pharmacol 1985, 113:61-67.
39. Berg T. Analysis of the pressor response to the K+ channel inhibitor 4-aminopyridine. Eur J Pharmacol 2002, 452:325-337.
40. Agoston S., Maestrone E., van Hezik E.J., Ket J.M., Houwertjes M.C., Uges D.R. Effective treatment of verapamil intoxication with 4-aminopyridine in the cat. J Clin Invest 1984, 73:1291-1296.
41. Rogers P.A., Chilian W.M., Bratz I.N., Bryan R.M., Dick G.M. H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. Am J Physiol Heart Circ Physiol 2007, 292:H1404-H1411.
42. Osipenko O.N., Tate R.J., Gurney A.M. Potential role for kv3.1b channels as oxygen sensors. Circ Res 2000, 86:534-540.
43. Perez-Garcia M.T., Lopez-Lopez J.R., Gonzalez C. Kvbeta1.2 subunit coexpression in HEK293 cells confers O2 sensitivity to kv4.2 but not to Shaker channels. J Gen Physiol 1999, 113:897-907.
44. Ohanyan V.A., Bratz I.N., Guarini G., Yin L., Chilian W.M. Kv1.5 channels play a critical role in coronary metabolic dilation. Circulation 2010, 122:A16997.
45. Ak G., Buyukberber S., Sevinc A., Turk H.M., Ates M., Sari R., et al. The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with Type 2 diabetes mellitus. J Diabetes Complications 2001, 15:150-157.
46. Ferri C., Bellini C., Desideri G., Baldoncini R., Properzi G., Santucci A., et al. Circulating endothelin-1 levels in obese patients with the metabolic syndrome. Exp Clin Endocrinol Diabetes 1997, 105(Suppl 2):38-40.
47. Hopfner R.L., Gopalakrishnan V. Endothelin: emerging role in diabetic vascular complications. Diabetologia 1999, 42:1383-1394.
48. Knudson J.D., Rogers P.A., Dincer U.D., Bratz I.N., Araiza A.G., Dick G.M., et al. Coronary vasomotor reactivity to endothelin-1 in the prediabetic metabolic syndrome. Microcirculation 2006, 13:209-218.
49. Mather K.J., Lteif A.A., Veeneman E., Fain R., Giger S., Perry K., et al. Role of endogenous ET-1 in the regulation of myocardial blood flow in lean and obese humans. Obesity (Silver Spring) 2010, 18:63-70.
50. Rainbow R.D., Norman R.I., Everitt D.E., Brignell J.L., Davies N.W., Standen N.B. Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes. Cardiovasc Res 2009, 83:493-500.
51. Payne G.A., Borbouse L., Kumar S., Neeb Z., Alloosh M., Sturek M., et al. Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-{beta} pathway. Arterioscler Thromb Vasc Biol 2010, 30:1711-1717.
52. Dincer U.D., Araiza A.G., Knudson J.D., Molina P.E., Tune J.D. Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome. Microcirculation 2006, 13:587-595.