Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies

British Journal of Pharmacology

Volumn 161, Issue 6, 2010, Pages 1266-1275

  Hill, Stephen J ^a   Williams, Christine ^b   May, Lauren T ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

CAMP; Drug discovery; G protein coupled receptor; Screen; Signalling

Indexed keywords

ADENINE; CYCLIC AMP; FIREFLY LUCIFERASE; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; PHOSPHODIESTERASE INHIBITOR; TRITIUM;

BIOSENSOR; FLUORESCENCE IMAGING; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; METHODOLOGY; PRIORITY JOURNAL; REPORTER GENE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BIOSENSING TECHNIQUES; CYCLIC AMP; DRUG DELIVERY SYSTEMS; HUMANS; INTRACELLULAR MEMBRANES; RECEPTORS, DRUG; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 78049363852     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00779.x     Document Type: Review

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