Modeling the spatial distribution of chronic tumor hypoxia: Implications for experimental and clinical studies

Computational and Mathematical Methods in Medicine

Volumn 2012, Issue , 2012, Pages

  Powathil, Gibin ^a,b   Kohandel, Mohammad ^a,b   Milosevic, Michael ^c   Sivaloganathan, Siv ^a,b  

^a UNIVERSITY OF WATERLOO   (Canada)

^b FIELDS INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ELECTRODES; NEEDLES; OXYGEN; OXYGENATION; POLAROGRAPHS; RADIATION EFFECTS; RADIOTHERAPY; SPATIAL DISTRIBUTION;

ACCURATE MEASUREMENT; ESTIMATION TECHNIQUES; OXYGEN DISTRIBUTION; PROGNOSTIC MARKERS; RADIATION RESPONSE; THEORETICAL SIMULATION; THERAPEUTIC STRATEGY; TUMOR MICROENVIRONMENT;

TUMORS;

ACCURACY; ARTICLE; CANCER CELL; ELECTRODE; HUMAN; HYPOXIA; MATHEMATICAL MODEL; MEASUREMENT; OXYGENATION; POLAROGRAPHY; PROGNOSIS; QUANTITATIVE ANALYSIS; RADIATION DOSE; SIMULATION; THEORETICAL STUDY; TREATMENT PLANNING; TUMOR; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; ANOXIA; BIOLOGICAL MODEL; COMPUTER SIMULATION; GLIOMA; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULARIZATION; XENOGRAFT;

OXYGEN;

ANOXIA; COMPUTER SIMULATION; GLIOMA; HUMANS; MODELS, BIOLOGICAL; OXYGEN; POLAROGRAPHY; TRANSPLANTATION, HETEROLOGOUS;

EID: 84858261909     PISSN: 1748670X     EISSN: 17486718     Source Type: Journal    
DOI: 10.1155/2012/410602     Document Type: Article

References (35)

1. Tannock I.F., Hill R. P., Bristow R. G., Harrington L., The Basic Science of Oncology 2005 4th New York, NY, USA McGraw-Hill
2. Bristow R. G., Hill R. P., Hypoxia, DNA repair and genetic instability Nature Reviews Cancer 2008 8 3 180 192
3. Vaupel P., Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis The Oncologist 2008 13 3 21 26
4. Ljungkvist A. S., Bussink J., Kaanders J. H. A. M., Van Der Kogel A. J., Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers Radiation Research 2007 167 2 127 145 (Pubitemid 46214661)
5. Chaplin D. J., Olive P. L., Durand R. E., Intermittent blood flow in a murine tumor: radiobiological effects Cancer Research 1987 47 2 597 601 (Pubitemid 17009632)
6. Hockel M., Knoop C., Schlenger K., Vorndran B., Knapstein P. G., Vaupel P., Intratumoral pO2 histography as predictive assay in advanced cancer of the uterine cervix Advances in Experimental Medicine and Biology 1994 345 445 450 (Pubitemid 24145783)
7. Nordsmark M., Overgaard M., Overgaard J., Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck Radiotherapy and Oncology 1996 41 1 31 39 (Pubitemid 26396294)
8. Brizel D. M., Sibley G. S., Prosnitz L. R., Scher R. L., Dewhirst M. W., Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck International Journal of Radiation Oncology Biology Physics 1997 38 2 285 289 (Pubitemid 27318643)
9. Trotter M. J., Chaplin D. J., Durand R. E., Olive P. L., The use of fluorescent probes to identify regions of transient perfusion in murine tumors International Journal of Radiation Oncology Biology Physics 1989 16 4 931 934 (Pubitemid 19154275)
10. Milosevic M., Fyles A., Hedley D., Hill R., The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure Seminars in Radiation Oncology 2004 14 3 249 258 (Pubitemid 38903229)
11. Kavanagh M. C., Sun A., Hu Q., Hill R. P., Comparing techniques of measuring tumor hypoxia in different murine tumors: eppendorf p O 2 histograph, [ 3 H]misonidazole binding and paired survival assay Radiation Research 1996 145 4 491 500 (Pubitemid 26107392)
12. Raleigh J. A., Chou S. C., Arteel G. E., Horsman M. R., Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors Radiation Research 1999 151 5 580 589 (Pubitemid 29381608)
13. Jenkins W. T., Evans S. M., Koch C. J., Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode International Journal of Radiation Oncology Biology Physics 2000 46 4 1005 1017 (Pubitemid 30114415)
14. Gerstner E. R., Sorensen A. G., Jain R. K., Batchelor T. T., Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas Current Opinion in Neurology 2008 21 6 728 735
15. Secomb T. W., Hsu R., Dewhirst M. W., Klitzman B., Gross J. F., Analysis of oxygen transport to tumor tissue by microvascular networks International Journal of Radiation Oncology Biology Physics 1993 25 3 481 489 (Pubitemid 23068715)
16. Dasu A., Toma-Dasu I., Karlsson M., Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia Physics in Medicine and Biology 2003 48 17 2829 2842 (Pubitemid 37121463)
17. Secomb T. W., Hsu R., Ong E. T., Gross J. F., Dewhirst M. W., Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors Acta Oncologica 1995 34 3 313 316
18. Kohandel M., Kardar M., Milosevic M., Sivaloganathan S., Dynamics of tumor growth and combination of anti-angiogenic and cytotoxic therapies Physics in Medicine and Biology 2007 52 13 3665 3677 (Pubitemid 46908587)
19. Rijken P. F. J. W., Bernsen H. J. J. A., Peters J. P. W., Hodgkiss R. J., Raleigh J. A., Van Der Kogel A. J., Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis International Journal of Radiation Oncology Biology Physics 2000 48 2 571 582
20. Matzavinos A., Kao C. Y., Green J. E. F., Sutradhar A., Miller M., Friedman A., Modeling oxygen transport in surgical tissue transfer Proceedings of the National Academy of Sciences of the United States of America 2009 106 29 12091 12096
21. Thames H. D., Hendry J. H., Fractionation in Radiotherapy 1987 London, UK Taylor Francis
22. Alper T., Howard-Flanders P., Role of oxygen in modifying the radiosensitivity of E. Coli B Nature 1956 178 4540 978 979
23. Wouters B. G., Brown J. M., Cells at intermediate oxygen levels can be more important than the hypoxic fraction in determining tumor response to fractionated radiotherapy Radiation Research 1997 147 5 541 550 (Pubitemid 27204090)
24. Dasu A., Toma-Dasu I., Karlsson M., The effects of hypoxia on the theoretical modelling of tumour control probability Acta Oncologica 2005 44 6 563 571 (Pubitemid 41503602)
25. Titz B., Jeraj R., An imaging-based tumour growth and treatment response model: investigating the effect of tumour oxygenation on radiation therapy response Physics in Medicine and Biology 2008 53 17 4471 4488
26. Palcic B., Skarsgard L. D., Reduced oxygen enhancement ratio at low doses of ionizing radiation Radiation Research 1984 100 2 328 339 (Pubitemid 15223907)
27. Skarsgard L. D., Harrison I., Dose dependence of the oxygen enhancement ratio (OER) in radiation inactivation of Chinese hamster V79-171 cells Radiation Research 1991 127 3 243 247
28. Freyer J. P., Jarrett K., Carpenter S., Raju M. R., Oxygen enhancement ratio as a function of dose and cell cycle phase for radiation-resistant and sensitive CHO cells Radiation Research 1991 127 3 297 307
29. Wong R. K. W., Fyles A., Milosevic M., Pintilie M., Hill R. P., Heterogeneity of polarographic oxygen tension measurements in cervix cancer: an evaluation of within and between tumor variability, probe position, and track depth International Journal of Radiation Oncology Biology Physics 1997 39 2 405 412
30. Toma-Dasu I., Waites A., Dau A., Denekamp J., Theoretical simulation of oxygen tension measurement in tissues using a microelectrode: I. The response function of the electrode Physiological Measurement 2001 22 4 713 725 (Pubitemid 33104657)
31. Brizel D. M., Rosner G. L., Prosnitz L. R., Dewhirst M. W., Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases International Journal of Radiation Oncology Biology Physics 1995 32 4 1121 1125
32. Olive P. L., Banath J. P., Aquino-Parsons C., Measuring hypoxia in solid tumours: is there a gold standard? Acta Oncologica 2001 40 8 917 923 (Pubitemid 34098477)
33. Nordsmark M., Loncaster J., Aquino-Parsons C., Chou S. C., Ladekarl M., Havsteen H., Lindegaard J. C., Davidson S. E., Varia M., West C., Hunter R., Overgaard J., Raleigh J. A., Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas Radiotherapy and Oncology 2003 67 1 35 44 (Pubitemid 36570438)
34. Vaupel P., Harrison L., Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response The Oncologist 2004 9 5 4 9 (Pubitemid 39658340)
35. Bussink J., Kaanders J. H. A. M., Rijken P. F. J. W., Peters J. P. W., Hodgkiss R. J., Marres H. A. M., Van Der Kogel A. J., Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide Radiotherapy and Oncology 1999 50 2 173 184 (Pubitemid 29155543)